Headache at onset of first-ever ischemic stroke: Clinical characteristics and predictors.

abstract：:Therapy-induced binding and neutralizing antibodies is a major problem in interferon (IFN)-beta treatment of multiple sclerosis. The objective of this study was to provide guidelines outlining the methods and clinical use of the measurements of binding and neutralizing antibodies. Systematic search of the Medline data...

journal_title：European journal of neurology

authors： Sørensen PS,Deisenhammer F,Duda P,Hohlfeld R,Myhr KM,Palace J,Polman C,Pozzilli C,Ross C,EFNS Task Force on Anti-IFN-beta Antibodies in Multiple Sclerosis.

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Peripapillary retinal nerve fibre layer (pRNFL) thickness is a strong candidate as a biomarker of axonal degeneration in multiple sclerosis (MS). The aim was to determine a cut-off value of pRNFL thinning rates in relapsing-remitting MS (RRMS) to discriminate between stable and progressing patien...

journal_title：European journal of neurology

authors： Bsteh G,Hegen H,Teuchner B,Berek K,Wurth S,Auer M,Di Pauli F,Deisenhammer F,Berger T

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Cardiac (123) I-metaiodobenzylguanidine ((123) I-MIBG) uptake in patients with idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) is markedly reduced, as in Parkinson's disease (PD). METHODS:We performed (123) I-MIBG scintigrams on patients with iRBD and PD. After the initial (123) I-MIBG sc...

journal_title：European journal of neurology

authors： Miyamoto T,Miyamoto M,Iwanami M,Hirata K

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Dermatomyositis (DM) with anti-nuclear matrix protein-2 (NXP-2) antibodies usually shows multifocal ischaemic lesions in muscle. Here, we aimed to investigate the microarteriopathy underlying muscle ischaemia in anti-NXP-2-positive DM. METHODS:A total of 16 patients diagnosed with anti-NXP-2-pos...

journal_title：European journal of neurology

authors： Liu Y,Zheng Y,Gang Q,Xie Z,Jin Y,Zhang X,Deng X,Hao H,Gao F,Zhang Z,Xiong H,Zhang W,Wang Z,Yuan Y

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Sporadic amyotrophic lateral sclerosis (sALS) is a disease with a focal clinical onset and contiguous spread. We examined patterns of disease spread following symptoms onset in sALS and whether the pattern of spread predicted survival. METHODS:Review of medical records (2003-2009) at London Onta...

journal_title：European journal of neurology

authors： Gargiulo-Monachelli GM,Janota F,Bettini M,Shoesmith CL,Strong MJ,Sica RE

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Studies investigating the association between 25-hydroxyvitamin D [25(OH)D] and cognition in the very old (85+) are lacking. METHODS:Cross-sectional (baseline) and prospective data (up to 3 years follow-up) from 775 participants in the Newcastle 85+ Study were analysed for global (measured by th...

journal_title：European journal of neurology

authors： Granic A,Hill TR,Kirkwood TB,Davies K,Collerton J,Martin-Ruiz C,von Zglinicki T,Saxby BK,Wesnes KA,Collerton D,Mathers JC,Jagger C

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There is limited data of neurovascular coupling on stroke patients, especially on comparison of different etiologies. We aim to test the hypothesis that patients with small vessel disease (SVD) are impaired on neurovascular coupling rather than stroke patient with large intracranial artery stenos...

journal_title：European journal of neurology

authors： Lin WH,Hao Q,Rosengarten B,Leung WH,Wong KS

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Associations with multiple sclerosis (MS) of living conditions in childhood and characteristics in adolescence including physical fitness, cognitive function and psychological stress resilience were investigated. METHODS:A cohort of male Swedish residents born 1952-1956 who were included in the ...

journal_title：European journal of neurology

authors： Gunnarsson M,Udumyan R,Bahmanyar S,Nilsagård Y,Montgomery S

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:  Although fatigue is recognized as a common and debilitating symptom in patients with Parkinson's disease (PD), little is known on how and when this symptom emerges during disease progression. The aim of the study was to explore the presence and severity of fatigue in patients with PD at the tim...

journal_title：European journal of neurology

authors： Herlofson K,Ongre SO,Enger LK,Tysnes OB,Larsen JP

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The diagnosis of cytomegalovirus encephalitis (CMV-E) in AIDS patients is challenging as other illnesses may obscure the symptoms. Here, we characterize the clinical symptoms of CMV-E and link them to post-mortem findings. Patients and methods In 254 homosexual men with AIDS, followed from HIV di...

