Abstract：
:We have studied the effect of milrinone on pulmonary vascular resistance (PVR) in dogs with hypoxic pulmonary vasoconstriction (HPV). Using a pulmonary arterial occlusion method, we measured effective pulmonary capillary pressure (Pcap) by which total PVR was partitioned into arterial (PVRa) and venous (PVRv) components. Hypoxic ventilation (FIO2 = 0.11-0.13) produced significant increases in mean pulmonary arterial pressure (PAP) and Pcap (P < 0.01) associated with increases in PVRa and PVRv (P < 0.01). During the hypoxic period, milrinone significantly decreased mean PAP and Pcap (P < 0.01), reflected in decreases in PVRa and PVRv (P < 0.01). The longitudinal distribution of PVR (PVRa/PVRv) remained unchanged throughout the experiment, indicating that HPV occurred equally in the arterial and venous segments and that milrinone-induced vasodilatation occurred equally in both segments. During hypoxia, milrinone did not produce an increase in cardiac output or a decrease in PaO2. Milrinone also produced significant decreases in mean systemic arterial pressure (P < 0.01) and systemic vascular resistance (P < 0.05) to a similar extent to the decreases in mean PAP and PVR, suggesting no selective dilating effect of milrinone on the pulmonary vasculature. These results indicate that in HPV, milrinone decreased the vascular tone of both pulmonary arterial and venous segments without increasing cardiac work or impairing pulmonary oxygenation. This suggests a potential for use in patients suffering from hypoxic pulmonary hypertension.
journal_name
Br J Anaesthjournal_title
British journal of anaesthesiaauthors
Kato R,Sato J,Nishino Tdoi
10.1093/bja/81.6.920subject
Has Abstractpub_date
1998-12-01 00:00:00pages
920-4issue
6eissn
0007-0912issn
1471-6771pii
S0007-0912(17)39469-2journal_volume
81pub_type
杂志文章abstract：BACKGROUND:We investigated the effects of spinal and general anaesthesia and surgical tourniquet on acute pain and early recovery after total knee arthroplasty (TKA). METHODS:Patients (n=413) were randomised to four parallel groups: spinal anaesthesia with or without tourniquet, and general anaesthesia with or without...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.bja.2020.03.036
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:Dexmedetomidine is an α-2-receptor agonist which might be used as an additive to local anaesthetics for various regional anaesthetic techniques. We therefore designed this prospective, double-blinded, controlled volunteer study to investigate the effects of dexmedetomidine as an adjuvant to ropivacaine on pe...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1093/bja/aes400
更新日期：2013-03-01 00:00:00
abstract：Background:In addition to general anaesthetic effects, sevoflurane can also induce hyperactive behaviours during induction and recovery, which may contribute to neurotoxicity; however, the mechanism of such effects is unclear. Volatile anaesthetics including isoflurane have been found to activate the kainate (GluK2) re...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aex043
更新日期：2017-11-01 00:00:00
abstract：BACKGROUND:Axillary vein catheterization via a distal approach is an alternative to the proximal approach to axillary/subclavian vein catheterization under ultrasound (US) guidance. The aim of this trial was to compare the two approaches. METHODS:In a randomized single-centre study, all patients requiring central vein...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1093/bja/aev458
更新日期：2016-02-01 00:00:00
abstract：:In clinical use, the concentrations of local anaesthetics at the site of action are unknown. With the method described here, concentrations of local anaesthetics can be predetermined and kept constant at the site of action. In six volunteers, a blister was raised on the ventral surface of the forearm. After removal of...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/70.5.552
更新日期：1993-05-01 00:00:00
abstract：:A method for the assessment and management of factors both causing and maintaining a primary metabolic alkalosis is presented. During a 2-year period 65 patients with metabolic alkalosis were treated with saline and potassium chloride infusions. In four patients the alkalosis was refractory and required additional the...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/49.8.811
更新日期：1977-08-01 00:00:00
abstract：BACKGROUND:Short-axis ultrasound-guided placement of central venous catheters (CVCs) is widely accepted as safe practice. However, utilizing the long-axis approach could further improve safety, as it allows for better visualization of the needle as it is advanced to the target vessel. However, the long-axis approach ha...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1093/bja/aer329
更新日期：2012-01-01 00:00:00
