Abstract:
:We examined clinical presentations, neuropsychological findings, and perfusion patterns of (99m)Tc-ethyl cysteinate dimer (ECD) single photon emission computed tomography (SPECT) in patients with early stage dementia with Lewy bodies (DLB) (n = 17) and Parkinson's disease (PD) (n = 16), with age-matched healthy controls (n = 10). Seven paired regions of interest (ROIs) were drawn manually including inferior frontal, temporal, parietal, occipital, parieto-occipital junction, striatum and thalamus for semiquantitative measurement. Neuropsychological tests were applied for clinical correlation. The SPECT results showed significant hypoperfusion in DLB group in frontal, parietal, thalamus, temporal ROIs compared with controls (P < 0.01) whilst signals in temporal areas was significantly reduced compared with PD group (P < 0.05). Neuropsychological tests showed that DLB patients had deficits in mental manipulation, short-term memory, abstract thinking, drawing and semantic verbal fluencies (P < 0.05, compared with control). In addition, DLB group had lower scores than those with PD in mental manipulation, drawing and semantic verbal fluency (P < 0.05). Our study showed that even in early stages of DLB, neuropsychological and perfusion patterns were evident and may be different from PD group, despite they shared certain similarities both in neuropsychological and image findings compared with age-matched controls.
journal_name
Eur J Neuroljournal_title
European journal of neurologyauthors
Chang CC,Liu JS,Chang YY,Chang WN,Chen SS,Lee CHdoi
10.1111/j.1468-1331.2007.02001.xsubject
Has Abstractpub_date
2008-01-01 00:00:00pages
61-5issue
1eissn
1351-5101issn
1468-1331pii
ENE2001journal_volume
15pub_type
杂志文章abstract:BACKGROUND AND PURPOSE:Chronic kidney disease (CKD) is associated with a higher risk of stroke and atrial fibrillation (AF). There are limited data on the comorbidity of renal dysfunction and AF in stroke patients. Our aim was to determine the frequency of kidney dysfunction in ischaemic stroke patients with and withou...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12528
更新日期:2015-01-01 00:00:00
abstract::In recent years, a number of potential new therapeutic indications of botulinum toxin injections have emerged, amongst which sialorrhea has attracted considerable attention. Based on open-label and controlled studies, botulinum toxin can be used to improve sialorrhea in patients with Parkinson's disease, parkinsonian ...
journal_title:European journal of neurology
pub_type: 杂志文章,评审
doi:10.1111/j.1468-1331.2006.01447.x
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:For Parkinson's disease (PD), an extended-release (ER) pramipexole formulation taken once daily, has shown efficacy, safety, and tolerability resembling those of immediate-release (IR) pramipexole taken three times daily. The present study assessed, in advanced PD, the success of an overnight swi...
journal_title:European journal of neurology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2013-01-01 00:00:00
abstract::Therapy-induced binding and neutralizing antibodies is a major problem in interferon (IFN)-beta treatment of multiple sclerosis. The objective of this study was to provide guidelines outlining the methods and clinical use of the measurements of binding and neutralizing antibodies. Systematic search of the Medline data...
journal_title:European journal of neurology
pub_type: 杂志文章,实务指引,评审
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更新日期:2005-11-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.1994.tb00060.x
更新日期:1994-11-01 00:00:00
abstract::An evaluation of general antiepileptic treatment patterns and utilization of particular drugs was carried out based on the prevalence study of adult active epilepsy in a sample of the Estonian population. The antiepileptic drugs (AEDs) used, and their doses were recorded and compared with clinical characteristics. Nin...
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doi:10.1111/j.1468-1331.2006.01268.x
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journal_title:European journal of neurology
pub_type: 杂志文章
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journal_title:European journal of neurology
pub_type: 杂志文章,评审
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journal_title:European journal of neurology
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更新日期:2019-06-01 00:00:00
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更新日期:2010-03-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.1999.630301.x
更新日期:1999-05-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.1997.tb00297.x
更新日期:1997-01-01 00:00:00
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更新日期:2019-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Spastic pes equinovarus is a frequent pathological posture of the lower extremity. Botulinum toxin (BoNT/A) has been successfully applied to treat lower limb spasticity. However, the best time to initiate treatment remains unclear. A beneficial effect of an early treatment has been suggested in p...
journal_title:European journal of neurology
pub_type: 杂志文章,随机对照试验
doi:10.1111/ene.12381
更新日期:2014-08-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2008.02227.x
更新日期:2008-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1468-1331.2008.02380.x
更新日期:2009-02-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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更新日期:2004-04-01 00:00:00
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journal_title:European journal of neurology
pub_type: 临床试验,杂志文章
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更新日期:2005-05-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
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更新日期:2014-03-01 00:00:00
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更新日期:2011-11-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
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更新日期:2020-12-16 00:00:00
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journal_title:European journal of neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2005-01-01 00:00:00
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journal_title:European journal of neurology
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更新日期:2016-04-01 00:00:00
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journal_title:European journal of neurology
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更新日期:2009-12-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章,随机对照试验
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更新日期:2008-08-01 00:00:00
abstract::Studies of the cephalic vascular system have markedly contributed towards an understanding of the mechanisms of migraine pain. Whereas cerebral blood flow changes, and thereby changes in the arterioles, correlate poorly with migraine headache, abnormal regulation of the large cranial arteries seems to play a significa...
journal_title:European journal of neurology
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doi:10.1111/j.1468-1331.1995.tb00149.x
更新日期:1995-11-01 00:00:00