Abstract:
:The analgesic efficacy of a 150-mg meptazinol suppository was compared with that of morphine 10 mg i.m. in the treatment of moderate postoperative pain. Two groups of 15 female patients took part in a 4-h, randomized double-blind, double-dummy study on the first day after elective abdominal hysterectomy. Meptazinol did not provide satisfactory analgesia in five patients (P less than 0.05). A decrease in mean pain scores (linear analogue scale and verbal rating scale) was seen after the administration of meptazinol, but this was not as great as that produced by morphine i.m., nor was it as long in duration. Significant changes in arterial pressure, heart rate and ventilatory rates were not seen in association with the administration of meptazinol, but were observed after the administration of morphine.
journal_name
Br J Anaesthjournal_title
British journal of anaesthesiaauthors
Moores MA,Frater R,Parry P,Hanning CDdoi
10.1093/bja/60.5.542subject
Has Abstractpub_date
1988-04-01 00:00:00pages
542-6issue
5eissn
0007-0912issn
1471-6771pii
S0007-0912(17)49504-3journal_volume
60pub_type
临床试验,杂志文章,随机对照试验abstract:BACKGROUND:Patients undergoing non-cardiac, non-vascular surgery are at risk of major cardiovascular complications. In non-cardiac surgery, troponin elevation has previously been shown to be an independent predictor of major adverse cardiac events and postoperative mortality; however, a majority of studies have focused...
journal_title:British journal of anaesthesia
pub_type: 杂志文章,meta分析,评审
doi:10.1093/bja/aew321
更新日期:2016-11-01 00:00:00
abstract::Summary While complex physiological mechanisms exist to regulate and optimize tissue oxygenation under various conditions, clinical and experimental evidence indicates that anaemia, unchecked, is associated with organ injury and unfavourable outcomes. More data (especially from human studies) are needed to answer ques...
journal_title:British journal of anaesthesia
pub_type: 杂志文章,评审
doi:10.1093/bja/aer350
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:The debate on lung-protective ventilation strategies for surgical patients is ongoing. Evidence suggests that the use of low tidal volume VT improves clinical outcomes. However, the optimal levels of PEEP and recruitment manoeuvre (RM) strategies incorporated into low VT ventilation remain unclear. METHODS:...
journal_title:British journal of anaesthesia
pub_type: 杂志文章,meta分析
doi:10.1016/j.bja.2019.10.024
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Pulse pressure variation (PPV) and stroke volume variation (SVV) are robust indicators of fluid responsiveness in mechanically ventilated supine patients. The aim of the study was to evaluate the ability of PPV and SVV to predict fluid responsiveness in mechanically ventilated patients in the prone position ...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/aeq031
更新日期:2010-04-01 00:00:00
abstract::In a controlled, randomized study, we evaluated duration of neuromuscular block in 80 patients undergoing routine abdominal surgery. Forty patients were aged 18-50 yr (control group) and 40 patients were more than 65 yr (elderly group). All patients had normal plasma creatinine concentrations. After induction of anaes...
journal_title:British journal of anaesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/bja/74.6.709
更新日期:1995-06-01 00:00:00
abstract:BACKGROUND:We developed a new neuromuscular transmission monitor, the compressomyograph (CMG, European patent number: EP 06018557.6, US patent number: US 60/824.541). This is the first preliminary report comparing neuromuscular block monitored by CMG and the Relaxometer mechanomyograph (MMG). METHODS:The two monitors ...
