Pharmacokinetic and clinical study of ropivacaine and bupivacaine in women receiving extradural analgesia in labour.

Abstract:

:We have compared, in a randomized, double-blind study, the pharmacokinetics of ropivacaine and bupivacaine during labour. Total and free plasma concentrations of ropivacaine and bupivacaine were measured after the first of two extradural doses. The main dose was 20 mg (test dose) and 30 mg, with a top-up dose of 25 mg when requested. After the main dose, Cpmax (total) of ropivacaine (0.50 mg litre-1) was similar to that of bupivacaine (0.48 mg litre-1). At 20 min, Cpmax (free) of ropivacaine (0.04 mg litre-1) was higher than that of bupivacaine (0.02 mg litre-1) (P = 0.0025). The clinical effectiveness of the block was similar in both groups.

journal_name

Br J Anaesth

authors

McCrae AF,Westerling P,McClure JH

doi

10.1093/bja/79.5.558

subject

Has Abstract

pub_date

1997-11-01 00:00:00

pages

558-62

issue

5

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)39779-9

journal_volume

79

pub_type

临床试验,杂志文章,随机对照试验
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