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Association of HLA-DRB1*15 allele and CSF oligoclonal bands in a Spanish multiple sclerosis cohort.

Abstract：

BACKGROUND AND OBJECTIVE:The HLA-DRB1*15 allele is consistently associated with multiple sclerosis (MS) susceptibility in most studied populations. This study investigated the association between HLA-DRB1 alleles and the presence of oligoclonal immunoglobulin G bands (OCB) in the cerebrospinal fluid (CSF) in a Spanish population with MS. METHODS:The HLA-DRB1 typing was performed in 268 patients with sporadic MS and the detection of OCB in CSF. HLA-DRB1 allelic frequencies were compared between OCB-positive and OCB-negative patients, and both groups were also compared with 1088 unrelated healthy controls. Moreover, we correlated the various HLA-DRB1 genotypes, considering all the combinations of both parental alleles found with the presence or absence of OCB. RESULTS:We found 206 OCB-positive and 62 OCB-negative patients. The HLA-DRB1*15 allele in OCB-positive patients had a higher frequency when compared with OCB-negative patients (39.3% in OCB-positive vs. 16.1% in OCB-negative, OR = 1.38 95% CI = 1.18-1.61, P < 0.001). The other alleles did not show differences. When we compared with controls, the HLA-DRB1*15 allele was associated with the disease only in the OCB-positive patients group. None of the 55 genotypes found showed any association with the presence or absence of OCB. CONCLUSIONS:HLA-DRB1*15 allele is associated with OCB-positive patients with MS when studying a Spanish MS population.

journal_name

Eur J Neurol

journal_title

European journal of neurology

authors

Romero-Pinel L,Martínez-Yélamos S,Bau L,Matas E,Gubieras L,María Pujal J,Morandeira F,Bas J,Arbizu T

doi

10.1111/j.1468-1331.2011.03379.x

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

1258-62

issue

10

eissn

1351-5101

issn

1468-1331

journal_volume

18

pub_type

杂志文章

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