Frequencies of falls and associated features at different stages of Parkinson's disease.

abstract：BACKGROUND AND PURPOSE:Quantification of intraepidermal nerve fibers (IENFs) in skin biopsies is now the tool of choice to diagnose small fiber neuropathies. An adequate normative dataset, necessary to assess normality cutoffs, is available for brightfield microscopy but not for immunofluorescence. METHODS:Intraepider...

journal_title：European journal of neurology

authors： Provitera V,Gibbons CH,Wendelschafer-Crabb G,Donadio V,Vitale DF,Stancanelli A,Caporaso G,Liguori R,Wang N,Santoro L,Kennedy WR,Nolano M

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Detection of occult atrial fibrillation (AF) is crucial for optimal secondary prevention in stroke patients. The AF detection rate was determined by implantable cardiac monitor (ICM) and compared to the prediction rate of the probability of incident AF by software based analysis of a continuously...

journal_title：European journal of neurology

authors： Reinke F,Bettin M,Ross LS,Kochhäuser S,Kleffner I,Ritter M,Minnerup J,Dechering D,Eckardt L,Dittrich R

更新日期：2018-04-01 00:00:00

abstract：:There are at least seven clinically indistinguishable but genetically different types of autosomal dominant pure spastic paraplegia (ADPSP). In this study we investigated electrophysiological characteristics in patients with ADPSP linked to chromosome 2p (SPG4). Twelve patients from six different families with ADPSP l...

journal_title：European journal of neurology

authors： Nielsen JE,Jennum P,Fenger K,Sørensen SA,Fuglsang-Frederiksen A

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Anticipatory postural adjustments (APAs), prior to step initiation, are bradykinetic in advanced Parkinson's disease (PD) and may be one of the factors associated with 'start hesitation'. However, little is known about APAs in the early stage of PD. In this study, we determined whether body-worn ...

journal_title：European journal of neurology

authors： Mancini M,Zampieri C,Carlson-Kuhta P,Chiari L,Horak FB

更新日期：2009-09-01 00:00:00

abstract：:The activities of the metalloproteinase gelatinase B, and the presence of IL-6, an inducer of metalloproteinase inhibitors, were investigated in CSF samples of 190 patients with multiple sclerosis (MS; n = 55), optic neuritis (ON; n = 46), other inflammatory neurological diseases (OIND; n = 27) or control patients (CO...

journal_title：European journal of neurology

authors： Paemen L,Olsson T,Söderström M,van Damme J,Opdenakker G

更新日期：1994-09-01 00:00:00

abstract：INTRODUCTION:Limited information is available about the impact of seizures on stroke outcome, health care delivery and resource utilization. OBJECTIVE:To determine whether the presence of seizures after stroke increases disability, mortality and health care utilization (length of hospital stay, ICU admission, consults...

journal_title：European journal of neurology

authors： Burneo JG,Fang J,Saposnik G,Investigators of the Registry of the Canadian Stroke Network.

更新日期：2010-01-01 00:00:00

abstract：BACKGROUNDAND PURPOSE:The purpose was to estimate the risk of epilepsy in a cohort of young individuals with celiac disease (CD) compared to that of matched references. METHODS:The cohort consisted of 213 635 individuals born during 1989-2011 and residing in Friuli-Venezia Giulia (Italy). 1215 individuals affected by ...

journal_title：European journal of neurology

authors： Canova C,Ludvigsson J,Barbiellini Amidei C,Zanier L,Zingone F

更新日期：2020-06-01 00:00:00

abstract：:The majority of patients with multiple sclerosis (MS) experience gradual progression of disability, either as secondary progressive MS (SPMS) or primary progressive MS (PPMS). A subgroup with relapsing-remitting MS shows a benign course with little or no disease progression and minimal disability decades after the fir...

journal_title：European journal of neurology

authors： Ramsaransing GS,Heersema DJ,De Keyser J

更新日期：2005-07-01 00:00:00

abstract：:Four hundred and sixty records of patients with primary torsion dystonia (296 women and 164 men) were evaluated. The mean age at disease onset was 48.3 +/- 17.7 years; 13 patients carried the DYT1 CAG deletion. The distribution of age at onset was represented by a bi-modal curve, with a nadir at 21 year separating ear...

journal_title：European journal of neurology

authors： Elia AE,Filippini G,Bentivoglio AR,Fasano A,Ialongo T,Albanese A

更新日期：2006-10-01 00:00:00

abstract：:In recent years, a number of potential new therapeutic indications of botulinum toxin injections have emerged, amongst which sialorrhea has attracted considerable attention. Based on open-label and controlled studies, botulinum toxin can be used to improve sialorrhea in patients with Parkinson's disease, parkinsonian ...

