Abstract：
BACKGROUND AND PURPOSE:Patients suffering from basilar artery occlusion (BAO) and treated with intravenous thrombolysis are, in some centers, started on adjunct anticoagulation in hyperacute settings. We aimed to assess the outcome of such patients and to compare low-molecular weight heparin (LMWH) and unfractionated heparin (UFH) in this context. METHODS:We examined 211 patients with angiography-proven BAO treated with intravenous thrombolysis and either adjunct UFH or LMWH. Main outcome variables were rate of symptomatic intracranial hemorrhage (sICH) according to European Cooperative Acute Stroke Study II criteria and modified Rankin Scale (mRS) at 3 months. RESULTS:The overall rate of sICH was 11.4% and driven by the UFH group (13.3%). None of the LMWH group developed sICH. Recanalization rate did not significantly differ between the LMWH and UFH groups. An additional propensity analysis was made to balance anticoagulation groups regarding baseline characteristics. Propensity analysis showed a significant difference in sICH rate (0.0% vs. 14.8%, P = 0.044) in favor of LMWH. Independent outcome (mRS score 0-2) was achieved in a total of 31.0% and in 44.8% and 29.1% in the LMWH and UFH group, respectively (P = 0.09). Propensity analysis showed a significant difference in the risk of ending up bedridden or dead (mRS score 5-6; 34.5% vs. 63.0%, P = 0.033) in favor of LMWH. CONCLUSIONS:Our study showed a lower rate of sICH and a shift towards improved outcome in thrombolysed patients with BAO treated with LMWH as compared with UFH.
journal_name
Eur J Neuroljournal_title
European journal of neurologyauthors
Ritvonen J,Strbian D,Silvennoinen H,Virtanen P,Salonen O,Lindsberg PJ,Sairanen Tdoi
10.1111/ene.13781subject
Has Abstractpub_date
2019-01-01 00:00:00pages
128-135issue
1eissn
1351-5101issn
1468-1331journal_volume
26pub_type
杂志文章abstract：:Glyceryl trinitrate, a prodrug of nitric oxide, induces a mild to moderate headache in healthy subjects, whilst migraineurs develop a more severe headache, resembling spontaneous migraine attacks. In order to investigate whether this increased nitric oxide sensitivity depends upon the frequency of spontaneously occurr...
journal_title：European journal of neurology
pub_type： 杂志文章
doi：10.1046/j.1468-1331.2000.00094.x
更新日期：2000-07-01 00:00:00
abstract：BACKGROUND:Investigations on cause of death may provide valuable information about life expectancy and on conditions of terminal dementia care, which perhaps can be ameliorated. METHODS:The autopsy reports were studied on all patients (n = 524; 55.3% females; median age 80 years) with a clinically and neuropathologica...
journal_title：European journal of neurology
pub_type： 杂志文章
doi：10.1111/j.1468-1331.2008.02503.x
更新日期：2009-04-01 00:00:00
abstract：BACKGROUND AND PURPOSE:The involvement of metabolic factors in the development of dementia has received much attention. However, previous studies have yielded conflicting results regarding how blood adipocytokine level impacts cognitive decline and dementia. This study aimed to clarify whether serum high-molecular-weig...
journal_title：European journal of neurology
pub_type： 杂志文章
doi：10.1111/ene.12915
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Calculation of the cerebrospinal fluid:serum glucose (CSF:SGlu ) ratio is part of the routine cerebrospinal fluid (CSF) work-up. Reference values have been defined for lumbar CSF, but are lacking for ventricular CSF. The objective of this study was to investigate whether the CSF:SGlu ratio is sim...
journal_title：European journal of neurology
pub_type： 杂志文章
doi：10.1111/ene.13513
更新日期：2018-02-01 00:00:00
abstract：:Upper limb spasticity affecting elbow, wrist, and finger flexors can be safely and effectively reduced with injections of botulinum toxin type-A (BoNT-A). It has been best studied in adults in the context of post-stroke spasticity. The clinical benefits include reduction in pain and deformity, improvement in washing a...
journal_title：European journal of neurology
pub_type： 共识发展会议,杂志文章,实务指引
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更新日期：2010-08-01 00:00:00
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journal_title：European journal of neurology
pub_type： 杂志文章
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journal_title：European journal of neurology
pub_type： 杂志文章
doi：10.1111/j.1468-1331.2006.01160.x
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journal_title：European journal of neurology
pub_type： 杂志文章
doi：10.1111/j.1468-1331.2008.02200.x
更新日期：2008-08-01 00:00:00
abstract：BACKGROUND AND PURPOSE:To examine the frequencies and clinical characteristics of fallers and non-fallers at different stages of Parkinson's disease (PD). METHODS:The sample consisted of 232 patients in an unselected cross-sectional cohort of patients with PD, 207 newly diagnosed and drug naive patients and 175 contro...
journal_title：European journal of neurology
pub_type： 杂志文章
doi：10.1111/j.1468-1331.2012.03821.x
更新日期：2013-01-01 00:00:00
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journal_title：European journal of neurology
pub_type： 杂志文章,评审
doi：10.1111/j.1468-1331.2012.03842.x
更新日期：2013-03-01 00:00:00
abstract：BACKGROUND:Migraine with aura (MA) has been found to be a risk factor for cardiovascular disease including ischaemic stroke and myocardial infarction. Studies have also reported a higher prevalence of unfavourable cardiovascular risk factors amongst migraineurs, but results have been conflicting as to whether this is r...