abstract：:The Swedish Society of Anaesthetists conducted a nationwide retrospective survey of clinical experience with extradural and intrathecal opiates. Special interest was focused on the frequency and type of ventilatory depression. The questionnaire was answered by 84 of 93 departments (90%). Up to May 1981 extradural morp...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/54.5.479
更新日期：1982-05-01 00:00:00
abstract：:We have investigated whether nitrous oxide antagonizes or augments the CNS stimulant action of laudanosine in mice by comparing the mean convulsive doses (CD50 (SE] of a control group and those following pretreatment with 65% nitrous oxide in oxygen for 20 and 180 min. Nitrous oxide significantly increased CD50 from 4...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/65.5.704
更新日期：1990-11-01 00:00:00
abstract：:This article briefly reviews psychological aspects of pain, paying special attention to chronic pain. The review considers the interruptive and interference effects of pain and its impact on a person's identity. The importance of processes related to interruption, interference, and identity will vary across people and...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,评审
doi：10.1093/bja/aen123
更新日期：2008-07-01 00:00:00
abstract：:We have investigated the effect of a bolus injection of atracurium 0.6 mg kg-1 on the cardiovascular system in 16 patients undergoing aortocoronary bypass surgery. H1- and H2-receptor antagonists were administered to eight patients before the neuromuscular blocker. A standard anaesthetic was used comprising fentanyl, ...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章
doi：10.1093/bja/68.2.155
更新日期：1992-02-01 00:00:00
abstract：:We have compared the postoperative morphine requirements and analgesic efficacy of four doses of i.m. ketorolac 30 mg administered 6-hourly with placebo in a double-blind study of patients undergoing major or minor orthopaedic surgery. During the 24-h postoperative study period which began at the end of surgery, patie...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/69.1.19
更新日期：1992-07-01 00:00:00
abstract：:The effect of the intrathecal administration of diamorphine on the hyperglycaemic, adrenocortical and cardiovascular responses to major colonic surgery were investigated, and the results compared with those obtained in a similar group of patients receiving low doses of fentanyl. In the group receiving intrathecal diam...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/57.4.389
更新日期：1985-04-01 00:00:00
abstract：:Patients are at risk for several types of lung injury in the perioperative period including atelectasis, pneumonia, pneumothorax, acute lung injury, and acute respiratory distress syndrome. Anaesthetic management can cause, exacerbate, or ameliorate these injuries. This review examines the effects of perioperative mec...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,评审
doi：10.1093/bja/aeq299
更新日期：2010-12-01 00:00:00
abstract：BACKGROUND:Left ventricular stroke volume variation (SVV) has been shown to be a predictor of fluid responsiveness in various subsets of patients. However, the accuracy and reliability of SVV are unproven in patients ventilated with low tidal volumes. METHODS:Fourteen patients were studied immediately after coronary a...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aeh280
更新日期：2004-12-01 00:00:00
abstract：:We describe the anaesthetic management of a patient undergoing lobectomy for cavitating lung abscess complicated by haemoptysis. Surgery for lung abscess is one of the absolute indications for the use of a double-lumen tube (DLT). Because pus or blood could impede fibreoptic-assisted DLT placement, a traditional, blin...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/85.5.791
更新日期：2000-11-01 00:00:00
abstract：BACKGROUND:Aortocaval compression (ACC) can result in haemodynamic disturbances and uteroplacental hypoperfusion in parturients. Its detection is difficult because in most patients, sympathetic compensation results in no signs or symptoms. However, profound hypotension may develop after sympathectomy during regional an...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1093/bja/aes349
更新日期：2012-12-01 00:00:00
abstract：:The analgesic effects of buprenorphine 2 microgram/kg--1 and 8 microgram. kg--1 were compared with those of pethidine 1 mg. kg--1 and pentazocine 0.6 mg.kg--1 in 172 patients recovering from surgery. The drugs were given by i.m. injection in the period immediately after operation and the quality of pain relief was ass...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章
doi：10.1093/bja/49.9.913
更新日期：1977-09-01 00:00:00
