Efficacy of palonosetron for the prevention of postoperative nausea and vomiting: a randomized, double-blinded, placebo-controlled trial.

abstract：:Pyridostigmine 0.143 mg kg-1 (maximum 10 mg) and atropine 0.0143 mg kg-1 (maximum 1 mg) were administered i.v. to six healthy male volunteers. Peripheral venous blood samples were drawn for measurement of serum cholinesterase activity. Maximum inhibition of the enzyme was found 5 min after injection with a decrease to...

journal_title：British journal of anaesthesia

authors： Feldt-Rasmussen BF,Gefke K,Mosbech H,Hanel HK

更新日期：1985-02-01 00:00:00

abstract：:Advances in cannabis research have paralleled developments in opioid pharmacology whereby a psychoactive plant extract has elucidated novel endogenous signalling systems with therapeutic significance. Cannabinoids (CBs) are chemical compounds derived from cannabis. The major psychotropic CB delta-9-tetrahydrocannabino...

journal_title：British journal of anaesthesia

authors： Hosking RD,Zajicek JP

更新日期：2008-07-01 00:00:00

abstract：:The effect of the combination of opiates and hypnotics on bispectral index (BIS) is unclear. This double-blind placebo-controlled trial investigated the effect on BIS and sedation of different infusion doses of remifentanil combined with a steady infusion of propofol. Forty patients initially received a target-control...

journal_title：British journal of anaesthesia

authors： Strachan AN,Edwards ND

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Dynamic variables reliably predict fluid responsiveness (FR) in adults, but no data are available regarding their performance in infants. The aim of this prospective study was to assess whether pulse pressure variation (PPV) and stroke volume variation (SVV), in contrast to central venous pressure (CVP) and ...

journal_title：British journal of anaesthesia

authors： Renner J,Broch O,Duetschke P,Scheewe J,Höcker J,Moseby M,Jung O,Bein B

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The effect of anaesthetic drugs on long-term oncological outcomes after cancer surgery is an area of current interest. Dexamethasone is widely used in anaesthetic practice; however, its effect on long-term survival and cancer outcomes is not known. This study presents the results of a 5-yr follow-up of patie...

journal_title：British journal of anaesthesia

authors： Singh PP,Lemanu DP,Taylor MH,Hill AG

更新日期：2014-07-01 00:00:00

abstract：:The pharmaceutical formulation of Althesin was shown to have a weak allergenic potential in the guinea pig maximization test. Alphadolone and alphaxalone acetate were found to be devoid of such potential, while the status of Cremophor EL remained equivocal. ...

journal_title：British journal of anaesthesia

authors： Tachon P,Descotes J,Laschi-Loquerie A,Guillot JP,Evreux JC

更新日期：1983-08-01 00:00:00

abstract：:In a prospective study, patients undergoing abdominal surgery were allocated randomly to receive intermittent morphine 10 mg i.m. (n = 41) or a single injection of buprenorphine 0.3 mg i.m. followed by sublingual buprenorphine 0.4 mg every 6 h (n = 39) for 3 days following operation. Patients receiving buprenorphine w...

journal_title：British journal of anaesthesia

authors： Cuschieri RJ,Morran CG,McArdle CS

更新日期：1984-08-01 00:00:00

abstract：BACKGROUND:Individual patient information from clinical trials is infrequently available, but can provide insights for clinical trials and practice. METHODS:We analysed individual patient information from five randomized trials (913 patients) of i.v. patient-controlled analgesia (IVPCA) plus epidural placebo, morphine...

journal_title：British journal of anaesthesia

authors： Mhuircheartaigh RJ,Moore RA,McQuay HJ

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Data on contributors to between-individual variability in overall tramadol clearance and O-demethyl tramadol (M1) formation in preterm neonates and young infants are limited. METHODS:A population pharmacokinetic analysis of tramadol and M1 was undertaken using non-linear mixed effects model. Covariate analy...

journal_title：British journal of anaesthesia

authors： Allegaert K,van den Anker JN,de Hoon JN,van Schaik RH,Debeer A,Tibboel D,Naulaers G,Anderson BJ

更新日期：2008-04-01 00:00:00

abstract：:Haemodynamic changes (supraventricular tachycardia, decreases in arterial pressure) were observed during laryngoscopy and intubation of the trachea in a patient receiving nifedipine and verapamil. Before the induced stresses of laryngoscopy and tracheal intubation, these drugs had controlled the patient's arterial pre...

journal_title：British journal of anaesthesia

authors： Gorven AM,Cooper GM,Prys-Roberts C

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND:Ultrasound-guided internal jugular venous access increases the rate of successful cannulation and reduces the incidence of complications, compared with the landmark technique. Three transducer orientation approaches have been proposed for this procedure: short-axis (SAX), long-axis (LAX) and oblique-axis (OA...

