Abstract:
BACKGROUND AND PURPOSE:Cerebrospinal fluid (CSF) removal improves clinical symptoms of many patients with idiopathic normal-pressure hydrocephalus (iNPH). The aim of this study was to investigate the correlation of changes in the optic nerve sheath diameter (ONSD) with patient responses to CSF removal. METHODS:Transorbital ultrasonography was performed to obtain ONSD measurements in 31 patients with iNPH before and after lumbar puncture. Measurements were obtained while patients were supine and upright. Changes in the ONSD between supine and upright positions [ONSD variability (ONSD-V)] were assessed and compared with those in 60 healthy volunteers. ONSD-V was correlated with relative changes in a validated iNPH severity (Boon) score. RESULTS:Mean pre-puncture ONSD-V was significantly lower in healthy volunteers and patients with no response to CSF removal (Fisher test) [0.05 ± 0.14 mm (SD)] than in responsive patients [0.37 ± 0.20 mm (SD), P < 0.001]. ONSD-V predicted response to the spinal tap test (odds ratio, 0.30; 95% confidence interval, 0.12-0.75 mm, P = 0.011). The higher the ONSD-V, the better the therapeutic effect (χ2 = 14.980, P < 0.001). The post-spinal tap test ONSD-V correlated significantly with clinical severity in the motor portion of the Boon score [0.16 ± 0.23 mm (SD), P = 0.003]. CONCLUSIONS:The ONSD-V before and after spinal tap test correlated well with the clinical effects of CSF removal. Transorbital ultrasonography seems to be a reliable, safe add-on to the Fisher test and may support selection of patients for shunt intervention.
journal_name
Eur J Neuroljournal_title
European journal of neurologyauthors
Ertl M,Aigner R,Krost M,Karnasová Z,Müller K,Naumann M,Schlachetzki Fdoi
10.1111/ene.13225subject
Has Abstractpub_date
2017-03-01 00:00:00pages
461-467issue
3eissn
1351-5101issn
1468-1331journal_volume
24pub_type
杂志文章abstract:BACKGROUND AND PURPOSE:Several studies have reported associations between brain iron deposits (IDs), white matter hyperintensities (WMHs) and cognitive ability in older individuals. Whether the association between brain IDs and cognitive abilities in older people is mediated by or independent of total brain tissue dama...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13006
更新日期:2016-07-01 00:00:00
abstract::Cytokines have a central role in multiple sclerosis (MS) pathogenesis and may contribute to the aetiology of MS. A polymorphism in the IFNA17 gene with an allele carrying a pre-mature stop codon has been suggested to convey a 26-fold increased risk for MS. We investigated the possible association between this polymorp...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2007.01953.x
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Previous antiplatelet therapy (APT) in cardiovascular prevention is common in patients with first-ever stroke. We aimed to evaluate the prognostic value of APT on early outcome in stroke patients. METHODS:All first-ever strokes from 1985 to 2011 were identified from the population-based Stroke R...
journal_title:European journal of neurology
pub_type: 杂志文章,多中心研究
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12437
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abstract:BACKGROUND AND PURPOSE:Current guidelines on cerebral venous thrombosis (CVT) diagnosis and management were issued by the European Federation of Neurological Societies in 2010. We aimed to update the previous European Federation of Neurological Societies guidelines using a clearer and evidence-based methodology. METHO...
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pub_type: 杂志文章,实务指引
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更新日期:2017-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Haemorrhagic transformation (HT) is common after acute ischaemic stroke. Whether liver function plays a role in HT remains an open question. METHODS:Acute ischaemic stroke patients within 7 days from stroke onset were included. Baseline data including liver function tests were collected. An inde...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12904
更新日期:2016-03-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
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更新日期:1998-09-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章,评审
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journal_title:European journal of neurology
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14086
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Despite advances in the understanding of Huntington's disease (HD), treatment remains symptomatic. Multidisciplinary rehabilitation, however, appears to impact disease progression. Here we show the feasibility, safety and efficacy of a 9-month multidisciplinary rehabilitation programme in a small...
