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Effect of interpleural morphine on postoperative pain and pulmonary function after thoracotomy.

Abstract：

:We have investigated the effect of interpleural morphine on postoperative pain and pulmonary function after thoracotomy. At the end of surgery, an interpleural catheter was inserted in 17 patients and, in a double-blind and randomized manner, either a bolus of morphine 2.5 mg interpleurally (i.p.) and normal saline i.v. (group I) or, as a control for systemic absorption, morphine 2.5 mg i.v. and i.p. saline (group II) was injected. After the initial bolus, a continuous infusion of morphine 0.5 mg h-1 i.p. and saline i.v. (group I) or morphine 0.5 mg i.v. and saline i.p. (group II) was maintained for 24 h. Postoperative pain was assessed by a visual analogue scale, a numerical rating scale and the McGill Pain Questionnaire. Pulmonary function was assessed by spirometry. Supplementary analgesics, side effects, degree of sedation, vital signs and chest tube drainage were recorded. All variables were assessed on the day before surgery and 1, 2, 3, 4, 5, 6 and 24 h and 7 days after surgery. Supplementary morphine was given upon request. There was no significant difference in any pain measure or postoperative pulmonary function variable between the groups. We conclude that, after thoracotomy, interpleural morphine does not provide superior analgesia or improve pulmonary function compared with systemic morphine.

journal_name

Br J Anaesth

journal_title

British journal of anaesthesia

authors

Welte M,Haimerl E,Groh J,Briegel J,Sunder-Plassmann L,Herz A,Peter K,Stein C

doi

10.1093/bja/69.6.637

subject

Has Abstract

pub_date

1992-12-01 00:00:00

pages

637-9

issue

6

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)45984-8

journal_volume

69

pub_type

临床试验,杂志文章,随机对照试验

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