Spontaneous recovery of the thumb twitch from neuromuscular block by suxamethonium in anaesthetized man.

Abstract:

:The neuromuscular blocking effect of repeated bolus administration of suxamethonium 1 mg/kg was observed in 10 healthy surgical patients under enflurane-nitrous oxide-oxygen anaesthesia. Tachyphylaxis and slow recovery of the thumb twitch occurred in close dose-relationships with transition of Phase I block to Phase II, using train-of-four fade as an indicator of the transition. Failure of the thumb twitch to recover to 75% of control, and subsequent step-wise depression from additional doses of suxamethonium had a sudden onset shortly after establishment of marked train-of-four fade.

journal_name

Br J Anaesth

authors

Lee C,Chen D,Nagel EL,Katz RL

doi

10.1093/bja/48.2.91

subject

Has Abstract

pub_date

1976-02-01 00:00:00

pages

91-5

issue

2

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)50711-4

journal_volume

48

pub_type

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