Effect of halothane, isoflurane and fentanyl on spectral components of heart rate variability.

Abstract:

:We have examined the effect of isoflurane, halothane and fentanyl on heart rate variability (HRV) using power spectral analysis (PSA). Forty patients were allocated randomly to receive one of four anaesthetic techniques. Anaesthesia was induced with propofol 2 mg kg-1 and all patients breathed a mixture of 66% nitrous oxide in oxygen. Twenty of these spontaneously breathing patients received 1.5% isoflurane and 20 received 0.75% halothane. Ten patients in each of these groups received fentanyl 1 microgram kg-1 before induction. PSA was performed on 5-min segments of beat-to-beat R-R interval data taken before and 5 min after induction. No significant difference was observed in time domain or spectral HRV measures between inhalation agents. Fentanyl was associated with significantly slower heart rates, although no difference was observed in the power spectrum of those receiving fentanyl. Analysis of pooled data from the 40 subjects showed that mean heart rate was unchanged and heart rate SD was decreased, as were total and individual powers in three frequency bands of the HRV spectrum (low 0.02-0.08 Hz, mid 0.08-0.15 Hz and high 0.15-0.45 Hz). A significant decrease in the ratio of high power to (low + mid) power indicated a shift towards sympatholysis with anaesthesia. However, a significantly greater depression of mid frequency components in comparison with low or high frequencies suggests that anaesthesia selectively depressed components of the HRV mechanism, independent of a general effect on autonomic tone.

journal_name

Br J Anaesth

authors

Galletly DC,Westenberg AM,Robinson BJ,Corfiatis T

doi

10.1093/bja/72.2.177

subject

Has Abstract

pub_date

1994-02-01 00:00:00

pages

177-80

issue

2

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)44582-X

journal_volume

72

pub_type

临床试验,杂志文章,随机对照试验
  • A possible means of rapid cooling in the emergency treatment of malignant hyperpyrexia.

    abstract::A possible means of rapid cooling in the emergency treatment of malignant hyperpyrexia, peritoneal dialysis using a cold dialysate, is described. Experimental observations in a young man on a regular peritoneal dialysis regime showed that significant heat extraction can be obtained when either a cool (20 degrees C) or...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/48.5.469

    authors: Gjessing J,Barsa J,Tomlin PJ

    更新日期:1976-05-01 00:00:00

  • Surgical pleth index in children younger than 24 months of age: a randomized double-blinded trial.

    abstract:BACKGROUND:The surgical pleth index (SPI) is a measurement of intraoperative nociception. Evidence of its usability in children is limited. Given that the autonomic nervous system is still developing during the first years of life, the performance of the SPI on small children cannot be concluded from studies carried ou...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/bja/aew215

    authors: Harju J,Kalliomäki ML,Leppikangas H,Kiviharju M,Yli-Hankala A

    更新日期:2016-09-01 00:00:00

  • Differential effects of neuromuscular blocking agents on suxamethonium-induced fasciculations and myalgia.

    abstract::The effect of pretreatment with suxamethonium, gallamine or pancuronium on suxamethonium-induced fasciculations and myalgia was studied in a controlled, randomized and double-blind clinical trial. Both fasciculations and myalgia were assessed on a four-point rating scale. There was no significant correlation between f...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/60.4.367

    authors: O'Sullivan EP,Williams NE,Calvey TN

    更新日期:1988-03-01 00:00:00

  • Evaluation of a disposable patient-controlled analgesia device in children.

    abstract::A disposable patient-controlled analgesia (PCA) device was evaluated in 20 children after major abdominal, urological and orthopaedic surgery. All patients were given a high dependency level of nursing care in general wards. Efficacy (as assessed by hourly pain scores) was comparable to that achieved in a matched cont...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/68.4.411

    authors: Irwin M,Gillespie JA,Morton NS

    更新日期:1992-04-01 00:00:00

  • Visual evoked potentials and nitrous oxide-induced neuronal depression: role for benzodiazepine receptors.

    abstract::We have examined the role of benzodiazepine receptors in nitrous oxide-induced neuronal depression in rats. The changes in neuronal excitability induced by nitrous oxide and the benzodiazepine inverse agonist, Ro15-4513, were monitored by measurement of visual evoked potentials (VEP). Administration of Ro15-4513 10 mg...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/77.4.522

    authors: Dzoljic M,Erdmann W,Dzoljic MR

    更新日期:1996-10-01 00:00:00

  • Drawover anaesthesia and preoxygenation.

