Abstract：
:The identification of a serum marker to assist in the diagnosis of cerebral injury after cardiac surgery is potentially useful. S100 protein is an early marker of cerebral damage. It is released after cardiac surgery performed under cardiopulmonary bypass (CPB). Its level is correlated with the duration of CPB, deep circulatory arrest and aortic cross-clamping. Increased levels of S100 protein are correlated with the age of the patient and the number of microemboli, especially during aortic cannulation. Perioperative cerebral complications such as stroke, delayed awakening and confusion are associated with increased levels of S100 protein directly after bypass and from 15 to 48 h after it. In addition, increased levels of S100 protein are related to neuropsychological dysfunction after cardiac surgery. S100 protein has early and late release patterns after CPB; the early pattern may be due to sub-clinical brain injury. The late release pattern may be due to perioperative cerebral complications. Patients undergoing intracardiac operations combined with coronary artery bypass surgery are more susceptible to brain injury and have higher levels of S100 after CPB. Furthermore, adults and children undergoing deep circulatory arrest are more susceptible to brain injury, in terms of higher S100 protein release after CPB. Serum S100 protein levels are reduced after using arterial line filtration and covalent-bonded heparin to coat the inner surface of the CPB circuit.
journal_name
Br J Anaesthjournal_title
British journal of anaesthesiaauthors
Ali MS,Harmer M,Vaughan Rdoi
10.1093/bja/85.2.287subject
Has Abstractpub_date
2000-08-01 00:00:00pages
287-98issue
2eissn
0007-0912issn
1471-6771pii
S0007-0912(17)37319-1journal_volume
85pub_type
杂志文章,评审abstract：:Cerebral emboli detected by transcranial Doppler imaging were recorded in 20 patients undergoing multiple-vessel coronary artery bypass surgery, either with or without cardiopulmonary bypass, in a prospective unblinded comparative study. Emboli were recorded continuously from the time of pericardial incision until 10 ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/84.5.629
更新日期：2000-05-01 00:00:00
abstract：BACKGROUND:The population in the UK is growing older and the number of elderly patients cared for on intensive care units (ICU) is increasing. This study was designed to identify risk factors for mortality in critically ill patients of >80 yr of age after surgery. METHODS:We identified 275 patients, aged 80 yr or grea...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aem307
更新日期：2007-12-01 00:00:00
abstract：:We have used the technique of double-blind sequential allocation to quantify the minimum local analgesic concentration (MLAC) of extradural bupivacaine for women in early (median cervical dilatation 2 cm) and late (median cervical dilatation 5 cm) labour. The first bolus was 20 ml of the bupivacaine test solution. The...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章
doi：10.1093/bja/80.1.11
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND:The molecular actions underlying the clinical effects of inhaled anaesthetics such as sevoflurane and isoflurane are not fully understood. Unexpected observations in positron emission tomography (PET) studies with [11C]AZD9272, a metabotropic glutamate receptor 5 (mGluR5) radioligand with possible affinity f...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1016/j.bja.2020.08.052
更新日期：2021-01-01 00:00:00
abstract：:Both the performance of breathing systems and recommendations for the fresh gas flows to be used in patients breathing spontaneously can be expressed in ml kg-1 min-1 or fresh gas: total ventilation ratio (VF:VE). We have examined the relationship between these two descriptions. The data of 106 subjects (awake volunte...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/71.6.796
更新日期：1993-12-01 00:00:00
abstract：:Postoperative management following major surgery in patients with neuromuscular disorders associated with scoliosis is frequently complicated by sputum retention and ventilatory failure. This report demonstrates the successful perioperative management of an 11-yr-old boy with type II spinal muscular atrophy undergoing...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aef227
更新日期：2002-10-01 00:00:00
abstract：:In this study, we simultaneously evaluated the spasmolytic effects of prostaglandin E1 (PGE1) on serotonin-induced bronchoconstriction and pulmonary hypertension. Eleven mongrel dogs (8-12 kg) anaesthetized with pentobarbital were assigned to two groups: saline (n = 4) and PGE1 (n = 7). Bronchoconstriction and pulmona...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/85.3.460
更新日期：2000-09-01 00:00:00