journal_title：British journal of anaesthesia

authors： Batllori M,Urra M,Uriarte E,Romero C,Pueyo J,López-Olaondo L,Cambra K,Ibáñez B

更新日期：2016-03-01 00:00:00

abstract：:Forty patients (age range 60-79 yr) undergoing transurethral surgery were allocated randomly to receive 0.5% plain bupivacaine 4 ml at the L2-3 (n = 20) or L4-5 (n = 20) space. The solution was injected over 30 s with the patient in the sitting position. The patient was kept sitting for 2 min, then placed supine and, ...

journal_title：British journal of anaesthesia

authors： Olsen KH,Nielsen TH,Kristoffersen E,Husegaard HC,Wernberg M,Dørup J

更新日期：1990-02-01 00:00:00

abstract：:We have compared, in a double-blind study, the efficacy of flumazenil with that of aminophylline in antagonizing the effects of midazolam in 60 patients (ASA I-II, mean age 66 yr) undergoing transurethral resection of prostate under spinal anaesthesia. All patients received midazolam 0.075 mg kg-1 i.v. and the test dr...

journal_title：British journal of anaesthesia

authors： Sibai AN,Sibai AM,Baraka A

更新日期：1991-05-01 00:00:00

abstract：:The analgesic effect of subanaesthetic concentrations of ether, trichloroethylene, methoxyflurane and halothane has been investigated previously using either clinical assessment or pain threshold measurements, but with conflicting results. The purpose of the present study was to evaluate the analgesic effect of isoflu...

journal_title：British journal of anaesthesia

authors： Petersen-Felix S,Arendt-Nielsen L,Bak P,Roth D,Fischer M,Bjerring P,Zbinden AM

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:Infraclavicular axillary vein cannulation is not commonly used for central venous access because identifying the surface landmarks is difficult. Ultrasound guided axillary vein puncture has not been well described. We assessed ultrasound imaging to guide catheterization of the infraclavicular axillary vein. ...

journal_title：British journal of anaesthesia

authors： Sharma A,Bodenham AR,Mallick A

更新日期：2004-08-01 00:00:00

abstract：:The pharmacokinetics of edrophonium were determined in patients anaesthetized with nitrous oxide and halothane undergoing kidney transplant nephrectomy (n=6) or transplantation of a live related donor kidney (n = 6). Serum concentrations of edrophonium were assayed by high pressure liquid chromatography and pharmacoki...

journal_title：British journal of anaesthesia

authors： Morris RB,Cronnelly R,Miller RD,Stanski DR,Fahey MR

更新日期：1981-12-01 00:00:00

abstract：:A patient with Ebstein's anomaly undergoing anaesthesia for the operation of hysterectomy is reported. The considerations relating to the risk of an increased right-to-left intracardiac shunt are discussed. The patient was anaesthetized successfully with a combination of nitrous oxide, droperidol and fentanyl. ...

journal_title：British journal of anaesthesia

authors： Bengtsson IM,Magno R,Wickström I

更新日期：1977-05-01 00:00:00

abstract：:We have assessed tracheal intubating conditions in 60 ASA I or II patients after induction of anaesthesia with propofol 2.5 mg kg-1 and alfentanil 10 or 20 micrograms kg-1 with or without i.v. lignocaine 1 mg kg-1. No neuromuscular blocking agents were administered. Patients were allocated randomly to four groups: gro...

journal_title：British journal of anaesthesia

authors： Davidson JA,Gillespie JA

更新日期：1993-02-01 00:00:00

abstract：:We compared psychomotor recovery after total intravenous anaesthesia (TIVA) with remifentanil/propofol and balanced anaesthesia (BAL) with etomidate/fentanyl/isoflurane in 40 patients, ASA I-III, aged > or =80 yr undergoing elective cataract surgery. Recovery times were recorded and psychomotor recovery was assessed a...

journal_title：British journal of anaesthesia

authors： Kubitz J,Epple J,Bach A,Motsch J,Martin E,Schmidt H

更新日期：2001-02-01 00:00:00

abstract：:Day-case anaesthesia requires rapidly eliminated anaesthetics which are relatively expensive. This multinational, multicentre European study assessed the relative costs of propofol or sevoflurane anaesthesia in 211 patients. Anaesthesia was induced and maintained with propofol in group 1, with propofol and sevoflurane...

