(99m)Tc-ethyl cysteinate dimer brain SPECT findings in early stage of dementia with Lewy bodies and Parkinson's disease patients: a correlation with neuropsychological tests.

Abstract:

:We examined clinical presentations, neuropsychological findings, and perfusion patterns of (99m)Tc-ethyl cysteinate dimer (ECD) single photon emission computed tomography (SPECT) in patients with early stage dementia with Lewy bodies (DLB) (n = 17) and Parkinson's disease (PD) (n = 16), with age-matched healthy controls (n = 10). Seven paired regions of interest (ROIs) were drawn manually including inferior frontal, temporal, parietal, occipital, parieto-occipital junction, striatum and thalamus for semiquantitative measurement. Neuropsychological tests were applied for clinical correlation. The SPECT results showed significant hypoperfusion in DLB group in frontal, parietal, thalamus, temporal ROIs compared with controls (P < 0.01) whilst signals in temporal areas was significantly reduced compared with PD group (P < 0.05). Neuropsychological tests showed that DLB patients had deficits in mental manipulation, short-term memory, abstract thinking, drawing and semantic verbal fluencies (P < 0.05, compared with control). In addition, DLB group had lower scores than those with PD in mental manipulation, drawing and semantic verbal fluency (P < 0.05). Our study showed that even in early stages of DLB, neuropsychological and perfusion patterns were evident and may be different from PD group, despite they shared certain similarities both in neuropsychological and image findings compared with age-matched controls.

journal_name

Eur J Neurol

authors

Chang CC,Liu JS,Chang YY,Chang WN,Chen SS,Lee CH

doi

10.1111/j.1468-1331.2007.02001.x

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

61-5

issue

1

eissn

1351-5101

issn

1468-1331

pii

ENE2001

journal_volume

15

pub_type

杂志文章
  • Prevalence of renal dysfunction in ischaemic stroke and transient ischaemic attack patients with or without atrial fibrillation.

    abstract:BACKGROUND AND PURPOSE:Chronic kidney disease (CKD) is associated with a higher risk of stroke and atrial fibrillation (AF). There are limited data on the comorbidity of renal dysfunction and AF in stroke patients. Our aim was to determine the frequency of kidney dysfunction in ischaemic stroke patients with and withou...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.12528

    authors: Laible M,Horstmann S,Rizos T,Rauch G,Zorn M,Veltkamp R

    更新日期:2015-01-01 00:00:00

  • Botulinum toxin treatment of sialorrhea: comparing different therapeutic preparations.

    abstract::In recent years, a number of potential new therapeutic indications of botulinum toxin injections have emerged, amongst which sialorrhea has attracted considerable attention. Based on open-label and controlled studies, botulinum toxin can be used to improve sialorrhea in patients with Parkinson's disease, parkinsonian ...

    journal_title:European journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1468-1331.2006.01447.x

    authors: Tan EK

    更新日期:2006-02-01 00:00:00

  • Success rate, efficacy, and safety/tolerability of overnight switching from immediate- to extended-release pramipexole in advanced Parkinson's disease.

    abstract:BACKGROUND AND PURPOSE:For Parkinson's disease (PD), an extended-release (ER) pramipexole formulation taken once daily, has shown efficacy, safety, and tolerability resembling those of immediate-release (IR) pramipexole taken three times daily. The present study assessed, in advanced PD, the success of an overnight swi...

    journal_title:European journal of neurology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1468-1331.2012.03822.x

    authors: Schapira AH,Barone P,Hauser RA,Mizuno Y,Rascol O,Busse M,Debieuvre C,Fraessdorf M,Poewe W

    更新日期:2013-01-01 00:00:00

  • Guidelines on use of anti-IFN-beta antibody measurements in multiple sclerosis: report of an EFNS Task Force on IFN-beta antibodies in multiple sclerosis.

    abstract::Therapy-induced binding and neutralizing antibodies is a major problem in interferon (IFN)-beta treatment of multiple sclerosis. The objective of this study was to provide guidelines outlining the methods and clinical use of the measurements of binding and neutralizing antibodies. Systematic search of the Medline data...

    journal_title:European journal of neurology

    pub_type: 杂志文章,实务指引,评审

    doi:10.1111/j.1468-1331.2005.01386.x

    authors: Sørensen PS,Deisenhammer F,Duda P,Hohlfeld R,Myhr KM,Palace J,Polman C,Pozzilli C,Ross C,EFNS Task Force on Anti-IFN-beta Antibodies in Multiple Sclerosis.

