Association between preoperative glucocorticoids and long-term survival and cancer recurrence after colectomy: follow-up analysis of a previous randomized controlled trial.


BACKGROUND:The effect of anaesthetic drugs on long-term oncological outcomes after cancer surgery is an area of current interest. Dexamethasone is widely used in anaesthetic practice; however, its effect on long-term survival and cancer outcomes is not known. This study presents the results of a 5-yr follow-up of patients receiving dexamethasone before elective colectomy as part of a previous randomized clinical trial. METHODS:Sixty patients who underwent elective open colonic resection for any indication between June 2006 and March 2008 were randomized to receive either 8 mg i.v. dexamethasone or placebo before surgery. A 5-yr follow-up analysis was conducted to evaluate overall survival, disease-free survival and recurrence specifically for patients undergoing resection for Stage I-III colon cancer. Kaplan-Meier analysis was performed and log-rank test was used to evaluate difference in survival between groups. RESULTS:Forty-three of the 60 subjects had Stage I-III colon cancer and were included in the follow-up analysis. Twenty received preoperative dexamethasone and 23 received placebo. There were no significant differences between groups in baseline or disease characteristics. No differences were found between groups for overall or disease-free survival. In the dexamethasone group, there was a significantly higher rate of distant recurrence (6 compared with 1, P=0.04). CONCLUSIONS:Preoperative dexamethasone was associated with a higher rate of distant recurrence in patients undergoing colectomy for colon cancer. Given the small sample size, this finding should be interpreted with caution, but warrants further investigation in a prospective study.


Br J Anaesth


Singh PP,Lemanu DP,Taylor MH,Hill AG




Has Abstract


2014-07-01 00:00:00










113 Suppl 1


  • Effect of changes in arterial-mixed venous oxygen content difference (C(a-v)O2) on indices of pulmonary oxygen transfer in a model ARDS lung.

    abstract::Many indices are used to quantify pulmonary oxygen transfer. Indices that use only measurements from arterial blood and inspired gas assume a constant C(a-v)O2. Though variations in C(a-v)O2 are recognized, indices such as PaO2/FIO2 remain popular and are often considered the best measure of pulmonary oxygen transfer ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Nirmalan M,Willard T,Columb MO,Nightingale P

    更新日期:2001-04-01 00:00:00

  • Use of the Walton-Brodie strain gauge arch to measure contractile force during anaesthesia.

    abstract::The Walton-Brodie strain gauge arch is an instrument that quantitatively measures CF. Like many methods, the strain gauge arch is affected by loading conditions and heart rate. Nevertheless, this methodology, when properly used, has proved very useful in describing the direct action of anaesthetic drugs. Knowledge fro...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,评审


    authors: Reves JG,Pruett JK

    更新日期:1988-01-01 00:00:00

  • Time course of increased haemodilution in hypotension induced by extradural anaesthesia.

    abstract::Volume loading with crystalloid solution results in more pronounced haemodilution in patients who develop arterial hypotension during induction of extradural anaesthesia than in those who remain normotensive. The aim of this study was to describe the time course of this increase in haemodilution. Heart rate, systolic ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Drobin D,Hahn RG

    更新日期:1996-08-01 00:00:00

  • Skin conductance monitoring compared with Bispectral Index to assess emergence from total i.v. anaesthesia using propofol and remifentanil.

    abstract:BACKGROUND:Arousal after sevoflurane anaesthesia has been detectable by monitoring changes in skin conductance (SC) with similar accuracy as monitoring Bispectral Index (BIS). As SC monitoring detects changes in sympathetic tone, the measurements might be confounded by the sympatholytic properties of propofol, a compon...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Ledowski T,Bromilow J,Paech MJ,Storm H,Hacking R,Schug SA

    更新日期:2006-12-01 00:00:00

  • Effects of a 5HT(2) receptor agonist on anaesthetized pigs susceptible to malignant hyperthermia.

    abstract:BACKGROUND:The pathophysiology of the serotoninergic system in malignant hyperthermia (MH) is not completely understood. The serotonin-2 (5HT(2A)) receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI) induces typical MH symptoms, including skeletal muscle rigidity, an increase in body tempe...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Gerbershagen MU,Wappler F,Fiege M,Kolodzie K,Weisshorn R,Szafarczyk W,Kudlik C,Schulte Am Esch J

    更新日期:2003-08-01 00:00:00

  • Study of the possible interaction between fentanyl and propofol using a computer-controlled infusion of propofol.

