Randomized placebo-controlled trial to assess the effect of remifentanil and propofol on bispectral index and sedation.

Abstract:

:The effect of the combination of opiates and hypnotics on bispectral index (BIS) is unclear. This double-blind placebo-controlled trial investigated the effect on BIS and sedation of different infusion doses of remifentanil combined with a steady infusion of propofol. Forty patients initially received a target-controlled infusion of propofol 2 micrograms ml-1 for 15 min. They were then randomized to receive either placebo, 0.01, 0.05 or 0.1 microgram kg-1 min-1 remifentanil for a further 15 min. We found a significant correlation between the dose of remifentanil and the change of BIS after 15 min of infusion. The correlation between all the sedation scores and their corresponding BIS was also significant. We concluded that remifentanil, in combination with propofol, reduces BIS when used for sedation.

journal_name

Br J Anaesth

authors

Strachan AN,Edwards ND

doi

10.1093/oxfordjournals.bja.a013474

subject

Has Abstract

pub_date

2000-04-01 00:00:00

pages

489-90

issue

4

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)38805-0

journal_volume

84

pub_type

临床试验,杂志文章,随机对照试验
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    authors: Daunderer M,Feuerecker MS,Scheller B,Pape NB,Schwender D,Kuhnle GE

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    doi:10.1093/bja/59.3.315

    authors: Lawes EG,Campbell I,Mercer D

    更新日期:1987-03-01 00:00:00

  • Possible effects of anaesthetic management on the 1 yr followed-up risk of herpes zoster after Caesarean deliveries.

    abstract:BACKGROUND:As general anaesthesia may compromise the immune system, it has been hypothesized that latent varicella-zoster virus is more likely to be reactivated and cause herpes zoster in mothers after Caesarean deliveries under general anaesthesia. Our study was thus aimed at investigating the risk of herpes zoster am...

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    doi:10.1093/bja/aer386

    authors: Chen YH,Rau RH,Keller JJ,Lin HC

    更新日期:2012-02-01 00:00:00

  • Electrical stimulation in chronic low-back pain.

    abstract::Since 1972, 367 patients with chronic low-back pain have been treated by electrical stimulation (e.s.). Patients with herniated disc lesions and spondylitis and allied conditions were included. Following e.s. 75-100% pain relief was obtained by 53% of the patients 50% pain relief by 27% and there was no improvement in...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/49.6.629

    authors: Rutkowski B,Niedzialkowska T,Otto J

    更新日期:1977-06-01 00:00:00

  • Preoxygenation--the importance of a good face mask seal.

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    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章

    doi:10.1093/bja/75.6.777

    authors: McGowan P,Skinner A

    更新日期:1995-12-01 00:00:00

  • Effect of different kinds of premedication on the induction properties of midazolam.

    abstract::The effects of different premedication (i.m. and i.v.) on the usefulness of midazolam or thiopentone as induction agents for minor surgery was studied in 194 women undergoing either dilatation and curettage or explorative fractionate curettage. Midazolam appeared to produce light sedation which required powerful preme...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章

    doi:10.1093/bja/54.5.507

    authors: Kanto J,Sjövall S,Vuori A

    更新日期:1982-05-01 00:00:00

  • Atropine and glycopyrronium show similar binding patterns to M2 (cardiac) and M3 (submandibular gland) muscarinic receptor subtypes in the rat.

    abstract::Atropine and glycopyrronium are frequently used for premedication to reduce oral and respiratory secretions and prevent bradycardia. Glycopyrronium is said to have similar antisialagogue effects, but is less likely to cause significant tachycardia than atropine. Different antimuscarinic receptor selectivity patterns c...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/74.5.549

    authors: Gomez A,Bellido I,Sanchez de la Cuesta F

    更新日期:1995-05-01 00:00:00

  • Pressure recording analytical method for measuring cardiac output in critically ill children: a validation study.

    abstract:BACKGROUND:Pressure recording analytical method (PRAM) is a novel, arterial pulse contour-based method for measuring cardiac output (CO). Validation studies of PRAM in children are few, and have not assessed both absolute accuracy and ability to track changes in CO across a broad case mix. We aimed to compare CO as mea...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aes420

    authors: Saxena R,Durward A,Puppala NK,Murdoch IA,Tibby SM

    更新日期:2013-03-01 00:00:00

  • Fatal myocardial infarction after lung resection in a patient with prophylactic preoperative coronary stenting.

    abstract::In this report we present the case of a 77-yr-old man who underwent resection of the upper lobe of the left lung for a carcinoma, six weeks after percutaneous transluminal coronary angioplasty (PTCA) with stenting of the left anterior descending (LAD) and circumflex coronary arteries. Antiplatelet therapy with clopido...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aeh110

    authors: Marcucci C,Chassot PG,Gardaz JP,Magnusson L,Ris HB,Delabays A,Spahn DR

    更新日期:2004-05-01 00:00:00

  • Expressiveness of global coagulation parameters in dilutional coagulopathy.

    abstract:BACKGROUND:Plasma-free volume replacement in haemorrhage often results in dilutional coagulopathy. Prothrombin time index (PTI) and activated partial thromboplastin time (aPTT) are used for monitoring haemostasis but have not yet been clinically evaluated. Our aim was to investigate the effects of haemodilution on the ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aeq199

    authors: Weiss G,Lison S,Spannagl M,Heindl B

    更新日期:2010-10-01 00:00:00

  • Intelligent dynamic clinical checklists improved checklist compliance in the intensive care unit.