    更新日期:2005-11-01 00:00:00

  • Diagnostic problems in "clinically definite" multiple sclerosis patients with normal CSF and multiple MRI abnormalities.

    abstract::Among patients who underwent cerebrospinal fluid (CSF) and magnetic resonance imaging (MRI) examination during a 5-year period, we found 18 patients at the multiple sclerosis center of the University of Rome and clinically definite multiple sclerosis, MRI white matter abnormalities, normal CSF examination, a disease d...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.1994.tb00060.x

    authors: Fieschi C,Gasperini C,Ristori G,Bastianello S,Girmenia F,Leuzzi V,Buttinelli C,Pozzilli C,Rasura M

    更新日期:1994-11-01 00:00:00

  • Use of antiepileptic drugs in Estonia: an epidemiologic study of adult epilepsy.

    abstract::An evaluation of general antiepileptic treatment patterns and utilization of particular drugs was carried out based on the prevalence study of adult active epilepsy in a sample of the Estonian population. The antiepileptic drugs (AEDs) used, and their doses were recorded and compared with clinical characteristics. Nin...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2006.01268.x

    authors: Oun A,Haldre S,Mägi M

    更新日期:2006-05-01 00:00:00

  • Genomic screening of Fabry disease in young stroke patients: the Taiwan experience and a review of the literature.

    abstract:BACKGROUND AND PURPOSE:Fabry disease is an X-linked disease, and enzyme-based screening methods are not suitable for female patients. METHODS:In total, 1000 young stroke patients (18-55 years, 661 with ischaemic stroke and 339 with hypertensive intracerebral hemorrhage) were recruited. The Sequenom iPLEX assay was use...

    journal_title:European journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1111/ene.13775

    authors: Lee TH,Yang JT,Lee JD,Chang KC,Peng TI,Chang TY,Huang KL,Liu CH,Ryu SJ,Burlina AP

    更新日期:2019-03-01 00:00:00

  • The societal cost of Huntington's disease: are we underestimating the burden?

    abstract:BACKGROUND AND PURPOSE:Approximately 9000 people in the UK are affected by Huntington's disease (HD). People with HD require ongoing health and social care support. There is a knowledge gap about costs of health and social care use associated with HD in the UK. This paper estimates the economic cost in the UK. METHODS...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.13107

    authors: Jones C,Busse M,Quinn L,Dawes H,Drew C,Kelson M,Hood K,Rosser A,Edwards RT

    更新日期:2016-10-01 00:00:00

  • Self-reference, emotion inhibition and somatosensory disturbance: preliminary investigation of network perturbations in conversion disorder.

    abstract:BACKGROUND AND PURPOSE:Conversion disorder (CD), or functional neurological disorder, is manifested as a neurological disturbance that is not macroscopically visible on clinical structural neuroimaging and is instead ascribed to underlying psychological stress. Known for many years in neuropsychiatry, a comprehensive e...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.13613

    authors: Monsa R,Peer M,Arzy S

    更新日期:2018-06-01 00:00:00

  • Water drinking in the management of orthostatic intolerance due to orthostatic hypotension, vasovagal syncope and the postural tachycardia syndrome.

    abstract::Water drinking recently has been shown to raise blood pressure in normal subjects and in patients with autonomic failure who have orthostatic hypotension. However, in normal young subjects, ingestion of approximately 500 ml has no pressor effect; but in older subjects there is an increase in blood pressure. An even gr...