journal_title：European journal of neurology

authors： Tan EK

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Action tremor may occur in patients with Parkinson's disease and cause misdiagnosis with other movement disorders such as essential tremor and dystonia. Data on the frequency of action tremor in Parkinson's disease and on the relationships with other motor and non-motor signs are limited. METHOD...

journal_title：European journal of neurology

authors： Gigante AF,Bruno G,Iliceto G,Guido M,Liuzzi D,Mancino PV,De Caro MF,Livrea P,Defazio G

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Randomized trials and meta-analyses indicate positive effects of stroke unit (SU) care on survival and dependency of patients with stroke. However, data on the advantages of SU in 'real-world' settings are limited. We prospectively assessed, in a large University Hospital, the effect of SU versus other conve...

journal_title：European journal of neurology

authors： Di Carlo A,Lamassa M,Wellwood I,Bovis F,Baldereschi M,Nencini P,Poggesi A,Cramaro A,Pescini F,Lucente G,Wolfe CD,Inzitari D,European Registers of Stroke (EROS) Project.

更新日期：2011-05-01 00:00:00

abstract：:Digital subtraction angiography (DSA) is considered to be the 'gold standard' for confirmation of severe (70-99%) stenoses of internal carotid arteries (ICAs). However, it is associated with a risk of complications. The aim of this study was to assess the accuracy of ultrasonography (US), computed tomographic angiogra...

journal_title：European journal of neurology

authors： Herzig R,Burval S,Krupka B,Vlachová I,Urbánek K,Mares J

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Several studies have reported associations between brain iron deposits (IDs), white matter hyperintensities (WMHs) and cognitive ability in older individuals. Whether the association between brain IDs and cognitive abilities in older people is mediated by or independent of total brain tissue dama...

journal_title：European journal of neurology

authors： Valdés Hernández M,Allerhand M,Glatz A,Clayson L,Muñoz Maniega S,Gow A,Royle N,Bastin M,Starr J,Deary I,Wardlaw J

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is a distinct epileptic syndrome with a broad range of severity even amongst affected members of the same pedigree, and the level of pharmacoresistance may reach 30%, close to that seen in sporadic focal epilepsies. METHODS:To investiga...

journal_title：European journal of neurology

authors： Labate A,Mumoli L,Fratto A,Quattrone A,Gambardella A

更新日期：2013-03-01 00:00:00

abstract：:Our aim was to conduct a meta-analysis of longitudinal studies assessing the association between Pittsburgh compound B (PiB) retention and the progression of cognitive status in healthy elderly, in patients with mild cognitive impairment (MCI) and in patients with Alzheimer's disease (AD). PubMed, MEDLINE, Embase and ...

journal_title：European journal of neurology

authors： Chen X,Li M,Wang S,Zhu H,Xiong Y,Liu X

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Despite advances in the understanding of Huntington's disease (HD), treatment remains symptomatic. Multidisciplinary rehabilitation, however, appears to impact disease progression. Here we show the feasibility, safety and efficacy of a 9-month multidisciplinary rehabilitation programme in a small...

journal_title：European journal of neurology

authors： Thompson JA,Cruickshank TM,Penailillo LE,Lee JW,Newton RU,Barker RA,Ziman MR

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:It is well established that patient-related constitutional features predispose to focal peripheral neuropathies. Some of these risk factors were investigated in common focal neuropathies encountered in patients referred for electromyography. METHODS:Gender, age, height and body mass index (BMI) ...

journal_title：European journal of neurology

authors： Martínez-Aparicio C,Jääskeläinen SK,Puksa L,Reche-Lorite F,Torné-Poyatos P,Paniagua Soto J,Falck B

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There is a high incidence of sleep-disordered breathing (SDB) in narcoleptic patients. Some narcoleptics with SDB may benefit from treatment with continuous positive airway pressure therapy (CPAP). The aim of this study was to examine the prevalence of SDB in narcoleptics referred to a tertiary s...

journal_title：European journal of neurology

authors： Pataka AD,Frangulyan RR,Mackay TW,Douglas NJ,Riha RL

更新日期：2012-05-01 00:00:00

abstract：:Multiple sclerosis (MS) is a T-cell-mediated autoimmune demyelinating disease of the central nervous system, associated with an altered cytokine network. We previously assayed peripheral blood T-lymphocyte binding for two prototypic cytokines, tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), and foun...

journal_title：European journal of neurology

authors： Bongioanni P,Lombardo F,Moscato G,Mosti S,Meucci G

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Several metabolic derangements associated with diabetes mellitus type 2 (DM) have been associated with a better outcome in amyotrophic lateral sclerosis (ALS), including hyperlipidemia and obesity. Here, we tested the hypothesis that DM would have a positive effect on the motor and cognitive findings of ALS....