journal_title：British journal of anaesthesia

authors： Smith I,Terhoeve PA,Hennart D,Feiss P,Harmer M,Pourriat JL,Johnson IA

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:The 'cannot intubate cannot oxygenate' (CICO) emergency requires urgent front of neck airway (FONA) access to prevent death. In cases reported to the 4th National Audit Project, the most successful FONA was a surgical technique, almost all of which were performed by surgeons. Subsequently, UK guidelines adop...

journal_title：British journal of anaesthesia

authors： Groom P,Schofield L,Hettiarachchi N,Pickard S,Brown J,Sandars J,Morton B

更新日期：2019-11-01 00:00:00

abstract：:The majority of patients with acute respiratory distress syndrome (ARDS) require mechanical ventilation. This support provides time for the lungs to heal, but the adverse effects of mechanical ventilation significantly influence patient outcome. Traditionally, these were ascribed to mechanical effects, such as haemody...

journal_title：British journal of anaesthesia

authors： Moloney ED,Griffiths MJ

更新日期：2004-02-01 00:00:00

abstract：Background.:Perioperative administration of cefazolin reduces the incidence of perioperative infections. Intraoperative re-dosing of cefazolin is commonly given between 2 and 5 h after the initial dose. This study was undertaken to determine whether intraoperative continuous infusions of cefazolin achieve better probab...

journal_title：British journal of anaesthesia

authors： Naik BI,Roger C,Ikeda K,Todorovic MS,Wallis SC,Lipman J,Roberts JA

更新日期：2017-06-01 00:00:00

abstract：:As constant hypoxaemia itself may trigger development of apnoea and periodic breathing, we have studied the effect of oxygen therapy on the occurrence of late postoperative episodic hypoxaemia. Thirty-five patients without cardiopulmonary disease and undergoing elective total hip replacement were monitored with a puls...

journal_title：British journal of anaesthesia

authors： Rosenberg J,Pedersen MH,Gebuhr P,Kehlet H

更新日期：1992-01-01 00:00:00

abstract：:The neuromuscular blocking effects of equipotent doses of the three putative metabolites of vecuronium (3-hydroxy vecuronium, 17-hydroxy vecuronium and 3,17-dihydroxy vecuronium) were compared with those of an equipotent dose of vecuronium. Results obtained with the liver excluded from the circulation and after intrap...

journal_title：British journal of anaesthesia

authors： Bencini AF,Houwertjes MC,Agoston S

更新日期：1985-08-01 00:00:00

abstract：BACKGROUND:Desflurane at more than 1 minimum alveolar concentration (MAC) has been shown to prolong the QT interval, but it is unclear whether this is the case at lower concentrations. The aim of this study was to determine whether desflurane concentrations of <1 MAC affect tracheal intubation-induced prolongation of t...

journal_title：British journal of anaesthesia

authors： Kim SH,Park SY,Chae WS,Jin HC,Lee JS,Kim YI

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:The Alaris AEP monitor(TM) (Alaris, UK, version 1.4) is the first commercially available auditory evoked potential (AEP) monitor designed to estimate the depth of anaesthesia. It generates an "Alaris AEP index" (AAI), which is a dimensionless number scaled from 100 (awake) to 0. This study was designed to co...

journal_title：British journal of anaesthesia

authors： Kreuer S,Bruhn J,Larsen R,Hoepstein M,Wilhelm W

更新日期：2003-09-01 00:00:00

abstract：:We have compared the effects of inhalation of aerosolized surfactant on experimental acute respiratory distress syndrome. Escherichia coli endotoxin (55 (SD 20) mg kg(-1)) was injected into the tracheas of 36 adult rats anaesthetized and mechanically ventilated with pure oxygen. When the Pa(O(2)) decreased to 11.3 (3....

journal_title：British journal of anaesthesia

authors： Tashiro K,Yamada K,Konzaki T,Yamamoto K,Ohmura S,Kobayashi T,Suzuki Y

更新日期：2001-08-01 00:00:00

abstract：:The activity of a new i.v. anesthetic agent ICI 35 868, a compound unrelated to currently used barbiturate, eugenol or steroid agents, has been examined in a range of animal species. Some of the properties of ICI 35 868 resemble those of thiopentone in that it is a rapidly acting agent which produces anaesthesia of sh...

journal_title：British journal of anaesthesia

authors： Glen JB

更新日期：1980-08-01 00:00:00

abstract：BACKGROUND:The Bispectral Index (BIS) monitor has been suggested as a potential tool to measure depth of sedation in paediatric intensive care unit (PICU) patients. The primary aim of our observational study was to assess the difference in BIS values between the left and right sides of the brain. Secondary aims were to...

journal_title：British journal of anaesthesia

authors： Froom SR,Malan CA,Mecklenburgh JS,Price M,Chawathe MS,Hall JE,Goodwin N

更新日期：2008-05-01 00:00:00