journal_title：European journal of neurology

authors： Pirskanen-Matell R,Grützmeier S,Nennesmo I,Sandström E,Ehrnst A

更新日期：2009-01-01 00:00:00

abstract：:The role of genetics and its technological development have been fundamental in advancing the field of movement disorders, opening the door to precision medicine. Starting from the revolutionary discovery of the locus of the Huntington's disease gene, we review the milestones of genetic discoveries in movement disorde...

journal_title：European journal of neurology

authors： Sturchio A,Marsili L,Mahajan A,Grimberg MB,Kauffman MA,Espay AJ

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To examine the relative risk (RR) for living in nursing homes for patients with Parkinson's disease (PD) compared with the general population and to ascertain society's costs related to nursing home placement for this patient group. METHODS:We evaluated the frequency of admission to nursing home...

journal_title：European journal of neurology

authors： Vossius C,Nilsen OB,Larsen JP

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Decompressive craniectomy is used regularly in traumatic brain injury (TBI) and malignant middle cerebral artery infarction. Its benefits for other causes of non-traumatic brain swelling, if any, are unclear, especially after a devastating primary event. METHODS:We evaluated the outcomes as well as treatmen...

journal_title：European journal of neurology

authors： Malmivaara K,Ohman J,Kivisaari R,Hernesniemi J,Siironen J

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Variations in the treatment of multiple sclerosis (MS) occur. This study was performed to obtain insight into the reasons why patients with MS use or do not use immunomodulating treatment (DMT). METHODS:We held a survey on the use of DMT in a group of 1572 patients with MS. RESULTS:Response rate was 89%. O...

journal_title：European journal of neurology

authors： Visser LH,van der Zande A

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Hereditary sensory and autonomic neuropathies (HSANs) are a group of clinically and genetically heterogeneous neurological disorders characterized by sensory dysfunctions. Here, 21 affected Chinese families are reported, including 19 with congenital insensitivity to pain with anhidrosis (CIPA; na...

journal_title：European journal of neurology

authors： Zhao F,Mao B,Geng X,Ren X,Wang Y,Guan Y,Li S,Li L,Zhang S,You Y,Cao Y,Yang T,Zhao X

更新日期：2020-08-01 00:00:00

abstract：:There are at least seven clinically indistinguishable but genetically different types of autosomal dominant pure spastic paraplegia (ADPSP). In this study we investigated electrophysiological characteristics in patients with ADPSP linked to chromosome 2p (SPG4). Twelve patients from six different families with ADPSP l...

journal_title：European journal of neurology

authors： Nielsen JE,Jennum P,Fenger K,Sørensen SA,Fuglsang-Frederiksen A

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:Investigations on cause of death may provide valuable information about life expectancy and on conditions of terminal dementia care, which perhaps can be ameliorated. METHODS:The autopsy reports were studied on all patients (n = 524; 55.3% females; median age 80 years) with a clinically and neuropathologica...

journal_title：European journal of neurology

authors： Brunnström HR,Englund EM

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Comorbidity in myasthenia gravis (MG) is important for diagnosis, treatment and prognosis. Disease complexity was assessed by examining total drug treatment, immune therapy and comorbidity in a complete national MG cohort. METHODS:All recipients of the MG-specific drug pyridostigmine 2004-2010 r...

journal_title：European journal of neurology

authors： Andersen JB,Owe JF,Engeland A,Gilhus NE

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Calculation of the cerebrospinal fluid:serum glucose (CSF:SGlu ) ratio is part of the routine cerebrospinal fluid (CSF) work-up. Reference values have been defined for lumbar CSF, but are lacking for ventricular CSF. The objective of this study was to investigate whether the CSF:SGlu ratio is sim...

journal_title：European journal of neurology

authors： Hegen H,Walde J,Auer M,Deisenhammer F

更新日期：2018-02-01 00:00:00

abstract：:Cytokines have a central role in multiple sclerosis (MS) pathogenesis and may contribute to the aetiology of MS. A polymorphism in the IFNA17 gene with an allele carrying a pre-mature stop codon has been suggested to convey a 26-fold increased risk for MS. We investigated the possible association between this polymorp...

journal_title：European journal of neurology

authors： Nyström M,Ruuth K,Lundgren E,Sundström P

更新日期：2007-11-01 00:00:00

abstract：:In this report, we present the clinical and pathological details of a kindred of four individuals with a novel missense mutation (V272A) of the presenilin 1 gene (PSEN1) that experienced a subcortical dementia. The age of onset of symptoms ranged 26-36-year old, with an age at death of 36-46 years. Initial symptom was...

journal_title：European journal of neurology

authors： Jimenez-Escrig A,Rabano A,Guerrero C,Simon J,Barquero MS,Güell I,Ginestal RC,Montero T,Orensanz L

