Abstract:
:We aimed to carry out a study of isolated, unexplained myelopathy which avoided as far as possible selection and referral bias. We used a prospective design with case ascertainment from both neurological and neurosurgical referrals. We wanted to establish the sensitivity, predictive value and possible redundancy of currently available tests as assessed by the proportion of such patients who finally developed clinically definite multiple sclerosis at follow up. Although MRI scanning of the spinal cord is now the investigation of choice for myelopathy, the case ascertainment for the present studies was completed, and follow-up commenced, before MRI became available to patients in our catchment region. We believe that this was an important factor in the ascertainment of a representative sample of undiagnosed myelopathies. Of 2104 patients having myelography in a 36-month period, 473 had signs of a myelopathy without lower motor neurone involvement Sixty-nine of these 473 patients (15%, 95% CI 11.8-18.2) eventually satisfied the entry criteria for the prospective trial. Fourteen of the 69 patients (20%) presented with acute or subacute cord syndromes, while 55 (80%) had chronic symptoms of more than 3 months duration. Approximately two-thirds of the chronic cases were progressive and one-third relapsing and remitting. Overall there was a female predominance (3:2) and a significant excess of HLA-DR2 antigen compared with a healthy control population (p < 0.0001). In this series the patients with chronic unexplained myelopathy were younger and had shorter symptom durations (mean 46.5 months) and less disability (mean EDSS 3.0) than cases in other comparable published series. The neurological findings, sex distribution and HLA characteristics were similar to those found in patients with clinically definite MS.
journal_name
Eur J Neuroljournal_title
European journal of neurologyauthors
Blumhardt LD,Sandercock PA,Moore AP,Woodrow J,Findlay Gdoi
10.1111/j.1468-1331.1995.tb00131.xsubject
Has Abstractpub_date
1995-09-01 00:00:00pages
297-305issue
4eissn
1351-5101issn
1468-1331journal_volume
2pub_type
杂志文章abstract:BACKGROUND AND PURPOSE:The prognostic value of serum neurofilament light chain (sNfL), a biomarker of neurodegeneration, compared to other prognostic factors of amyotrophic lateral sclerosis (ALS) at the time of diagnosis, remains unclear. METHODS:Sera from ALS patients were prospectively collected at the first diagno...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14063
更新日期:2020-02-01 00:00:00
abstract::Immunological abnormality is often found in amyotrophic lateral sclerosis (ALS). Antibodies to sulfoglucuronyl paragloboside (SGPG) were reported in ALS, although the pathogenetic significance of the antibodies is still unknown. We have already demonstrated that SGPG, a unique glycolipid, is present in both peripheral...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2000.t01-1-00114.x
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Blood pressure (BP) levels in acute intracerebral hemorrhage (ICH) and mortality have not been thoroughly studied in the young. METHODS:The relationship between BP and mortality was assessed in consecutive patients with first-ever, non-traumatic acute ICH at ≤50 years of age, enrolled in the Hel...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13662
更新日期:2018-08-01 00:00:00
abstract::The prognosis of cerebellar hemorrhage with brain stem compression is known to be poor, and patients who can usually survive are severely disabled with limited benefit from conventional rehabilitation. An innovative cutaneous stimulation was administered to a chronic patient (2 years after the incidence) who has sever...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2003.00573.x
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND:The presence of the apolipoprotein E (ApoE) 4 genotype is associated with an earlier age of onset for Alzheimer's disease (AD) and several other neurodegenerative disorders. The objective of this study was to investigate the effect of ApoE genotypes on the clinical course of amyotrophic lateral sclerosis (AL...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2010.03225.x
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Concerning the great importance of brainstem involvement in multiple sclerosis (MS), the aim of this study was to explore the role of the newly developed vestibular evoked myogenic potentials (VEMP) score as a possible marker of brainstem involvement in MS patients. PATIENTS AND METHODS:This was...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12557
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND: Myasthenia gravis (MG) is an autoimmune disorder mediated by antibodies against the acethylcholine receptor (AchR) of the neuromuscular junction in the majority of patients. METHODS: Here, we examined IgG antibodies against the type 1 nuclear antigen of Epstein-Barr virus (EBNA-1) in the sera of 158 patien...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2011.03636.x
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Recent studies have demonstrated that Alzheimer's disease (AD) and subcortical vascular dementia (SVaD) have white matter (WM) microstructural changes. However, previous studies on AD and SVaD rarely eliminated the confounding effects of patients with mixed Alzheimer's and cerebrovascular disease...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12645
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:CACNA1S encodes Cav 1.1, a voltage sensor for muscle excitation-contraction coupling, which activates the ryanodine receptor 1 (RYR1) leading to calcium release from the sarcoplasmic reticulum. CACNA1S mutations cause hypokalemic periodic paralysis, malignant hyperthermia and congenital myopathy....