    journal_title:European journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1468-1331.2004.00840.x

    authors: Mathias CJ,Young TM

    更新日期:2004-09-01 00:00:00

  • Peripapillary retinal nerve fibre layer thinning rate as a biomarker discriminating stable and progressing relapsing-remitting multiple sclerosis.

    abstract:BACKGROUND AND PURPOSE:Peripapillary retinal nerve fibre layer (pRNFL) thickness is a strong candidate as a biomarker of axonal degeneration in multiple sclerosis (MS). The aim was to determine a cut-off value of pRNFL thinning rates in relapsing-remitting MS (RRMS) to discriminate between stable and progressing patien...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.13897

    authors: Bsteh G,Hegen H,Teuchner B,Berek K,Wurth S,Auer M,Di Pauli F,Deisenhammer F,Berger T

    更新日期:2019-06-01 00:00:00

  • Changes in regional cerebral blood flow in the right cortex homologous to left language areas are directly affected by left hemispheric damage in aphasic stroke patients: evaluation by Tc-ECD SPECT and novel analytic software.

    abstract:BACKGROUND:The objective of this study was to clarify the influence of regional cerebral blood flow (rCBF) changes in language-relevant areas of the dominant hemisphere on rCBF in each region in the non-dominant hemisphere in post-stroke aphasic patients. METHODS:The study subjects were 27 aphasic patients who suffere...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2009.02849.x

    authors: Uruma G,Kakuda W,Abo M

    更新日期:2010-03-01 00:00:00

  • Clinical and molecular analysis of 11 Sicilian SCA2 families: influence of gender on age at onset.

    abstract::Autosomal dominant cerebellar ataxias (ADCAs) are a complex group of slowly progressive neurodegenerative disorders characterized by gait and stance ataxia, dysarthria and other symptoms of nervous system involvement. ADCA type I is the commonest form and is genetically heterogeneous; several loci have been identified...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1046/j.1468-1331.1999.630301.x

    authors: Giuffrida S,Lanza S,Restivo DA,Saponara R,Valvo SC,Le Pira F,Trovato Salinaro A,Spinella F,Nicoletti A,Condorelli DF

    更新日期:1999-05-01 00:00:00

  • Dutch normal pressure hydrocephalus study: baseline characteristics with emphasis on clinical findings.

    abstract::We present the baseline characteristics of 101 patients with normal pressure hydrocephalus (NPH), entering a study that evaluates the diagnostic reliability of CSF outflow resistance. Patients were assessed by a gait scale consisting of 10 features of walking and the number of steps and seconds necessary for 10 m, a d...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.1997.tb00297.x

    authors: Boon AJ,Tans JT,Delwel EJ,Egeler-Peerdeman SM,Hanlo PW,Wurzer JA,Hermans J

    更新日期:1997-01-01 00:00:00

  • (CAG)n loci as genetic modifiers of age at onset in patients with spinocerebellar ataxia type 1 from mainland China.

    abstract:BACKGROUND AND PURPOSE:The expanded repeat length in ATXN1 negatively correlates with age at onset (AAO) of spinocerebellar ataxia type 1 (SCA1) but can explain only part of it, indicating that other factors affect AAO. Some studies have explored the influence of non-causative CAG repeats on the AAO of SCA patients. Ho...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.13954

    authors: Wang P,Chen Z,Peng Y,Cao L,Li X,Wang C,Yang H,Peng H,Shi Y,Zhou X,Li T,Feng L,Wu C,Qiu R,Xia K,Tang B,Jiang H

    更新日期:2019-08-01 00:00:00

  • Early botulinum toxin treatment for spastic pes equinovarus--a randomized double-blind placebo-controlled study.

    abstract:BACKGROUND AND PURPOSE:Spastic pes equinovarus is a frequent pathological posture of the lower extremity. Botulinum toxin (BoNT/A) has been successfully applied to treat lower limb spasticity. However, the best time to initiate treatment remains unclear. A beneficial effect of an early treatment has been suggested in p...

    journal_title:European journal of neurology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/ene.12381

    authors: Fietzek UM,Kossmehl P,Schelosky L,Ebersbach G,Wissel J

    更新日期:2014-08-01 00:00:00

  • Near-nerve needle sensory and medial plantar nerve conduction studies in patients with small-fiber sensory neuropathy.

