Extradural analgesia: the influence of volume and concentration of bupivacaine on the mode of delivery, analgesic efficacy and motor block.

Abstract:

:Five hundred and seventeen women in labour receiving extradural analgesia, using bupivacaine plain solution, were randomly allocated to one of three groups. Group A received 6-8ml of 0.5% solution, group B 10-14ml of 0.25% solution, and group C 6-8 ml of 0.25% solution. Spontaneous delivery occurred in 31.7% of patients in group A, 38.7% in group B and 53% in group C (P less than 0.001). The percentage of rotational forceps, ventouse and Caesarean section deliveries was similar in the three groups. Analgesia was most effective in group A, and at least in group C, both during labour and at delivery, although assessment by linear analogue score suggested that the differences between the three groups were slight. Motor block was most frequent and rapidly progressive in groups A, but was progressive in all groups, and after five or more top-up injections, was similar in the three groups. Difficulties with micturition following delivery were significantly more common in group A.

journal_name

Br J Anaesth

authors

Thorburn J,Moir DD

doi

10.1093/bja/53.9.933

subject

Has Abstract

pub_date

1981-09-01 00:00:00

pages

933-9

issue

9

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)46870-X

journal_volume

53

pub_type

临床试验,杂志文章,随机对照试验
  • Efficacy of nitroglycerin inhalation in reducing pulmonary arterial hypertension in children with congenital heart disease.

    abstract:BACKGROUND:There has been a renewed interest in nitric oxide donor drugs, such as nitroglycerin, delivered by the inhalational route for treatment of pulmonary arterial hypertension (PAH). We investigated the acute effects of inhaled nitroglycerin on pulmonary and systemic haemodynamics in children with PAH associated ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/ael112

    authors: Goyal P,Kiran U,Chauhan S,Juneja R,Choudhary M

    更新日期:2006-08-01 00:00:00

  • Evaluation of postural stability after low-dose droperidol in outpatients undergoing gynaecological dilatation and curettage procedure.

    abstract:BACKGROUND:Low-dose droperidol is suggested to be cost-effective in preventing nausea and vomiting after ambulatory surgery. This clinical study evaluated patient postural stability using a computerized force platform after an i.v. dose of droperidol 0.625 mg in outpatients undergoing gynaecological dilatation and cure...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/88.6.819

    authors: Song D,Chung F,Yogendran S,Wong J

    更新日期:2002-06-01 00:00:00

  • Use of the Walton-Brodie strain gauge arch to measure contractile force during anaesthesia.

    abstract::The Walton-Brodie strain gauge arch is an instrument that quantitatively measures CF. Like many methods, the strain gauge arch is affected by loading conditions and heart rate. Nevertheless, this methodology, when properly used, has proved very useful in describing the direct action of anaesthetic drugs. Knowledge fro...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1093/bja/60.suppl_1.78s

    authors: Reves JG,Pruett JK

    更新日期:1988-01-01 00:00:00

  • Monitoring of the responsiveness to noxious stimuli during anaesthesia with propofol and remifentanil by using RIII reflex threshold and bispectral index.

    abstract:BACKGROUND:Movement responses are an important indicator of noxious perception in the unconscious state. To allow for a continual monitoring of the responsiveness to noxious stimuli during general anaesthesia, surrogate parameters are needed. Here we compare the performance of the bispectral index (BIS) and the RIII th...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aep357

    authors: von Dincklage F,Hackbarth M,Mager R,Rehberg B,Baars JH

    更新日期:2010-02-01 00:00:00

  • Changes in the effect of propofol in response to altered plasma protein binding during normothermic cardiopulmonary bypass.

    abstract:BACKGROUND:During normothermic cardiopulmonary bypass (CPB), the effect on propofol pharmacokinetics of changes in its binding to plasma proteins is consistent with the predictions of the well-stirred model of hepatic elimination for nonrestrictively cleared drug. However, whether changes in binding lead to clinically ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/bja/aei293

    authors: Takizawa E,Hiraoka H,Takizawa D,Goto F

    更新日期:2006-02-01 00:00:00

  • Analgesic effect of aprotinin in the rat and its inhibition by naloxone.

