Abstract:
BACKGROUND:Several medications have proved to be useful in preventing postoperative nausea and vomiting (PONV). However, routine antiemetic prophylaxis is not cost-effective. We evaluated the accuracy and discriminating power of an artificial neural network (ANN) to predict PONV. METHODS:We analysed data from 1086 in-patients who underwent various surgical procedures under general anaesthesia without antiemetic prophylaxis. Predictors used for ANN training were selected by computing the value of chi(2) statistic and information gain with respect to PONV. The configuration of the ANN was chosen by using a software tool. Then the training of the ANN was performed based on data from a training set (n=656). Testing validation was performed with the remaining patients (n=430) whose outcome regarding PONV was unknown to the ANN. Area under the receiver operating characteristic (ROC) curves were used to quantify predictive performance. ANN performance was compared with those of the Naïve Bayesian classifier model, logistic regression model, simplified Apfel score and Koivuranta score. RESULTS:ANN accuracy was 83.3%, sensitivity 77.9% and specificity 85.0% in predicting PONV. The areas under the ROC curve follow: ANN, 0.814 (0.774-0.850); Naïve Bayesian classifier, 0.570 (0.522-0.617); logistic regression, 0.669 (0.623-0.714); Koivuranta score, 0.626 (0.578-0.672); simplified Apfel score, 0.624 (0.576-0.670). ANN discriminatory power was superior to those of the other predicting models (P<0.05). CONCLUSIONS:The ANN provided the best predictive performance among all tested models.
journal_name
Br J Anaesthjournal_title
British journal of anaesthesiaauthors
Peng SY,Wu KC,Wang JJ,Chuang JH,Peng SK,Lai YHdoi
10.1093/bja/ael282subject
Has Abstractpub_date
2007-01-01 00:00:00pages
60-5issue
1eissn
0007-0912issn
1471-6771pii
S0007-0912(17)35297-2journal_volume
98pub_type
杂志文章abstract::We tested the hypothesis that premedication with i.m. midazolam decreases core temperature dose-dependently. We studied six male volunteers, in random order, on 3 days: (1) no midazolam administration (control day), (2) midazolam 0.025 mg kg-1 i.m., (3) midazolam 0.075 mg kg-1 i.m. On the first day, subjects were main...
journal_title:British journal of anaesthesia
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更新日期:1997-04-01 00:00:00
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journal_title:British journal of anaesthesia
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journal_title:British journal of anaesthesia
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journal_title:British journal of anaesthesia
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更新日期:1987-09-01 00:00:00
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abstract::Mice, previously immunized with sheep erythrocytes, were anaesthetized with halothane and the splenic lymphoid cells were incubated with 3H-thymidine at 1-h intervals. Abiphasic response was observed; 0.9 and 1.5% halothane reduced 3H-thymidine incorporation into the primed lymphoid cells by 83 and 94% respectively, w...
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journal_title:British journal of anaesthesia
pub_type: 杂志文章
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更新日期:1996-03-01 00:00:00
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更新日期:2007-12-01 00:00:00
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abstract::The neuromuscular blocking effects of equipotent doses of the three putative metabolites of vecuronium (3-hydroxy vecuronium, 17-hydroxy vecuronium and 3,17-dihydroxy vecuronium) were compared with those of an equipotent dose of vecuronium. Results obtained with the liver excluded from the circulation and after intrap...
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journal_title:British journal of anaesthesia
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更新日期:1994-10-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2006-11-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2007-01-01 00:00:00
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journal_title:British journal of anaesthesia
pub_type: 杂志文章,随机对照试验
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更新日期:2007-12-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1992-10-01 00:00:00
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journal_title:British journal of anaesthesia
pub_type: 杂志文章,随机对照试验
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