Implicit memory formation in sedated ICU patients after cardiac surgery.

Abstract:

BACKGROUND:Recent research into memory formation under sedation has generated conflicting results. We investigated explicit and implicit memory in ICU patients during moderate to deep propofol sedation following cardiac surgery. METHODS:Two different methods of memory testing were used; (1). free-association (F-A) word-pair testing (n=33) to test conceptual implicit memory and (2). process dissociation procedure (PDP) (n=26) to detect perceptual implicit and explicit memory. One hour after surgery, whilst sedated, the F-A group received one of two lists of 10 category-exemplar word-pairs through headphones, while the PDP group was presented with one of two lists of 16 five-letter words. When awake and co-operative, the F-A group was tested using F-A testing, and the PDP group was tested using the PDP. RESULTS:The F-A group had a mean (SD) correct response rate of 7 (9)% for the target list, and 9 (8)% for the distractor list. The PDP group had a mean (SD) correct response rate of 11 (14) and 10 (13)% for the inclusion and exclusion lists, respectively, with mean correct response rates of 13 (14)% for both the corresponding distractor lists. Neither group showed any significant differences between their responses and a list of distractor words (Wilcoxon tests). CONCLUSION:We found no evidence for memory formation in post-cardiac surgery patients under moderate to deep propofol sedation.

journal_name

Br J Anaesth

authors

Clark J,Voss L,Barnard J,Sleigh J

doi

10.1093/bja/aeg274

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

810-4

issue

6

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)36263-3

journal_volume

91

pub_type

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