Dose-response relationships for neostigmine antagonism of rocuronium-induced neuromuscular block in children and adults.

abstract：:Plasma concentrations of amethocaine were measured after topical application of amethocaine cream 2 g (5% w/w) to the dorsum of the right hand of 10 adult volunteers. The cream was applied for 240 min and plasma was assayed for amethocaine and its metabolite p-n-butylaminobenzoic acid at 0, 30, 60, 90, 120 and 240 min...

journal_title：British journal of anaesthesia

authors： Mazumdar B,Tomlinson AA,Faulder GC

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND:Arterial cannulation is a common anaesthetic procedure that can be challenging and time-consuming in small children. By visualizing the position of the radial artery, near-infrared vascular imaging systems (NIRVISs) might be of assistance in arterial cannulation. The present study evaluates the effectiveness...

journal_title：British journal of anaesthesia

authors： Cuper NJ,de Graaff JC,Hartman BJ,Verdaasdonk RM,Kalkman CJ

更新日期：2012-09-01 00:00:00

abstract：:We have studied the effects of mivacurium after induction of anaesthesia with alfentanil-propofol in healthy adult oral surgical patients. Anaesthesia was maintained with nitrous oxide and 0.75% (end-tidal) enflurane in oxygen after nasotracheal intubation. Recordings were made of the rectified compound adductor polli...

journal_title：British journal of anaesthesia

authors： Goldhill DR,Whitehead JP,Emmott RS,Griffith AP,Bracey BJ,Flynn PJ

更新日期：1991-09-01 00:00:00

abstract：:In a prospective randomized multi-centre study, the mortality following internal fixation surgery for fracture of the upper femur was investigated in 538 elderly patients allocated to receive subarachnoid blockade or general (narcotic-relaxant) anaesthesia. The 28-day mortality was 6.6% with subarachnoid, and 5.9% wit...

journal_title：British journal of anaesthesia

authors： Davis FM,Woolner DF,Frampton C,Wilkinson A,Grant A,Harrison RT,Roberts MT,Thadaka R

更新日期：1987-09-01 00:00:00

abstract：:For 6 months after renal transplant serum cholinesterase concentrations were measured in 10 patients. The value decreased in the first 15 days after operation, but was normal thereafter. Liver function tests were normal throughout the study; the cholinesterase changes were independent of immunosuppressive therapy. ...

journal_title：British journal of anaesthesia

authors： Ryan DW

更新日期：1979-09-01 00:00:00

abstract：:The influence of sodium nitroprusside (SNP) on mitochondrial respiration was examined in rat liver mitochondria. The addition of SNP 1 mmol litre-1 during state 3 respiration inhibited the oxygen uptake by 63.4%. A mixture of SNP 1 mmol litre-1 and glutathione (GSH) 1 mmol litre-1 inhibited the oxygen uptake more mark...

journal_title：British journal of anaesthesia

authors： Nakamura S,Shin T,Hirokata Y,Shigematsu A

更新日期：1977-12-01 00:00:00

abstract：:Frailty is a syndrome of cumulative decline across multiple physiological systems, which predisposes vulnerable adults to adverse events. Assessing vulnerable patients can potentially lead to interventions that improve surgical outcomes. Anaesthesiologists who care for older patients can identify frailty to improve pr...

journal_title：British journal of anaesthesia

authors： Bentov I,Kaplan SJ,Pham TN,Reed MJ

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:The low and moderate doses of dexmedetomidine reduce arterial pressure and heart rate (HR), suggesting attenuation of sympathetic activity and dominance of cardiac-vagal activity. These autonomic responses under dexmedetomidine sedation may attenuate cardiovascular reflex responses to temporal reduction in a...

journal_title：British journal of anaesthesia

authors： Kato J,Ogawa Y,Kojima W,Aoki K,Ogawa S,Iwasaki K

更新日期：2009-10-01 00:00:00

abstract：:Arterial pressure is still one of the most important measures in estimating the required dose of inhaled anaesthetics. It is measured easily and reacts rapidly which makes it suitable as a variable for feedback control of depth of anaesthesia. Fuzzy logic, a novel approach to feedback control, was used to control arte...

journal_title：British journal of anaesthesia

authors： Zbinden AM,Feigenwinter P,Petersen-Felix S,Hacisalihzade S

更新日期：1995-01-01 00:00:00

abstract：:We have examined the effects of the highly selective alpha 2-adrenoceptor agonist, dexmedetomidine, on noradrenaline release and cell firing in isolated, superfused slices of rat locus coeruleus. Dexmedetomidine decreased both noradrenaline release and cell firing rate in a concentration-dependent fashion, with an EC5...

