Abstract:
:We examined the prevalence and correlates of apathy and irritability in a consecutive series of 101 patients with probable Alzheimer's disease (AD). Based on clinical criteria, 46 (46%) patients had apathy, and 13 (13%) patients had irritability. Apathy was significantly associated with more severe impairments in activities of daily living, significantly more severe extrapyramidal signs, and a significantly higher frequency of both major depression and dysthymia. Patients with irritability had significantly more severe impairments in activities of daily living and significantly higher depression and anosognosia scores. On the other hand, neither apathy nor irritability were significantly associated with deficits in specific cognitive domains.
journal_name
Eur J Neuroljournal_title
European journal of neurologyauthors
Starkstein SE,Migliorelli R,Manes F,Tesón A,Petracca G,Chemerinski E,Sabe L,Leiguarda Rdoi
10.1111/j.1468-1331.1995.tb00171.xsubject
Has Abstractpub_date
1995-12-01 00:00:00pages
540-6issue
6eissn
1351-5101issn
1468-1331journal_volume
2pub_type
杂志文章abstract::The activities of the metalloproteinase gelatinase B, and the presence of IL-6, an inducer of metalloproteinase inhibitors, were investigated in CSF samples of 190 patients with multiple sclerosis (MS; n = 55), optic neuritis (ON; n = 46), other inflammatory neurological diseases (OIND; n = 27) or control patients (CO...
journal_title:European journal of neurology
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doi:10.1111/j.1468-1331.1994.tb00051.x
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Disease-modifying therapies provide new horizons for hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN) to slow neuropathic progression. Initiating treatment at the earliest time requires biomarkers reflecting both small- and large-fiber degeneration in carriers. METHODS:This st...
journal_title:European journal of neurology
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journal_title:European journal of neurology
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journal_title:European journal of neurology
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doi:10.1111/j.1468-1331.2005.01009.x
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Superficial siderosis of the central nervous system is a sporadic finding in magnetic resonance imaging, resulting from recurrent bleedings into the subarachnoid space. This study aimed to determine the frequency of spinal dural cerebrospinal fluid (CSF) leaks amongst patients with a symmetric in...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14611
更新日期:2020-10-24 00:00:00
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journal_title:European journal of neurology
pub_type: 临床试验,杂志文章
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abstract:BACKGROUND AND PURPOSE:Headache has been associated with various lifestyle and psychosocial factors, one of which is smoking. The aim of the present study was to investigate whether the association between smoking intensity and headache is likely to be causal. METHOD:A total of 58 316 participants from the Nord-Trønde...
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journal_title:European journal of neurology
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doi:10.1046/j.1468-1331.2003.00668.x
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journal_title:European journal of neurology
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doi:10.1111/ene.12539
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2000.00139.x
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abstract:BACKGROUND AND PURPOSE:Improved biomarkers are needed to facilitate clinical decision-making and as surrogate endpoints in clinical trials in multiple sclerosis (MS). We assessed whether neurodegenerative and neuroinflammatory markers in cerebrospinal fluid (CSF) at initial sampling could predict disease activity durin...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13274
更新日期:2017-05-01 00:00:00
abstract::Astasia, inability to stand unsupported despite good strength, resembles the marked balance impairment of patients with vestibulocerebellar disease. We describe a patient with unilateral thalamic infarct that presented with astasia. A 76-year-old hypertensive woman was admitted to our hospital because of marked unstea...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2004.01020.x
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although there are a number of positive reports on the therapeutic effects of repetitive transcranial magnetic stimulation (rTMS) for treatment of tinnitus, there are few details about the duration of treatment effects or the relative efficiency of different rTMS protocols. METHODS:Sixty six pat...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2008.02522.x
更新日期:2009-03-01 00:00:00
abstract::The levels of malondialdehyde (MDA), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD-1) were measured in the red blood cells (RBC) of 34 patients with acute ischemic hemispheric stroke on the first and seventh day after their stroke onset, and compared with 30 control individuals matched for sex, age and...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2001.00166.x
更新日期:2001-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-10-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12718
更新日期:2015-07-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Corticobasal syndrome (CBS) is a clinical entity characterized by higher cortical dysfunctions associated with asymmetric onset of levodopa-resistant parkinsonism, dystonia and myoclonus. One of the most typical and distressful features of CBS is limb apraxia, which affects patients in their ever...
journal_title:European journal of neurology
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journal_title:European journal of neurology
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journal_title:European journal of neurology
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journal_title:European journal of neurology
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13225
更新日期:2017-03-01 00:00:00
abstract::Histamine has a selective affinity for H3-receptors and it may specifically inhibit the neurogenic edema response involved in migraine pathophysiology. The objective of this study was to evaluate the therapeutic potential of subcutaneous administration of histamine in migraine prophylaxis, compared with oral administr...
journal_title:European journal of neurology
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1468-1331.2007.01744.x
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE: Although fatigue is recognized as a common and debilitating symptom in patients with Parkinson's disease (PD), little is known on how and when this symptom emerges during disease progression. The aim of the study was to explore the presence and severity of fatigue in patients with PD at the tim...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2012.03663.x
更新日期:2012-07-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2011.03652.x
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Calculation of the cerebrospinal fluid:serum glucose (CSF:SGlu ) ratio is part of the routine cerebrospinal fluid (CSF) work-up. Reference values have been defined for lumbar CSF, but are lacking for ventricular CSF. The objective of this study was to investigate whether the CSF:SGlu ratio is sim...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13513
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:To compare the frequency of intrathecal immunoglobulin (Ig) synthesis in patients with symptomatic epilepsy and epilepsy of unknown etiology ('cryptogenic'). METHODS:Patients with epileptic (n = 301) and non-epileptic (n = 10) seizures were retrospectively screened for autochthonous intrathecal ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13348
更新日期:2017-09-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章,随机对照试验
doi:10.1111/ene.13403
更新日期:2017-11-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2002.00442.x
更新日期:2002-09-01 00:00:00
abstract::This report discusses a biopsy proven case of cerebral amyloid angiopathy, with additional prominent vascular inflammatory features, characterized by a rapidly progressive dementia and leukoencephalopathy, where the clinical and radiological abnormalities resolved rapidly with minimal therapeutic intervention. We prop...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1351-5101.2003.00707.x
更新日期:2004-01-01 00:00:00