journal_title：European journal of neurology

authors： Jawaid A,Salamone AR,Strutt AM,Murthy SB,Wheaton M,McDowell EJ,Simpson E,Appel SH,York MK,Schulz PE

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The prognostic value of serum neurofilament light chain (sNfL), a biomarker of neurodegeneration, compared to other prognostic factors of amyotrophic lateral sclerosis (ALS) at the time of diagnosis, remains unclear. METHODS:Sera from ALS patients were prospectively collected at the first diagno...

journal_title：European journal of neurology

authors： Thouvenot E,Demattei C,Lehmann S,Maceski-Maleska A,Hirtz C,Juntas-Morales R,Pageot N,Esselin F,Alphandéry S,Vincent T,Camu W

更新日期：2020-02-01 00:00:00

abstract：:In this report, we present the clinical and pathological details of a kindred of four individuals with a novel missense mutation (V272A) of the presenilin 1 gene (PSEN1) that experienced a subcortical dementia. The age of onset of symptoms ranged 26-36-year old, with an age at death of 36-46 years. Initial symptom was...

journal_title：European journal of neurology

authors： Jimenez-Escrig A,Rabano A,Guerrero C,Simon J,Barquero MS,Güell I,Ginestal RC,Montero T,Orensanz L

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The detection rate of diffusion-weighted (DWI) hyperintense lesions varies widely in patients with transient global amnesia (TGA). The aim was to examine the association of hyperintense lesions on DWI magnetic resonance imaging (MRI) with patient characteristics, precipitating factors, clinical p...

journal_title：European journal of neurology

authors： Higashida K,Okazaki S,Todo K,Sasaki T,Ohara N,Kohara N,Yamamoto S,Yamagami H,Hashikawa K,Yoshimoto T,Ihara M,Koga M,Szabo K,Mochizuki H

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Melkersson-Rosenthal syndrome (MRS) is a rare neuro-mucocutaneous disease. In addition to the traditional clinical triad, there is also a diversity of clinical signs, and it may be related to other systemic diseases. METHODS:In the present study, we report a case of MRS with endocrine disorders ...

journal_title：European journal of neurology

authors： Wang S,Wang H,Shi X,Wu F,Lv L,Hu M,Sun W,Wu L,Zhou H

更新日期：2020-12-03 00:00:00

abstract：BACKGROUND AND PURPOSE:Functional connectivity studies revealed alterations within thalamic, salience, and default mode networks in restless legs syndrome patients. METHODS:Eighty-two patients with restless legs syndrome (untreated, n = 30; on dopaminergic medication, n = 42; on alpha-2-delta ligands as mono- or polyt...

journal_title：European journal of neurology

authors： Tuovinen N,Stefani A,Mitterling T,Heidbreder A,Frauscher B,Gizewski ER,Poewe W,Högl B,Scherfler C

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The etiological classification of patients with transient ischaemic attack (TIA) is a difficult endeavor and the use of serum biomarkers could improve the diagnostic accuracy. The aim of this study was to correlate atrial fibrillation, the main cardioembolic etiology (CE), with different serum bi...

journal_title：European journal of neurology

authors： Purroy F,Suárez-Luis I,Mauri-Capdevila G,Cambray S,Farré J,Sanahuja J,Piñol-Ripoll G,Quílez A,González-Mingot C,Begué R,Gil MI,Fernández E,Benabdelhak I

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In amyotrophic lateral sclerosis, studies using threshold-tracking transcranial magnetic stimulation (TMS) have identified corticomotoneuronal dysfunction as a key pathogenic mechanism. Some patients, however, display no motor response at maximal TMS intensities, termed here an 'inexcitable' moto...

journal_title：European journal of neurology

authors： Dharmadasa T,Howells J,Matamala JM,Simon NG,Burke D,Vucic S,Kiernan MC

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The multiple sclerosis prodrome remains poorly understood. We aimed to examine the prodrome in people with relapsing remitting multiple sclerosis at onset (RMS) and primary progressive multiple sclerosis (PPMS). METHODS:We conducted a matched cohort study using clinical and linked health adminis...

journal_title：European journal of neurology

authors： Wijnands JMA,Zhu F,Kingwell E,Zhao Y,Evans C,Fisk JD,Marrie RA,Tremlett H

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Intracerebral hemorrhage (ICH) is a devastating cerebrovascular disorder with high morbidity and mortality. Minocycline is a matrix metalloproteinase-9 (MMP-9) inhibitor that may attenuate secondary mechanisms of injury in ICH. The feasibility and safety of minocycline in ICH patients were evalua...

journal_title：European journal of neurology

authors： Chang JJ,Kim-Tenser M,Emanuel BA,Jones GM,Chapple K,Alikhani A,Sanossian N,Mack WJ,Tsivgoulis G,Alexandrov AV,Pourmotabbed T

更新日期：2017-11-01 00:00:00