Glyceryl trinitrate induced headache in migraineurs - relation to attack frequency.

Abstract:

:Glyceryl trinitrate, a prodrug of nitric oxide, induces a mild to moderate headache in healthy subjects, whilst migraineurs develop a more severe headache, resembling spontaneous migraine attacks. In order to investigate whether this increased nitric oxide sensitivity depends upon the frequency of spontaneously occurring migraine attacks, intravenous infusion of glyceryl trinitrate (0.5 microg/kg/min) was given to 15 migraine patients with rare attacks (/=12 attacks/year) and 14 healthy subjects served as controls. No significant difference between the migraine groups for any of several parameters was detected, although the trend was always towards more headaches in frequent migraineurs. Both migraineurs with frequent and rare attacks experienced a headache that was significantly more severe, longer lasting, and fulfilled the diagnostic criteria for migraine without aura more often, compared to the healthy subjects (P = 0.0001). Conclusively, supersensitivity to glyceryl trinitrate in migraineurs seems to be related to a basic - probably genetically determined - pathophysiological mechanism involving nitric oxide, and not to the environmental influences, which to a large extent determine the expression of migraine.

journal_name

Eur J Neurol

authors

Christiansen I,Daugaard D,Lykke Thomsen L,Olesen J

doi

10.1046/j.1468-1331.2000.00094.x

subject

Has Abstract

pub_date

2000-07-01 00:00:00

pages

405-11

issue

4

eissn

1351-5101

issn

1468-1331

pii

ene094

journal_volume

7

pub_type

杂志文章
  • Electromyographic evaluation of the sound and involved side during gait of spastic hemiplegic children with cerebral palsy.

    abstract::The purpose of this study was to investigate the surface electromyogram (EMG) of the lower limbs of hemiplegic children with spastic cerebral palsy during gait. The EMG of seven muscles was analyzed for 17 children (5-12 years old). The EMG of the involved side was decreased for the examined shank muscles and increase...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2005.01047.x

    authors: Patikas D,Wolf S,Döderlein L

    更新日期:2005-09-01 00:00:00

  • Multiple antibody detection in 'seronegative' myasthenia gravis patients.

    abstract:BACKGROUND AND PURPOSE:Myasthenia gravis (MG) is an autoimmune disease caused by antibody mediated impairment in the neuromuscular junction. Seronegative MG (SNMG) without antibodies against acetylcholine receptor (AChR) and muscle-specific kinase (MuSK) by routine assays accounts for about 20% of all MG patients. MET...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.13300

    authors: Hong Y,Zisimopoulou P,Trakas N,Karagiorgou K,Stergiou C,Skeie GO,Hao HJ,Gao X,Owe JF,Zhang X,Yue YX,Romi F,Wang Q,Li HF,Gilhus NE,Tzartos SJ

    更新日期:2017-06-01 00:00:00

  • Serum high-molecular-weight adiponectin level and incident dementia in patients with vascular risk factors.

    abstract:BACKGROUND AND PURPOSE:The involvement of metabolic factors in the development of dementia has received much attention. However, previous studies have yielded conflicting results regarding how blood adipocytokine level impacts cognitive decline and dementia. This study aimed to clarify whether serum high-molecular-weig...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.12915

    authors: Kitagawa K,Miwa K,Okazaki S,Sakaguchi M,Mochizuki H

    更新日期:2016-03-01 00:00:00

  • The epidemiology of epilepsy in Europe - a systematic review.

    abstract::Population-based epidemiological studies on epilepsy are available mainly from the UK and the Nordic, Baltic and western Mediterranean countries. No studies were identified from large areas of Europe, especially from the former eastern Europe (except the Baltic countries) and the eastern Mediterranean countries. Based...

    journal_title:European journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1468-1331.2004.00992.x

    authors: Forsgren L,Beghi E,Oun A,Sillanpää M

    更新日期:2005-04-01 00:00:00

  • Incidence and prognosis of immune reconstitution inflammatory syndrome in HIV-associated progressive multifocal leucoencephalopathy.

