Recovery and skills related to driving after intravenous sedation: dose-response relationship with diazepam.

Abstract:

:Skills related to driving, the ability to discriminate the fusion of flickering light, and hand and foot proprioception, were measured double-blind in 34 healthy volunteers before and after three doses of i.v. diazepam. The effects of diazepam were most harmful to co-ordination. With 0.15 mg/kg, 0.30 mg/kg and 0.45 mg/kg of diazepam the impairment of co-ordinative skills was statistically significant (P less than 0.05) up to 2, 6 and 8 hr respectively. No impairment of performance on any test was measurable at 6 hr after 0.15 mg/kg or at 10 hr after 0.30 or 0.45 mg/kg of diazepam. There were large interindividual variations in serum concentrations of diazepam within each dose level. The increases in serum concentrations of diazepam after the intake of food support the concept of an enterohepatic cycle for diazepam. It was concluded that patients should not drive or operate machinery for at least 6 hr after 0.15 mg/kg of i.v. diazepam and at least 10 hr after 0.30 mg/kg and 0.45 mg/kg.

journal_name

Br J Anaesth

authors

Korttila K,Linnoila M

doi

10.1093/bja/47.4.457

subject

Has Abstract

pub_date

1975-04-01 00:00:00

pages

457-63

issue

4

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)48750-2

journal_volume

47

pub_type

临床试验,杂志文章
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    pub_type: 杂志文章

    doi:10.1093/bja/aeh026

    authors: Friederich P,Solth A,Schillemeit S,Isbrandt D

    更新日期:2004-01-01 00:00:00

  • Comparison of decreases in ventilation caused by enflurane and fentanyl during anaesthesia.

    abstract::Two groups of six patients were studied during light general anaesthesia using 2% enflurane and 66% nitrous oxide in oxygen, combined with regional anaesthesia, for hernia and varicose vein surgery. The effects of 3% enflurane were compared with those of fentanyl 0.3 microgram kg-1 i.v., by measuring inspired flow, ti...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/55.9.825

    authors: Drummond GB

    更新日期:1983-09-01 00:00:00

  • Detection of oesophageal intubations using cuff pressures in a pig trachea oesophagus model.

    abstract:BACKGROUND:The cuff pressures may be different in oesophageal and tracheal intubations. We conducted a study to evaluate if cuff pressures of endotracheal tubes (ETTs) could provide information to distinguish tracheal or oesophageal intubations in a pig trachea-oesophagus model. METHODS:In each preparation of pig trac...

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    pub_type: 杂志文章

    doi:10.1093/bja/aem244

    authors: Lin HJ,Chen KT,Foo NP,Hsu CC,Guo HR

    更新日期:2007-11-01 00:00:00

  • Intradermal compared with prick testing in the diagnosis of anaesthetic allergy.

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    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章

    doi:10.1093/bja/79.1.59

    authors: Fisher MM,Bowey CJ

    更新日期:1997-07-01 00:00:00

  • Continuous infusions of propofol administered to dogs: effects on ICG and propofol disposition.

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    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/72.4.451

    authors: Sear JW,Diedericks J,Foex P

    更新日期:1994-04-01 00:00:00

  • Cardiovascular and electroencephalographic effects of laudanosine in "nephrectomized" cats.

    abstract::We studied a cat model simulating laudanosine accumulation in the "anephric" patient. Cardiovascular effects were seen only with the bolus doses of laudanosine 2 mg kg-1, and at plasma laudanosine concentrations unlikely to be achieved clinically. Similarly, EEG and power spectra analysis showed no evidence of epilept...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/58.suppl_1.14s

    authors: Ingram MD,Sclabassi RJ,Cook DR,Stiller RL,Bennett MH

    更新日期:1986-01-01 00:00:00

  • Isoflurane-induced myocardial preconditioning is dependent on phosphatidylinositol-3-kinase/Akt signalling.

    abstract:BACKGROUND:Isoflurane and other volatile anaesthetics have a cardioprotective effect and limit myocardial infarct size to the same extent as ischaemic preconditioning. Phosphatidylinositol-3-kinase (PI3K) was found to play a key role in myocardial protection by ischaemic preconditioning. The aim of the present investig...

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    pub_type: 杂志文章

    doi:10.1093/bja/aei264

    authors: Raphael J,Rivo J,Gozal Y

    更新日期:2005-12-01 00:00:00

  • Effect of early tracheostomy on resource utilization and clinical outcomes in critically ill patients: meta-analysis of randomized controlled trials.