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13528
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Isolated rapid eye movement sleep behaviour disorder (iRBD) is a parasomnia, recently recognized as a risk factor for progression to Parkinson's disease, dementia with Lewy body and multiple system atrophy. Biomarker studies in iRBD are relevant due to lack of evidence in this condition. The iden...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14215
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:High levels of glutamic acid decarboxylase (GAD)-ab were initially described in patients with stiff person syndrome, and have since also been observed in patients with other neurological diseases. Temporal lobe epilepsy (TLE) seems to be specially associated. Our purpose is to describe the preval...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2011.03609.x
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Impaired cortical inhibiton and maladaptive cortical plasticity are functional hallmarks of sporadic focal dystonias. Whether or not these mechanisms translate to generalized dystonias and whether these features reflect state or trait characteristics are topics of research in hereditary dystonias. METHODS:W...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2010.03054.x
更新日期:2010-07-01 00:00:00
abstract::Multiple sclerosis (MS) is a T-cell-mediated autoimmune demyelinating disease of the central nervous system, associated with an altered cytokine network. We previously assayed peripheral blood T-lymphocyte binding for two prototypic cytokines, tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), and foun...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2000.00139.x
更新日期:2000-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Benign paroxysmal positional vertigo (BPPV) is a frequently encountered condition that can severely affect the quality of life. In this study, we aimed to assess the possible relations between serum uric acid (SUA) levels and BPPV. METHODS:Fifty patients with BPPV, and 40 age- and sex-matched co...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12248
更新日期:2014-01-01 00:00:00
abstract::Therapy-induced binding and neutralizing antibodies is a major problem in interferon (IFN)-beta treatment of multiple sclerosis. The objective of this study was to provide guidelines outlining the methods and clinical use of the measurements of binding and neutralizing antibodies. Systematic search of the Medline data...
