New V272A presenilin 1 mutation with very early onset subcortical dementia and parkinsonism.

abstract：BACKGROUND AND PURPOSE:In 2005, we presented for the first time overall estimates of annual costs for brain disorders (mental and neurologic disorders) in Europe. This new report presents updated, more accurate, and comprehensive 2010 estimates for 30 European countries. METHODS:One-year prevalence and annual cost per...

journal_title：European journal of neurology

authors： Olesen J,Gustavsson A,Svensson M,Wittchen HU,Jönsson B,CDBE2010 study group.,European Brain Council.

更新日期：2012-01-01 00:00:00

abstract：:Charcot-Marie-Tooth disease (CMT) has been classified into two types: demyelinating forms (CMT1) and axonal forms (CMT2). Mutations in the CMT2A locus have been linked to the KIF1B and the mitofusin 2 (MFN2) genes. Here, we report a German patient with CMT2 with an underlying spontaneous mutation (c.281G-->A) in the M...

journal_title：European journal of neurology

authors： Neusch C,Senderek J,Eggermann T,Elolff E,Bähr M,Schneider-Gold C

更新日期：2007-05-01 00:00:00

abstract：:Myelitis is one of the most severe central nervous system complications seen in association with Mycoplasma pneumoniae infections and both acute transverse myelitis (ATM) as well as acute disseminated encephalomyelitis (ADEM) have been observed. We reviewed all available literature on cases of Mycoplasma spp. associat...

journal_title：European journal of neurology

authors： Tsiodras S,Kelesidis T,Kelesidis I,Voumbourakis K,Giamarellou H

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The clinical predictors of health-related quality of life (HRQoL) in multiple sclerosis (MS) have mainly been studied in patients with long-standing disease. The objective of this study was to investigate the longitudinal association among HRQoL and clinical characteristics in early MS. METHODS:...

journal_title：European journal of neurology

authors： Nourbakhsh B,Julian L,Waubant E

更新日期：2016-09-01 00:00:00

abstract：:The Oslo Multiple Sclerosis (MS) Registry was established in 1990, and this is the first report on the prevalence and incidence of MS in the city of Oslo, Norway. The prevalence rate of definite MS on 1 January 1995 was 120.4/10(5). Inclusion of patients of native Norwegian ancestry only and exclusion of non-Norwegian...

journal_title：European journal of neurology

authors： Celius EG,Vandvik B

更新日期：2001-09-01 00:00:00

abstract：:The present review of epidemiologic studies on migraine and headache in Europe is part of a larger initiative by the European Brain Council to estimate the costs incurred because of brain disorders. Summarizing the data on 1-year prevalence, the proportion of adults in Europe reporting headache was 51%, migraine 14%, ...

journal_title：European journal of neurology

authors： Stovner LJ,Zwart JA,Hagen K,Terwindt GM,Pascual J

更新日期：2006-04-01 00:00:00

abstract：:To determine the clinical features, prognostic factors, and therapeutic results of Guillain-Barré syndrome (GBS) in order to improve the therapeutic strategy for this disease. We retrospectively reviewed the electrodiagnostic study and medical records of patients with GBS admitted to Chang Gung Memorial Hospital, Kaoh...

journal_title：European journal of neurology

authors： Cheng BC,Chang WN,Chang CS,Chee CY,Huang CR,Chen JB,Chang CJ,Hung PL,Wang KW,Chang HW,Lu CH

更新日期：2003-11-01 00:00:00

abstract：:The aim of this narrative review is to evaluate the pathogenesis, clinical features, diagnosis, treatment and prognosis of intracranial artery dissection (IAD). IAD is a rare and often unrecognized cause of stroke or subarachnoid haemorrhage (SAH), especially in young adults. Two types of IAD can be identified: a subi...

journal_title：European journal of neurology

authors： Sikkema T,Uyttenboogaart M,Eshghi O,De Keyser J,Brouns R,van Dijk JM,Luijckx GJ

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:  A low ankle-brachial index (ABI) is predictive of peripheral arterial disease (PAD). For unknown reasons, patients with PAD demonstrate higher vascular mortality during follow-up than do those without. Initial stroke severity is a strong predictor of long-term outcome and may be different between patients ...

journal_title：European journal of neurology

authors： Lee DH,Kim J,Lee HS,Cha MJ,Kim YD,Nam HS,Nam CM,Heo JH

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Although Wernicke encephalopathy (WE) is a preventable and treatable disease it still often remains undiagnosed during life. OBJECTIVES:To create practical guidelines for diagnosis, management and prevention of the disease. METHODS:We searched MEDLINE, EMBASE, LILACS, Cochrane Library. CONCLUSIONS AND REC...

journal_title：European journal of neurology

authors： Galvin R,Bråthen G,Ivashynka A,Hillbom M,Tanasescu R,Leone MA,EFNS.