journal_title:British journal of anaesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1093/bja/aem379
更新日期:2008-03-01 00:00:00
abstract::We studied a cat model simulating laudanosine accumulation in the "anephric" patient. Cardiovascular effects were seen only with the bolus doses of laudanosine 2 mg kg-1, and at plasma laudanosine concentrations unlikely to be achieved clinically. Similarly, EEG and power spectra analysis showed no evidence of epilept...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/58.suppl_1.14s
更新日期:1986-01-01 00:00:00
abstract::We have studied the immediate and long term (up to 28 days) effects of short and long bevelled needle impalement of the rat sciatic nerve. Three techniques were used to assess neural trauma and its consequences: stained longitudinal nerve sections were assessed by light microscopy and scored for injury; the extravasat...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/69.5.433
更新日期:1992-11-01 00:00:00
abstract::Using human nasal cytological brushings, we have investigated the effects of morphine on ciliary function by measurement of cilia beat frequency in vitro, and we have also determined opioid receptor binding in these specimens. We obtained ciliated samples from seven volunteers, and measured cilia beat frequency using ...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/76.2.274
更新日期:1996-02-01 00:00:00
abstract::General anaesthesia for emergency surgery in a pressurized habitat is likely to involve the use of i.v. agents. The anaesthetic property of such agents is known to be antagonized by pressure, but the effect on their duration of action is not easily predicted. The recovery of mice from a single i.v. dose of Althesin, k...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/53.5.455
更新日期:1981-05-01 00:00:00
abstract::Zomepirac 100 mg and dihydrocodeine 30 mg were compared with placebo in a controlled randomized, double-blind, single-dose postoperative study. Patients continued to receive either zomepirac or dihydrocodeine for pain relief for 5 days at home in a double-blind study, being allowed to titrate the consumption of tablet...
journal_title:British journal of anaesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/bja/57.4.412
更新日期:1985-04-01 00:00:00
abstract::In obstetric patients undergoing postpartum tubal ligation, we found that metoclopramide produced dose-dependent prolongation of suxamethonium-induced neuromuscular block. Mean block times after suxamethonium 1 mg kg-1 were 8.0 min, 9.83 min and 12.45 min for control and metoclopramide 10 mg and metoclopramide 20 mg g...
journal_title:British journal of anaesthesia
pub_type: 临床试验,杂志文章
doi:10.1093/bja/65.2.220
更新日期:1990-08-01 00:00:00
abstract:BACKGROUND:The AirWay Scope (AWS) is a fibreoptic device that allows for intubation without alignment of the oral, pharyngeal, and tracheal axes. It may be useful for patients with an unstable cervical-spine (C-spine) or when C-spine movement is undesirable. This study was conducted to fluoroscopically evaluate upper C...
journal_title:British journal of anaesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1093/bja/aen207
更新日期:2008-10-01 00:00:00
abstract::As the physiology of deliberate hypotension has been unravelled, and as each new pharmacological agent has become available which either depresses or blocks peripheral vascular tone, depresses myocardial performance, or interferes with the conducting tissues within the myocardium, its possible incorporation into the a...
journal_title:British journal of anaesthesia
pub_type: 历史文章,杂志文章
doi:10.1093/bja/47.7.745
更新日期:1975-07-01 00:00:00
abstract:BACKGROUND:Thermal, mechanical, and electrical stimuli are often used in acute pain studies and cause qualitatively different pain sensations. Yet, the comparative electroencephalogram (EEG) changes caused by these stimuli have not been studied. We hypothesized that because these stimuli cause different pain sensations...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/ael377
更新日期:2007-03-01 00:00:00
abstract::Hypertensive patients were monitored for myocardial ischaemia during anaesthesia and surgery with the V5 lead of a standard electrocardiograph. Myocardial ischaemia was detected in 11 of 39 untreated hypertensive patients and in four of seven receiving therapy with a diuretic, but in none of 44 receiving atenolol. Fou...
journal_title:British journal of anaesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/bja/61.6.675
更新日期:1988-12-01 00:00:00
abstract::In a prospective study, patients undergoing abdominal surgery were allocated randomly to receive intermittent morphine 10 mg i.m. (n = 41) or a single injection of buprenorphine 0.3 mg i.m. followed by sublingual buprenorphine 0.4 mg every 6 h (n = 39) for 3 days following operation. Patients receiving buprenorphine w...
journal_title:British journal of anaesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/bja/56.8.855
更新日期:1984-08-01 00:00:00
abstract::We have investigated the effects of clonidine on gastric emptying of liquids in 30 patients. In a double-blind, randomized design, clonidine 150 micrograms, morphine 10 mg or saline in 1 ml was given i.m. One hour later, the patient drank a paracetamol solution (1.5 g in 50 ml water). Venous blood samples were obtaine...
