Use of antiepileptic drugs in Estonia: an epidemiologic study of adult epilepsy.


:An evaluation of general antiepileptic treatment patterns and utilization of particular drugs was carried out based on the prevalence study of adult active epilepsy in a sample of the Estonian population. The antiepileptic drugs (AEDs) used, and their doses were recorded and compared with clinical characteristics. Nineteen per cent of the subjects did not take any AED on the prevalence day; 83% of those on medication were taking a single drug, 15% two, and 2% three AEDs. Localization-related symptomatic epilepsies were most frequently treated with AEDs and were also the largest group receiving polytherapy. The most common agent was carbamazepine (68%), followed by barbiturates. Valproate and phenytoin were used much less. The study design and its impact on the interpretation of results is discussed. The percentage of sodium-channel blockers is generally comparable with that reported from other European countries. The small share of valproate is probably a result of the extensive utilization of barbiturates, and is partially related to the age distribution in the study. The high figure of AED-free cases, and small percentage of polytherapy indicates a tendency for undertreatment. Some points for improvement in AED therapy are discussed.


Eur J Neurol


Oun A,Haldre S,Mägi M




Has Abstract


2006-05-01 00:00:00














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    journal_title:European journal of neurology

    pub_type: 杂志文章


    authors: Bongioanni P,Lombardo F,Moscato G,Mosti S,Meucci G

    更新日期:2000-11-01 00:00:00

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    abstract:BACKGROUND AND PURPOSE:There is large variability in the diagnostic approach and clinical management in functional movement disorders (FMD). This study aimed to examine whether opinions and clinical practices related to FMD have changed over the past decade. METHODS:Adapted from a 2008 version, we repeated the survey ...

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    pub_type: 杂志文章


    authors: LaFaver K,Lang AE,Stone J,Morgante F,Edwards M,Lidstone S,Maurer CW,Hallett M,Dwivedi AK,Espay AJ

    更新日期:2020-06-01 00:00:00

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    abstract::Water drinking recently has been shown to raise blood pressure in normal subjects and in patients with autonomic failure who have orthostatic hypotension. However, in normal young subjects, ingestion of approximately 500 ml has no pressor effect; but in older subjects there is an increase in blood pressure. An even gr...

    journal_title:European journal of neurology

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    authors: Mathias CJ,Young TM

    更新日期:2004-09-01 00:00:00

  • Systemic involvement in adult-onset leukoencephalopathy with intracranial calcifications and cysts (Labrune syndrome) with a novel mutation of the SNORD118 gene.

    abstract:BACKGROUND AND PURPOSE:Although Labrune syndrome is a well-known disorder characterized by a typical neuroradiological triad, namely leukoencephalopathy, intracranial calcifications and cysts, there are no reports of systemic involvement in this disorder. This paper attempts to describe a peculiar clinical manifestatio...

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    pub_type: 杂志文章


    authors: Bonomo G,Monfrini E,Borellini L,Bonomo R,Arienti F,Saetti MC,Di Fonzo A,Locatelli M

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    authors: Kassubek J,Sperfeld AD,Baumgartner A,Huppertz HJ,Riecker A,Juengling FD

    更新日期:2006-08-01 00:00:00

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    authors: Struhal W,Sellner J,Lisnic V,Vécsei L,Müller E,Grisold W

    更新日期:2011-04-01 00:00:00

  • Genomic screening of Fabry disease in young stroke patients: the Taiwan experience and a review of the literature.

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    pub_type: 杂志文章,评审


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    更新日期:2019-03-01 00:00:00

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    authors: Burneo JG,Fang J,Saposnik G,Investigators of the Registry of the Canadian Stroke Network.

    更新日期:2010-01-01 00:00:00

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    journal_title:European journal of neurology

    pub_type: 杂志文章


    authors: de Mendonça A,Ribeiro F,Guerreiro M,Palma T,Garcia C

    更新日期:2005-02-01 00:00:00

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    journal_title:European journal of neurology

    pub_type: 临床试验,杂志文章,随机对照试验


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    更新日期:2002-11-01 00:00:00

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    pub_type: 杂志文章,meta分析


    authors: Lampl C,You X,Limmroth V

    更新日期:2012-01-01 00:00:00

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    journal_title:European journal of neurology

    pub_type: 杂志文章,评审


    authors: Pugliatti M,Rosati G,Carton H,Riise T,Drulovic J,Vécsei L,Milanov I

    更新日期:2006-07-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:2020-11-01 00:00:00

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    authors: Kim YJ,Kwon HK,Lee JM,Kim YJ,Kim HJ,Jung NY,Kim ST,Lee KH,Na DL,Seo SW

    更新日期:2015-04-01 00:00:00

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    journal_title:European journal of neurology

    pub_type: 杂志文章


    authors: Arboix A,Bechich S,Oliveres M,García-Eroles L,Massons J,Targa C

    更新日期:2001-03-01 00:00:00

  • Minocycline and matrix metalloproteinase inhibition in acute intracerebral hemorrhage: a pilot study.