    abstract::Experiments were performed on rats using two analgesimetric tests (tail-flick; hot-plate) before and after injection i.v. of graded doses of aprotinin (12.5, 25.0 and 50 KIU g-1). A dose-related analgesic effect was noted with both tests. Prior administration of naloxone 0.001 mg g-1 i.p. inhibited the analgesic actio...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/52.11.1107

    authors: Novelli GP,Pieraccioli E,Peduto VA,Festimanni F

    更新日期:1980-11-01 00:00:00

  • Impact of balanced tetrastarch raw material on perioperative blood loss: a randomized double blind controlled trial.

    abstract:BACKGROUND:As 6% hydroxyethyl starch (HES) 130/0.40 or 130/0.42 can originate from different vegetable sources, they might have different clinical effects. The purpose of this prospective, randomized, double-blind controlled trial was to compare two balanced tetrastarch solutions, one maize-derived and one potato-deriv...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/bja/aew249

    authors: Joosten A,Tircoveanu R,Arend S,Wauthy P,Gottignies P,Van der Linden P

    更新日期:2016-10-01 00:00:00

  • A measure of consciousness and memory during isoflurane administration: the coherent frequency.

    abstract::The coherent frequency (CF) of the auditory evoked response (AER) is derived using auditory clicks presented at frequencies in the range 5-47 Hz. CF and psychological performance were measured while seven subjects breathed isoflurane in doses increasing from 0% to 0.2%, 0.4% and 0.8% end-tidal concentration and then d...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/71.5.633

    authors: Munglani R,Andrade J,Sapsford DJ,Baddeley A,Jones JG

    更新日期:1993-11-01 00:00:00

  • A study of intracuff pressure measurements, trends and behaviour in patients during prolonged periods of tracheal intubation.

    abstract::Intracuff pressure (c.p.) was measured continuously in 12 patients during prolonged periods of tracheal intubation. High residual volume--low pressure (floppy) and low residual volume--high pressure (conventional) cuffs were studied. The mean baseline c.p. at minimal occluding pressure was significantly smaller in flo...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/53.1.97

    authors: Jacobson L,Greenbaum R

    更新日期:1981-01-01 00:00:00

  • Heat retention using passive systems during anaesthesia: comparison of two plastic wraps, one with reflective properties.

    abstract::Hypothermia during prolonged surgery may be prevented by active and passive warming methods. We have compared randomly two types of occlusive body wraps in groups of 20 patients. One wrap had additional reflective properties which, by reducing radiative in addition to convective and evaporative heat loss, was expected...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/79.6.766

    authors: Deacock S,Holdcroft A

    更新日期:1997-12-01 00:00:00

  • Noninvasive continuous cardiac output monitoring in perioperative and intensive care medicine.

    abstract::The determination of blood flow, i.e. cardiac output, is an integral part of haemodynamic monitoring. This is a review on noninvasive continuous cardiac output monitoring in perioperative and intensive care medicine. We present the underlying principles and validation data of the following technologies: thoracic elect...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1093/bja/aeu447

    authors: Saugel B,Cecconi M,Wagner JY,Reuter DA

    更新日期:2015-04-01 00:00:00

  • Effects of levobupivacaine and ropivacaine on rat sciatic nerve blood flow.

    abstract:BACKGROUND:Ischaemia is one of the causative mechanisms of peripheral nerve injury, a documented complication of regional anaesthesia. Local anaesthetics per se and/or vasopressor adjuvants may account for changes in peripheral nerve blood flow. The aim of this study was to test the effects of levobupivacaine and ropiv...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aei242

    authors: Bouaziz H,Iohom G,Estèbe JP,Campana WM,Myers RR

    更新日期:2005-11-01 00:00:00

  • Extradural analgesia with clonidine and fentanyl compared with 0.25% bupivacaine in the first stage of labour.

    abstract::Conventional extradural analgesia during labour with 0.25-0.375% bupivacaine may induce motor weakness and subjective sensory deficit, reducing maternal satisfaction. Even in a regimen for ambulatory extradural analgesia (0.1% bupivacaine-fentanyl 2 micrograms ml-1), a potential for proprioreception impairment exists,...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/76.2.319

    authors: Buggy DJ,MacDowell C

    更新日期:1996-02-01 00:00:00

  • Temperature monitoring during general anaesthesia.

    abstract::A study of core temperature monitoring during general anesthesia indicates that this can be introduced as a routine procedure in order to reduce mortality from malignant hyperpyrexia. The temperature profiles of 2410 patients are presented. Both mean rectal and mean oesophageal temperatures decreased during general an...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/52.12.1223

    authors: Crocker BD,Okumura F,McCuaig DI,Denborough MA

    更新日期:1980-12-01 00:00:00

  • Assessment of changes in lactate concentration with intravascular microdialysis during high-risk cardiac surgery using the trend interchangeability method.

    abstract:Background:Blood lactate is a strong predictor of mortality, and repeated blood lactate assays are recommended during surgery in high-risk patients. We hypothesized that the use of intravascular microdialysis incorporated in a central venous catheter would be interchangeable with the reference blood gas technique to mo...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aex338

    authors: Gouëzel C,Lorne E,Bonnet V,Fradin S,Saplacan V,Gérard JL,Hanouz JL,Fellahi JL,Fischer MO,FHT (French Hemodynamic Team).