    abstract:BACKGROUND AND PURPOSE:The aim of this prospective study was to show and compare the rate of large-fiber involvement with near-nerve needle sensory (NNNS) nerve conduction study (NCS) and with medial plantar NCS recorded with surface electrodes in a group of patients who had clinically pure small-fiber sensory neuropat...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2008.02227.x

    authors: Uluc K,Temucin CM,Ozdamar SE,Demirci M,Tan E

    更新日期:2008-09-01 00:00:00

  • Parkinson's disease and nursing home placement: the economic impact of the need for care.

    abstract:BACKGROUND AND PURPOSE:To examine the relative risk (RR) for living in nursing homes for patients with Parkinson's disease (PD) compared with the general population and to ascertain society's costs related to nursing home placement for this patient group. METHODS:We evaluated the frequency of admission to nursing home...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2008.02380.x

    authors: Vossius C,Nilsen OB,Larsen JP

    更新日期:2009-02-01 00:00:00

  • Metabolic syndrome in female migraine patients is associated with medication overuse headache: a clinic-based study in China.

    abstract:BACKGROUND AND PURPOSE:Migraine and metabolic syndrome have been reported to coexist to a marked degree, especially in women migraine patients, but the relationship between these two conditions is still unclear. This study was performed to evaluate the association of headache characteristics and its comorbidities with ...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.12732

    authors: He Z,Dong L,Zhang Y,Kong Q,Tan G,Zhou J

    更新日期:2015-08-01 00:00:00

  • Fatigue and depression predict quality of life in patients with early multiple sclerosis: a longitudinal study.

    abstract:BACKGROUND AND PURPOSE:The clinical predictors of health-related quality of life (HRQoL) in multiple sclerosis (MS) have mainly been studied in patients with long-standing disease. The objective of this study was to investigate the longitudinal association among HRQoL and clinical characteristics in early MS. METHODS:...

    journal_title:European journal of neurology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/ene.13102

    authors: Nourbakhsh B,Julian L,Waubant E

    更新日期:2016-09-01 00:00:00

  • A 2-year follow-up study of cigarette smoking and risk of dementia.

    abstract::The report focused on investigating the relationship between cigarette smoking and dementia in elderly people through prospective studies. We did a 2-year follow-up study of elderly people. A total of 2820 participants aged 60 years old and over from six communities of Chongqing agreed to take part. Dementia was diagn...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1046/j.1468-1331.2003.00779.x

    authors: Juan D,Zhou DH,Li J,Wang JY,Gao C,Chen M

    更新日期:2004-04-01 00:00:00

  • Actometry in measuring the symptom severity of restless legs syndrome.

    abstract::In a previous, controlled study we demonstrated that the general lower limb activity measured by three-channel actometry is a promising objective measure of restless legs syndrome (RLS) severity. In the present study we have further evaluated the method in measuring RLS symptom severity in an open, single-day pramipex...

    journal_title:European journal of neurology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1468-1331.2004.00960.x

    authors: Tuisku K,Holi MM,Wahlbeck K,Ahlgren AJ,Lauerma H

    更新日期:2005-05-01 00:00:00

  • The distribution of cerebral microbleeds determines their association with arterial stiffness in non-cardioembolic acute stroke patients.

    abstract:BACKGROUND AND PURPOSE:Increased arterial stiffness causes vessel damage in the end-organs. Therefore small vessels in the brain may be susceptible to increased arterial stiffness. Cerebral microbleeds (CMBs) are topographically or pathophysiologically categorized as deep or infratentorial type and strictly lobar type....