    abstract::A computer-controlled infusion of propofol designed to achieve a target blood concentration of propofol 3 microgram ml-1 was used to investigate the possibility of an interaction between propofol and fentanyl in 32 patients undergoing body surface surgery. In 16 patients who were not receiving a neuromuscular blocker ...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Dixon J,Roberts FL,Tackley RM,Lewis GT,Connell H,Prys-Roberts C

    更新日期:1990-02-01 00:00:00

  • A simple method for computing acid-base state.

    abstract::Simple methods are described for computing the variables derived from the Siggaard-Andersen nomogram, where the in vitro buffer line is either established by direct measurement or calculated from measurements of pH, Pco2 and haemoglobin. Calculations are performed using the equation of the pH-log Pco2 buffer line, the...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Blackburn JP,Preston TD,Strickland DA

    更新日期:1975-04-01 00:00:00

  • Determination of cardiac output by ultrasound dilution technique in infants and children: a validation study against direct Fick principle.

    abstract:BACKGROUND:In critically ill children, monitoring of cardiac output (CO) is essential to guide haemodynamic management and facilitate cardiovascular therapy. The ultrasound dilution technique (UDT), a novel minimally invasive indicator method, was recently introduced to determine CO. We validated UDT against the 'gold ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Boehne M,Baustert M,Paetzel V,Köditz H,Schoof S,Happel CM,Bertram H

    更新日期:2014-03-01 00:00:00

  • The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.

    abstract:BACKGROUND:Anaesthetic drugs act at sites within the brain that undergo profound changes during typical ageing. We postulated that anaesthesia-induced brain dynamics observed in the EEG change with age. METHODS:We analysed the EEG in 155 patients aged 18-90 yr who received propofol (n=60) or sevoflurane (n=95) as the ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Purdon PL,Pavone KJ,Akeju O,Smith AC,Sampson AL,Lee J,Zhou DW,Solt K,Brown EN

    更新日期:2015-07-01 00:00:00

  • The role of an anaesthetist in a field hospital during the cholera epidemic among Rwandan refugees in Goma.

    abstract::In 1849 John Snow, already the leading anaesthetic practitioner and innovator of his day, made a historic contribution to the epidemiology of infectious disease by his famous study of the distribution of cholera around the area of Broad Street in London. We report on our experience as anaesthetists in a field hospital...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Ginosar Y,Shapira SC

    更新日期:1995-12-01 00:00:00

  • Procedural sedation of elderly patients by emergency physicians: a safety analysis of 740 patients.

    abstract:BACKGROUND:The elderly are perceived as a high-risk group for procedural sedation. Concern exists regarding the safety of sedation of this patient group by emergency physicians, particularly when using propofol. METHODS:We analysed prospectively collected data on patients aged 75 yr or older undergoing sedation betwee...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Homfray G,Palmer A,Grimsmo-Powney H,Appelboam A,Lloyd G

    更新日期:2018-12-01 00:00:00

  • Environmental and economic impact of using increased fresh gas flow to reduce carbon dioxide absorbent consumption in the absence of inhalational anaesthetics.

    abstract:BACKGROUND:Increasing fresh gas flow (FGF) to a circle breathing system reduces carbon dioxide (CO2) absorbent consumption. We assessed the environmental and economic impacts of this trade-off between gas flow and absorbent consumption when no inhalational anaesthetic agent is used. METHODS:A test lung with fixed CO2 ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Zhong G,Abbas A,Jones J,Kong S,McCulloch T

    更新日期:2020-11-01 00:00:00

  • Induction dose-response of propofol in unpremedicated children.

    abstract::The induction dose requirements of propofol were compared in three age groups in 300 unpremedicated healthy Chinese children: group A, younger than 2 yr (n = 48); group B, 2-5 yr (n = 117); group C, 6-12 yr (n = 135). Patients in each group were allocated randomly to receive one of eight doses of propofol (1.2, 1.4, 1...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Aun CS,Short SM,Leung DH,Oh TE

    更新日期:1992-01-01 00:00:00

  • Effect of local anaesthetic volume (20 vs 5 ml) on the efficacy and respiratory consequences of ultrasound-guided interscalene brachial plexus block.

