Pharmacokinetics and pharmacodynamics of ketamine enantiomers in surgical patients using a stereoselective analytical method.

abstract：BACKGROUND:Positive end-expiratory pressure (PEEP) is widely used to improve oxygenation and prevent alveolar collapse in mechanically ventilated patients with the acute respiratory distress syndrome (ARDS). Although PEEP improves arterial oxygenation predictably, high-PEEP strategies have demonstrated equivocal improv...

journal_title：British journal of anaesthesia

authors： Chikhani M,Das A,Haque M,Wang W,Bates DG,Hardman JG

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:The diagnosis of abdominal compartment syndrome depends upon the demonstration of an elevated intra-abdominal pressure (IAP). Direct measures of IAP are impractical in the critical care unit; intravesical pressure (IVP) and intragastric pressure (IGP) should represent acceptable surrogate measures. IVP is th...

journal_title：British journal of anaesthesia

authors： Turnbull D,Webber S,Hamnegard CH,Mills GH

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:The safety of performing spinal anaesthesia for both patients and anaesthetists alike in the presence of active infection with the novel coronavirus disease 2019 (COVID-19) is unclear. Here, we report the clinical characteristics and outcomes for both patients with COVID-19 and the anaesthetists who provided...

journal_title：British journal of anaesthesia

authors： Zhong Q,Liu YY,Luo Q,Zou YF,Jiang HX,Li H,Zhang JJ,Li Z,Yang X,Ma M,Tang LJ,Chen YY,Zheng F,Ke JJ,Zhang ZZ

更新日期：2020-06-01 00:00:00

abstract：:The water soluble benzodiazepine midazolam was compared with diazepam, in doses of 0.07 mg kg-1 and 0.15 mg kg-1 respectively, administered i.v. to 100 patients undergoing gastroscopy. The degree of sedation, ease of endoscopy and recovery were comparable in the two groups. The effects of both drugs on arterial pressu...

journal_title：British journal of anaesthesia

authors： Whitwam JG,Al-Khudhairi D,McCloy RF

更新日期：1983-08-01 00:00:00

abstract：:A patient with a foreign body penetrating the neck and chest was found to have physical signs which were consistent with serious tracheal injury and included a large movement of air through the lower part of the neck. The subsequent management of the patient and the difficult problem of securing an airway are describe...

journal_title：British journal of anaesthesia

authors： Brierley JK,Oates J,Bogod DG

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:The revised cardiac risk index (RCRI) is associated strongly with increased cardiac ischaemic risk and perioperative death. Associations with non-cardiac morbidity in non-cardiac surgery have not been explored. In the elective orthopaedic surgical population, morbidity is common but preoperative predictors a...

journal_title：British journal of anaesthesia

authors： Ackland GL,Harris S,Ziabari Y,Grocott M,Mythen M,SOuRCe Investigators.

更新日期：2010-12-01 00:00:00

abstract：:Bilateral superior laryngeal nerve block was combined with topical application of local anaesthetic 140 times in 135 patients to anaesthetize the upper airway and facilitate tracheal intubation, laryngeal instrumentation, or to diminish the response to the endotracheal tube, in a patient already intubated. The techniq...

journal_title：British journal of anaesthesia

authors： Gotta AW,Sullivan CA

更新日期：1981-10-01 00:00:00

abstract：:We randomized women having elective Caesarean section to receive either no preload (control group, n=33) or 4% gelatin solution (Gelofusine) 15 ml kg(-1) (colloid group, n=35) i.v. before spinal anaesthesia. Intravenous metaraminol was titrated at 0.25-0.75 mg min(-1) to maintain systolic arterial pressure (SAP) in th...

journal_title：British journal of anaesthesia

authors： Ngan Kee WD,Khaw KS,Lee BB,Ng FF,Wong MM

更新日期：2001-11-01 00:00:00

abstract：:Several risk scores have been developed to calculate the probability of postoperative nausea and vomiting (PONV). However, the power to discriminate which individual will suffer from PONV is still limited. Thus, we wondered how the number of predictors in a score affects the discriminating power and how the characteri...

journal_title：British journal of anaesthesia

authors： Apfel CC,Kranke P,Greim CA,Roewer N

更新日期：2001-06-01 00:00:00

abstract：:We calculated oxygen consumption by the reverse Fick principle (cVO2) using cardiac output measured with a new technique of continuous thermal dilution and compared these values with measurements made at the same time using a gas exchange method (mVO2). We studied nine patients in a stable condition after cardiac surg...

