Effect of glatiramer acetate on disease reactivation in MS patients discontinuing natalizumab.

abstract：:An alanin-9valin (Ala-9Val) polymorphism in the mitochondrial targeting sequence of manganese-containing superoxide dismutase (Mn-SOD) has recently been described. We studied this polymorphism in 72 Swedish patients with sporadic motor neuron diseases (MND) and controls using an oligonucleotide ligation assay. There w...

journal_title：European journal of neurology

authors： Van Landeghem GF,Tabatabaie P,Beckman G,Beckman L,Andersen PM

更新日期：1999-11-01 00:00:00

abstract：:This study is aimed at assessing the prevalence and features of psychotic symptoms in a sample of 180 patients with Alzheimer's disease (AD). Sixty-four patients (35.5% of the sample) showed one or more psychotic symptoms. The presence of these symptoms correlated with the severity of the patients' cognitive impairmen...

journal_title：European journal of neurology

authors： Sala SD,Francescani A,Muggia S,Spinnler H

更新日期：1998-11-01 00:00:00

abstract：:The aim of this study was to compare the seizure outcome of two different types of epilepsy surgery, selective amygdalohippocampectomy (AHE) and anterior temporal lobectomy (ATLE) in patients with temporal lobe epilepsy. We included 114 patients who had mesio-temporal lobe epilepsy and hippocampal sclerosis or gliosis...

journal_title：European journal of neurology

authors： Bate H,Eldridge P,Varma T,Wieshmann UC

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Detection of occult atrial fibrillation (AF) is crucial for optimal secondary prevention in stroke patients. The AF detection rate was determined by implantable cardiac monitor (ICM) and compared to the prediction rate of the probability of incident AF by software based analysis of a continuously...

journal_title：European journal of neurology

authors： Reinke F,Bettin M,Ross LS,Kochhäuser S,Kleffner I,Ritter M,Minnerup J,Dechering D,Eckardt L,Dittrich R

更新日期：2018-04-01 00:00:00

abstract：:Cortical excitability of the primary motor cortex is altered in patients with Parkinson's disease (PD). Therefore, modulation of cortical excitability by high frequency repetitive transcranial magnetic stimulation (rTMS) of the motor cortex might result in beneficial effects on motor functions in PD. The present study...

journal_title：European journal of neurology

authors： Khedr EM,Farweez HM,Islam H

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Despite recent advances in neurogenetics that have facilitated the identification of a number of dystonia genes, many familial dystonia syndromes remain without known cause. The aim of the study was to identify the cause of autosomal dominant tremulous myoclonus-dystonia in a UK kindred with affe...

journal_title：European journal of neurology

authors： Balint B,Guerreiro R,Carmona S,Dehghani N,Latorre A,Cordivari C,Bhatia KP,Bras J

更新日期：2020-08-01 00:00:00

abstract：:We report a long-term outcome of motor function in a patient with adult-onset adrenoleukodystrophy after bone marrow transplantation (BMT). Clinically motor function gradually improved and became almost normal in 2 years after BMT. Serial transcranial magnetic stimulation showed gradual improvement of central motor co...

journal_title：European journal of neurology

authors： Hitomi T,Mezaki T,Tomimoto H,Ikeda A,Shimohama S,Okazaki T,Uchiyama T,Shibasaki H

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In a longitudinal population-based dataset of patients with multiple sclerosis (MS), we have previously observed a substantial increase in the female to male sex ratio in Canada over the last 50 years. Here, we aimed to determine whether this change in sex ratio is related to the clinical course ...

journal_title：European journal of neurology

authors： Ramagopalan SV,Byrnes JK,Orton SM,Dyment DA,Guimond C,Yee IM,Ebers GC,Sadovnick AD

更新日期：2010-04-01 00:00:00

abstract：:Recent studies suggest an association between Chlamydia pneumoniae infection with atherosclerosis, including cerebrovascular disease. We investigated the prevalence of Chlamydial seropositivity in patients with acute ischaemic stroke syndrome compared with age- and sex-matched control subjects. Specific antibodies (Ig...

journal_title：European journal of neurology

authors： Madre JG,Garcia JL,Gonzalez RC,Montero JM,Paniagua EB,Escribano JR,Martinez JD,Cenjor RF

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Patients with Parkinson's disease (PD) and chronically treated with L-DOPA exhibit, in a percentage of 10-30%, supra-physiological levels of plasma total homocysteinemia (tHcy). In this study, we have investigated, in a group of hyper-homocysteinemic PD patients, the time of hyper-tHcy recurrence after disco...

journal_title：European journal of neurology

authors： Belcastro V,Pierguidi L,Castrioto A,Menichetti C,Gorgone G,Ientile R,Pisani F,Rossi A,Calabresi P,Tambasco N