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.12332

    authors: Song TJ,Kim J,Kim YD,Nam HS,Lee HS,Nam CM,Heo JH

    更新日期:2014-03-01 00:00:00

  • Reasons patients give to use or not to use immunomodulating agents for multiple sclerosis.

    abstract:BACKGROUND:Variations in the treatment of multiple sclerosis (MS) occur. This study was performed to obtain insight into the reasons why patients with MS use or do not use immunomodulating treatment (DMT). METHODS:We held a survey on the use of DMT in a group of 1572 patients with MS. RESULTS:Response rate was 89%. O...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2011.03411.x

    authors: Visser LH,van der Zande A

    更新日期:2011-11-01 00:00:00

  • Headache at onset of first-ever ischemic stroke: Clinical characteristics and predictors.

    abstract::No studies have prospectively investigated headache at onset of first-ever ischemic stroke along with a large concurrent control group. Our aims were to answer two important questions: (i) Are headaches at stroke onset causally related to the stroke, and what are their typical clinical characteristics? (ii) What etiol...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.14684

    authors: Lebedeva ER,Ushenin AV,Gurary NM,Tsypushkina TS,Gilev DV,Kislyak NV,Olesen J

    更新日期:2020-12-16 00:00:00

  • A randomly assigned double-blind cross-over study examining the relative anti-parkinsonian tremor effects of pramipexole and pergolide.

    abstract::This study examined the relative anti-Parkinson's disease (PD) tremor potencies of pergolide and pramipexole in people with PD, using a 3-month double-blind cross-over design. Patients were randomly assigned to receive either pergolide and then pramipexole (n=9) or vice versa (n=8). The dose of the respective dopamine...

    journal_title:European journal of neurology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1468-1331.2004.01019.x

    authors: Navan P,Findley LJ,Undy MB,Pearce RK,Bain PG

    更新日期:2005-01-01 00:00:00

  • Quantitation of intrathecal immunoglobulin synthesis - a new empirical formula.

    abstract:BACKGROUND AND PURPOSE:Intrathecal immunoglobulin (Ig) synthesis occurs in various chronic inflammatory neurological diseases. Different formulae have been developed for quantitative determination of Ig synthesis within the cerebrospinal fluid (CSF) compartment. The hyperbolic formula of Reiber is frequently used which...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.12924

    authors: Auer M,Hegen H,Zeileis A,Deisenhammer F

    更新日期:2016-04-01 00:00:00

  • An exploration of anger phenomenology in multiple sclerosis.

    abstract:BACKGROUND AND PURPOSE:Multiple sclerosis (MS) patients are often emotionally disturbed. We investigated anger in these patients in relation to demographic, clinical, and mood characteristics. PATIENTS AND METHODS:About 195 cognitively unimpaired MS patients (150 relapsing-remitting and 45 progressive) were evaluated ...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2009.02727.x

    authors: Nocentini U,Tedeschi G,Migliaccio R,Dinacci D,Lavorgna L,Bonavita S,Bresciamorra V,Comanducci G,Coniglio G,Livrea P,Mannu R,Orefice G,Paciello M,Patti F,Quattrone A,Salemi G,Savettieri G,Simone IL,Valentino P,Zappia

    更新日期:2009-12-01 00:00:00

  • Upper limb corticomotor projections and physiological changes that occur with botulinum toxin-A therapy in children with hemiplegic cerebral palsy.

    abstract:AIM:To investigate the corticomotor projection to the upper limb in children with hemiplegic cerebral palsy (CP) and the changes that occur with botulinum toxin (BTX)-A. METHODS:The study design is a pilot prospective randomized trial. Twenty-two children with hemiplegic CP aged 7 years to 13 years 11 months were recr...

    journal_title:European journal of neurology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1468-1331.2008.02194.x

    authors: Redman TA,Gibson N,Finn JC,Bremner AP,Valentine J,Thickbroom GW

    更新日期:2008-08-01 00:00:00

  • Arterial mechanisms in the pathophysiology of migraine headache-implications for modern therapy.

    abstract::Studies of the cephalic vascular system have markedly contributed towards an understanding of the mechanisms of migraine pain. Whereas cerebral blood flow changes, and thereby changes in the arterioles, correlate poorly with migraine headache, abnormal regulation of the large cranial arteries seems to play a significa...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.1995.tb00149.x

    authors: Thomsen LL

    更新日期:1995-11-01 00:00:00