    abstract::We have studied the efficacy of preoxygenation using the Triservice Anaesthetic Apparatus (TSA) in healthy patients and found it to be unsatisfactory. An alternative technique suitable for field use was explored. The Mapleson D system (Bain) was found to be suitable for preoxygenation with a fresh gas flow of only 4 l...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/66.2.196

    authors: Lowe DM,McFadzean W

    更新日期:1991-02-01 00:00:00

  • Haemodynamic disturbances during anaesthesia in a patient receiving calcium channel blockers.

    abstract::Haemodynamic changes (supraventricular tachycardia, decreases in arterial pressure) were observed during laryngoscopy and intubation of the trachea in a patient receiving nifedipine and verapamil. Before the induced stresses of laryngoscopy and tracheal intubation, these drugs had controlled the patient's arterial pre...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/58.3.357

    authors: Gorven AM,Cooper GM,Prys-Roberts C

    更新日期:1986-03-01 00:00:00

  • Effects of levobupivacaine and ropivacaine on rat sciatic nerve blood flow.

    abstract:BACKGROUND:Ischaemia is one of the causative mechanisms of peripheral nerve injury, a documented complication of regional anaesthesia. Local anaesthetics per se and/or vasopressor adjuvants may account for changes in peripheral nerve blood flow. The aim of this study was to test the effects of levobupivacaine and ropiv...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aei242

    authors: Bouaziz H,Iohom G,Estèbe JP,Campana WM,Myers RR

    更新日期:2005-11-01 00:00:00

  • Effect of intravenous parecoxib on post-craniotomy pain.

    abstract:BACKGROUND:Pain management in craniotomy patients is challenging, with mild-to-moderate pain intensity, moderate-to-high risk of postoperative nausea and vomiting (PONV), and potentially catastrophic consequences of analgesic-related side-effects. The aim of this study was to determine whether i.v. parecoxib administer...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/aer223

    authors: Williams DL,Pemberton E,Leslie K

    更新日期:2011-09-01 00:00:00

  • Zomepirac, dihydrocodeine and placebo compared in postoperative pain after day-case surgery. The relationship between the effects of single and multiple doses.

    abstract::Zomepirac 100 mg and dihydrocodeine 30 mg were compared with placebo in a controlled randomized, double-blind, single-dose postoperative study. Patients continued to receive either zomepirac or dihydrocodeine for pain relief for 5 days at home in a double-blind study, being allowed to titrate the consumption of tablet...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/57.4.412

    authors: McQuay HJ,Bullingham RE,Moore RA,Carroll D,Evans PJ,O'Sullivan G,Collin J,Lloyd JW

    更新日期:1985-04-01 00:00:00

  • The role of an anaesthetist in a field hospital during the cholera epidemic among Rwandan refugees in Goma.

    abstract::In 1849 John Snow, already the leading anaesthetic practitioner and innovator of his day, made a historic contribution to the epidemiology of infectious disease by his famous study of the distribution of cholera around the area of Broad Street in London. We report on our experience as anaesthetists in a field hospital...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/75.6.810

    authors: Ginosar Y,Shapira SC

    更新日期:1995-12-01 00:00:00

  • Ro 15-1788 antagonizes the effects of diazepam in man without affecting its bioavailability.

    abstract::In a double-blind, placebo-controlled three-way cross over study, the efficacy of Ro 15-1788 200 mg, a new benzodiazepine antagonist, in blocking the amnesic, cognitive, psychomotor and subjective effects of diazepam 20 mg, was investigated in a group of six healthy male volunteers. The amnesic effects of diazepam wer...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/55.4.349

    authors: O'Boyle C,Lambe R,Darragh A,Taffe W,Brick I,Kenny M

    更新日期:1983-04-01 00:00:00

  • Cumulation of neomycin and its residual potentiation of tubocurarine in the cat.

    abstract::Cumulation and interaction of neuromuscular blocking effects of neomycin and tubocurarine were determined on responses of the tibialis anterior muscle of the anaesthetized cat to indirect stimulation. Neuromuscular block produced by neomycin was cumulative despite rapid and apparent full recovery of twitch tension and...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/53.6.571

    authors: Durant NN,Lee C,Katz RL

    更新日期:1981-06-01 00:00:00

  • Intravenous infusion of lidocaine significantly reduces propofol dose for colonoscopy: a randomised placebo-controlled study.