更新日期：2004-10-01 00:00:00

abstract：BACKGROUNDAND PURPOSE:The purpose was to estimate the risk of epilepsy in a cohort of young individuals with celiac disease (CD) compared to that of matched references. METHODS:The cohort consisted of 213 635 individuals born during 1989-2011 and residing in Friuli-Venezia Giulia (Italy). 1215 individuals affected by ...

journal_title：European journal of neurology

authors： Canova C,Ludvigsson J,Barbiellini Amidei C,Zanier L,Zingone F

更新日期：2020-06-01 00:00:00

abstract：:We report a long-term outcome of motor function in a patient with adult-onset adrenoleukodystrophy after bone marrow transplantation (BMT). Clinically motor function gradually improved and became almost normal in 2 years after BMT. Serial transcranial magnetic stimulation showed gradual improvement of central motor co...

journal_title：European journal of neurology

authors： Hitomi T,Mezaki T,Tomimoto H,Ikeda A,Shimohama S,Okazaki T,Uchiyama T,Shibasaki H

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In amyotrophic lateral sclerosis, studies using threshold-tracking transcranial magnetic stimulation (TMS) have identified corticomotoneuronal dysfunction as a key pathogenic mechanism. Some patients, however, display no motor response at maximal TMS intensities, termed here an 'inexcitable' moto...

journal_title：European journal of neurology

authors： Dharmadasa T,Howells J,Matamala JM,Simon NG,Burke D,Vucic S,Kiernan MC

更新日期：2021-01-01 00:00:00

abstract：:Our aim was to conduct a meta-analysis of longitudinal studies assessing the association between Pittsburgh compound B (PiB) retention and the progression of cognitive status in healthy elderly, in patients with mild cognitive impairment (MCI) and in patients with Alzheimer's disease (AD). PubMed, MEDLINE, Embase and ...

journal_title：European journal of neurology

authors： Chen X,Li M,Wang S,Zhu H,Xiong Y,Liu X

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is a distinct epileptic syndrome with a broad range of severity even amongst affected members of the same pedigree, and the level of pharmacoresistance may reach 30%, close to that seen in sporadic focal epilepsies. METHODS:To investiga...

journal_title：European journal of neurology

authors： Labate A,Mumoli L,Fratto A,Quattrone A,Gambardella A

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Polymorphisms of the interleukin-1 (IL-1) gene family have been proposed as potential variants for different diseases including multiple sclerosis (MS). With respect to MS, IL-1 beta (-511 C/T; rs16944), IL-1 beta (+3954 C/T; rs1143634), IL-1 alpha (-889 C/T; rs1800587), IL-1 alpha (+4845 G/T; rs17561), and ...

journal_title：European journal of neurology

authors： Borzani I,Tola MR,Caniatti L,Collins A,De Santis G,Luiselli D,Mamolini E,Scapoli C

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVE:To investigate changes in serum complements and their regulators in the pathogenesis of myasthenia gravis (MG). METHODS:Forty-four patients with acetylcholine receptor antibody-positive MG, as well as 20 patients with non-inflammatory neurological disorders were enrolled. Serum complements (C3, C4 and solubl...

journal_title：European journal of neurology

authors： Ozawa Y,Uzawa A,Yasuda M,Kojima Y,Oda F,Himuro K,Kawaguchi N,Kuwabara S

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Multinodular and vacuolating neuronal tumor (MVNT) of the cerebrum is a rare brain lesion with suggestive imaging features. The aim of our study was to report the largest series of MVNTs so far and to evaluate the utility of advanced multiparametric magnetic resonance (MR) techniques. METHODS:Th...

journal_title：European journal of neurology

authors： Lecler A,Broquet V,Bailleux J,Carsin B,Adle-Biassette H,Baloglu S,Forestier G,Bonneville F,Calvier E,Chauvet D,Comby PO,Cottier JP,Cotton F,Deschamps R,Diard-Detoeuf C,Ducray F,Drissi C,Elmaleh M,Farras J,Aguilar Ga

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Several metabolic derangements associated with diabetes mellitus type 2 (DM) have been associated with a better outcome in amyotrophic lateral sclerosis (ALS), including hyperlipidemia and obesity. Here, we tested the hypothesis that DM would have a positive effect on the motor and cognitive findings of ALS....

journal_title：European journal of neurology

authors： Jawaid A,Salamone AR,Strutt AM,Murthy SB,Wheaton M,McDowell EJ,Simpson E,Appel SH,York MK,Schulz PE

更新日期：2010-05-01 00:00:00