    abstract:BACKGROUND AND PURPOSE:Progressive multifocal leucoencephalopathy-associated immune reconstitution inflammatory syndrome (PML-IRIS) is the paradoxical worsening or unmasking of preexisting infection with JC virus attributable to a rapid recovery of the immune system after highly active antiretroviral therapy (HAART) in...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.12963

    authors: Sainz-de-la-Maza S,Casado JL,Pérez-Elías MJ,Moreno A,Quereda C,Moreno S,Corral I

    更新日期:2016-05-01 00:00:00

  • Molecular genetic analysis in 21 Chinese families with congenital insensitivity to pain with or without anhidrosis.

    abstract:BACKGROUND AND PURPOSE:Hereditary sensory and autonomic neuropathies (HSANs) are a group of clinically and genetically heterogeneous neurological disorders characterized by sensory dysfunctions. Here, 21 affected Chinese families are reported, including 19 with congenital insensitivity to pain with anhidrosis (CIPA; na...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.14234

    authors: Zhao F,Mao B,Geng X,Ren X,Wang Y,Guan Y,Li S,Li L,Zhang S,You Y,Cao Y,Yang T,Zhao X

    更新日期:2020-08-01 00:00:00

  • Mitofusin 2 gene mutation (R94Q) causing severe early-onset axonal polyneuropathy (CMT2A).

    abstract::Charcot-Marie-Tooth disease (CMT) has been classified into two types: demyelinating forms (CMT1) and axonal forms (CMT2). Mutations in the CMT2A locus have been linked to the KIF1B and the mitofusin 2 (MFN2) genes. Here, we report a German patient with CMT2 with an underlying spontaneous mutation (c.281G-->A) in the M...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2006.01688.x

    authors: Neusch C,Senderek J,Eggermann T,Elolff E,Bähr M,Schneider-Gold C

    更新日期:2007-05-01 00:00:00

  • Medium-term functional benefits in children with cerebral palsy treated with botulinum toxin type A: 1-year follow-up using gross motor function measure.

    abstract::One of the main goals when treating spasticity is to relieve pain and improve function. Intramuscular injection of botulinum toxin type A (BTX-A) has gained widespread acceptance in the treatment of spastic cerebral palsy. Several studies have clearly shown the short-term functional benefit of BTX-A treatment. Informa...

    journal_title:European journal of neurology

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1468-1331.2001.00044.x

    authors: Linder M,Schindler G,Michaelis U,Stein S,Kirschner J,Mall V,Berweck S,Korinthenberg R,Heinen F

    更新日期:2001-11-01 00:00:00

  • COVID-19 pandemic and mental distress in multiple sclerosis: implications for clinical management.

    abstract:BACKGROUND AND PURPOSE:In multiple sclerosis (MS), disease-related factors and dysfunctional coping might favor the development of mental distress induced by COVID-19 containment measures. Aim of this study was exploring the relationship between disability, coping strategies, daily life reorganization and neuropsychiat...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.14580

    authors: Costabile T,Carotenuto A,Lavorgna L,Borriello G,Moiola L,Inglese M,Petruzzo M,Trojsi F,Ianniello A,Nozzolillo A,Cellerino M,Boffa G,Rosa L,Servillo G,Moccia M,Bonavita S,Filippi M,Lanzillo R,Brescia Morra V,Petracca

    更新日期:2020-10-11 00:00:00

  • Intracortical inhibition and facilitation are impaired in patients with early Parkinson's disease: a paired TMS study.

    abstract::Twelve patients with early Parkinson's disease (PD), none of whom had received any previous L-DOPA treatment, but using other antiparkinsonian drugs, were studied using transcranial magnetic stimulation (TMS). Contralateral and ipsilateral hemispheres were examined, with a focus on the more pronounced parkinsonian sym...

    journal_title:European journal of neurology

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1468-1331.2003.00610.x

    authors: Bares M,Kanovský P,Klajblová H,Rektor I

    更新日期:2003-07-01 00:00:00

  • The Symbol Digit Modalities Test as sentinel test for cognitive impairment in multiple sclerosis.

    abstract:BACKGROUND AND PURPOSE:Cognitive impairment (CI) is found in about half of the multiple sclerosis (MS) population and is an important contributor to employment status and social functioning. CI is encountered in all disease stages and correlates only moderately with disease duration or Expanded Disability Status Scale ...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.12463

    authors: Van Schependom J,D'hooghe MB,Cleynhens K,D'hooge M,Haelewyck MC,De Keyser J,Nagels G