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    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/bja/aex129

    authors: De Bie AJR,Nan S,Vermeulen LRE,Van Gorp PME,Bouwman RA,Bindels AJGH,Korsten HHM

    更新日期:2017-08-01 00:00:00

  • Gastric emptying in pregnancy.

    abstract::The rate of gastric emptying in pregnancy was measured indirectly using the rate of paracetamol absorption in four groups of 15 patients: non-pregnant controls, first trimester patients presenting for termination of pregnancy, second trimester patients presenting for prostaglandin termination of pregnancy, and patient...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/67.1.54

    authors: Macfie AG,Magides AD,Richmond MN,Reilly CS

    更新日期:1991-07-01 00:00:00

  • Extradural analgesia with clonidine and fentanyl compared with 0.25% bupivacaine in the first stage of labour.

    abstract::Conventional extradural analgesia during labour with 0.25-0.375% bupivacaine may induce motor weakness and subjective sensory deficit, reducing maternal satisfaction. Even in a regimen for ambulatory extradural analgesia (0.1% bupivacaine-fentanyl 2 micrograms ml-1), a potential for proprioreception impairment exists,...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/76.2.319

    authors: Buggy DJ,MacDowell C

    更新日期:1996-02-01 00:00:00

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    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aev435

    authors: Hensel M,Schmidbauer W,Geppert D,Sehner S,Bogusch G,Kerner T

    更新日期:2016-02-01 00:00:00

  • Nitrous oxide does not change the incidence of postoperative delirium or cognitive decline in elderly surgical patients.

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    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/bja/ael106

    authors: Leung JM,Sands LP,Vaurio LE,Wang Y

    更新日期:2006-06-01 00:00:00

  • Training course in local anaesthesia of the airway and fibreoptic intubation using course delegates as subjects.

    abstract:BACKGROUND:We describe a practical method of training anaesthetists in the technique of awake fibreoptic intubation. This is performed on a training course using the delegates as subjects. METHODS:The first 15 subjects underwent cardiovascular monitoring during airway fibreoptic endoscopy performed by other course mem...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aef226

    authors: Patil V,Barker GL,Harwood RJ,Woodall NM

    更新日期:2002-10-01 00:00:00

  • Nitrous oxide antagonizes CNS stimulation by laudanosine in mice.

    abstract::We have investigated whether nitrous oxide antagonizes or augments the CNS stimulant action of laudanosine in mice by comparing the mean convulsive doses (CD50 (SE] of a control group and those following pretreatment with 65% nitrous oxide in oxygen for 20 and 180 min. Nitrous oxide significantly increased CD50 from 4...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/65.5.704

    authors: Avramov MN,Mori K

    更新日期:1990-11-01 00:00:00

  • Halothane hepatitis in a young child.

    abstract::A 4-year-old girl developed severe hepatitis following the fourth administration of halothane in a period of 5 months. She was shown to have a circulating antibody which acted specifically against rabbit hepatocyte previously sensitized to halothane. The patient made a full recovery from the hepatitis, but 5 months la...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/54.3.349

    authors: Lewis RB,Blair M

    更新日期:1982-03-01 00:00:00

  • Impact of echocardiography on patient management in the intensive care unit: an audit of district general hospital practice.

    abstract:BACKGROUND:Echocardiography has been shown to positively impact on the management of the critically ill patient. However, many published studies have a significant bias towards inclusion of cardiothoracic patients. We present an audit of the impact of echocardiography on the management of patients in a district general...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aen378

    authors: Orme RM,Oram MP,McKinstry CE

    更新日期:2009-03-01 00:00:00

  • Depression of cortical somatosensory evoked potentials by nitrous oxide.

    abstract::The effects of the inhalation of 50% nitrous oxide on somatosensory evoked potentials during a fentanyl-oxygen anaesthetic technique for central nervous system surgery were evaluated. The latency and amplitude of the first cortical wave were obtained using conventional somatosensory techniques with median or posterior...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/57.9.849

    authors: Sloan TB,Koht A

    更新日期:1985-09-01 00:00:00

  • Surgical pleth index: prospective validation of the score to predict moderate-to-severe postoperative pain.

