Remifentanil in combination with propofol for spontaneous ventilation anaesthesia.

Abstract:

:We have investigated the effect of four doses of remifentanil on the incidence of respiratory depression and somatic response at incision. Remifentanil was administered as a loading dose of 0.125, 0.25, 0.375 or 0.5 microgram kg-1 and at a maintenance infusion rate of 0.025, 0.05, 0.075 or 0.1 microgram kg-1 min-1, respectively, with an infusion of propofol 6 mg kg-1 h-1. Responses occurred in 88% of patients with remifentanil 0.025 microgram kg-1 min-1 compared with 30-40% in the other groups. Respiratory depression after incision increased from 6% with remifentanil 0.025 microgram kg-1 min-1 to 73% with 0.1 microgram kg-1 min-1. Increases in propofol infusion rate to 7.2-8.4 mg kg-1 h-1 produced adequate maintenance of anaesthesia. Reductions in remifentanil doses to 0.025-0.05 microgram kg-1 min-1 resulted in adequate respiration at the end of surgery in 88% of patients. Maintenance infusions of the two drugs for spontaneous ventilation are likely to be in these ranges. However, the ideal loading doses and infusion rates for induction remain to be established.

journal_name

Br J Anaesth

authors

Peacock JE,Luntley JB,O'Connor B,Reilly CS,Ogg TW,Watson BJ,Shaikh S

doi

10.1093/bja/80.4.509

subject

Has Abstract

pub_date

1998-04-01 00:00:00

pages

509-11

issue

4

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)40474-0

journal_volume

80

pub_type

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