journal_title：British journal of anaesthesia

authors： Jorm CM,Stamford JA

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:Dexmedetomidine (DEX) has been shown to provide good perioperative haemodynamic stability with decreased intraoperative opioid requirements. It may have neural protective effects, and thus may be a suitable anaesthetic adjuvant to neurosurgical anaesthesia. METHODS:Fifty-four patients scheduled for elective...

journal_title：British journal of anaesthesia

authors： Tanskanen PE,Kyttä JV,Randell TT,Aantaa RE

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:The solubility of desflurane compared with sevoflurane suggests more rapid recovery from desflurane anaesthesia. This could be important after prolonged anaesthesia and fast recovery may be advantageous in the elderly where slow recovery of mental function is a concern. We compared emergence from desflurane ...

journal_title：British journal of anaesthesia

authors： Heavner JE,Kaye AD,Lin BK,King T

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:Prolonged postoperative decrease in lung function is common after major upper abdominal surgery. Evidence suggests that ventilation with low tidal volumes may limit the damage during mechanical ventilation. We compared postoperative lung function of patients undergoing upper abdominal surgery, mechanically v...

journal_title：British journal of anaesthesia

authors： Treschan TA,Kaisers W,Schaefer MS,Bastin B,Schmalz U,Wania V,Eisenberger CF,Saleh A,Weiss M,Schmitz A,Kienbaum P,Sessler DI,Pannen B,Beiderlinden M

更新日期：2012-08-01 00:00:00

abstract：:Dysregulation of the immuno-inflammatory response, as seen in sepsis, may culminate in host cell and organ damage. Lipopolysaccharide from Gram-negative bacterial cell walls induces gene activation and subsequent inflammatory mediator expression. Gene activation is regulated by a number of transcription factors at the...

journal_title：British journal of anaesthesia

authors： Macdonald J,Galley HF,Webster NR

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:The second gas effect (SGE) is considered to be significant only during periods of large volume N(2)O uptake (VN(2)O); however, the SGE of small VN(2)O has not been studied. We hypothesized that the SGE of N(2)O on sevoflurane would become less pronounced when sevoflurane administration is started 60 min aft...

journal_title：British journal of anaesthesia

authors： Hendrickx JF,Carette R,Lemmens HJ,De Wolf AM

更新日期：2006-03-01 00:00:00

abstract：:We have investigated the value of lower oesophageal contractility (LOC) in detecting awareness during anaesthesia in 20 human volunteer patients. LOC was measured either with subjects awake or after induction with propofol, during induction with propofol, and then as consciousness returned. Statistically significant c...

journal_title：British journal of anaesthesia

authors： Isaac PA,Rosen M

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND:Better education of clinicians is expected to enhance patient safety. An important component of education is adherence to standard protocols, which are mainly available in written form. Believing in the potential power of videos, we hypothesized that the introduction of an educational video, based on an inst...

journal_title：British journal of anaesthesia

authors： Kandler L,Tscholl DW,Kolbe M,Seifert B,Spahn DR,Noethiger CB

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Opioids can increase sensitivity to noxious stimuli and cause opioid-induced hyperalgesia. We performed a systematic review to evaluate the clinical consequences of intra-operative doses of opioid. METHODS:We identified randomized controlled trials which compared intra-operative opioid to lower doses or pla...

journal_title：British journal of anaesthesia

authors： Fletcher D,Martinez V

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Acute pulmonary embolism (APE) is an important clinical problem in patients after major surgery and often remains a difficult diagnosis because of unspecific clinical symptoms. Therefore, we investigated the role of N-terminal prohormone of brain natriuretic peptide (NT-proBNP) for the detection of APE. MET...

journal_title：British journal of anaesthesia

authors： Winkler BE,Schuetz W,Froeba G,Muth CM

更新日期：2012-12-01 00:00:00

abstract：:Nociceptin/orphanin FQ, N/OFQ, and its receptor NOP represent a non-opioid branch of the opioid superfamily that were first studied for their effects on pain responses. Both N/OFQ and NOP are involved in a wide range of 'non-pain' responses including immunomodulation and cardiovascular control. There is now growing in...

