Abstract:
BACKGROUND AND PURPOSE:Subjective cognitive decline (SCD) is a self-experienced decline in cognitive capacity with normal performance on standardized cognitive tests and has been shown to increase the risk of Alzheimer's disease (AD). SCD could also be related to other conditions such as normal aging, psychiatric, neurological or medical disorders. The SCD Initiative proposed a set of features (SCD-plus) that increase the likelihood of preclinical AD in individuals with SCD. Our aim was to assess the effect of these features on the risk of conversion from SCD to AD. METHODS:In total 150 SCD subjects who underwent extensive neuropsychological investigation, assessment of cognitive complaints and apolipoprotein E (ApoE) genotyping at baseline and clinical-neuropsychological follow-up for a mean time of 11 years were included. RESULTS:During the follow-up, 20 subjects developed AD. Considering SCD-plus features, age at onset ≥60 years and ApoE ε4 significantly increased the risk of conversion from SCD to AD. When our sample was stratified into three groups (no risk factor, one risk factor, two risk factors), the proportion of conversion was statistically significantly different between the three groups. CONCLUSIONS:Our model allows the risk of AD to be stratified in patients experiencing SCD according to age at onset and ApoE genotype.
journal_name
Eur J Neuroljournal_title
European journal of neurologyauthors
Mazzeo S,Padiglioni S,Bagnoli S,Carraro M,Piaceri I,Bracco L,Nacmias B,Sorbi S,Bessi Vdoi
10.1111/ene.14167subject
Has Abstractpub_date
2020-05-01 00:00:00pages
894-899issue
5eissn
1351-5101issn
1468-1331journal_volume
27pub_type
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