    abstract:BACKGROUND:Propofol use during sedation for colonoscopy can result in cardiopulmonary complications. Intravenous lidocaine can alleviate visceral pain and decrease propofol requirements during surgery. We tested the hypothesis that i.v. lidocaine reduces propofol requirements during colonoscopy and improves post-colono...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.bja.2018.06.019

    authors: Forster C,Vanhaudenhuyse A,Gast P,Louis E,Hick G,Brichant JF,Joris J

    更新日期:2018-11-01 00:00:00

  • Factors associated with prophylactic plasma transfusion before vascular catheterization in non-bleeding critically ill adults with prolonged prothrombin time: a case-control study.

    abstract:BACKGROUND:Fresh-frozen plasma (FFP) is widely used in critically ill patients, despite a weak evidence base. Factors that influence the decision to transfuse FFP before intravascular catheter insertion are poorly described. METHODS:We undertook a case-controlled study based on a prospective cohort study of 1923 admis...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aes337

    authors: Hall DP,Lone NI,Watson DM,Stanworth SJ,Walsh TS,Intensive Care Study of Coagulopathy (ISOC) Investigators.

    更新日期:2012-12-01 00:00:00

  • Regurgitation of gastric contents during general anaesthesia using the laryngeal mask airway.

    abstract::We have investigated the incidence of regurgitation of gastric contents during general anaesthesia administered via a laryngeal mask airway (LMA) or face mask and Guedel airway in 56 patients with no risk factors for regurgitation. Patients swallowed a gelatin capsule containing methylene blue 10 min before induction ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/69.3.314

    authors: Barker P,Langton JA,Murphy PJ,Rowbotham DJ

    更新日期:1992-09-01 00:00:00

  • Haemodynamic response to simulated haemorrhage in the rabbit: interaction of i.v. anaesthesia and hypoxia.

    abstract::We have studied in eight rabbits the cardiovascular effects of midazolam, propofol and alfentanil with graded hypoxia. Central blood volume was reduced progressively by gradual inflation of a thoracic vena cava cuff so that cardiac index (CI) decreased at a constant rate. Under control conditions the haemodynamic resp...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/75.5.610

    authors: Blake DW,Van Leeuwen AF,Petring OU,Ludbrook J,Ventura S

    更新日期:1995-11-01 00:00:00

  • Malignant hyperpyrexia and sudden infant death syndrome.

    abstract::This paper reports three investigations of the suggested relationship between sudden infant death syndrome (SIDS) and malignant hyperpyrexia (MH). In the first study 151 MH-susceptible families completed a questionnaire designed to identify the incidence of SIDS within their own pedigree. In the second study 106 SIDS ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/60.1.28

    authors: Ellis FR,Halsall PJ,Harriman DG

    更新日期:1988-01-01 00:00:00

  • Comparison of intubating laryngeal mask airway and Bullard laryngoscope for oro-tracheal intubation in adult patients with simulated limitation of cervical movements.

    abstract:BACKGROUND:Intubation of a patient with limited cervical spine movement or in whom movement of the cervical spine is not desirable is always a challenge even to the most experienced anaesthesiologist. The intubating laryngeal mask airway (ILMA) and the Bullard laryngoscope (BL) are two instruments recommended for endot...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/bja/aem127

    authors: Nileshwar A,Thudamaladinne A

    更新日期:2007-08-01 00:00:00

  • Pharmacokinetic and clinical study of ropivacaine and bupivacaine in women receiving extradural analgesia in labour.

    abstract::We have compared, in a randomized, double-blind study, the pharmacokinetics of ropivacaine and bupivacaine during labour. Total and free plasma concentrations of ropivacaine and bupivacaine were measured after the first of two extradural doses. The main dose was 20 mg (test dose) and 30 mg, with a top-up dose of 25 mg...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/79.5.558

    authors: McCrae AF,Westerling P,McClure JH

    更新日期:1997-11-01 00:00:00

  • Hepatic disposition of methohexitone in patients undergoing coronary bypass surgery.

    abstract::In order to clarify the relative contribution of hepatic metabolism to the short term disposition of methohexitone, we have measured hepatic blood flow during induction of anaesthesia with a 1.5-mg kg-1 i.v. bolus dose of methohexitone. Median hepatic clearance was 1.01 litre min-1 and hepatic extraction 87%. As a con...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/69.5.478

    authors: Lange H,Stephan H,Brand C,Zielmann S,Sonntag H

    更新日期:1992-11-01 00:00:00

  • Analgesic effects of parecoxib following total abdominal hysterectomy.

    abstract:BACKGROUND:Forty-eight ASA I-II patients undergoing total abdominal hysterectomy (TAH) were studied in a double blind, randomized placebo controlled trial of parecoxib for postoperative analgesia. METHODS:All patients were given propofol 2-4 mg kg(-1) i.v., a non-depolarizing muscle relaxant, morphine 10 mg i.v. and p...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/aeg139

    authors: Ng A,Smith G,Davidson AC

    更新日期:2003-06-01 00:00:00

  • Double-blind randomized controlled trial to determine extent of amnesia with midazolam given immediately before general anaesthesia.

