Abstract：
BACKGROUND:To study adequate antinociception during general anaesthesia, tetanic stimulus of 5-10 s duration has been used previously as a standardized nociceptive stimulus. However, such stimuli have been found to correlate poorly with intraoperative nociception. We hypothesized that an electrical tetanic stimulus of the ulnar nerve, lasting 30 s, would provide a reliable experimental pain model. METHODS:Thirty-three patients, undergoing open abdominal surgery, were studied. Propofol and remifentanil were used for anaesthesia. Patients were randomized to receive remifentanil at three target-controlled infusion levels (1, 3, or 5 ng ml(-1)) during short (5 s, Tet5) and a long-lasting (30 s, Tet30) tetanic (50 mA, 50 Hz) stimulus and skin incision. RR intervals (RRI) were obtained from the ECG and the mean RRI before each stimulus (Tet5, Tet30, incision) was compared with that after the stimulus. RESULTS:At remifentanil level 1 ng ml(-1), the RRI responses to tetanic stimuli and skin incision were prominent but with higher concentrations (3 and 5 mg ml(-1)), responses were very small. Tet30 (r(2)=0.780) was the best predictor of the RRI response to skin incision when compared with Tet5 (r(2)=0.611), remifentanil level (r(2)=0.340), or propofol level (r(2)=0.036). CONCLUSIONS:Long-lasting tetanic stimulus of ulnar nerve may provide a better experimental pain model for surgical pain during general anaesthesia than shorter stimuli, which have been applied in earlier studies.
journal_name
Br J Anaesthjournal_title
British journal of anaesthesiaauthors
Rantanen M,Yppärilä-Wolters H,van Gils M,Yli-Hankala A,Huiku M,Kymäläinen M,Korhonen Idoi
10.1093/bja/aem200subject
Has Abstractpub_date
2007-10-01 00:00:00pages
509-13issue
4eissn
0007-0912issn
1471-6771pii
S0007-0912(17)35466-1journal_volume
99pub_type
杂志文章,随机对照试验abstract：:Loss of resistance dorsal to the ligamentum flavum was recorded in 10 of 16 patients aged 43--75 yr whilst performing extradural anaesthesia at the L2--3 interspace via the midline approach. Degeneration of the interspinous ligament with cavity formation is observed frequently in the elderly and may account for false ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/51.3.253
更新日期：1979-03-01 00:00:00
abstract：:In 105 patients undergoing day-case surgery recovery of consciousness was significantly faster after enfluane compared with halothane anaesthesia. There was no difference in postoperative morbidity between the two anaesthetic groups. ...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/51.12.1143
更新日期：1979-12-01 00:00:00
abstract：:Advances in cannabis research have paralleled developments in opioid pharmacology whereby a psychoactive plant extract has elucidated novel endogenous signalling systems with therapeutic significance. Cannabinoids (CBs) are chemical compounds derived from cannabis. The major psychotropic CB delta-9-tetrahydrocannabino...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,评审
doi：10.1093/bja/aen119
更新日期：2008-07-01 00:00:00
abstract：BACKGROUND:Rapid, preoperative identification of patients with the highest risk for medical complications is necessary to ensure that limited infrastructure and human resources are directed towards those most likely to benefit. Existing risk scores either lack specificity at the patient level or utilise the American So...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1016/j.bja.2019.07.030
更新日期：2019-12-01 00:00:00
abstract：:The relative sensitivity of sympathetic preganglionic and postganglionic axons, B and C fibres, respectively, to two structurally dissimilar local anaesthetics was examined. The concentration of amethocaine (ester-linked tertiary amine) or prilocaine (amide-linked secondary amine) required to reduce the B fibre compou...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/47.11.1135
更新日期：1975-11-01 00:00:00
abstract：:Diltiazem inhibited and antagonized the abnormal contractures induced by halothane, caffeine and potassium chloride in isolated skeletal muscle from pigs susceptible to malignant hyperpyrexia (MHS). Contractile responses to caffeine and electrical stimulation also were suppressed by diltiazem in control tissue. Simila...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/62.5.566
更新日期：1989-05-01 00:00:00
abstract：:A new method has been developed to measure end-tidal carbon dioxide partial pressure (PECO2) during high frequency jet ventilation (HFJV). A digital flow controller incorporated in a computerized high frequency jet ventilator was used to deliver either a single deep breath or a series of three deep breaths. On user re...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/63.7.47
更新日期：1989-01-01 00:00:00
