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Long-term clinical experience with weekly interferon beta-1a in relapsing multiple sclerosis.

Abstract：

:Post-marketing surveillance studies are needed to assess the long-term safety, compliance and clinical efficacy of interferon beta-1a (IFNbeta-1a) therapy in multiple sclerosis (MS) patients. The goals of this study were to (i) assess the safety, compliance and clinical efficacy of long-term intramuscular (i.m.) IFNbeta-1a therapy in a large cohort of patients, and (ii) suggest possible predictors of therapeutic response. A total of 255 patients were included in the study. Mean time on therapy was 31.7 +/- 19.3 months. Within 3 years, 31% of patients discontinued treatment, mainly for disease activity. No significant sustained blood analysis alteration was observed over time, apart from a decrease of cholesterol levels. After 3 years of treatment, mean Expanded Disability Status Scale (EDSS) scores increased by 0.4 points compared with baseline. The mean annual relapse rate was reduced compared with baseline. Patients with < or = 2 relapses in the previous 2 years and with baseline EDSS scores of < or = 2 had a longer estimated time to first relapse and to progression and first relapse, respectively. These results confirm the safety and suggest a sustained effectiveness of i.m. IFNbeta-1a, extending the reported follow-up period to 6.3 years, and hypothesize the presence of possible predictors of clinical outcome.

journal_name

Eur J Neurol

journal_title

European journal of neurology

authors

Coppola G,Lanzillo R,Florio C,Orefice G,Vivo P,Ascione S,Schiavone V,Pagano A,Vacca G,De Michele G,Morra VB

doi

10.1111/j.1468-1331.2006.01422.x

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

1014-21

issue

9

eissn

1351-5101

issn

1468-1331

pii

ENE1422

journal_volume

13

pub_type

临床试验,杂志文章,多中心研究

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