abstract：:This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief, Professor Hugh Hemmings, based on the recommendations of Justus-Liebig-University Giessen f...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,撤回出版物
doi：10.1016/j.bja.2020.07.036
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND:Short-axis ultrasound-guided placement of central venous catheters (CVCs) is widely accepted as safe practice. However, utilizing the long-axis approach could further improve safety, as it allows for better visualization of the needle as it is advanced to the target vessel. However, the long-axis approach ha...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1093/bja/aer329
更新日期：2012-01-01 00:00:00
abstract：:A blind comparison was made of butorphanol 2 mg with morphine 10 mg i.m. as the sole premedication in four groups, each of 10 women, undergoing total abdominal hysterectomy. On both subjective and objective grounds, butorphanol was as effective as morphine with the advantage of fewer unwanted side-effects, although on...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/56.4.363
更新日期：1984-04-01 00:00:00
abstract：:A double-blind trial was undertaken to compare the effects of trimeprazine tartrate (2 mg kg-1 or 4 mg kg-1) plus atropine 0.03 mg kg-1 for oral premedication of 192 children undergoing tonsillectomy. Demeanour before operation, side-effects after operation, recovery times and fluid balance were studied. Behaviour in ...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/53.8.821
更新日期：1981-08-01 00:00:00
abstract：:Respiratory mass spectrometry and on-line computation were used to estimate lung volume in normal subjects by a rebreathing technique, using oxygen, nitrogen and argon as indicators. The computation had previously been tested in a numerical model. In real normal lungs, it performed well enough for practical purposes, ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/56.5.509
更新日期：1984-05-01 00:00:00
abstract：BACKGROUND:Inconsistent and poorly coordinated systems of tracheostomy care commonly result in frustrations, delays, and harm. Quality improvement strategies described by exemplar hospitals of the Global Tracheostomy Collaborative have potential to mitigate such problems. This 3 yr guided implementation programme inves...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,多中心研究
doi：10.1016/j.bja.2020.04.064
更新日期：2020-07-01 00:00:00
abstract：:This article briefly reviews psychological aspects of pain, paying special attention to chronic pain. The review considers the interruptive and interference effects of pain and its impact on a person's identity. The importance of processes related to interruption, interference, and identity will vary across people and...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,评审
doi：10.1093/bja/aen123
更新日期：2008-07-01 00:00:00
abstract：:Artery-to-muscle (A-M) onset time for five neuromuscular blocking agents was studied in 50 female patients under light endotracheal anaesthesia. Circulation to the right arm was occluded by a tourniquet and released 1 min after the injection i.v. into the left arm of a myoneural blocking drug. Muscle twitches were rec...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/52.4.403
更新日期：1980-04-01 00:00:00
abstract：BACKGROUND:Multi-injection targeted intracluster injection ultrasound-guided supraclavicular brachial plexus block has been advocated to provide a faster onset of anaesthesia compared with a double injection technique. By placing the needle within clusters of hypoechoic structures, corresponding to neural tissue, this ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1016/j.bja.2019.01.006
更新日期：2019-06-01 00:00:00
abstract：:The central venous catheter (CVC) is associated with numerous complications more so during the process of insertion. We report for the first time how an indwelling catheter was entrapped by a replacement catheter on the same side, after being speared by the introducer needle and guidewire. The diagnosis was made when ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/ael286
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:Chronic pain is no longer an effective warning system, but a syndrome with co-morbidities and many causes, needing a careful evaluation. Questions remain about the pain behaviour of chronic pain patients compared with patients with acute pain, or healthy subjects that we investigated. METHODS:We compared th...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章
doi：10.1016/j.bja.2018.04.042
更新日期：2018-09-01 00:00:00
abstract：:We have compared, in a randomized study in 26 patients, immediate and late postoperative recovery after elective laparoscopic cholecystectomy using the gasless, mechanical abdominal wall lift method with conventional carbon dioxide pneumoperitoneum. After the gasless method, tracheal extubation was performed significa...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/77.5.576
