当前位置： SCI文献检索 > EUROPEAN JOURNAL OF NEUROLOGY期刊下所有文献 > In-vivo signatures of neurodegeneration in isolated rapid eye movement sleep behaviour disorder.

In-vivo signatures of neurodegeneration in isolated rapid eye movement sleep behaviour disorder.

Abstract：

BACKGROUND AND PURPOSE:Isolated rapid eye movement sleep behaviour disorder (iRBD) is a parasomnia, recently recognized as a risk factor for progression to Parkinson's disease, dementia with Lewy body and multiple system atrophy. Biomarker studies in iRBD are relevant due to lack of evidence in this condition. The identification of biomarkers able to predict progression to synucleinopathy diseases is critical for iRBD. Fluorodeoxyglucose-positron emission tomography (FDG-PET) imaging might provide information about ongoing neurodegenerative processes. In the present study, we tested for presence of brain hypometabolism patterns as biomarkers of neurodegeneration in single iRBD individuals. METHODS:We recruited 37 subjects with polysomnography-confirmed iRBD, with neuropsychological assessment and available FDG-PET scan. Images were analysed with a validated statistical parametric mapping procedure, providing individual hypometabolism maps. RESULTS:According to the neuropsychological evaluation, 22 subjects with iRBD had normal cognition and 15 subjects showed impairments, particularly in visuoperceptive/visuospatial and memory domains. One-fifth of the cases were impaired on the Qualitative Scoring of Pentagon Test. In 32 iRBD cases, FDG-PET statistical parametric maps revealed significant cerebral hypometabolism, namely in the occipital lobes (n = 5), occipital and cerebellar regions (n = 13), occipitoparietal regions (n = 13) and a selective cerebellar hypometabolism (n = 1). Five cases had normal FDG-PET scans. CONCLUSIONS:These imaging findings indicate that brain neurodegenerative processes are present and already detectable in iRBD. The different hypometabolism patterns in the single individuals may reflect specific early pathophysiological events due to the underlying synucleinopathy, with a specific neural vulnerability for the occipital cortex that might pre-date a risk of progression towards dementia with Lewy body.

journal_name

Eur J Neurol

journal_title

European journal of neurology

authors

Carli G,Caminiti SP,Galbiati A,Marelli S,Casoni F,Padovani A,Ferini-Strambi L,Perani D

doi

10.1111/ene.14215

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

1285-1295

issue

eissn

1351-5101

issn

1468-1331

journal_volume

pub_type

杂志文章

在线工具

In-vivo signatures of neurodegeneration in isolated rapid eye movement sleep behaviour disorder.