abstract：:Relative humidity of air produced by simple compressors used to drive ventilators was measured at different working pressures. At normal working pressures, a relative humidity of 100% was found and condensation occurred, mainly at the high pressure air/oxygen mixer valve. This resulted in blockages and loss of accurac...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/53.5.549
更新日期：1981-05-01 00:00:00
abstract：:The oxygen delivery (DO2) and consumption (VO2) relationship in brain-dead organ donors is unknown. Therefore, in a prospective study, we determined the DO2/VO2 relationship in 21 consecutive brain-dead patients. Patients were allocated to one of two groups, according to plasma lactate concentration: normal (group NL,...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/76.6.783
更新日期：1996-06-01 00:00:00
abstract：:We have investigated the effect of volatile anaesthetics on protein synthesis and secretion in Hartley male guinea pig liver slices. The slices (250-300 microns thick) were incubated in sealed roller vials containing Krebs-Henseleit buffer at 37 degrees C under 95% oxygen. Volatile anaesthetics were vaporized in the v...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/68.2.172
更新日期：1992-02-01 00:00:00
abstract：:Five-year survival following cardiac transplantation approaches 50% and such patients occasionally present for non-cardiac surgery. The application of a simple general anaesthetic technique is described in a patient undergoing minor surgery, and the problems involved in managing heart transplant recipients are discuss...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/57.6.634
更新日期：1985-06-01 00:00:00
abstract：:The effect of incubation at 37 degrees C, 46 degrees C, 47 degrees C and 48 degrees C for 1 h on the osmotic fragility of blood was determined. Blood taken from volunteers into ACD and CPD was examined after 1, 7, 14 and 21 days of storage. In addition, 22-day-old blood stored in CPD was examined. The osmotic fragilit...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/50.8.815
更新日期：1978-08-01 00:00:00
abstract：:A patient with a foreign body penetrating the neck and chest was found to have physical signs which were consistent with serious tracheal injury and included a large movement of air through the lower part of the neck. The subsequent management of the patient and the difficult problem of securing an airway are describe...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/66.6.724
更新日期：1991-06-01 00:00:00
abstract：:We conducted a prospective, randomized, double-blind study to compare analgesia obtained by wound infiltration using 29 ml of 0.25% bupivacaine alone, or with the addition of clonidine hydrochloride 150 micrograms. A third group received bupivacaine wound infiltration with clonidine 150 micrograms i.m. to control for ...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/79.4.446
更新日期：1997-10-01 00:00:00
abstract：:Bupivacaine is used widely as a local anaesthetic but has potential for severe cardiovascular and central nervous system (CNS) toxicity. It has an asymmetric carbon atom giving it a chiral centre, and the commercial preparation is a racemic mixture of its two enantiomers: dextro or R(+)-bupivacaine and levo or S(-)-bu...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/80.5.594
更新日期：1998-05-01 00:00:00
abstract：BACKGROUND:Multiple studies have shown that cerebral tissue oxygen saturation (Sct(O(2))) is decreased after phenylephrine treatment. We hypothesized that the negative impact of phenylephrine administration on Sct(O(2)) is affected by arterial blood carbon dioxide partial pressure (Pa(CO(2))) because CO(2) is a powerfu...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章
doi：10.1093/bja/aes023
更新日期：2012-05-01 00:00:00
abstract：BACKGROUND:Arousal after sevoflurane anaesthesia has been detectable by monitoring changes in skin conductance (SC) with similar accuracy as monitoring Bispectral Index (BIS). As SC monitoring detects changes in sympathetic tone, the measurements might be confounded by the sympatholytic properties of propofol, a compon...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/ael278
更新日期：2006-12-01 00:00:00
abstract：BACKGROUND:Restrictive transfusion triggers are safe for most critically ill patients, but doubts exist for patients with ischaemic heart disease (IHD). We investigated the prevalence of reported IHD at admission to the intensive care unit (ICU) and investigated how this influenced red cell transfusion triggers. We als...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,多中心研究
doi：10.1093/bja/aei073
更新日期：2005-04-01 00:00:00
abstract：BACKGROUND:The usefulness of the PFA-100 in assessing the risk of bleeding in non-cardiac surgery is not clear. This study aims to examine this by correlating preoperative PFA-100 measurement with perioperative bleeding in patients receiving cyclooxygenase (COX) inhibitors. METHODS:PFA-100 with adenosine-5'-diphosphat...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aep091