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The aim was to study the prevalence of epilepsy in a hospital-based systemic lupus erythematosus (SLE) cohort and to investigate the relationship between epilepsy and other manifestations of neuropsychiatric SLE (NPSLE). METHODS:The study population consisted of 440 SLE patients recruited from 1...

journal_title：European journal of neurology

authors： Hopia L,Andersson M,Svenungsson E,Khademi M,Piehl F,Tomson T

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:There is increasing evidence that repetitive transcranial magnetic stimulation (rTMS) can reduce chronic tinnitus. However, treatment results are characterized by high interindividual variability. Therefore, the identification of predictors for treatment response is of high clinical relevance. METHODS:Clini...

journal_title：European journal of neurology

authors： Frank G,Kleinjung T,Landgrebe M,Vielsmeier V,Steffenhagen C,Burger J,Frank E,Vollberg G,Hajak G,Langguth B

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although there is growing and convincing evidence that socially deprived patients are at higher risk of stroke and worse outcomes, it remains controversial whether or not they suffer more severe stroke. This study aimed to evaluate the influence of social deprivation on initial clinical severity ...

journal_title：European journal of neurology

authors： Béjot Y,Guilloteau A,Joux J,Lannuzel A,Mimeau E,Mislin-Tritsch C,Fournel I,Bonithon-Kopp C,INDIA Study Group.

更新日期：2017-05-01 00:00:00

abstract：:Botulinum A toxin (BT) has been successfully used for the management of spasticity in cerebral palsy (CP). However, the long-term results of BT have not yet been determined. We have studied the evolution of a homogeneous group of patients with CP treated with BT. All these patients had an equinus gait resulting from c...

journal_title：European journal of neurology

authors： García Ruiz PJ,Pascual Pascual I,Sánchez Bernardos V

更新日期：2000-03-01 00:00:00

abstract：:We report here 39 cases in which definite multiple sclerosis (MS) was precipitated or exacerbated by specific hyperextension-hyperflexion cervical cord trauma. The worsening or onset of the symptomatic disease bore a striking temporal relationship to the focal injury. Our data suggests that central nervous system (CNS...

journal_title：European journal of neurology

authors： Chaudhuri A,Behan PO

更新日期：2001-11-01 00:00:00

abstract：:This study examined the relative anti-Parkinson's disease (PD) tremor potencies of pergolide and pramipexole in people with PD, using a 3-month double-blind cross-over design. Patients were randomly assigned to receive either pergolide and then pramipexole (n=9) or vice versa (n=8). The dose of the respective dopamine...

journal_title：European journal of neurology

authors： Navan P,Findley LJ,Undy MB,Pearce RK,Bain PG

更新日期：2005-01-01 00:00:00

abstract：:In this report, we present the clinical and pathological details of a kindred of four individuals with a novel missense mutation (V272A) of the presenilin 1 gene (PSEN1) that experienced a subcortical dementia. The age of onset of symptoms ranged 26-36-year old, with an age at death of 36-46 years. Initial symptom was...

journal_title：European journal of neurology

authors： Jimenez-Escrig A,Rabano A,Guerrero C,Simon J,Barquero MS,Güell I,Ginestal RC,Montero T,Orensanz L

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Haemorrhagic transformation (HT) is common after acute ischaemic stroke. Whether liver function plays a role in HT remains an open question. METHODS:Acute ischaemic stroke patients within 7 days from stroke onset were included. Baseline data including liver function tests were collected. An inde...

journal_title：European journal of neurology

authors： Tan G,Lei C,Hao Z,Chen Y,Yuan R,Liu M

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:The burden of multiple sclerosis (MS) includes fatigue, depression and worsening of health-related quality of life (HRQOL). These changes have not been yet measured in neuromyelitis optica (NMO). Our aim was to assess the HRQOL, fatigue and depression in NMO. METHODS:We administered French validated self-qu...

journal_title：European journal of neurology

authors： Chanson JB,Zéphir H,Collongues N,Outteryck O,Blanc F,Fleury M,Vermersch P,de Seze J

更新日期：2011-06-01 00:00:00

abstract：:The present review of epidemiologic studies on migraine and headache in Europe is part of a larger initiative by the European Brain Council to estimate the costs incurred because of brain disorders. Summarizing the data on 1-year prevalence, the proportion of adults in Europe reporting headache was 51%, migraine 14%, ...

journal_title：European journal of neurology

authors： Stovner LJ,Zwart JA,Hagen K,Terwindt GM,Pascual J

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:  A low ankle-brachial index (ABI) is predictive of peripheral arterial disease (PAD). For unknown reasons, patients with PAD demonstrate higher vascular mortality during follow-up than do those without. Initial stroke severity is a strong predictor of long-term outcome and may be different between patients ...

