The effects of interferon-beta on interleukin-10 in multiple sclerosis patients.

abstract：OBJECTIVE:To investigate changes in serum complements and their regulators in the pathogenesis of myasthenia gravis (MG). METHODS:Forty-four patients with acetylcholine receptor antibody-positive MG, as well as 20 patients with non-inflammatory neurological disorders were enrolled. Serum complements (C3, C4 and solubl...

journal_title：European journal of neurology

authors： Ozawa Y,Uzawa A,Yasuda M,Kojima Y,Oda F,Himuro K,Kawaguchi N,Kuwabara S

更新日期：2021-01-01 00:00:00

abstract：:We examined clinical presentations, neuropsychological findings, and perfusion patterns of (99m)Tc-ethyl cysteinate dimer (ECD) single photon emission computed tomography (SPECT) in patients with early stage dementia with Lewy bodies (DLB) (n = 17) and Parkinson's disease (PD) (n = 16), with age-matched healthy contro...

journal_title：European journal of neurology

authors： Chang CC,Liu JS,Chang YY,Chang WN,Chen SS,Lee CH

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:A transient ischemic attack (TIA) can occur without self-awareness of symptoms. We aimed to investigate characteristics of patients with a tissue-based diagnosis of TIA but having no self-awareness of their symptoms and whose symptoms were witnessed by bystanders. METHODS:We used data from the m...

journal_title：European journal of neurology

authors： Tanaka K,Uehara T,Ohara T,Sato S,Hayakawa M,Kimura K,Okada Y,Hasegawa Y,Tanahashi N,Suzuki A,Nakagawara J,Arii K,Nagahiro S,Ogasawara K,Uchiyama S,Matsumoto M,Iihara K,Toyoda K,Minematsu K,PROMISE-TIA study Investig

更新日期：2021-02-01 00:00:00

abstract：:In a previous, controlled study we demonstrated that the general lower limb activity measured by three-channel actometry is a promising objective measure of restless legs syndrome (RLS) severity. In the present study we have further evaluated the method in measuring RLS symptom severity in an open, single-day pramipex...

journal_title：European journal of neurology

authors： Tuisku K,Holi MM,Wahlbeck K,Ahlgren AJ,Lauerma H

更新日期：2005-05-01 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic and potentially highly disabling disorder with considerable social impact and economic consequences. It is the major cause of non-traumatic disability in young adults. The social costs associated with MS are high because of its long duration, the early loss of productivity, the nee...

journal_title：European journal of neurology

authors： Pugliatti M,Rosati G,Carton H,Riise T,Drulovic J,Vécsei L,Milanov I

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Oxidative stress plays an important role in acute ischaemic stroke. However, the association of oxidative lipoprotein markers, including oxidized low-density lipoprotein (oxLDL), oxLDL:high-density lipoprotein (HDL) and oxLDL:low-density lipoprotein (LDL), with functional outcome of minor stroke ...

journal_title：European journal of neurology

authors： Wang A,Zhang X,Li S,Zhao X,Liu L,Johnston SC,Meng X,Lin J,Zuo Y,Li H,Wang Y,Wang Y,CHANCE Study Group.

更新日期：2019-08-01 00:00:00

abstract：:Urinary dysfunction is very common in idiopathic Parkinson's disease (PD) and manifests primarily with symptoms of overactive bladder (OAB). Affection of central serotonergic systems has been suggested to play a role in OAB. The objective of this study was to evaluate whether in PD patients with OAB symptoms a specifi...

journal_title：European journal of neurology

authors： Walter U,Dressler D,Wolters A,Wittstock M,Benecke R

更新日期：2006-12-01 00:00:00

abstract：:We evaluated the cerebral hemodynamic features of severe bilateral carotid stenosis by assessing and comparing cerebral vasomotor reactivity (VMR) in the middle cerebral (MCA) and vertebral arteries (VA) by transcranial Doppler and the Diamox (1 g acetazolamide i.v.) test. VMR was evaluated by recording the percentage...

journal_title：European journal of neurology

authors： Gur AY,Bornstein NM

更新日期：2006-02-01 00:00:00

abstract：:Cortical excitability of the primary motor cortex is altered in patients with Parkinson's disease (PD). Therefore, modulation of cortical excitability by high frequency repetitive transcranial magnetic stimulation (rTMS) of the motor cortex might result in beneficial effects on motor functions in PD. The present study...

journal_title：European journal of neurology

authors： Khedr EM,Farweez HM,Islam H

更新日期：2003-09-01 00:00:00

abstract：:Since the 1970s, intravenous (IV) phenytoin (PHT) has traditionally been used as second-stage treatment for convulsive status epilepticus (SE) after failure of benzodiazepines. The aim of this review was to critically assess the evidence supporting the use of IV PHT as treatment of convulsive SE in patients of any age...