journal_title：European journal of neurology
pub_type： 杂志文章
doi：10.1111/j.1468-1331.2010.03199.x
更新日期：2011-03-01 00:00:00
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journal_title：European journal of neurology
pub_type： 杂志文章
doi：10.1111/j.1468-1331.1994.tb00060.x
更新日期：1994-11-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Botulinum toxin type A (BoNT/A) is a highly effective and well-tolerated treatment for focal dystonias. The BoNT/A in Botox and Dysport is part of a high-molecular-weight complex that contains hemagglutinins and other non-toxic proteins, whilst Xeomin is a highly purified BoNT/A free of such comp...
journal_title：European journal of neurology
pub_type： 临床试验,杂志文章
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更新日期：2009-12-01 00:00:00
abstract：BACKGROUND AND PURPOSE:The clinical predictors of health-related quality of life (HRQoL) in multiple sclerosis (MS) have mainly been studied in patients with long-standing disease. The objective of this study was to investigate the longitudinal association among HRQoL and clinical characteristics in early MS. METHODS:...
journal_title：European journal of neurology
pub_type： 杂志文章,随机对照试验
doi：10.1111/ene.13102
更新日期：2016-09-01 00:00:00
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journal_title：European journal of neurology
pub_type： 杂志文章
doi：10.1046/j.1351-5101.2003.00707.x
更新日期：2004-01-01 00:00:00
abstract：:A comprehensive battery of neuropsychological tests sampling a wide range of cognitive functions was administrated to 36 patients with systemic lupus erythematosus (SLE), and a control group consisting of 31 patients with persistent symptoms after whiplash injury. Our results demonstrated significant group differences...
journal_title：European journal of neurology
pub_type： 杂志文章
doi：10.1111/j.1468-1331.1997.tb00323.x
更新日期：1997-03-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Despite advances in the understanding of Huntington's disease (HD), treatment remains symptomatic. Multidisciplinary rehabilitation, however, appears to impact disease progression. Here we show the feasibility, safety and efficacy of a 9-month multidisciplinary rehabilitation programme in a small...
journal_title：European journal of neurology
pub_type： 杂志文章,随机对照试验
doi：10.1111/ene.12053
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journal_title：European journal of neurology
pub_type： 杂志文章
doi：10.1111/ene.12427
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journal_title：European journal of neurology
pub_type： 杂志文章
doi：10.1111/j.1468-1331.1995.tb00119.x
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journal_title：European journal of neurology
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journal_title：European journal of neurology
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journal_title：European journal of neurology
pub_type： 杂志文章
doi：10.1111/j.1468-1331.2006.01268.x
更新日期：2006-05-01 00:00:00
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journal_title：European journal of neurology
pub_type： 杂志文章
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更新日期：2020-11-01 00:00:00
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journal_title：European journal of neurology
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更新日期：2019-01-01 00:00:00
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journal_title：European journal of neurology
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更新日期：2021-02-01 00:00:00
abstract：:The aim of the study was to use functional transcranial Doppler to investigate the possibility of revealing different activation patterns during healthy subjects' performance of meaningful and meaningless actions. Mean flow velocity (MFV) changes were recorded in middle cerebral arteries (MCAs) of 26 normal subjects d...
journal_title：European journal of neurology
pub_type： 杂志文章
doi：10.1111/j.1468-1331.2006.01219.x
更新日期：2006-01-01 00:00:00
abstract：:This study examined the relative anti-Parkinson's disease (PD) tremor potencies of pergolide and pramipexole in people with PD, using a 3-month double-blind cross-over design. Patients were randomly assigned to receive either pergolide and then pramipexole (n=9) or vice versa (n=8). The dose of the respective dopamine...
journal_title：European journal of neurology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期：2005-01-01 00:00:00
abstract：:We studied specific aspects of speed performance in neuropsychological tests and functional and vocational long-term outcome among moderate or severe traumatic brain injury (TBI) patients admitted to a rehabilitation programme. A group of 140 patients with mild, moderate or severe TBI was followed up for a minimum of ...
journal_title：European journal of neurology
pub_type： 杂志文章
doi：10.1111/j.1468-1331.1999.tb00011.x
更新日期：1999-03-01 00:00:00
abstract：:Histamine has a selective affinity for H3-receptors and it may specifically inhibit the neurogenic edema response involved in migraine pathophysiology. The objective of this study was to evaluate the therapeutic potential of subcutaneous administration of histamine in migraine prophylaxis, compared with oral administr...
journal_title：European journal of neurology
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1468-1331.2007.01744.x
更新日期：2007-10-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Accumulation of iron (Fe) is often detected in brains of people suffering from neurodegenerative diseases. However, no studies have compared the Fe load between these disease entities. The present study investigates by T2*-weighted gradient-echo 7.0 T magnetic resonance imaging (MRI) the Fe conte...
journal_title：European journal of neurology
pub_type： 杂志文章
doi：10.1111/ene.12432
更新日期：2014-07-01 00:00:00