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    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,meta分析,评审

    doi:10.1093/bja/aeu440

    authors: Szakmany T,Russell P,Wilkes AR,Hall JE

    更新日期:2015-03-01 00:00:00

  • Proportion of surgical patients with undiagnosed obstructive sleep apnoea.

    abstract:BACKGROUND:Obstructive sleep apnoea (OSA) affects ~9-24% of the general population, and 90% remain undiagnosed. Those patients with undiagnosed moderate-to-severe OSA may be associated with an increased risk of perioperative complications. Our objective was to evaluate the proportion of surgical patients with undiagnos...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aes465

    authors: Singh M,Liao P,Kobah S,Wijeysundera DN,Shapiro C,Chung F

    更新日期:2013-04-01 00:00:00

  • Anaesthetic properties of dimethylthiourea.

    abstract::We have examined dimethylthiourea, a potent scavenger of free radicals, for its anaesthetic properties in mice and rats. In mice, dimethylthiourea abolished the righting reflex at intraperitoneal doses greater than 1.5 mg g-1 bodyweight; in rats, it decreased the MAC value for isoflurane in a dose-dependent fashion. D...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/70.4.456

    authors: Koblin DD,Laster MJ,Liu J

    更新日期:1993-04-01 00:00:00

  • Surgical pleth index in children younger than 24 months of age: a randomized double-blinded trial.

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    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/bja/aew215

    authors: Harju J,Kalliomäki ML,Leppikangas H,Kiviharju M,Yli-Hankala A

    更新日期:2016-09-01 00:00:00

  • Association between intraoperative electroencephalographic suppression and postoperative mortality.

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    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/bja/aeu105

    authors: Willingham M,Ben Abdallah A,Gradwohl S,Helsten D,Lin N,Villafranca A,Jacobsohn E,Avidan M,Kaiser H

    更新日期:2014-12-01 00:00:00

  • Comparison of speed of onset of analgesic effect of diamorphine and morphine.

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    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/66.6.656

    authors: Morrison LM,Payne M,Drummond GB

    更新日期:1991-06-01 00:00:00

  • Autotransfusion performed on a patient with cis AB blood group.

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    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/83.3.491

    authors: Kawahito S,Kitahata H,Kimura H,Tanaka K,Oshita S

    更新日期:1999-09-01 00:00:00

  • The pneuPAC hyperbaric variant HB: a ventilator suitable for use within a one-man hyperbaric chamber.

    abstract::We describe the performance of the pneuPAC hyperbaric variant HB, a ventilator designed for use in a one-man hyperbaric chamber. The ventilator delivered minute volumes of 11-23 litre at 1 atm abs to 7.6-16 litre at 2.5 atm abs. The delivered minute volume may be controlled easily from outside the chamber by manipulat...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/67.4.488

    authors: Spittal MJ,Hunter SJ,Jones L

    更新日期:1991-10-01 00:00:00

  • Differential effects of neuromuscular blocking agents on suxamethonium-induced fasciculations and myalgia.

    abstract::The effect of pretreatment with suxamethonium, gallamine or pancuronium on suxamethonium-induced fasciculations and myalgia was studied in a controlled, randomized and double-blind clinical trial. Both fasciculations and myalgia were assessed on a four-point rating scale. There was no significant correlation between f...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/60.4.367

    authors: O'Sullivan EP,Williams NE,Calvey TN

    更新日期:1988-03-01 00:00:00

  • High-sensitive cardiac troponin T measurements in prediction of non-cardiac complications after major abdominal surgery.

    abstract:BACKGROUND:Postoperative non-cardiac complication rates are as high as 11-28% after high-risk abdominal procedures. Emerging evidence indicates that postoperative cardiac troponin T elevations are associated with adverse outcome in non-cardiac surgery. The aim of this study was to determine the relationship between pos...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章

    doi:10.1093/bja/aev027

    authors: Noordzij PG,van Geffen O,Dijkstra IM,Boerma D,Meinders AJ,Rettig TC,Eefting FD,van Loon D,van de Garde EM,van Dongen EP

    更新日期:2015-06-01 00:00:00

  • Levobupivacaine vs bupivacaine as infiltration anaesthesia in inguinal herniorrhaphy.

    abstract::We have compared the anaesthetic and analgesic efficacy of levobupivacaine with that of racemic bupivacaine in 66 male patients undergoing ambulatory primary inguinal herniorrhaphy. Patients were allocated randomly in a double-blind manner to local infiltration anaesthesia (0.25% w/v 50 ml) with either racemic bupivac...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/82.2.280

    authors: Bay-Nielsen M,Klarskov B,Bech K,Andersen J,Kehlet H

    更新日期:1999-02-01 00:00:00

  • Skin conductance monitoring compared with Bispectral Index to assess emergence from total i.v. anaesthesia using propofol and remifentanil.

    abstract:BACKGROUND:Arousal after sevoflurane anaesthesia has been detectable by monitoring changes in skin conductance (SC) with similar accuracy as monitoring Bispectral Index (BIS). As SC monitoring detects changes in sympathetic tone, the measurements might be confounded by the sympatholytic properties of propofol, a compon...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/ael278

    authors: Ledowski T,Bromilow J,Paech MJ,Storm H,Hacking R,Schug SA

    更新日期:2006-12-01 00:00:00

  • Spinal anaesthesia for paediatric day-case surgery: a double-blind, randomized, parallel group, prospective comparison of isobaric and hyperbaric bupivacaine.