    abstract:BACKGROUND:Reported outcome benefits after surgical pleth index (SPI, GE Healthcare, Helsinki, Finland) guided anaesthesia are conflicting. One potential explanation may be the lack of evidence for the selection of meaningful SPI target values. A recently published trial found an SPI cut-off of 30 as a 'best-fit' to pr...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1016/j.bja.2018.10.066

    authors: Ledowski T,Schneider M,Gruenewald M,Goyal RK,Teo SR,Hruby J

    更新日期:2019-08-01 00:00:00

  • Effect of interpleural morphine on postoperative pain and pulmonary function after thoracotomy.

    abstract::We have investigated the effect of interpleural morphine on postoperative pain and pulmonary function after thoracotomy. At the end of surgery, an interpleural catheter was inserted in 17 patients and, in a double-blind and randomized manner, either a bolus of morphine 2.5 mg interpleurally (i.p.) and normal saline i....

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/69.6.637

    authors: Welte M,Haimerl E,Groh J,Briegel J,Sunder-Plassmann L,Herz A,Peter K,Stein C

    更新日期:1992-12-01 00:00:00

  • The Leiden anaesthesia simulator.

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    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/73.3.287

    authors: Chopra V,Engbers FH,Geerts MJ,Filet WR,Bovill JG,Spierdijk J

    更新日期:1994-09-01 00:00:00

  • Printed three-dimensional airway model assists planning of single-lung ventilation in a small child.

    abstract:BACKGROUND:Single-lung ventilation in infants and small children is challenging because suitable sizes of double-lumen cuffed tracheal tubes are not available. A 6-yr-old child required pulmonary saline washout for primary alveolar proteinosis, and therefore needed sequential single-lung ventilation in order to achieve...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aev305

    authors: Wilson CA,Arthurs OJ,Black AE,Schievano S,Hunt C,van Hoog S,Wallis C,Sury MR

    更新日期:2015-10-01 00:00:00

  • Prediction of tracheostomy tube size for paediatric long-term ventilation: an audit of children with spinal cord injury.

    abstract:BACKGROUND:There are no published data to predict tracheostomy tube size as growth proceeds in children requiring long-term ventilation. METHODS:A retrospective audit was undertaken of children having long-term ventilation, managed from the Southport spinal injuries unit. The dates of step-up in size of tracheostomy t...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aeh296

    authors: Behl S,Watt JW

    更新日期:2005-01-01 00:00:00

  • High PEEP in acute respiratory distress syndrome: quantitative evaluation between improved arterial oxygenation and decreased oxygen delivery.

    abstract:BACKGROUND:Positive end-expiratory pressure (PEEP) is widely used to improve oxygenation and prevent alveolar collapse in mechanically ventilated patients with the acute respiratory distress syndrome (ARDS). Although PEEP improves arterial oxygenation predictably, high-PEEP strategies have demonstrated equivocal improv...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aew314

    authors: Chikhani M,Das A,Haque M,Wang W,Bates DG,Hardman JG

    更新日期:2016-11-01 00:00:00

  • Myoneural effects of pethidine and droperidol.

    abstract::In vitro experiments on the rat phrenic nerve-hemidiaphragm preparation, stimulated directly or indirectly with supramaximal impulses at 0.1 Hz revealed that pethidine in concentrations greater than 5 micrograms ml-1 caused a rapid increase of the twitch. This was maximal (60% increase during direct and 70% increase d...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/56.2.195

    authors: Boros M,Chaudhry IA,Nagashima H,Duncalf RM,Sherman EH,Foldes FF

    更新日期:1984-02-01 00:00:00

  • Periodic cardiovascular and ventilatory activity during midazolam sedation.

    abstract::We have examined the effects of sedation with midazolam 0.1 mg kg-1 and reversal with flumazenil 0.5 mg on beat-to-beat heart rate (HR) variability (HRV), systolic arterial pressure (SAP), finger photoplethysmograph amplitude (PLA) and impedence pneumography in eight volunteers. With the onset of sedation there was a ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/76.4.503

    authors: Galletly DC,Williams TB,Robinson BJ

    更新日期:1996-04-01 00:00:00

  • Antinociception by intrathecal midazolam involves endogenous neurotransmitters acting at spinal cord delta opioid receptors.

    abstract::Intrathecal midazolam causes antinociception by combining with spinal cord benzodiazepine receptors. This effect is reversible with doses of naloxone, suggesting involvement of spinal kappa or delta but not mu opioid receptors. The antinociceptive effects of intrathecally administered drugs in the spinal cord were dem...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/77.6.758

    authors: Goodchild CS,Guo Z,Musgreave A,Gent JP

    更新日期:1996-12-01 00:00:00

  • Respiratory complications and hypoxic episodes during inhalation induction with isoflurane in children.

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    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/66.3.327

    authors: Warde D,Nagi H,Raftery S

    更新日期:1991-03-01 00:00:00