    更新日期:2014-09-01 00:00:00

  • Foetal malformations and seizure control: 52 months data of the Australian Pregnancy Registry.

    abstract::The Australian Pregnancy Registry, affiliated European Register of Antiepileptic drugs in Pregnancy (EURAP), recruits informed consenting women with epilepsy on treatment with antiepileptic drugs (AEDs), those untreated, and women on AEDs for other indications. Enrolment is considered prospective if it has occurred be...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2006.01359.x

    authors: Vajda FJ,Hitchcock A,Graham J,Solinas C,O'Brien TJ,Lander CM,Eadie MJ

    更新日期:2006-06-01 00:00:00

  • Does combined levodopa and bromocriptine therapy in Parkinson's disease prevent late motor complications?

    abstract::Levodopa-carbidopa (LD) in low dosages adequately controls symptoms in most patients with Parkinson's disease and delays the appearance of fluctuations and dyskinesias. It has been suggested that early combination therapy with bromocriptine and levodopa delays or prevents the onset of late treatment complication assoc...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1046/j.1468-1331.1998.530255.x

    authors: Alarcon F,Cevallos N,Lees AJ

    更新日期:1998-05-01 00:00:00

  • A multi-center, multinational age- and gender-adjusted normative dataset for immunofluorescent intraepidermal nerve fiber density at the distal leg.

    abstract:BACKGROUND AND PURPOSE:Quantification of intraepidermal nerve fibers (IENFs) in skin biopsies is now the tool of choice to diagnose small fiber neuropathies. An adequate normative dataset, necessary to assess normality cutoffs, is available for brightfield microscopy but not for immunofluorescence. METHODS:Intraepider...

    journal_title:European journal of neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/ene.12842

    authors: Provitera V,Gibbons CH,Wendelschafer-Crabb G,Donadio V,Vitale DF,Stancanelli A,Caporaso G,Liguori R,Wang N,Santoro L,Kennedy WR,Nolano M

    更新日期:2016-02-01 00:00:00

  • Embolic strokes of undetermined source in young adults: baseline characteristics and long-term outcome.

    abstract:BACKGROUND AND PURPOSE:Embolic strokes of undetermined source (ESUS) are a recent entity, not yet thoroughly investigated in young stroke patients. The clinical characteristics and long-term risks of vascular events and all-cause mortality between young-onset ESUS and other aetiological subgroups were compared. METHOD...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.13540

    authors: Martinez-Majander N,Aarnio K,Pirinen J,Lumikari T,Nieminen T,Lehto M,Sinisalo J,Kaste M,Tatlisumak T,Putaala J

    更新日期:2018-03-01 00:00:00

  • Magnetic resonance imaging findings in 22 cases of myelitis: comparison between patients with and without multiple sclerosis.

    abstract::We reviewed the magnetic resonance imaging (MRI) database of the Dent Neurologic Institute to study the abnormal findings in myelitis. We identified 22 patients, and compared non-MS-related acute transverse myelitis (ATM, n = 9), to myelitis associated with multiple sclerosis (MS-myelitis, n = 13). The ATM patients we...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1046/j.1468-1331.1998.510035.x

    authors: Bakshi R,Kinkel PR,Mechtler LL,Bates VE,Lindsay BD,Esposito SE,Kinkel WR

    更新日期:1998-01-01 00:00:00

  • Rebound intracranial hypertension after treatment of spontaneous intracranial hypotension.

    abstract::Spontaneous intracranial hypotension (SIH) is characterized by orthostatic headache and the cause is usually cerebrospinal fluid leaks in spine level. Most patients with SIH have a benign course. Epidural blood patch (EBP) is the treatment of choice when initial conservative managements are ineffective. We reported a ...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2006.01369.x

    authors: Tsui H,Wu S,Kuo H,Chen C

    更新日期:2006-07-01 00:00:00

  • N-terminal pro-brain natriuretic peptide level determined at different times identifies transient ischaemic attack patients with atrial fibrillation.