journal_title：European journal of neurology

authors： Brigo F,Bragazzi NL,Lattanzi S,Nardone R,Trinka E

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Antecedent surgery has been described to trigger Guillain-Barré syndrome (GBS), but its evidence is poor and based on case reports only. METHODS:We performed a retrospective analysis of 63 patients with GBS admitted to the University Hospital Basel and University Children's Hospital Basel from J...

journal_title：European journal of neurology

authors： Gensicke H,Datta AN,Dill P,Schindler C,Fischer D

更新日期：2012-09-01 00:00:00

abstract：:The authors report results of a retrospective pilot study showing a strong association between patients with stroke/TIA and the presence of circulating IgG and IgA antibodies to Chlamydia pneumoniae. These results support the hypothesis that chronic active or persistent infection may play a role in the mechanism of th...

journal_title：European journal of neurology

authors： Bucurescu G,Stieritz DD

更新日期：2003-07-01 00:00:00

abstract：:Although visual hallucinations (VH) are relatively frequent in Parkinson's disease (PD) patients, their neural substrates are only known from neuropathological and functional magnetic resonance studies. The aim of this study was to investigate possible structural brain changes on MRI in non-demented PD patients with V...

journal_title：European journal of neurology

authors： Ramírez-Ruiz B,Martí MJ,Tolosa E,Giménez M,Bargalló N,Valldeoriola F,Junqué C

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The deleterious effect of hyperthermia on intracerebral hemorrhage (ICH) has been studied. However, the results are not conclusive and new studies are needed to elucidate clinical factors that influence the poor outcome. The aim of this study was to identify the clinical factors (including ICH et...

journal_title：European journal of neurology

authors： Iglesias-Rey R,Rodríguez-Yáñez M,Arias S,Santamaría M,Rodríguez-Castro E,López-Dequidt I,Hervella P,Sobrino T,Campos F,Castillo J

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Parkinson's disease (PD) is a progressive neurodegenerative disorder with motor and non-motor symptoms, including cognitive deficits. Several magnetic resonance imaging approaches have been applied to investigate brain atrophy in PD. The aim of this study was to detect early structural cortical a...

journal_title：European journal of neurology

authors： Danti S,Toschi N,Diciotti S,Tessa C,Poletti M,Del Dotto P,Lucetti C

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Associations with multiple sclerosis (MS) of living conditions in childhood and characteristics in adolescence including physical fitness, cognitive function and psychological stress resilience were investigated. METHODS:A cohort of male Swedish residents born 1952-1956 who were included in the ...

journal_title：European journal of neurology

authors： Gunnarsson M,Udumyan R,Bahmanyar S,Nilsagård Y,Montgomery S

更新日期：2015-07-01 00:00:00

abstract：:The aim of our study was to analyse clinical and paraclinical characteristics of patients with multiple sclerosis (MS) with previous diagnosis of primary-progressive (PP) MS according to the Poser's criteria and further investigate if they fulfil the McDonald's diagnostic criteria for this disorder. A total of 561 MS ...

journal_title：European journal of neurology

authors： Dujmović I,Mesaros S,Pekmezović T,Lević Z,Drulović J

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Pre-treatment with antiplatelet agents (AP) is present amongst 30% of acute stroke patients. Previous studies have shown conflicting results on the effect of these drugs regarding haemorrhagic transformation after thrombolytic therapy. The hypothesis that pre-treatment with AP may increase the risk of cerebr...

journal_title：European journal of neurology

authors： Dorado L,Millán M,de la Ossa NP,Guerrero C,Gomis M,López-Cancio E,Ricciardi AC,Dávalos A

更新日期：2010-02-01 00:00:00

abstract：:To determine whether eosinophils play a critical role in muscle fiber damage in patients with eosinophilic myositis (EM). We investigated expression of eosinophilic major basic protein (MBP) and interleukin (IL)-5 at the protein and mRNA levels in muscle biopsies from three patients with idiopathic EM. MBP deposits we...

journal_title：European journal of neurology

authors： Murata K,Sugie K,Takamure M,Fujimoto T,Ueno S

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There is increasing interest in using patient-reported outcome measures (PROMs) in clinical studies to capture individual changes over time. However, PROMs have also been criticized because they are entirely subjective. Our objective was to examine the relationship between a subjective PROM and a...

journal_title：European journal of neurology

authors： Draak TH,Gorson KC,Vanhoutte EK,van Nes SI,van Doorn PA,Cornblath DR,van den Berg LH,Faber CG,Merkies IS,PeriNomS Study Group.