    abstract::We have compared bupivacaine 5 mg ml-1, either isobaric in saline 0.9% or hyperbaric in 8% glucose, for spinal anaesthesia in 100 children, aged 2-115 months, in a double-blind, randomized, parallel group, prospective study. Children were premedicated with diazepam 0.5 mg kg-1 orally. Seventy-two children were sedated...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/81.4.502

    authors: Kokki H,Tuovinen K,Hendolin H

    更新日期:1998-10-01 00:00:00

  • Isobutene formation during halothane anaesthesia in man.

    abstract::The concentrations of volatile hydrocarbons were studied in breath samples from patients before and after anaesthesia. In patients to whom halothane was administered, there was a significant increase in the concentration of isobutene (from 0.43 +/- 0.09 to 4.66 +/- 2.22 nmol litre-1). There was no change in the concen...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/52.10.989

    authors: Hempel V,May R,Frank H,Remmer H,Köster U

    更新日期:1980-10-01 00:00:00

  • Relationship of perioperative anaphylaxis to neuromuscular blocking agents, obesity, and pholcodine consumption: a case-control study.

    abstract:BACKGROUND:The observation that patients presenting for bariatric surgery had a high incidence of neuromuscular blocking agent (NMBA) anaphylaxis prompted this restricted case-control study to test the hypothesis that obesity is a risk factor for NMBA anaphylaxis, independent of differences in pholcodine consumption. ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1016/j.bja.2020.12.018

    authors: Sadleir PHM,Clarke RC,Goddard CE,Day C,Weightman W,Middleditch A,Platt PR

    更新日期:2021-01-13 00:00:00

  • Early thromboelastometry variables predict maximum clot firmness in children undergoing cardiac and non-cardiac surgery.

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    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,多中心研究

    doi:10.1093/bja/aev369

    authors: Perez-Ferrer A,Vicente-Sanchez J,Carceles-Baron MD,Van der Linden P,Faraoni D

    更新日期:2015-12-01 00:00:00

  • Perioperative management of clopidogrel therapy: the effects on in-hospital cardiac morbidity in older patients with hip fractures.

    abstract:BACKGROUND:Increasing numbers of older patients prescribed clopidogrel are presenting for urgent hip fracture surgery. Best practice for the management of clopidogrel therapy is unknown, although delays to surgery are associated with increased mortality. We investigated the influence of perioperative management of clop...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aer288

    authors: Collyer TC,Reynolds HC,Truyens E,Kilshaw L,Corcoran T

    更新日期:2011-12-01 00:00:00

  • Pharmacokinetics and haemodynamics of ketamine in intensive care patients with brain or spinal cord injury.

    abstract:BACKGROUND:Ketamine is used as an anaesthetic agent for short surgical procedures, and as a sedative and analgesic in intensive care patients. Intensive care patients with brain or spinal cord injury may have physiological changes that could alter the pharmacokinetics of ketamine. The pharmacokinetics of ketamine have ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aeg028

    authors: Hijazi Y,Bodonian C,Bolon M,Salord F,Boulieu R

    更新日期:2003-02-01 00:00:00

  • Hypertension, hypertensive heart disease and perioperative cardiac risk.

    abstract::The evidence for an association between hypertensive disease, elevated admission arterial pressure, and perioperative cardiac outcome is reviewed. A systematic review and meta-analysis of 30 observational studies demonstrated an odds ratio for the association between hypertensive disease and perioperative cardiac outc...

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    pub_type: 杂志文章,meta分析,评审

    doi:10.1093/bja/aeh091

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    更新日期:2004-04-01 00:00:00

  • Transoesophageal echocardiographic monitoring of pulmonary venous obstruction induced by sternotomy closure during infant heart transplantation.

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    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/88.4.590

    authors: Lin CP,Chan KC,Chou YM,Wang MJ,Tsai SK

    更新日期:2002-04-01 00:00:00

  • A brief historical review of non-anaesthetic causes of fires and explosions in the operating room.

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    journal_title:British journal of anaesthesia

    pub_type: 历史文章,杂志文章

    doi:10.1093/bja/73.6.847

    authors: Macdonald AG

    更新日期:1994-12-01 00:00:00

  • Effect of changes in arterial-mixed venous oxygen content difference (C(a-v)O2) on indices of pulmonary oxygen transfer in a model ARDS lung.

    abstract::Many indices are used to quantify pulmonary oxygen transfer. Indices that use only measurements from arterial blood and inspired gas assume a constant C(a-v)O2. Though variations in C(a-v)O2 are recognized, indices such as PaO2/FIO2 remain popular and are often considered the best measure of pulmonary oxygen transfer ...

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    pub_type: 杂志文章

    doi:10.1093/bja/86.4.477

    authors: Nirmalan M,Willard T,Columb MO,Nightingale P

    更新日期:2001-04-01 00:00:00

  • Pharmacokinetics of edrophonium in anephric and renal transplant patients.

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    doi:10.1093/bja/53.12.1311

    authors: Morris RB,Cronnelly R,Miller RD,Stanski DR,Fahey MR

    更新日期:1981-12-01 00:00:00