    abstract:BACKGROUND:Interscalene brachial plexus block (ISBPB) is an effective nerve block for shoulder surgery. However, a 100% incidence of phrenic nerve palsy limits the application of ISBPB for patients with limited pulmonary reserve. We examined the incidence of phrenic nerve palsy with a low-volume ISBPB compared with a s...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验


    authors: Riazi S,Carmichael N,Awad I,Holtby RM,McCartney CJ

    更新日期:2008-10-01 00:00:00

  • Medication safety in the operating room: literature and expert-based recommendations.

    abstract::Human error poses significant risk for hospitalized patients causing an estimated 100,000 to 400,000 deaths in the USA annually. Medication errors contribute, with error occurring in 5.3% of medication administrations during surgery. In this study 70.3% of medication errors were deemed preventable. Given the paucity o...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,评审


    authors: Wahr JA,Abernathy JH 3rd,Lazarra EH,Keebler JR,Wall MH,Lynch I,Wolfe R,Cooper RL

    更新日期:2017-01-01 00:00:00

  • In vitro interaction of propanidid and suxamethonium with pooled human plasma cholinesterase. A kinetic study.

    abstract::Human plasma cholinesterase (E.C. was shown to be inhibited by physiological concentrations of propanidid and suxamethonium using a colourimetric assay at 25 degrees C and pH 7.2 unit with butyrylthiocholine as substrate. Propanidid inhibited the enzyme in a non-competitive manner (I50 = 2.0 mmol litre-1; app...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Taussig PE,Stojak HE,Bennett NR

    更新日期:1979-03-01 00:00:00

  • Neostigmine with glycopyrrolate does not increase the incidence or severity of postoperative nausea and vomiting in outpatients undergoing gynaecological laparoscopy.

    abstract::We studied 100 healthy women undergoing outpatient gynaecological laparoscopy in a randomized, double-blind and placebo-controlled study to evaluate the effect of neostigmine on postoperative nausea and vomiting (PONV). After induction of anaesthesia with propofol, anaesthesia was maintained with sevoflurane and 66% n...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Nelskylä K,Yli-Hankala A,Soikkeli A,Korttila K

    更新日期:1998-11-01 00:00:00

  • Using educational video to enhance protocol adherence for medical procedures.

    abstract:BACKGROUND:Better education of clinicians is expected to enhance patient safety. An important component of education is adherence to standard protocols, which are mainly available in written form. Believing in the potential power of videos, we hypothesized that the introduction of an educational video, based on an inst...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Kandler L,Tscholl DW,Kolbe M,Seifert B,Spahn DR,Noethiger CB

    更新日期:2016-05-01 00:00:00

  • Circadian distribution of sleep phases after major abdominal surgery.

    abstract:BACKGROUND:It is believed that the severely disturbed night-time sleep architecture after surgery is associated with increased cardiovascular morbidity with rebound of rapid eye movement (REM). The daytime sleep pattern of patients after major general surgery has not been investigated before. We decided to study the ci...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Gögenur I,Wildschiøtz G,Rosenberg J

    更新日期:2008-01-01 00:00:00

  • Ability of stroke volume variation measured by oesophageal Doppler monitoring to predict fluid responsiveness during surgery.

    abstract:BACKGROUND:The objective of this study was to test whether non-invasive assessment of respiratory stroke volume variation (ΔrespSV) by oesophageal Doppler monitoring (ODM) can predict fluid responsiveness during surgery in a mixed population. The predictive value of ΔrespSV was evaluated using a grey zone approach. ME...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Guinot PG,de Broca B,Abou Arab O,Diouf M,Badoux L,Bernard E,Lorne E,Dupont H

    更新日期:2013-01-01 00:00:00

  • Intravenous oxytocin bolus of 2 units is superior to 5 units during elective Caesarean section.

    abstract:BACKGROUND:The optimal dose of oxytocin at Caesarean section is unclear. Oxytocin may cause adverse cardiovascular effects, including tachycardia and hypotension, whereas an inadequate dose can result in increased uterine bleeding. We compared the effects of two doses of oxytocin in a randomized double-blind trial. ME...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验


    authors: Sartain JB,Barry JJ,Howat PW,McCormack DI,Bryant M

    更新日期:2008-12-01 00:00:00

  • Fentanyl and midazolam anaesthesia for coronary bypass surgery: a clinical study of bispectral electroencephalogram analysis, drug concentrations and recall.

    abstract::Bispectral index (BIS) was assessed as a monitor of depth of anaesthesia during fentanyl and midazolam anaesthesia for coronary bypass surgery. In 10 patients given morphine premedication, anaesthesia was induced with a combination of midazolam and fentanyl and thereafter maintained with a continuous infusion of a mix...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章


    authors: Barr G,Anderson RE,Samuelsson S,Owall A,Jakobsson JG

    更新日期:2000-06-01 00:00:00

  • Randomized controlled trial of the haemodynamic and recovery effects of xenon or propofol anaesthesia.