更新日期：2009-06-01 00:00:00
abstract：:Plasma concentrations of pancuronium were measured in nine patients undergoing surgery because of total biliary obstruction. When compared with the averaged model-independent pharmacokinetic parameters obtained for normal patients, the terminal half-life of 270 min was more than twice normal (132 min, P less than 0.00...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/49.11.1103
更新日期：1977-11-01 00:00:00
abstract：BACKGROUND:Target-controlled infusion (TCI) systems use pharmacokinetic (PK) models to predict the drug infusion rates necessary to achieve a desired target plasma or effect-site concentration. As new PK models are developed and implemented in TCI systems, there can be uncertainty as to which target concentrations are ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1016/j.bja.2020.05.051
更新日期：2020-10-01 00:00:00
abstract：:In theory, setting an infrared multi-gas analyser to measure a volatile anaesthetic different from that in the sampled gas mixture may cause interference with carbon dioxide and nitrous oxide readings. The theory was investigated during evaluation of the Dräger Cicero EM anaesthetic workstation for the Medical Devices...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/76.5.737
更新日期：1996-05-01 00:00:00
abstract：BACKGROUND:Recent investigations showed that isoflurane can induce pharmacological preconditioning. The present study aimed to compare the potency of four different halogenated anaesthetics to induce preconditioning. METHODS:Anaesthetized open-chest rabbits underwent 30 min of coronary artery occlusion followed by 3 h...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：BACKGROUND:The safe performance of regional anaesthesia (RA) requires theoretical knowledge and good manual skills. Virtual reality (VR)-based simulators may offer trainees a safe environment to learn and practice different techniques. However, currently available VR simulators do not consider individual anatomy, which...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aep224
更新日期：2009-10-01 00:00:00
abstract：:A randomized, double-blind study of 38 patients undergoing total knee replacement was undertaken to compare the efficacy and respiratory effects of low-dose spinal morphine and patient-controlled i.v. morphine against patient-controlled i.v. morphine alone. Patients received either morphine 0.3 mg or saline 0.3 ml wit...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/85.2.233
更新日期：2000-08-01 00:00:00
abstract：:The effects of the inhalation of 50% nitrous oxide on somatosensory evoked potentials during a fentanyl-oxygen anaesthetic technique for central nervous system surgery were evaluated. The latency and amplitude of the first cortical wave were obtained using conventional somatosensory techniques with median or posterior...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/57.9.849
更新日期：1985-09-01 00:00:00
abstract：:Dose-response relationships for the antagonism of intermediate-acting neuromuscular blocking agents have not been evaluated previously in children. We have examined the dose-response relationships for neostigmine antagonism of 90% rocuronium-induced neuromuscular block in children and adults, during nitrous oxide-1 MA...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/77.6.710
更新日期：1996-12-01 00:00:00
abstract：:The neuromuscular blocking effect of repeated bolus administration of suxamethonium 1 mg/kg was observed in 10 healthy surgical patients under enflurane-nitrous oxide-oxygen anaesthesia. Tachyphylaxis and slow recovery of the thumb twitch occurred in close dose-relationships with transition of Phase I block to Phase I...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/48.2.91
更新日期：1976-02-01 00:00:00
abstract：:In nine patients, undergoing repeat operations because of severe intra-abdominal infection developing after major abdominal surgery, serum potassium concentrations were monitored during induction of anaesthesia. Four patients showed an increase of serum potassium ranging from 2.5 to 3.1 mmol/litre above baseline value...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/48.6.557
更新日期：1976-06-01 00:00:00
abstract：:The efficacy of nitroglycerine, verapamil and nifedipine in controlling post-sternotomy hypertension was compared in four groups of 20 patients anaesthetized with fentanyl 100 micrograms kg-1 undergoing elective coronary artery surgery. Vasodilators were started before surgery and adjusted to maintain systolic arteria...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/58.3.267
更新日期：1986-03-01 00:00:00
