Clinical significance of subcortical vascular disease in patients with mild cognitive impairment.

Abstract:

:Patients with mild cognitive impairment (MCI) typically present with memory complaints. Some of these patients have subcortical vascular disease on computed tomography (CT) scan, namely white matter changes and lacunar infarcts, however it is not known whether these findings are associated with more pronounced cognitive deficits. In the present study we compare demographic, clinical and neuropsychological characteristics of MCI patients according to the presence or the absence of subcortical vascular disease. Forty consecutive patients with memory complaints, at least one neuropsychological memory test below 1 SD the normal for age and education, and maintained activities of daily living, were included. Patients with dementia, history of stroke or transient ischemic attack, or other brain disorders, were excluded. Twenty-five (62.5%) patients with MCI had no ischemic lesions on CT scan, and 15 (37.5%) were found to have subcortical vascular changes. MCI patients with subcortical vascular changes were older (77.1 +/- 6.8 vs. 70.8 +/- 7.5 years old), and more often males. The number of vascular risk factors, the frequency of neurological signs, the Hachinski score and the neuropsychological tests scores were not significantly different. The presence of subcortical vascular disease on CT scan is frequent in older patients with MCI, but does not appear to be associated with the severity of cognitive deficits.

journal_name

Eur J Neurol

authors

de Mendonça A,Ribeiro F,Guerreiro M,Palma T,Garcia C

doi

10.1111/j.1468-1331.2004.00892.x

subject

Has Abstract

pub_date

2005-02-01 00:00:00

pages

125-30

issue

2

eissn

1351-5101

issn

1468-1331

pii

ENE892

journal_volume

12

pub_type

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