Abstract:
BACKGROUND AND PURPOSE:Although there are a number of positive reports on the therapeutic effects of repetitive transcranial magnetic stimulation (rTMS) for treatment of tinnitus, there are few details about the duration of treatment effects or the relative efficiency of different rTMS protocols. METHODS:Sixty six patients with chronic tinnitus were divided into four groups, receiving sham rTMS, 1, 10 and 25 Hz rTMS applied each day for 10 days over left temporoparietal cortex. They were followed up at 4 months and 1 year using the tinnitus questionnaire [Tinnitus Handicap Inventory(THI)] and self ratings of annoyance as well as measures of residual inhibition. RESULTS:A two factor anova revealed a significant 'rTMS' x 'time' interaction indicating that real and sham rTMS had different effects on the THI scale and annoyance of tinnitus (P = 0.026 and 0.046 respectively). After 1 year, the tinnitus was absent in one or both ears of 10 patients who had received real rTMS: one of these was in the 1 Hz group, four patients were in the 10 Hz group and five patients were in the 25 Hz group. CONCLUSION:Some patients show a lasting benefit at 1 year after 10 days of rTMS treatment. It appears that treatment at 10 or 25 Hz may be more beneficial than at 1 Hz, although more work is necessary to validate this conclusion.
journal_name
Eur J Neuroljournal_title
European journal of neurologyauthors
Khedr EM,Rothwell JC,El-Atar Adoi
10.1111/j.1468-1331.2008.02522.xsubject
Has Abstractpub_date
2009-03-01 00:00:00pages
404-8issue
3eissn
1351-5101issn
1468-1331pii
ENE2522journal_volume
16pub_type
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journal_title:European journal of neurology
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journal_title:European journal of neurology
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pub_type: 杂志文章
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journal_title:European journal of neurology
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journal_title:European journal of neurology
pub_type: 杂志文章
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2008.02227.x
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pub_type: 杂志文章
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journal_title:European journal of neurology
pub_type: 杂志文章,随机对照试验
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更新日期:2006-10-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2001.00292.x
更新日期:2001-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:For Parkinson's disease (PD), an extended-release (ER) pramipexole formulation taken once daily, has shown efficacy, safety, and tolerability resembling those of immediate-release (IR) pramipexole taken three times daily. The present study assessed, in advanced PD, the success of an overnight swi...
journal_title:European journal of neurology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2013-01-01 00:00:00
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journal_title:European journal of neurology
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pub_type: 杂志文章,随机对照试验
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更新日期:2016-03-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.1998.510035.x
更新日期:1998-01-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章,随机对照试验
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更新日期:2008-08-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2018-01-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
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更新日期:2003-11-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:European journal of neurology
pub_type: 杂志文章,多中心研究
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更新日期:2010-01-01 00:00:00
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journal_title:European journal of neurology
pub_type: 共识发展会议,杂志文章,实务指引
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更新日期:2010-03-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
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更新日期:2019-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Dimethyl fumarate (DMF) causes a mean lymphocyte count drop of approximately 30% in relapsing-remitting multiple sclerosis (RRMS) patients. The relationship between this reduction and DMF effectiveness is controversial. The objective was to investigate if the decrease in absolute lymphocyte count...
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pub_type: 杂志文章
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更新日期:2021-01-01 00:00:00