abstract：:We present a case of pulmonary thromboendarterectomy performed successfully in a patient with stomatocytosis. Stomatocytosis is a rare condition of abnormal erythrocyte morphology in which haemolysis and hyperkalaemia occur at cooler temperatures. A 35-yr-old male with stomatocytosis was referred for pulmonary thrombo...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aeg237
更新日期：2003-11-01 00:00:00
abstract：:In vitro experiments on the rat phrenic nerve-hemidiaphragm preparation, stimulated directly or indirectly with supramaximal impulses at 0.1 Hz revealed that pethidine in concentrations greater than 5 micrograms ml-1 caused a rapid increase of the twitch. This was maximal (60% increase during direct and 70% increase d...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/56.2.195
更新日期：1984-02-01 00:00:00
abstract：:In order to investigate the analgesic effect of timing of administration of ketorolac 10 mg i.v., we recorded patient-controlled use of diamorphine at 2, 4 and 12 h after abdominal hysterectomy. In a randomized, double-blind trial, 30 patients received ketorolac before skin incision and 28 after skin closure. A contro...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/75.1.15
更新日期：1995-07-01 00:00:00
abstract：BACKGROUND:Assessments of labour pain focus on pain intensity, not on duration. We aimed to assess the importance labouring women apply to pain intensity and duration before labour and post-delivery. METHODS:Forty healthy women scheduled for labour induction were enrolled in this institutional review board-approved, p...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aeu149
更新日期：2014-09-01 00:00:00
abstract：:We investigated the effects of anaesthesia on dynamic nitric oxide production, concentrations of tetrahydrobiopterin and the accumulation of cyclic GMP (cGMP) in the rat central nervous system (CNS). Rats were assigned to anaesthesia with halothane, isoflurane, pentobarbital, diazepam, ketamine or xenon (n=6 per group...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/86.3.388
更新日期：2001-03-01 00:00:00
abstract：BACKGROUND:As general anaesthesia may compromise the immune system, it has been hypothesized that latent varicella-zoster virus is more likely to be reactivated and cause herpes zoster in mothers after Caesarean deliveries under general anaesthesia. Our study was thus aimed at investigating the risk of herpes zoster am...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aer386
更新日期：2012-02-01 00:00:00
abstract：:The aim of this study was to find, using modern techniques, any histological differences in muscle biopsies between malignant hyperthermia (MH) susceptible (MHS), MH equivocal (MHE) and MH negative (MHN) patients. On the basis of the European MH contracture test carried out in 83 patients, 23 were shown to be MHS, nin...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/79.3.327
更新日期：1997-09-01 00:00:00
abstract：:Respiratory mass spectrometry and on-line computation were used to estimate lung volume in normal subjects by a rebreathing technique, using oxygen, nitrogen and argon as indicators. The computation had previously been tested in a numerical model. In real normal lungs, it performed well enough for practical purposes, ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/56.5.509
更新日期：1984-05-01 00:00:00
abstract：:Gastric (GP) and lower oesophageal sphincter pressures (LOSP) were measured in non-pregnant female volunteers (group I) and pregnant women with (group III) or without (group II) heartburn. Patients in early pregnancy had greater gastric pressures than group I. Mean barrier pressure (LOSP-GP) was significantly decrease...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/53.4.381
更新日期：1981-04-01 00:00:00
abstract：BACKGROUND:Transitions into and out of the anaesthetised state exhibit resistance to state transitions known as neural inertia. As a consequence, emergence from anaesthesia occurs at a consistently lower anaesthetic concentration than induction. Motivated by stochastic switching between discrete activity patterns obser...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1016/j.bja.2018.02.035
更新日期：2018-07-01 00:00:00
abstract：:The physical and pharmacological properties of the structural isomers isoflurane and enflurane differ from each other and from those of other potent inhaled anaesthetics. The minimum alveolar concentration (MAC) for isoflurane (1.15%) is one-and-one-half times that for halothane (0.75%) and two-thirds that for enflura...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,评审
doi：
更新日期：1984-01-01 00:00:00
abstract：:Eighty-one consenting women undergoing elective Caesarean section under spinal anaesthesia were randomly divided into two groups. In Group O patients, ondansetron 4 mg was given intravenously at the end of the surgery and 8 mg added to the morphine solution in the PCA syringe. Patients in Group P received only morphin...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/87.3.502
更新日期：2001-09-01 00:00:00