更新日期：1996-11-01 00:00:00
abstract：:General anaesthesia for emergency surgery in a pressurized habitat is likely to involve the use of i.v. agents. The anaesthetic property of such agents is known to be antagonized by pressure, but the effect on their duration of action is not easily predicted. The recovery of mice from a single i.v. dose of Althesin, k...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/53.5.455
更新日期：1981-05-01 00:00:00
abstract：BACKGROUND:Endothelial dysfunction might be involved in the development of cerebral vasospasm after aneurysmal subarachnoid haemorrhage (SAH). METHODS:This prospective observational study of 48 SAH subjects and 23 control subjects examined associations between reactive hyperaemia index (RHI) measured by peripheral art...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aet331
更新日期：2014-02-01 00:00:00
abstract：:Changes in intragastric pressure after the administration of suxamethonium 1.5 mg kg-1 i.v. were studied in 32 children (mean age 6.9 yr) pretreated with either physiological saline or alfentanil 50 micrograms kg-1. Anaesthesia was induced with thiopentone 5 mg kg-1. The incidence and intensity of muscle fasciculation...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/60.2.176
更新日期：1988-02-01 00:00:00
abstract：BACKGROUND:The aim of this study was to evaluate the efficacy of palonosetron, the latest 5-HT3 receptor antagonist, for the prevention of postoperative nausea and vomiting (PONV) during the first 72 h after operation. METHODS:In this randomized, double-blinded, placebo-controlled study, 204 healthy inpatients who wer...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1093/bja/aet340
更新日期：2014-03-01 00:00:00
abstract：:The use of atracurium in 25 patients undergoing general surgical procedures is described, neuromuscular function being monitored by the "train-of-four" stimuli. An initial dose of atracurium 0.5 mg kg-1 proved to be clinically acceptable, giving good conditions for endotracheal intubation and adequate muscle relaxatio...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/54.12.1243
更新日期：1982-12-01 00:00:00
abstract：BACKGROUND:Prolonged postoperative decrease in lung function is common after major upper abdominal surgery. Evidence suggests that ventilation with low tidal volumes may limit the damage during mechanical ventilation. We compared postoperative lung function of patients undergoing upper abdominal surgery, mechanically v...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1093/bja/aes140
更新日期：2012-08-01 00:00:00
abstract：:In order to investigate the analgesic effect of timing of administration of ketorolac 10 mg i.v., we recorded patient-controlled use of diamorphine at 2, 4 and 12 h after abdominal hysterectomy. In a randomized, double-blind trial, 30 patients received ketorolac before skin incision and 28 after skin closure. A contro...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/75.1.15
更新日期：1995-07-01 00:00:00
abstract：:In 105 patients undergoing day-case surgery recovery of consciousness was significantly faster after enfluane compared with halothane anaesthesia. There was no difference in postoperative morbidity between the two anaesthetic groups. ...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/51.12.1143
更新日期：1979-12-01 00:00:00
abstract：:Amethocaine 1% solution was mixed with equal volumes of water, 0.9% saline or 10% dextrose to prepare respectively, hypobaric, isobaric and hyperbaric solutions which were compared for intradural spinal anaesthesia in 60 patients. Thirty patients received 10 mg and 30 patients received 15 mg of amethocaine. Injections...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/52.6.589
更新日期：1980-06-01 00:00:00
abstract：BACKGROUND:The properties of methadone suggest a potential advantage for epidural over i.v. administration for pain relief, but little supportive evidence exists. METHODS:To investigate the pharmacokinetic and the pharmacodynamic properties of epidural and i.v. methadone, four doses of methadone (0.1, 0.25, 0.5, and 0...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aet234
更新日期：2014-01-01 00:00:00
abstract：:We have investigated, in six healthy male volunteers, the effect of high thoracic extradural anaesthesia on the ventilatory pattern and hypercapnic ventilatory response. Ventilatory variables were determined using a respiratory inductive plethysmograph. Duration of inspiration, rib cage excursion and its contribution ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/62.4.362
更新日期：1989-04-01 00:00:00