    abstract:BACKGROUND AND PURPOSE:The etiological classification of patients with transient ischaemic attack (TIA) is a difficult endeavor and the use of serum biomarkers could improve the diagnostic accuracy. The aim of this study was to correlate atrial fibrillation, the main cardioembolic etiology (CE), with different serum bi...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.12222

    authors: Purroy F,Suárez-Luis I,Mauri-Capdevila G,Cambray S,Farré J,Sanahuja J,Piñol-Ripoll G,Quílez A,González-Mingot C,Begué R,Gil MI,Fernández E,Benabdelhak I

    更新日期:2014-04-01 00:00:00

  • A nationwide retrospective analysis on the effect of immune therapies in patients with chronic inflammatory demyelinating polyradiculoneuropathy.

    abstract:BACKGROUND AND PURPOSE:The guidelines for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) therapy suggest to use immunoglobulins (IVIg) and steroid as first-line therapies. Patients who do not respond to one of the two drugs should be switched to the other drug. We collected therapeutic outcome data in...

    journal_title:European journal of neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1468-1331.2009.02802.x

    authors: Cocito D,Paolasso I,Antonini G,Benedetti L,Briani C,Comi C,Fazio R,Jann S,Matà S,Mazzeo A,Sabatelli M,Nobile-Orazio E,Italian Network for CIDP Register.

    更新日期:2010-02-01 00:00:00

  • Practice recommendations for neurovascular ultrasound investigations of acute stroke patients in the setting of the COVID-19 pandemic: an expert consensus from the European Society of Neurosonology and Cerebral Hemodynamics.

    abstract:BACKGROUND AND PURPOSE:Patients with acute ischemic stroke are at high-risk for contracting COVID-19 infection. Additionally, healthcare professionals including neurovascular ultrasound providers are also at risk of being infected by SARS-CoV-2 virus. Yet, preparedness to continue to guarantee hyperacute treatment is v...

    journal_title:European journal of neurology

    pub_type: 杂志文章,实务指引

    doi:10.1111/ene.14334

    authors: Baracchini C,Pieroni A,Kneihsl M,Azevedo E,Diomedi M,Pascazio L,Wojczal J,Lucas C,Bartels E,Bornstein NM,Csiba L,Valdueza J,Tsivgoulis G,Malojcic B

    更新日期:2020-09-01 00:00:00

  • Dysautonomia in prodromal α-synucleinopathy: peripheral versus central autonomic degeneration.

    abstract:BACKGROUND AND PURPOSE:There is an urgent need for early predictive markers for the course of disease in prodromal α-synucleinopathies such as idiopathic rapid eye movement (REM) sleep behaviour disorder. Autonomic cardiac/vascular dysfunction is a prominent feature in advanced α-synucleinopathies, but its diagnostic v...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.12957

    authors: Dahms C,Guenther A,Schwab M,Schultze T,Nowack S,Hoyer D,Ehrhardt J,Witte OW,Mayer G,Rupprecht S

    更新日期:2016-05-01 00:00:00

  • MxA protein--an interferon beta biomarker in primary progressive multiple sclerosis patients.

    abstract:BACKGROUND AND PURPOSE:Interferon beta (IFNbeta) preparations have some effect on the progressive phase of multiple sclerosis (MS). This limited effect might be partially because of a certain number of IFNbeta non-responders. Myxovirus resistance protein A (MxA)--a marker of IFNbeta bioactivity--was correlated with the...

    journal_title:European journal of neurology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1468-1331.2008.02190.x

    authors: Millonig A,Dressel A,Bahner D,Bitsch A,Bogumil T,Elitok E,Kitze B,Tumani H,Weber F,Gneiss C,Deisenhammer F

    更新日期:2008-08-01 00:00:00

  • A case-control study of Guillain-Barré syndrome in Harbin, China.

    abstract::We evaluated the putative factors for the onset of Guillain-Barré syndrome (GBS) in Harbin, China by a case-control study based on the information from GBS patients identified from a population-based incidence survey, which is the first study of this kind in China. Sixty-nine GBS patients were identified during a 1-ye...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2006.01390.x

    authors: Cheng Q,Wang DS,Jiang GX,Han H,Zhang Y,Wang WZ,Fredrikson S

    更新日期:2006-09-01 00:00:00

  • Cardioembolic stroke secondary to non-bacterial endocarditis in Wegener disease.