journal_title:European journal of neurology
pub_type: 杂志文章,实务指引,评审
doi:10.1111/j.1468-1331.2005.01386.x
更新日期:2005-11-01 00:00:00
abstract::We evaluated the cerebral hemodynamic features of severe bilateral carotid stenosis by assessing and comparing cerebral vasomotor reactivity (VMR) in the middle cerebral (MCA) and vertebral arteries (VA) by transcranial Doppler and the Diamox (1 g acetazolamide i.v.) test. VMR was evaluated by recording the percentage...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2006.01160.x
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:A Consensus document on palliative care and neurology has made recommendations on the care of people with chronic and progressive neurological disease. This study aimed to investigate whether these recommendations are understood by, acceptable to and used in practice by neurologists in Belgium. ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13325
更新日期:2017-07-01 00:00:00
abstract::Frontotemporal dementia (FTD) often presents with behavioural changes warranting treatment with antipsychotic medications. It is known that patients with Lewy body dementia are sensitive to developing extrapyramidal symptoms (EPS) from these medications. This has not been emphasized in FTD. We report three patients wi...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2007.02032.x
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Amyotrophic lateral sclerosis (ALS)-related genes and mutations have been increasingly discovered recently and an improved understanding of genotype-phenotype relationships may help to predict the disease course and refine genetic diagnosis. METHODS:We collected clinical data and blood samples f...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14213
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Several studies have reported associations between brain iron deposits (IDs), white matter hyperintensities (WMHs) and cognitive ability in older individuals. Whether the association between brain IDs and cognitive abilities in older people is mediated by or independent of total brain tissue dama...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13006
更新日期:2016-07-01 00:00:00
abstract::Cytokines have a central role in multiple sclerosis (MS) pathogenesis and may contribute to the aetiology of MS. A polymorphism in the IFNA17 gene with an allele carrying a pre-mature stop codon has been suggested to convey a 26-fold increased risk for MS. We investigated the possible association between this polymorp...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2007.01953.x
更新日期:2007-11-01 00:00:00
abstract::The majority of patients with multiple sclerosis (MS) experience gradual progression of disability, either as secondary progressive MS (SPMS) or primary progressive MS (PPMS). A subgroup with relapsing-remitting MS shows a benign course with little or no disease progression and minimal disability decades after the fir...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2005.01009.x
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Mutations in fused in sarcoma (FUS) were recently identified as a cause of familial amyotrophic lateral sclerosis (ALS). The frequency of occurrence of mutations in FUS in sets of patients with familial ALS remains to be established. METHODS:We sequenced the FUS gene in a cohort of patients with...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2009.02859.x
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Although Wernicke encephalopathy (WE) is a preventable and treatable disease it still often remains undiagnosed during life. OBJECTIVES:To create practical guidelines for diagnosis, management and prevention of the disease. METHODS:We searched MEDLINE, EMBASE, LILACS, Cochrane Library. CONCLUSIONS AND REC...
journal_title:European journal of neurology
pub_type: 杂志文章,实务指引
doi:10.1111/j.1468-1331.2010.03153.x
更新日期:2010-12-01 00:00:00
abstract::Recent studies suggest an association between Chlamydia pneumoniae infection with atherosclerosis, including cerebrovascular disease. We investigated the prevalence of Chlamydial seropositivity in patients with acute ischaemic stroke syndrome compared with age- and sex-matched control subjects. Specific antibodies (Ig...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2002.00408.x
更新日期:2002-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Botulinum toxin type A (BoNT/A) is a highly effective and well-tolerated treatment for focal dystonias. The BoNT/A in Botox and Dysport is part of a high-molecular-weight complex that contains hemagglutinins and other non-toxic proteins, whilst Xeomin is a highly purified BoNT/A free of such comp...
journal_title:European journal of neurology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1468-1331.2009.02878.x
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The aim of this study was to examine the association amongst remote diffusion-weighted imaging lesions (R-DWILs), imaging markers of cerebral small vessel disease (cSVD) and total cSVD burden in patients with primary intracerebral haemorrhage (ICH). METHODS:In total, 344 consecutive primary ICH ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13915
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Falling is considered an important public health problem among older people. A recent cross-sectional study suggested that cognitive frailty (CF) is associated with falls. We aimed to explore whether CF is a risk factor for falls in a population-based longitudinal study. METHODS:Using data from ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14572
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There is large variability in the diagnostic approach and clinical management in functional movement disorders (FMD). This study aimed to examine whether opinions and clinical practices related to FMD have changed over the past decade. METHODS:Adapted from a 2008 version, we repeated the survey ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14200
更新日期:2020-06-01 00:00:00
abstract::To establish the phenotypic variation and frequency of SPAST mutations or deletions in Norwegian patients with hereditary spastic paraplegia (HSP), we examined 59 unrelated patients with HSP and screened for DNA point mutations and microdeletions in SPG4. Forty-one had a familial history, 35 had a clear dominant inher...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2007.01861.x
更新日期:2007-07-01 00:00:00