journal_title：British journal of anaesthesia

authors： Bizouarn P,Blanloeil Y,Pinaud M

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:Risks and costs of allogeneic blood transfusions mandate strategies to reduce blood loss in surgery. The objective of this study was to assess the efficacy of antifibrinolytic treatment in reducing perioperative blood loss during total knee replacement. METHODS:A double-blind, randomized and placebo-control...

journal_title：British journal of anaesthesia

authors： Camarasa MA,Ollé G,Serra-Prat M,Martín A,Sánchez M,Ricós P,Pérez A,Opisso L

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Isoflurane and other volatile anaesthetics have a cardioprotective effect and limit myocardial infarct size to the same extent as ischaemic preconditioning. Phosphatidylinositol-3-kinase (PI3K) was found to play a key role in myocardial protection by ischaemic preconditioning. The aim of the present investig...

journal_title：British journal of anaesthesia

authors： Raphael J,Rivo J,Gozal Y

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Axillary vein catheterization via a distal approach is an alternative to the proximal approach to axillary/subclavian vein catheterization under ultrasound (US) guidance. The aim of this trial was to compare the two approaches. METHODS:In a randomized single-centre study, all patients requiring central vein...

journal_title：British journal of anaesthesia

authors： Buzançais G,Roger C,Bastide S,Jeannes P,Lefrant JY,Muller L

更新日期：2016-02-01 00:00:00

abstract：:We have examined the extradural space using a flexible extraduroscope in 74 patients undergoing extradural anaesthesia at the L2-3 interspace. Extraduroscopy showed that the extradural space becomes widely patent and the fatty tissue in the extradural space diminishes with increasing age. We postulate that these age-r...

journal_title：British journal of anaesthesia

authors： Igarashi T,Hirabayashi Y,Shimizu R,Saitoh K,Fukuda H,Mitsuhata H

更新日期：1997-02-01 00:00:00

abstract：:The rapid detection and evaluation of patients presenting with perioperative neurological dysfunction is of great clinical relevance. Biomarkers have been defined as biological molecules that can be used as an indicator of new onset or progression of a biological process or effect of treatment. Biomarkers have become ...

journal_title：British journal of anaesthesia

authors： Cata JP,Abdelmalak B,Farag E

更新日期：2011-12-01 00:00:00

abstract：:Puerperal women are reported to have a rate of cerebral infarction 13 times greater than non-pregnant females. We report a case of cerebral ischaemia in a 30-yr-old healthy parturient after epidural analgesia for labour, complicated by dural puncture treated with two epidural blood patches. Investigations showed the d...

journal_title：British journal of anaesthesia

authors： Mercieri M,Mercieri A,Paolini S,Arcioni R,Lupoi D,Passarelli F,Pinto G,Celleno D

更新日期：2003-01-01 00:00:00

abstract：:In a prospective randomized multi-centre study, the mortality following internal fixation surgery for fracture of the upper femur was investigated in 538 elderly patients allocated to receive subarachnoid blockade or general (narcotic-relaxant) anaesthesia. The 28-day mortality was 6.6% with subarachnoid, and 5.9% wit...

journal_title：British journal of anaesthesia

authors： Davis FM,Woolner DF,Frampton C,Wilkinson A,Grant A,Harrison RT,Roberts MT,Thadaka R

更新日期：1987-09-01 00:00:00

abstract：:We describe the management of three patients undergoing awake carotid surgery who developed signs of cerebral ischaemia after carotid cross-clamping. Drug treatment to increase arterial blood pressure above baseline reversed the neurological deficit and an internal carotid artery shunt was not needed. Shunt insertion ...

journal_title：British journal of anaesthesia

authors： Stoneham MD,Warner O

更新日期：2001-10-01 00:00:00

abstract：:Bupivacaine 2.5 mg kg-1 (0.5 ml kg-1 of 0.5% solution), with or without adrenaline 5 micrograms ml-1, was administered by interpleural injection to 12 patients after elective cholecystectomy. Noncompartmental analysis indicated that the addition of adrenaline had no effect on total body clearance, apparent volume of d...

journal_title：British journal of anaesthesia

authors： Gin T,Chan K,Kan AF,Gregory MA,Wong YC,Oh TE

更新日期：1990-06-01 00:00:00

abstract：:Thiopentone 4 mg/kg, Althesin 0.055 ml/kg and ketamine 2 mg/kg were compared in 157 children undergoing minor otolaryngological surgery, mostly adenotonsillectomy. Premedication was with pethidine and atropine and anaesthesia was maintained with nitrous oxide in oxygen and halothane. Tracheal intubation was facilitate...