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The severity of Wilson's disease (WD) is linked to free copper accumulating in the liver and brain. Exchangeable copper (CuEXC) is a new technique to determine plasmatic copper and is useful in the diagnosis of WD. It is hypothesized that it may also enable a good evaluation of extra-hepatic invo...

journal_title：European journal of neurology

authors： Poujois A,Trocello JM,Djebrani-Oussedik N,Poupon J,Collet C,Girardot-Tinant N,Sobesky R,Habès D,Debray D,Vanlemmens C,Fluchère F,Ory-Magne F,Labreuche J,Preda C,Woimant F

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Improved biomarkers are needed to facilitate clinical decision-making and as surrogate endpoints in clinical trials in multiple sclerosis (MS). We assessed whether neurodegenerative and neuroinflammatory markers in cerebrospinal fluid (CSF) at initial sampling could predict disease activity durin...

journal_title：European journal of neurology

authors： Håkansson I,Tisell A,Cassel P,Blennow K,Zetterberg H,Lundberg P,Dahle C,Vrethem M,Ernerudh J

更新日期：2017-05-01 00:00:00

abstract：:Upper limb spasticity affecting elbow, wrist, and finger flexors can be safely and effectively reduced with injections of botulinum toxin type-A (BoNT-A). It has been best studied in adults in the context of post-stroke spasticity. The clinical benefits include reduction in pain and deformity, improvement in washing a...

journal_title：European journal of neurology

authors： Sheean G,Lannin NA,Turner-Stokes L,Rawicki B,Snow BJ,Cerebral Palsy Institute.

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Dopamine is an important neurotransmitter in the regulation of the sleep-wake cycle, and parkinsonian patients suffer from prominent sleep abnormalities. Hence, the question arises whether the disrupted sleep pattern in Parkinson's disease (PD) is responsive to dopaminergic treatment. METHODS:Thirty-two pat...

journal_title：European journal of neurology

authors： Wailke S,Herzog J,Witt K,Deuschl G,Volkmann J

更新日期：2011-04-01 00:00:00

abstract：:A case is described in which non-convulsive status epilepticus (NCSE) prompted further investigation leading to the diagnosis of Lafora body disease (LBD). The onset of NCSE was temporally related to the withdrawal of sodium valproate and introduction of carbamazepine, which may have been precipitating factors. NCSE h...

journal_title：European journal of neurology

authors： Corkill RG,Hardie RJ

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Recent studies have demonstrated that Alzheimer's disease (AD) and subcortical vascular dementia (SVaD) have white matter (WM) microstructural changes. However, previous studies on AD and SVaD rarely eliminated the confounding effects of patients with mixed Alzheimer's and cerebrovascular disease...

journal_title：European journal of neurology

authors： Kim YJ,Kwon HK,Lee JM,Kim YJ,Kim HJ,Jung NY,Kim ST,Lee KH,Na DL,Seo SW

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Despite advances in the understanding of Huntington's disease (HD), treatment remains symptomatic. Multidisciplinary rehabilitation, however, appears to impact disease progression. Here we show the feasibility, safety and efficacy of a 9-month multidisciplinary rehabilitation programme in a small...

journal_title：European journal of neurology

authors： Thompson JA,Cruickshank TM,Penailillo LE,Lee JW,Newton RU,Barker RA,Ziman MR

更新日期：2013-09-01 00:00:00

abstract：:We examined the peripheral-central sensory conduction by using somatosensory evoked potential (SEP) in a 48 year old diabetic patient with acute painful neuropathy. The sural, ulnar and median sensory nerve conduction and SEP elicited by wrist stimulation showed no abnormalities, nevertheless, the tibial nerve SEP rev...

journal_title：European journal of neurology

authors： Shimamura H,Baba M,Ozaki I,Matsunaga M,Onuma T

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Elevation of cardiac troponin (cTn), a sensitive biomarker of myocardial injury, is frequently observed in severe acute neurological disorders. Case reports suggest that cardiac dysfunction may also occur in patients with transient global amnesia (TGA). Until now, no study has systematically asse...

journal_title：European journal of neurology

authors： Erdur H,Siegerink B,Ganeshan R,Audebert HJ,Endres M,Nolte CH,Scheitz JF

更新日期：2019-07-01 00:00:00

abstract：:Immunological abnormality is often found in amyotrophic lateral sclerosis (ALS). Antibodies to sulfoglucuronyl paragloboside (SGPG) were reported in ALS, although the pathogenetic significance of the antibodies is still unknown. We have already demonstrated that SGPG, a unique glycolipid, is present in both peripheral...

journal_title：European journal of neurology

authors： Ikeda J,Kohriyama T,Nakamura S

更新日期：2000-09-01 00:00:00