Postoperative hypoxaemia: continuous extradural infusion of bupivacaine and morphine vs patient-controlled analgesia with intravenous morphine.

Abstract:

:We carried out a randomized prospective study in 60 patients who had undergone major abdominal surgery for cancer. For postoperative pain control, 30 patients received continuous extradural infusion of 0.125% bupivacaine 12.5 mg h-1 and morphine 0.25 mg h-1 (EXI group) and 30 received patient-controlled analgesia (PCA) with intravenous morphine (1 mg bolus, 5-min lock-out and maximum dose 20 mg 4h-1). Both groups had general anaesthesia. The two groups were compared for postoperative pain scores, satisfaction, sedation and oxygen saturation. Oxygen saturation was recorded continuously the night before surgery and for two consecutive postoperative nights. Episodes of moderate desaturation (90% > SpO2 85%) were more frequent in the EXI group than in the PCA group (P < 0.05). Pain scores were lower in the EXI group compared with the PCA group at rest and while coughing (P < 0.05). No significant difference was found for patient sedation and satisfaction.

journal_name

Br J Anaesth

authors

Motamed C,Spencer A,Farhat F,Bourgain JL,Lasser P,Jayr C

doi

10.1093/bja/80.6.742

subject

Has Abstract

pub_date

1998-06-01 00:00:00

pages

742-7

issue

6

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)40382-5

journal_volume

80

pub_type

临床试验,杂志文章,随机对照试验
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