Abstract:
BACKGROUND AND PURPOSE:In a longitudinal population-based dataset of patients with multiple sclerosis (MS), we have previously observed a substantial increase in the female to male sex ratio in Canada over the last 50 years. Here, we aimed to determine whether this change in sex ratio is related to the clinical course of MS. METHODS:We calculated sex ratios by birth year in 11 868 patients with relapsing-remitting (RR) MS and 2825 patients with primary progressive (PP) MS identified as part of the Canadian Collaborative Project on the Genetic Susceptibility to MS. RESULTS:Year of birth was a significant predictor for sex ratio in RR MS (P < 0.0001, chi(2) = 21.2; Spearman's rank correlation r = 0.67), but not for PP MS (P = 0.44, chi(2) = 0.6; Spearman's rank correlation r = 0.11). CONCLUSIONS:An increase in the number of female RR MS patients over time accounts for the increasing sex ratio of MS. This has implications for pathogenesis, for assessment of clinical trial results and for disease prevention. The factors underlying the selective increase in MS in females need to be uncovered.
journal_name
Eur J Neuroljournal_title
European journal of neurologyauthors
Ramagopalan SV,Byrnes JK,Orton SM,Dyment DA,Guimond C,Yee IM,Ebers GC,Sadovnick ADdoi
10.1111/j.1468-1331.2009.02850.xsubject
Has Abstractpub_date
2010-04-01 00:00:00pages
634-7issue
4eissn
1351-5101issn
1468-1331pii
ENE2850journal_volume
17pub_type
杂志文章abstract:BACKGROUND AND PURPOSE:High levels of glutamic acid decarboxylase (GAD)-ab were initially described in patients with stiff person syndrome, and have since also been observed in patients with other neurological diseases. Temporal lobe epilepsy (TLE) seems to be specially associated. Our purpose is to describe the preval...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2011.03609.x
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Body mass index (BMI), hyperglycaemia and type 2 diabetes and their interactive effects are associated with brain volume atrophy in ageing. It remains to be established if these risk factors are particularly concerning in individuals with high or low brain volumes. METHODS:Demographics, venous b...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13780
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abstract:BACKGROUND AND PURPOSE:Information about metabolic comorbidities in patients with multiple sclerosis (MS) is scarce. Our aim was to examine the prevalence of the metabolic syndrome (MetS) and its components in patients with long duration of MS and significant disability. METHODS:Demographic and clinical data, weight, ...
journal_title:European journal of neurology
pub_type: 杂志文章
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journal_title:European journal of neurology
pub_type: 杂志文章,评审
doi:10.1111/ene.12022
更新日期:2013-01-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2005.01098.x
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abstract::Treatment outcome in patients with neuropathic pain (NP) is often variable and disappointing. We tested the hypothesis that patients with clear evidence of nervous system lesion respond better to pharmacological treatment with documented effect on NP than patients with poor or no evidence of nervous system lesion. Fur...
journal_title:European journal of neurology
pub_type: 临床试验,杂志文章
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更新日期:2004-08-01 00:00:00
abstract::Twelve patients with early Parkinson's disease (PD), none of whom had received any previous L-DOPA treatment, but using other antiparkinsonian drugs, were studied using transcranial magnetic stimulation (TMS). Contralateral and ipsilateral hemispheres were examined, with a focus on the more pronounced parkinsonian sym...
journal_title:European journal of neurology
pub_type: 临床试验,杂志文章
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.1996.tb00433.x
更新日期:1996-05-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
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journal_title:European journal of neurology
pub_type: 杂志文章,随机对照试验
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journal_title:European journal of neurology
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journal_title:European journal of neurology
pub_type: 杂志文章
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journal_title:European journal of neurology
pub_type: 杂志文章
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更新日期:2003-09-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章,评审
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journal_title:European journal of neurology
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2009.02589.x
更新日期:2009-07-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2009.02843.x
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Dimethyl fumarate (DMF) causes a mean lymphocyte count drop of approximately 30% in relapsing-remitting multiple sclerosis (RRMS) patients. The relationship between this reduction and DMF effectiveness is controversial. The objective was to investigate if the decrease in absolute lymphocyte count...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14538
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journal_title:European journal of neurology
pub_type: 杂志文章
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journal_title:European journal of neurology
pub_type: 杂志文章
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journal_title:European journal of neurology
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journal_title:European journal of neurology
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journal_title:European journal of neurology
pub_type: 杂志文章
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journal_title:European journal of neurology
pub_type: 杂志文章
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journal_title:European journal of neurology
pub_type: 临床试验,杂志文章
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journal_title:European journal of neurology
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