    更新日期:2017-12-01 00:00:00

  • Collaborative study of the frequency of the fluoride-resistant cholinesterase variant in patients with malignant hyperpyrexia.

    abstract::Cholinesterase phenotyping studies have been carried out in two laboratories on blood specimens from 28 patients shown to be susceptible to malignant hyperpyrexia. In contrast to previously published reports, no evidence could be found for an increase in the frequency of the E1u E1f genotype above that known to occur ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/53.3.245

    authors: Evans RT,Iqbal J,Ellis FR,Halsall PJ,Dietz AA,Lubrano T,Rubinstein HM

    更新日期:1981-03-01 00:00:00

  • Fentanyl and bupivacaine mixtures for extradural blockade.

    abstract::In a prospective double-blind study, single dose lumbar extradural blockade was instituted in 80 healthy male patients undergoing lower abdominal surgery. Patients were assigned randomly to one of four groups. Each group received treatment with 0.5% bupivacaine 20 ml containing adrenaline 1:200 000. To this solution w...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/57.3.275

    authors: Rucci FS,Cardamone M,Migliori P

    更新日期:1985-03-01 00:00:00

  • Extradural morphine for the relief of pain following caesarean section.

    abstract::Thirty patients took part in a double-blind trial to compare morphine 10 mg i.m. with morphine 5 mg into the extradural space for pain relief following Caesarean section. With the extradural route the mean time to first analgesia was 7.95 h compared with 4.75 h for the i.m. route. The mean number of further doses of d...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章

    doi:10.1093/bja/55.12.1201

    authors: Chambers WA,Mowbray A,Wilson J

    更新日期:1983-12-01 00:00:00

  • Increase of paradoxical excitement response during propofol-induced sedation in hazardous and harmful alcohol drinkers.

    abstract:BACKGROUND:Paradoxical excitement response during sedation consists of loss of affective control and abnormal movements. Chronic alcohol abuse has been proposed as a predisposing factor despite lack of supporting evidence. Because alcohol and propofol have a common site of action, we postulated that paradoxical excitem...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aer275

    authors: Jeong S,Lee HG,Kim WM,Jeong CW,Lee SH,Yoon MH,Choi JI

    更新日期:2011-12-01 00:00:00

  • Prospective study of device-related complications in intensive care unit detected by virtual autopsy.

    abstract:BACKGROUND:There has been increasing use of invasive techniques, such as extracorporeal organ support, in intensive care units (ICU), and declining autopsy rates. Thus, new measures are needed to maintain high-quality standards. We investigated the potential of computed tomography (CT)-based virtual autopsy to substitu...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1016/j.bja.2018.02.031

    authors: Wichmann D,Heinemann A,Zähler S,Vogel H,Höpker W,Püschel K,Kluge S

    更新日期:2018-06-01 00:00:00

  • Ambient air contamination in a dental outpatient theatre.

    abstract::The extent of air contamination by halothane in an operating session was correlated with the number of patients, the total usage of halothane, refilling a vaporizer and the number of hyperventilating patients per session. Trichloroethylene content of theatre air correlated only with total usage and refilling a vaporiz...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/51.9.845

    authors: Thompson JM,Barratt RS,Hutton P,Robinson JS,Belcher R,Stephen WI

    更新日期:1979-09-01 00:00:00

  • In vitro interaction of propanidid and suxamethonium with pooled human plasma cholinesterase. A kinetic study.

    abstract::Human plasma cholinesterase (E.C. 3.1.1.8) was shown to be inhibited by physiological concentrations of propanidid and suxamethonium using a colourimetric assay at 25 degrees C and pH 7.2 unit with butyrylthiocholine as substrate. Propanidid inhibited the enzyme in a non-competitive manner (I50 = 2.0 mmol litre-1; app...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/51.3.181

    authors: Taussig PE,Stojak HE,Bennett NR

    更新日期:1979-03-01 00:00:00

  • Caesarean section associated with gross obesity.