journal_title：European journal of neurology

authors： Lee DH,Kim J,Lee HS,Cha MJ,Kim YD,Nam HS,Nam CM,Heo JH

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Dopamine is an important neurotransmitter in the regulation of the sleep-wake cycle, and parkinsonian patients suffer from prominent sleep abnormalities. Hence, the question arises whether the disrupted sleep pattern in Parkinson's disease (PD) is responsive to dopaminergic treatment. METHODS:Thirty-two pat...

journal_title：European journal of neurology

authors： Wailke S,Herzog J,Witt K,Deuschl G,Volkmann J

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Oxidative stress is a central factor in the pathogenesis of Parkinson's disease (PD). Heme oxygenase-1 (HO-1) is an antioxidant protein expressed in response to oxidative challenge, and its expression levels are inversely correlated with glycogen synthase kinase-3beta (GSK3beta) activity. Underexpression of ...

journal_title：European journal of neurology

authors： Infante J,García-Gorostiaga I,Sánchez-Juan P,Sierra M,Martín-Gurpegui JL,Terrazas J,Mateo I,Rodríguez-Rodríguez E,Berciano J,Combarros O

更新日期：2010-05-01 00:00:00

abstract：:The clinical outcomes of isocitrate dehydrogenase-wild-type (IDH-wt) lower-grade glioma (LGG) have been the subject of debate for some time. In this meta-analysis, we aimed to assess the prognostic values of several known genetic markers (e.g. TERT promoter mutation, H3F3A mutation, CDKN2A loss) in this tumor group. F...

journal_title：European journal of neurology

authors： Vuong HG,Tran TTK,Ngo HTT,Pham TQ,Nakazawa T,Fung KM,Hassell L,Katoh R,Kondo T

更新日期：2019-03-01 00:00:00

abstract：:The objective of this study was to investigate the efficacy, safety and tolerability of triptans in patients who suffer from familial or sporadic hemiplegic migraine. Seventy-six subjects had used triptans at least once as an abortive treatment. Average triptan response was 6.9 (SD +/-3.1) and adverse event severity 4...

journal_title：European journal of neurology

authors： Artto V,Nissilä M,Wessman M,Palotie A,Färkkilä M,Kallela M

更新日期：2007-09-01 00:00:00

abstract：:One of the main goals when treating spasticity is to relieve pain and improve function. Intramuscular injection of botulinum toxin type A (BTX-A) has gained widespread acceptance in the treatment of spastic cerebral palsy. Several studies have clearly shown the short-term functional benefit of BTX-A treatment. Informa...

journal_title：European journal of neurology

authors： Linder M,Schindler G,Michaelis U,Stein S,Kirschner J,Mall V,Berweck S,Korinthenberg R,Heinen F

更新日期：2001-11-01 00:00:00

abstract：:This paper describes a technique for treatment of relative sialorrhoea by injection of botulinum toxin type A. It includes the rationale for treatment, a description of the regional anatomy, the physiological basis for treatment and the applied pharmacology of the drug. Included also is a case report which is intended...

journal_title：European journal of neurology

authors： Glickman S,Deaney CN

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Hereditary sensory and autonomic neuropathies (HSANs) are a group of clinically and genetically heterogeneous neurological disorders characterized by sensory dysfunctions. Here, 21 affected Chinese families are reported, including 19 with congenital insensitivity to pain with anhidrosis (CIPA; na...

journal_title：European journal of neurology

authors： Zhao F,Mao B,Geng X,Ren X,Wang Y,Guan Y,Li S,Li L,Zhang S,You Y,Cao Y,Yang T,Zhao X

更新日期：2020-08-01 00:00:00

abstract：:We aimed to carry out a study of isolated, unexplained myelopathy which avoided as far as possible selection and referral bias. We used a prospective design with case ascertainment from both neurological and neurosurgical referrals. We wanted to establish the sensitivity, predictive value and possible redundancy of cu...

journal_title：European journal of neurology

authors： Blumhardt LD,Sandercock PA,Moore AP,Woodrow J,Findlay G

更新日期：1995-09-01 00:00:00

abstract：:Epilepsies are amongst the most frequent chronic neurological conditions. Patients suffer from spontaneously recurring seizures because of sudden extensive electrical gray matter discharges. Although the current drug therapy allows many patients at least some degree of a satisfying course of the disease, a substantial...

journal_title：European journal of neurology

authors： Stefan H,Steinhoff BJ

更新日期：2007-10-01 00:00:00