    abstract:BACKGROUND:There is limited clinical experience with xenon in a large number of patients. We present intra- and postoperative haemodynamic and recovery data comparing xenon and total intravenous anaesthesia with propofol. METHODS:A total of 160 patients aged 18-60 years (ASA I and II) undergoing elective surgery took ...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Coburn M,Kunitz O,Baumert JH,Hecker K,Haaf S,Zühlsdorff A,Beeker T,Rossaint R

    更新日期:2005-02-01 00:00:00

  • Thiopental to desflurane - an anaesthetic journey. Where are we going next?

    abstract::Development targets in anaesthetic pharmacology have evolved from minimizing harm caused by unwanted effects through an era in which rapid onset and offset of drug effect were prioritised. Today's anaesthetists have access to a library of effective drugs whose characteristics offer controllable hypnosis, analgesia and...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,评审


    authors: Sneyd JR

    更新日期:2017-12-01 00:00:00

  • Helium-induced late preconditioning in the rat heart in vivo.

    abstract:BACKGROUND:A recent study showed that the noble gas helium induces early myocardial preconditioning. Cyclooxygenase-2 (COX-2) has been shown to be an important mediator in the signal transduction of late preconditioning. In the present study, we investigated whether helium induces late preconditioning in a concentratio...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Huhn R,Heinen A,Weber NC,Hieber S,Hollmann MW,Schlack W,Preckel B

    更新日期:2009-05-01 00:00:00

  • Retraction notice to "Volume replacement in the surgical patient--does the type of solution make a difference?" [Br J Anaesth 84 (2000) 783-93].

    abstract::This article has been retracted: please see Elsevier Policy on Article Withdrawal ( This article has been retracted at the request of the Editor-in-Chief, Professor Hugh Hemmings, based on the recommendations of Justus-Liebig-University Giessen f...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,撤回出版物


    authors: Boldt J

    更新日期:2020-09-01 00:00:00

  • Recovery of fibrinogen after administration of fibrinogen concentrate to patients with severe bleeding after cardiopulmonary bypass surgery.

    abstract:BACKGROUND:Normalization of plasma fibrinogen levels may be associated with satisfactory haemostasis and reduced bleeding. The aim of this retrospective study was to assess fibrinogen recovery parameters after administration of fibrinogen concentrate (Haemocomplettan P) to patients with diffuse bleeding in cardiovascul...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Solomon C,Pichlmaier U,Schoechl H,Hagl C,Raymondos K,Scheinichen D,Koppert W,Rahe-Meyer N

    更新日期:2010-05-01 00:00:00

  • Levobupivacaine vs bupivacaine as infiltration anaesthesia in inguinal herniorrhaphy.

    abstract::We have compared the anaesthetic and analgesic efficacy of levobupivacaine with that of racemic bupivacaine in 66 male patients undergoing ambulatory primary inguinal herniorrhaphy. Patients were allocated randomly in a double-blind manner to local infiltration anaesthesia (0.25% w/v 50 ml) with either racemic bupivac...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bay-Nielsen M,Klarskov B,Bech K,Andersen J,Kehlet H

    更新日期:1999-02-01 00:00:00

  • Administration of magnesium sulphate before rocuronium: effects on speed of onset and duration of neuromuscular block.

    abstract::The speeds of onset of pancuronium, atracurium and vecuronium are increased by prior administration of magnesium sulphate. A prospective, randomized, double-blind, controlled, clinical study was performed to examine the effects of prior i.v. administration of magnesium sulphate 60 mg kg-1 on the neuromuscular blocking...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kussman B,Shorten G,Uppington J,Comunale ME

    更新日期:1997-07-01 00:00:00

  • Haemodynamic effects of pretreatment with metoprolol in hypertensive patients undergoing surgery.

    abstract::Thirty hypertensive patients scheduled for cholecystectomy or hernia repair under general anaesthesia with thiopentone-fentanyl-nitrous oxide-pancuronium were divided into two groups of 15. One group received metoprolol tablets 200 mg in a slow release form, once daily for at least 2 weeks including the morning of sur...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Magnusson J,Thulin T,Werner O,Järhult J,Thomson D

    更新日期:1986-03-01 00:00:00