    abstract::The anaesthetic and surgical problems associated with Caesarean section in eight grossly obese patients (weight 150-204 kg) are described. In addition to an increase in the frequency and severity of the complications of obesity, those weighing more than 150 kg present a panniculus which may weigh 70 kg. Extradural ana...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/52.9.919

    authors: Hodgkinson R,Husain FJ

    更新日期:1980-09-01 00:00:00

  • Studies of the neuromuscular blocking effects of BW 403C65 in frog and cat muscle.

    abstract::BW 403C65, an isoquinolinium bisquaternary compound, was investigated for its neuromuscular blocking properties. In vitro in from preparations, low concentrations induced an increase in miniature endplate potentials (m.e.p.p.) frequency without altering their amplitude. With increasing concentrations m.e.p.p. frequenc...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/47.9.929

    authors: Post EL,Sokoll MD,Gergis SD,Dretchen KL,Cronnelly R

    更新日期:1975-09-01 00:00:00

  • Performing perioperative optimization of the high-risk surgical patient.

    abstract::Perioperative risk of death after general surgery is quoted as overall less than 1%. However, each individual's risk varies widely according to many identified factors with some having a significantly increased risk of a worse outcome. The observation that manipulating and targeting certain physiological parameters in...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1093/bja/ael102

    authors: Tote SP,Grounds RM

    更新日期:2006-07-01 00:00:00

  • Differentiating the cellular and humoral components of neuromuscular blocking agent-induced anaphylactic reactions in patients undergoing anaesthesia.

    abstract:BACKGROUND:The significance of IgE antibodies to neuromuscular blocking agent (NMBA)-induced anaphylactic reactions during anaesthesia is unclear. We investigated the relevance of IgE to rocuronium using an in vitro technique. METHODS:Serum samples from 61 patients with anaphylactic reactions during anaesthesia were i...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aer028

    authors: Aalberse RC,Kleine Budde I,Mulder M,Stapel SO,Paulij W,Leynadier F,Hollmann MW

    更新日期:2011-05-01 00:00:00

  • One-lung ventilation induces hyperperfusion and alveolar damage in the ventilated lung: an experimental study.

    abstract:BACKGROUND:One-lung ventilation (OLV) increases mechanical stress in the lung and affects ventilation and perfusion (V, Q). There are no data on the effects of OLV on postoperative V/Q matching. Thus, this controlled study evaluates the influence of OLV on V/Q distribution in a pig model using a gamma camera technique ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aen021

    authors: Kozian A,Schilling T,Fredén F,Maripuu E,Röcken C,Strang C,Hachenberg T,Hedenstierna G

    更新日期:2008-04-01 00:00:00

  • Effect of baricity on spinal anaesthesia with amethocaine.

    abstract::Amethocaine 1% solution was mixed with equal volumes of water, 0.9% saline or 10% dextrose to prepare respectively, hypobaric, isobaric and hyperbaric solutions which were compared for intradural spinal anaesthesia in 60 patients. Thirty patients received 10 mg and 30 patients received 15 mg of amethocaine. Injections...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/52.6.589

    authors: Brown DT,Wildsmith JA,Covino BG,Scott DB

    更新日期:1980-06-01 00:00:00

  • Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity.

    abstract::The study of rare families with inherited pain insensitivity can identify new human-validated analgesic drug targets. Here, a 66-yr-old female presented with nil requirement for postoperative analgesia after a normally painful orthopaedic hand surgery (trapeziectomy). Further investigations revealed a lifelong history...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1016/j.bja.2019.02.019

    authors: Habib AM,Okorokov AL,Hill MN,Bras JT,Lee MC,Li S,Gossage SJ,van Drimmelen M,Morena M,Houlden H,Ramirez JD,Bennett DLH,Srivastava D,Cox JJ

    更新日期:2019-08-01 00:00:00

  • Preoxygenation--the importance of a good face mask seal.

    abstract::We have studied 16 healthy volunteers whose lungs were preoxygenated six times each in order to assess the amount of room air entrained during tidal volume preoxygenation if a good seal is not maintained between the face mask and the face. With a fresh gas flow of 10 litre min-1, we found that using gravity alone to h...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章

    doi:10.1093/bja/75.6.777

    authors: McGowan P,Skinner A

    更新日期:1995-12-01 00:00:00