journal_title:British journal of anaesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/bja/78.1.28
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:State entropy (SE) is a newly available monitor for depth of anaesthesia. We investigated whether the relationship between predicted effect-site propofol concentration and Bispectral Index (BIS) and SE values is useful for predicting loss of verbal contact and loss of consciousness during steady-state condit...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/aei075
更新日期:2005-04-01 00:00:00
abstract::We have assessed tracheal intubating conditions in 60 ASA I or II patients after induction of anaesthesia with propofol 2.5 mg kg-1 and alfentanil 10 or 20 micrograms kg-1 with or without i.v. lignocaine 1 mg kg-1. No neuromuscular blocking agents were administered. Patients were allocated randomly to four groups: gro...
journal_title:British journal of anaesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/bja/70.2.163
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:The analgesic efficacy of continuous transversus abdominis plane (TAP) blocks in comparison with that of single-injection TAP blocks is not clear. This randomized, triple-blind, placebo-controlled trial investigated the benefits of adding continuous TAP blocks to single-injection TAP blocks after a laparotom...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/aew339
更新日期:2016-12-01 00:00:00
abstract::We have documented the changes in gas exchange, haemodynamic state and associated physiological variables which occurred after graft reperfusion in 20 patients undergoing uncomplicated orthotopic liver transplantation. Gas exchange was measured during constant ventilation using a metabolic monitor. After reperfusion, ...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/81.3.311
更新日期:1998-09-01 00:00:00
abstract::Patients with metastatic carcinoid tumours often undergo surgical procedures to reduce the tumour burden and associated debilitating symptoms. These procedures and anaesthesia can precipitate a life-threatening carcinoid crisis. To assess perioperative outcomes, we studied retrospectively the medical records of adult ...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/87.3.447
更新日期:2001-09-01 00:00:00
abstract::The effect of pretreatment with suxamethonium, gallamine or pancuronium on suxamethonium-induced fasciculations and myalgia was studied in a controlled, randomized and double-blind clinical trial. Both fasciculations and myalgia were assessed on a four-point rating scale. There was no significant correlation between f...
journal_title:British journal of anaesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/bja/60.4.367
更新日期:1988-03-01 00:00:00
abstract::Six patients with airway stenosis were submitted to bronchoscopy under general anaesthesia. Each was ventilated with a gas mixture of 50% oxygen and nitrogen using successively manual jet insufflation (JV) using the Sanders technique at 20 b.p.m., and high frequency jet ventilation (HFJV) at rates of 150, 300 and 500 ...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/55.10.969
更新日期:1983-10-01 00:00:00
abstract::Two groups of six patients were studied during light general anaesthesia using 2% enflurane and 66% nitrous oxide in oxygen, combined with regional anaesthesia, for hernia and varicose vein surgery. The effects of 3% enflurane were compared with those of fentanyl 0.3 microgram kg-1 i.v., by measuring inspired flow, ti...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/55.9.825
更新日期:1983-09-01 00:00:00
abstract::Using in vivo microdialysis, we have investigated the effects of propofol on acetylcholine (ACh) release from various regions of the rat brain. Propofol 25 and 50 mg kg-1 i.p. decreased basal ACh release from the frontal cortex by 70% and 85%, respectively. Propofol 25 and 50 mg kg-1 i.p. decreased basal ACh release f...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/80.5.644
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND:Recent research into memory formation under sedation has generated conflicting results. We investigated explicit and implicit memory in ICU patients during moderate to deep propofol sedation following cardiac surgery. METHODS:Two different methods of memory testing were used; (1). free-association (F-A) wor...
journal_title:British journal of anaesthesia
pub_type: 杂志文章
doi:10.1093/bja/aeg274
更新日期:2003-12-01 00:00:00
abstract::Bupivacaine is used widely as a local anaesthetic but has potential for severe cardiovascular and central nervous system (CNS) toxicity. It has an asymmetric carbon atom giving it a chiral centre, and the commercial preparation is a racemic mixture of its two enantiomers: dextro or R(+)-bupivacaine and levo or S(-)-bu...
journal_title:British journal of anaesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/bja/80.5.594
更新日期:1998-05-01 00:00:00
abstract::Anaesthetic and sedative drugs transiently disrupt normal neural activity to facilitate healthcare procedures in children, but they can also cause long-term brain injury in experimental animal models. The US Food and Drug Administration (FDA) has recently advised that repeated or lengthy exposures to anaesthetic and s...
journal_title:British journal of anaesthesia
pub_type: 杂志文章,评审
doi:10.1093/bja/aex141
更新日期:2017-09-01 00:00:00