Comparison of decreases in ventilation caused by enflurane and fentanyl during anaesthesia.

Abstract:

:Two groups of six patients were studied during light general anaesthesia using 2% enflurane and 66% nitrous oxide in oxygen, combined with regional anaesthesia, for hernia and varicose vein surgery. The effects of 3% enflurane were compared with those of fentanyl 0.3 microgram kg-1 i.v., by measuring inspired flow, tidal volume, the timing of inspiration and expiration, and occlusion pressure. Three per cent enflurane decreased ventilation by 12%. Tidal volume, mean inspiratory flow and occlusion pressure were decreased in approximately equal proportions (14, 12 and 8%, respectively). The timing of breathing did not change significantly. Fentanyl did not influence tidal volume. Ventilation was decreased by 28% as a result of a 10% decrease in inspiratory flow and a marked increase in the duration of expiration by 45%. The pattern of activation of the inspiratory muscles, as indicated by occlusion pressure, was changed by fentanyl. During enflurane and nitrous oxide anaesthesia, depression of ventilation by fentanyl or increases in enflurane concentration was not by a common central depressant mechanism.

journal_name

Br J Anaesth

authors

Drummond GB

doi

10.1093/bja/55.9.825

subject

Has Abstract

pub_date

1983-09-01 00:00:00

pages

825-35

issue

9

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)42489-5

journal_volume

55

pub_type

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