journal_title：British journal of anaesthesia

authors： Serrano-Gomez A,Thompson JP,Lambert DG

更新日期：2011-01-01 00:00:00

abstract：:Plasma concentrations of pancuronium were measured in nine patients undergoing surgery because of total biliary obstruction. When compared with the averaged model-independent pharmacokinetic parameters obtained for normal patients, the terminal half-life of 270 min was more than twice normal (132 min, P less than 0.00...

journal_title：British journal of anaesthesia

authors： Somogyi AA,Shanks CA,Triggs EJ

更新日期：1977-11-01 00:00:00

abstract：BACKGROUND:Pressure recording analytical method (PRAM) is a novel, arterial pulse contour-based method for measuring cardiac output (CO). Validation studies of PRAM in children are few, and have not assessed both absolute accuracy and ability to track changes in CO across a broad case mix. We aimed to compare CO as mea...

journal_title：British journal of anaesthesia

authors： Saxena R,Durward A,Puppala NK,Murdoch IA,Tibby SM

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Dynamic arterial elastance (Eadyn) has been proposed as an indicator of vascular tone that predicts the decrease in arterial pressure in response to changes in norepinephrine (NE). The purpose of this study was to determine whether Eadyn measured by uncalibrated pulse contour analysis (UPCA) can predict a de...

journal_title：British journal of anaesthesia

authors： Bar S,Leviel F,Abou Arab O,Badoux L,Mahjoub Y,Dupont H,Lorne E,Guinot PG

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:It is believed that the severely disturbed night-time sleep architecture after surgery is associated with increased cardiovascular morbidity with rebound of rapid eye movement (REM). The daytime sleep pattern of patients after major general surgery has not been investigated before. We decided to study the ci...

journal_title：British journal of anaesthesia

authors： Gögenur I,Wildschiøtz G,Rosenberg J

更新日期：2008-01-01 00:00:00

abstract：:The analgesic efficacy of a 150-mg meptazinol suppository was compared with that of morphine 10 mg i.m. in the treatment of moderate postoperative pain. Two groups of 15 female patients took part in a 4-h, randomized double-blind, double-dummy study on the first day after elective abdominal hysterectomy. Meptazinol di...

journal_title：British journal of anaesthesia

authors： Moores MA,Frater R,Parry P,Hanning CD

更新日期：1988-04-01 00:00:00

abstract：:The rate of gastric emptying in pregnancy was measured indirectly using the rate of paracetamol absorption in four groups of 15 patients: non-pregnant controls, first trimester patients presenting for termination of pregnancy, second trimester patients presenting for prostaglandin termination of pregnancy, and patient...

journal_title：British journal of anaesthesia

authors： Macfie AG,Magides AD,Richmond MN,Reilly CS

更新日期：1991-07-01 00:00:00

abstract：:Alcuronium 0.16 mg kg-1 was used to provide neuromuscular blockade in patients with chronic renal failure undergoing renal transplantation. Relaxation was found to be adequate for intubation and surgery. There were minimal alterations to cardiovascular variables. The dose required was small, and complete reversal occu...

journal_title：British journal of anaesthesia

authors： Kaushik S,Grover VK,Singh H,Yadav RV

更新日期：1984-11-01 00:00:00

abstract：:We describe an obstetric patient who presented for removal of a retained placenta. After insertion of the spinal anaesthetic, she developed a severe headache, and a subarachnoid haemorrhage was diagnosed. We discuss the differential diagnosis of the headache, the occurrence of intracranial haemorrhages after dural pun...

journal_title：British journal of anaesthesia

authors： Eggert SM,Eggers KA

更新日期：2001-03-01 00:00:00

abstract：:Cerebral emboli detected by transcranial Doppler imaging were recorded in 20 patients undergoing multiple-vessel coronary artery bypass surgery, either with or without cardiopulmonary bypass, in a prospective unblinded comparative study. Emboli were recorded continuously from the time of pericardial incision until 10 ...

journal_title：British journal of anaesthesia

authors： Watters MP,Cohen AM,Monk CR,Angelini GD,Ryder IG

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Even mild perioperative hypothermia is associated with several severe adverse effects. Resistive heating has possible advantages compared with other active warming systems because it can heat several fields independently. To assess this new warming system, we measured core temperature in patients during surg...

journal_title：British journal of anaesthesia

authors： Matsuzaki Y,Matsukawa T,Ohki K,Yamamoto Y,Nakamura M,Oshibuchi T

更新日期：2003-05-01 00:00:00