Cerebral embolism in a patient with polycythemia rubra vera.

Abstract:

:Polycythemia rubra vera (PRV) is a rare haematological disorder that has a high risk of stroke, although the pathophysiological origin of the cerebral ischaemia in this disease is not well known. We report a case of a stroke patient with PRV in whom bilateral embolic signals were detected by transcranial Doppler (TCD). Cerebral computed tomography showed a cortical middle cerebral artery infarction, echocardiography was normal, duplex-scan showed moderate left carotid stenosis and digital angiography disclosed right siphon stenosis. TCD examinations in the acute phase repeatedly showed a great number of bilateral microembolic signals (MESs). Four months later magnetic resonance angiography showed no flow signal in the right siphon and a severe stenosis of the proximal right MCA. The detection of bilateral MESs in the absence of cardiac sources of embolism observed in this patient suggests that ischaemic cerebral events in PRV may have an embolic origin favoured by a prothrombotic state.

journal_name

Eur J Neurol

authors

Segura T,Serena J,Teruel J,Dávalos A

doi

10.1046/j.1468-1331.2000.00008.x

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

87-90

issue

1

eissn

1351-5101

issn

1468-1331

pii

ene008

journal_volume

7

pub_type

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