    abstract:BACKGROUND:Anterograde, but not retrograde, amnesia has been demonstrated following midazolam administration. However, there have been no studies investigating whether or not immediate retrograde amnesia can be produced with midazolam. METHODS:After ethics committee approval and consent, 40 adult patients undergoing s...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/aei040

    authors: Bulach R,Myles PS,Russnak M

    更新日期:2005-03-01 00:00:00

  • Dose requirements of propofol by infusion during nitrous oxide anaesthesia in man. I: Patients premedicated with morphine sulphate.

    abstract::The study was performed to determine the ED50 and ED95 of a continuous infusion of the emulsion formulation of propofol during 67% nitrous oxide anaesthesia in 57 patients premedicated with morphine sulphate 0.15 mg kg-1. Anaesthesia was induced with propofol 2 mg kg-1, and maintained before incision with a fixed-rate...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/58.10.1080

    authors: Spelina KR,Coates DP,Monk CR,Prys-Roberts C,Norley I,Turtle MJ

    更新日期:1986-10-01 00:00:00

  • An unusual complication of extradural catheterization in obstetric anaesthesia.

    abstract::An extradural catheter was inserted at the third lumbar interspace for relief of pain during labour in a 21-year-old gravid patient. Attempts to withdraw the catheter met with resistance and produced severe pain in the distribution of the second left lumbar nerve. Radiography revealed an acutely angled loop of the cat...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/55.5.473

    authors: Sidhu MS,Asrani RV,Bassell GM

    更新日期:1983-05-01 00:00:00

  • Comparison of the effects of thoracic and lumbar epidural anaesthesia on induction and maintenance doses of propofol during total i.v. anaesthesia.

    abstract:BACKGROUND:In this randomized, double-blind study, the effects of thoracic and lumbar epidural anaesthesia on the induction doses (IDs) and maintenance doses (MDs) of propofol during bispectral index (BIS) guided total i.v. anaesthesia were compared. METHODS:Fifty-four patients (three groups, n=18 each) undergoing uro...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/bja/aen160

    authors: Sentürk M,Güçyetmez B,Ozkan-Seyhan T,Karadeniz M,Dinçer S,Akpir D,Sengül T,Denkel T

    更新日期:2008-08-01 00:00:00

  • Components of the inspiratory-arterial isoflurane partial pressure difference.

    abstract::We have measured the partial pressure of isoflurane simultaneously in inspired gas (PIiso), end-expired gas (PE'iso), mixed-expired gas (PEiso), arterial (Paiso) and mixed venous blood (Pviso) in six patients (aged 57-79 yr) anaesthetized with nitrous oxide, oxygen and isoflurane before surgery and after PE'iso had be...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/70.6.605

    authors: Landon MJ,Matson AM,Royston BD,Hewlett AM,White DC,Nunn JF

    更新日期:1993-06-01 00:00:00

  • Prolonged brachial plexus block with 0.42% bupivacaine.

    abstract::A 55-yr-old man received a left supraclavicular brachial plexus block with 0.42% bupivacaine; he had profound motor and sensory block 26 h after injection; complete recovery occurred at 40 h. ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/63.5.604

    authors: Brockway MS,Winter AW,Wildsmith JA

    更新日期:1989-11-01 00:00:00

  • Isoflurane induces endoplasmic reticulum stress and caspase activation through ryanodine receptors.

    abstract:BACKGROUND:Isoflurane has been reported to induce caspase-3 activation, which may induce neurotoxicity and contribute to the pathogenesis of Alzheimer's disease. However, the underlying mechanism is largely unknown, especially whether or not isoflurane can induce ryanodine receptors (RyRs)-associated endoplasmic reticu...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aeu053

    authors: Wang H,Dong Y,Zhang J,Xu Z,Wang G,Swain CA,Zhang Y,Xie Z

    更新日期:2014-10-01 00:00:00

  • The effects of general anaesthetics on ligand-gated ion channels.

    abstract::The experimental effort that has been expended in investigating the effects of general anaesthetics on LGICs has been enormous over the past decade. Members of all three LGIC superfamilies have been examined using electrophysiological techniques. Anaesthetics that have been examined include volatile anaesthetics, gase...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1093/bja/aef161

    authors: Dilger JP

    更新日期:2002-07-01 00:00:00