    abstract::Wegener granulomatosis is a systemic vasculitis that mainly affects the upper and lower respiratory tract and the kidneys. The presence of an ischemic stroke in this disease is very rare. A 40-year-old man, smoker with cavitated lesions in both lungs, and inflammation in the nasal mucosa and vocal cords developed an i...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2007.01726.x

    authors: Jiménez Caballero PE,Segura Martín T

    更新日期:2007-06-01 00:00:00

  • The 'hot cross bun' sign in the patients with spinocerebellar ataxia.

    abstract:BACKGROUND AND PURPOSE:The 'hot cross bun' sign (HCBS), typically seen in the patients with multiple system atrophy, refers to a cruciform hyperintensity in the pons on T2-weighted MRI. Little is known about its pathological basis and prevalence in other degenerative cerebellar diseases and healthy population. We inves...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2008.02524.x

    authors: Lee YC,Liu CS,Wu HM,Wang PS,Chang MH,Soong BW

    更新日期:2009-04-01 00:00:00

  • Impaired neurovascular coupling in ischaemic stroke patients with large or small vessel disease.

    abstract:BACKGROUND AND PURPOSE:There is limited data of neurovascular coupling on stroke patients, especially on comparison of different etiologies. We aim to test the hypothesis that patients with small vessel disease (SVD) are impaired on neurovascular coupling rather than stroke patient with large intracranial artery stenos...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2010.03262.x

    authors: Lin WH,Hao Q,Rosengarten B,Leung WH,Wong KS

    更新日期:2011-05-01 00:00:00

  • Functional connectivity and topology in patients with restless legs syndrome: a case-control resting-state functional magnetic resonance imaging study.

    abstract:BACKGROUND AND PURPOSE:Functional connectivity studies revealed alterations within thalamic, salience, and default mode networks in restless legs syndrome patients. METHODS:Eighty-two patients with restless legs syndrome (untreated, n = 30; on dopaminergic medication, n = 42; on alpha-2-delta ligands as mono- or polyt...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.14577

    authors: Tuovinen N,Stefani A,Mitterling T,Heidbreder A,Frauscher B,Gizewski ER,Poewe W,Högl B,Scherfler C

    更新日期:2021-02-01 00:00:00

  • High anti-EBNA-1 IgG levels are associated with early-onset myasthenia gravis.

    abstract:BACKGROUND: Myasthenia gravis (MG) is an autoimmune disorder mediated by antibodies against the acethylcholine receptor (AchR) of the neuromuscular junction in the majority of patients. METHODS: Here, we examined IgG antibodies against the type 1 nuclear antigen of Epstein-Barr virus (EBNA-1) in the sera of 158 patien...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2011.03636.x

    authors: Csuka D,Banati M,Rozsa C,Füst G,Illes Z

    更新日期:2012-06-01 00:00:00

  • Association of HLA-DRB1*15 allele and CSF oligoclonal bands in a Spanish multiple sclerosis cohort.

    abstract:BACKGROUND AND OBJECTIVE:The HLA-DRB1*15 allele is consistently associated with multiple sclerosis (MS) susceptibility in most studied populations. This study investigated the association between HLA-DRB1 alleles and the presence of oligoclonal immunoglobulin G bands (OCB) in the cerebrospinal fluid (CSF) in a Spanish ...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2011.03379.x

    authors: Romero-Pinel L,Martínez-Yélamos S,Bau L,Matas E,Gubieras L,María Pujal J,Morandeira F,Bas J,Arbizu T

    更新日期:2011-10-01 00:00:00

  • Pyridostigmine bromide versus fludrocortisone in the treatment of orthostatic hypotension in Parkinson's disease - a randomized controlled trial.

    abstract:BACKGROUND AND PURPOSE:Evidence for effective treatment options for orthostatic hypotension (OH) in Parkinson's disease (PD) is scarce. Elevation of cholinergic tone with pyridostigmine bromide has been reported as a way to improve blood pressure (bp) regulation in neurogenic hypotension without causing supine hyperten...

    journal_title:European journal of neurology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/ene.13260

    authors: Schreglmann SR,Büchele F,Sommerauer M,Epprecht L,Kägi G,Hägele-Link S,Götze O,Zimmerli L,Waldvogel D,Baumann CR

    更新日期:2017-04-01 00:00:00