Sex ratio of multiple sclerosis and clinical phenotype.

Abstract:

BACKGROUND AND PURPOSE:In a longitudinal population-based dataset of patients with multiple sclerosis (MS), we have previously observed a substantial increase in the female to male sex ratio in Canada over the last 50 years. Here, we aimed to determine whether this change in sex ratio is related to the clinical course of MS. METHODS:We calculated sex ratios by birth year in 11 868 patients with relapsing-remitting (RR) MS and 2825 patients with primary progressive (PP) MS identified as part of the Canadian Collaborative Project on the Genetic Susceptibility to MS. RESULTS:Year of birth was a significant predictor for sex ratio in RR MS (P < 0.0001, chi(2) = 21.2; Spearman's rank correlation r = 0.67), but not for PP MS (P = 0.44, chi(2) = 0.6; Spearman's rank correlation r = 0.11). CONCLUSIONS:An increase in the number of female RR MS patients over time accounts for the increasing sex ratio of MS. This has implications for pathogenesis, for assessment of clinical trial results and for disease prevention. The factors underlying the selective increase in MS in females need to be uncovered.

journal_name

Eur J Neurol

authors

Ramagopalan SV,Byrnes JK,Orton SM,Dyment DA,Guimond C,Yee IM,Ebers GC,Sadovnick AD

doi

10.1111/j.1468-1331.2009.02850.x

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

634-7

issue

4

eissn

1351-5101

issn

1468-1331

pii

ENE2850

journal_volume

17

pub_type

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