Comparison of morphine alone with morphine plus clonidine for postoperative patient-controlled analgesia.

Abstract:

BACKGROUND:Clonidine is an alpha 2 adrenergic agonist with analgesic properties. This study aimed to see if the addition of clonidine to morphine when given by patient-controlled analgesia (PCA) would improve analgesia beyond the first 12 h after surgery. METHODS:Sixty patients undergoing lower abdominal surgery were recruited into a randomized double blind study. At the end of surgery Group C received an infusion of clonidine 4 micrograms kg-1 over 20 min, PCA clonidine 20 micrograms and morphine 1 mg bolus. Group M received an infusion of saline and then PCA morphine 1 mg bolus. Pain, sedation and nausea and vomiting were assessed after 12, 24 and 36 h, and satisfaction with analgesia was assessed at 36 h. RESULTS:Pain scores were significantly lower in Group C between 0 and 12 h, but thereafter there was no difference. Morphine consumption was the same for both groups until 24-36 h. Nausea and vomiting was significantly reduced in Group C between 0 and 24 h. Patients in Group C were significantly happier with their pain relief (four-point scale).

journal_name

Br J Anaesth

authors

Jeffs SA,Hall JE,Morris S

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

424-7

issue

3

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)36905-2

journal_volume

89

pub_type

临床试验,杂志文章,随机对照试验
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    更新日期:1979-06-01 00:00:00

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    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

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    pub_type: 杂志文章

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