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    authors: Chang JJ,Kim-Tenser M,Emanuel BA,Jones GM,Chapple K,Alikhani A,Sanossian N,Mack WJ,Tsivgoulis G,Alexandrov AV,Pourmotabbed T

    更新日期:2017-11-01 00:00:00

  • Early changes of nerve integrity in preclinical carriers of hereditary transthyretin Ala117Ser amyloidosis with polyneuropathy.

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    journal_title:European journal of neurology

    pub_type: 杂志文章


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    更新日期:2020-12-28 00:00:00

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    journal_title:European journal of neurology

    pub_type: 杂志文章


    authors: Schoenegger K,Oberndorfer S,Wuschitz B,Struhal W,Hainfellner J,Prayer D,Heinzl H,Lahrmann H,Marosi C,Grisold W

    更新日期:2009-07-01 00:00:00

  • Treatment of relative sialorrhoea with botulinum toxin type A: description and rationale for an injection procedure with case report.

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    journal_title:European journal of neurology

    pub_type: 杂志文章,评审


    authors: Glickman S,Deaney CN

    更新日期:2001-11-01 00:00:00

  • Xeomin in the treatment of cervical dystonia.

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    journal_title:European journal of neurology

    pub_type: 临床试验,杂志文章


    authors: Benecke R

    更新日期:2009-12-01 00:00:00

  • COVID-19 pandemic and mental distress in multiple sclerosis: implications for clinical management.

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    journal_title:European journal of neurology

    pub_type: 杂志文章


    authors: Costabile T,Carotenuto A,Lavorgna L,Borriello G,Moiola L,Inglese M,Petruzzo M,Trojsi F,Ianniello A,Nozzolillo A,Cellerino M,Boffa G,Rosa L,Servillo G,Moccia M,Bonavita S,Filippi M,Lanzillo R,Brescia Morra V,Petracca

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    journal_title:European journal of neurology

    pub_type: 杂志文章


    authors: Fauser S,Soellner C,Bien CG,Tumani H

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    journal_title:European journal of neurology

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    authors: Sakuma R,Abe K,Aoki M,Ikeda M,Okita N,Hiwatari M,Sakurai M,Itoyama Y

    更新日期:1995-09-01 00:00:00

  • Neuromelanin or DaT-SPECT: which is the better marker for discriminating advanced Parkinson's disease?

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    journal_title:European journal of neurology

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    journal_title:European journal of neurology

    pub_type: 杂志文章


    authors: Spittel S,Maier A,Kettemann D,Walter B,Koch B,Krause K,Norden J,Münch C,Meyer T

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    journal_title:European journal of neurology

    pub_type: 杂志文章


    authors: Reinke F,Bettin M,Ross LS,Kochhäuser S,Kleffner I,Ritter M,Minnerup J,Dechering D,Eckardt L,Dittrich R

    更新日期:2018-04-01 00:00:00

  • Lesions to the posterior insular cortex cause dysarthria.

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    journal_title:European journal of neurology

    pub_type: 杂志文章


    authors: Baier B,zu Eulenburg P,Glassl O,Dieterich M

    更新日期:2011-12-01 00:00:00

  • Success rate, efficacy, and safety/tolerability of overnight switching from immediate- to extended-release pramipexole in advanced Parkinson's disease.

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    journal_title:European journal of neurology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Schapira AH,Barone P,Hauser RA,Mizuno Y,Rascol O,Busse M,Debieuvre C,Fraessdorf M,Poewe W

    更新日期:2013-01-01 00:00:00

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    journal_title:European journal of neurology

    pub_type: 杂志文章


    authors: Caeiro L,Ferro JM,Figueira ML

    更新日期:2012-02-01 00:00:00

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    journal_title:European journal of neurology

    pub_type: 杂志文章


    authors: Gómez-Garre P,Jesús S,Periñán MT,Adarmes A,Alonso-Canovas A,Blanco-Ollero A,Buiza-Rueda D,Carrillo F,Catalán-Alonso MJ,Del Val J,Escamilla-Sevilla F,Espinosa-Rosso R,Fernández-Moreno MC,García-Moreno JM,García-Ruiz PJ,Giaco

    更新日期:2020-11-11 00:00:00