journal_title:European journal of neurology
pub_type: 杂志文章,随机对照试验
doi:10.1111/ene.12053
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We previously reported that certain optical coherence tomography (OCT) measures were sensitive and reliable in identifying idiopathic intracranial hypertension (IIH). This prospective study aimed to define OCT measures that allow differentiation of IIH with and without papilledema, thereby helpin...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13893
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2008.02200.x
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:Consensus guidelines on the definition, investigation, and treatment of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) have been previously published in European Journal of Neurology and Journal of the Peripheral Nervous System. OBJECTIVES:To revise these guidelines. METHODS:Disease exper...
journal_title:European journal of neurology
pub_type: 共识发展会议,杂志文章,实务指引
doi:10.1111/j.1468-1331.2009.02930.x
更新日期:2010-03-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12432
更新日期:2014-07-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14072
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Decompressive craniectomy is used regularly in traumatic brain injury (TBI) and malignant middle cerebral artery infarction. Its benefits for other causes of non-traumatic brain swelling, if any, are unclear, especially after a devastating primary event. METHODS:We evaluated the outcomes as well as treatmen...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2010.03162.x
更新日期:2011-03-01 00:00:00
abstract::The Oslo Multiple Sclerosis (MS) Registry was established in 1990, and this is the first report on the prevalence and incidence of MS in the city of Oslo, Norway. The prevalence rate of definite MS on 1 January 1995 was 120.4/10(5). Inclusion of patients of native Norwegian ancestry only and exclusion of non-Norwegian...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2001.00269.x
更新日期:2001-09-01 00:00:00
abstract::The incidence of the neuropathological lesions and the severity of the clinical symptoms in multiple sclerosis (MS) are correlated with the amount of the transferred autoreactive T cells. The balance between the T helper 1 (Th1) and T helper 2 (Th2) cytokine phenotypes may affect the activity of the disease in MS pati...
journal_title:European journal of neurology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1468-1331.2004.00986.x
更新日期:2005-03-01 00:00:00
abstract::Intracranial internal carotid artery (ICA) aneurysms are frequently treated either by microsurgical clipping of the aneurysm neck, by endovascular coiling of the aneurysm sac or by balloon occlusion of the parent vessel. For some broad-based aneurysms that may not be suitable for any of these options, microsurgical wr...
journal_title:European journal of neurology
pub_type: 杂志文章
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journal_title:European journal of neurology
pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13613
更新日期:2018-06-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2011.03473.x
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The clinical predictors of health-related quality of life (HRQoL) in multiple sclerosis (MS) have mainly been studied in patients with long-standing disease. The objective of this study was to investigate the longitudinal association among HRQoL and clinical characteristics in early MS. METHODS:...
journal_title:European journal of neurology
pub_type: 杂志文章,随机对照试验
doi:10.1111/ene.13102
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In multiple sclerosis (MS), disease-related factors and dysfunctional coping might favor the development of mental distress induced by COVID-19 containment measures. Aim of this study was exploring the relationship between disability, coping strategies, daily life reorganization and neuropsychiat...
journal_title:European journal of neurology
pub_type: 杂志文章
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更新日期:2020-10-11 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2009.02946.x
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Venous drainage of dural arteriovenous fistula (DAVF) with dementia has never been reported. The aim of this study was to discover if specific vascular conditions exist to develop dementia in patients with DAVF. METHODS:Venous drainage in patients embolized in our centre between 1996 and 2012 fo...
journal_title:European journal of neurology
pub_type: 杂志文章
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更新日期:2014-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Risk-stratification models based on patient and disease characteristics are useful for aiding clinical decisions and for comparing the quality of care between different physicians or hospitals. In addition, prediction of mortality is beneficial for optimizing resource utilization. We evaluated th...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2010.02955.x
更新日期:2010-07-01 00:00:00
abstract::Post-marketing surveillance studies are needed to assess the long-term safety, compliance and clinical efficacy of interferon beta-1a (IFNbeta-1a) therapy in multiple sclerosis (MS) patients. The goals of this study were to (i) assess the safety, compliance and clinical efficacy of long-term intramuscular (i.m.) IFNbe...
journal_title:European journal of neurology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1111/j.1468-1331.2006.01422.x
更新日期:2006-09-01 00:00:00