journal_title：British journal of anaesthesia

authors： Saarnivaara L

更新日期：1977-04-01 00:00:00

abstract：BACKGROUND:Endothelial dysfunction might be involved in the development of cerebral vasospasm after aneurysmal subarachnoid haemorrhage (SAH). METHODS:This prospective observational study of 48 SAH subjects and 23 control subjects examined associations between reactive hyperaemia index (RHI) measured by peripheral art...

journal_title：British journal of anaesthesia

authors： Bergström A,Staalsø JM,Romner B,Olsen NV

更新日期：2014-02-01 00:00:00

abstract：:We have studied in eight rabbits the cardiovascular effects of midazolam, propofol and alfentanil with graded hypoxia. Central blood volume was reduced progressively by gradual inflation of a thoracic vena cava cuff so that cardiac index (CI) decreased at a constant rate. Under control conditions the haemodynamic resp...

journal_title：British journal of anaesthesia

authors： Blake DW,Van Leeuwen AF,Petring OU,Ludbrook J,Ventura S

更新日期：1995-11-01 00:00:00

abstract：Background:Blood lactate is a strong predictor of mortality, and repeated blood lactate assays are recommended during surgery in high-risk patients. We hypothesized that the use of intravascular microdialysis incorporated in a central venous catheter would be interchangeable with the reference blood gas technique to mo...

journal_title：British journal of anaesthesia

authors： Gouëzel C,Lorne E,Bonnet V,Fradin S,Saplacan V,Gérard JL,Hanouz JL,Fellahi JL,Fischer MO,FHT (French Hemodynamic Team).

更新日期：2017-12-01 00:00:00

abstract：:We have compared iontophoretically and locally applied lidocaine for relief of pain on propofol injection. Pain was assessed on insertion of a 20-gauge i.v. cannula and at 10-s intervals for 30 s after injection of propofol. Pain scores on cannulation were significantly less in the iontophoresis group (median 1.1) tha...

journal_title：British journal of anaesthesia

authors： Sadler PJ,Thompson HM,Maslowski P,Liddle A,Rowbotham DJ

更新日期：1999-03-01 00:00:00

abstract：:Postoperative management following major surgery in patients with neuromuscular disorders associated with scoliosis is frequently complicated by sputum retention and ventilatory failure. This report demonstrates the successful perioperative management of an 11-yr-old boy with type II spinal muscular atrophy undergoing...

journal_title：British journal of anaesthesia

authors： Marchant WA,Fox R

更新日期：2002-10-01 00:00:00

abstract：:A method for the assessment and management of factors both causing and maintaining a primary metabolic alkalosis is presented. During a 2-year period 65 patients with metabolic alkalosis were treated with saline and potassium chloride infusions. In four patients the alkalosis was refractory and required additional the...

journal_title：British journal of anaesthesia

authors： Worthley LI

更新日期：1977-08-01 00:00:00

abstract：:The circulating blood volume (CBV) of critically ill patients may be difficult to estimate on the basis of history and physical examination. The aim of this study was to evaluate the ability of seven clinical signs and central venous pressure (CVP) to predict CBV in critically ill patients; CBV was evaluated with the ...

journal_title：British journal of anaesthesia

authors： Stéphan F,Flahault A,Dieudonné N,Hollande J,Paillard F,Bonnet F

更新日期：2001-06-01 00:00:00

abstract：:Diltiazem inhibited and antagonized the abnormal contractures induced by halothane, caffeine and potassium chloride in isolated skeletal muscle from pigs susceptible to malignant hyperpyrexia (MHS). Contractile responses to caffeine and electrical stimulation also were suppressed by diltiazem in control tissue. Simila...

journal_title：British journal of anaesthesia

authors： Foster PS,Denborough MA

更新日期：1989-05-01 00:00:00

abstract：:We have investigated the effect of four doses of remifentanil on the incidence of respiratory depression and somatic response at incision. Remifentanil was administered as a loading dose of 0.125, 0.25, 0.375 or 0.5 microgram kg-1 and at a maintenance infusion rate of 0.025, 0.05, 0.075 or 0.1 microgram kg-1 min-1, re...

journal_title：British journal of anaesthesia

authors： Peacock JE,Luntley JB,O'Connor B,Reilly CS,Ogg TW,Watson BJ,Shaikh S

更新日期：1998-04-01 00:00:00

abstract：:The effect of the topical application of a lignocaine-prilocaine cream (EMLA) on the pain of venous cannulation was tested in a double-blind manner. Sixty boys and girls between the ages of 4 and 10 yr who were to undergo surgery participated in the study. No analgesic premedication was given and the venous cannulatio...

journal_title：British journal of anaesthesia

authors： Maunuksela EL,Korpela R

更新日期：1986-11-01 00:00:00