更新日期：2010-12-01 00:00:00

abstract：:The diagnosis of mitochondrial encephalomyopathies is complex and a system for classification of the diagnosis as definite, probable, and possible has been proposed. The objective of this study was to explore the spectrum of epileptic disorders associated with probable and definite mitochondrial disease in children us...

journal_title：European journal of neurology

authors： Sadleir LG,Connolly MB,Applegarth D,Hendson G,Clarke L,Rakshi C,Farrell K

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:An immune activation response resembling virus or type I interferon responses has been observed in untreated multiple sclerosis (MS), but its pathogenic significance is uncertain. We studied the relationship between a type I interferon-like response in untreated patients with MS and disease activity. METHODS...

journal_title：European journal of neurology

authors： Hesse D,Krakauer M,Lund H,Søndergaard HB,Limborg SJ,Sørensen PS,Sellebjerg F

更新日期：2011-02-01 00:00:00

abstract：:Four hundred and sixty records of patients with primary torsion dystonia (296 women and 164 men) were evaluated. The mean age at disease onset was 48.3 +/- 17.7 years; 13 patients carried the DYT1 CAG deletion. The distribution of age at onset was represented by a bi-modal curve, with a nadir at 21 year separating ear...

journal_title：European journal of neurology

authors： Elia AE,Filippini G,Bentivoglio AR,Fasano A,Ialongo T,Albanese A

更新日期：2006-10-01 00:00:00

abstract：:In recent years, evidence has emerged for a bidirectional relationship between sleep and neurological and psychiatric disorders. First, sleep-wake disorders (SWDs) are very common and may be the first/main manifestation of underlying neurological and psychiatric disorders. Secondly, SWDs may represent an independent r...

journal_title：European journal of neurology

authors： Bassetti CL,Ferini-Strambi L,Brown S,Adamantidis A,Benedetti F,Bruni O,Cajochen C,Dolenc-Groselj L,Ferri R,Gais S,Huber R,Khatami R,Lammers GJ,Luppi PH,Manconi M,Nissen C,Nobili L,Peigneux P,Pollmächer T,Randerath W

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Efficacy and safety data have not previously been compiled for intramuscular interferon beta-1a (IM IFNβ-1a) in patients with multiple sclerosis (MS) ≥ 50 years of age. We investigated the efficacy and safety of IM IFNβ-1a in patients segregated by 50 and 40 years of age in separate meta-analyses. METHODS:T...

journal_title：European journal of neurology

authors： Lampl C,You X,Limmroth V

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Migraine with aura (MA) has been found to be a risk factor for cardiovascular disease including ischaemic stroke and myocardial infarction. Studies have also reported a higher prevalence of unfavourable cardiovascular risk factors amongst migraineurs, but results have been conflicting as to whether this is r...

journal_title：European journal of neurology

authors： Winsvold BS,Hagen K,Aamodt AH,Stovner LJ,Holmen J,Zwart JA

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:CACNA1A encodes the α1 subunit of the neuronal calcium channel P/Q. CACNA1A mutations underlie three allelic disorders: familial hemiplegic migraine type 1 (FHM1), episodic ataxia type 2 (EA2) and spinocerebellar ataxia type 6 (SCA6). A clear-cut genotype-phenotype correlation is often lacking si...

journal_title：European journal of neurology

authors： Indelicato E,Nachbauer W,Karner E,Eigentler A,Wagner M,Unterberger I,Poewe W,Delazer M,Boesch S

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Lower urinary tract symptoms (LUTS) including frequent urination, nocturia and urge urinary incontinence negatively impact quality of life. This project aimed at characterizing the prevalence and severity of urinary incontinence in multiple sclerosis (MS) patients and its association with demogra...

journal_title：European journal of neurology

authors： Zecca C,Riccitelli GC,Disanto G,Singh A,Digesu GA,Panicari L,Puccini F,Mattioli M,Tubaro A,Gobbi C

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Elevated total homocysteine (tHcy) levels may be caused by vitamin B12 deficiency and are linked to Alzheimers disease (AD) in some studies, although the evidence is mixed. Another marker of vitamin B12 deficiency, holo-transcobalamin (holo-TC), has not been studied in a prospective setting. OBJECTIVE:To in...

journal_title：European journal of neurology

authors： Kivipelto M,Annerbo S,Hultdin J,Bäckman L,Viitanen M,Fratiglioni L,Lökk J

更新日期：2009-07-01 00:00:00

abstract：:Eur J Neurol 6:113 Copyright Lippincott Williams & Wilkins ...

journal_title：European journal of neurology

authors： Boller F,Petrov AM

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Risk-stratification models based on patient and disease characteristics are useful for aiding clinical decisions and for comparing the quality of care between different physicians or hospitals. In addition, prediction of mortality is beneficial for optimizing resource utilization. We evaluated th...

journal_title：European journal of neurology

authors： Peng SY,Chuang YC,Kang TW,Tseng KH

更新日期：2010-07-01 00:00:00

abstract：:Intracranial internal carotid artery (ICA) aneurysms are frequently treated either by microsurgical clipping of the aneurysm neck, by endovascular coiling of the aneurysm sac or by balloon occlusion of the parent vessel. For some broad-based aneurysms that may not be suitable for any of these options, microsurgical wr...

journal_title：European journal of neurology

authors： Berger C,Hartmann M,Wildemann B

更新日期：2003-03-01 00:00:00

abstract：:The Mini-Mental State Examination (MMSE), a brief test to assess cognitive status, is heavily influenced by age and education. It was administered to 1019 elderly subjects (aged 65-89 years) living in three different Italian cities. A statistical non-linear regression model was built up in order to obtain adjustment c...

journal_title：European journal of neurology

authors： Magni E,Binetti G,Bianchetti A,Rozzini R,Trabucchi M

更新日期：1996-05-01 00:00:00

abstract：:Wegener granulomatosis is a systemic vasculitis that mainly affects the upper and lower respiratory tract and the kidneys. The presence of an ischemic stroke in this disease is very rare. A 40-year-old man, smoker with cavitated lesions in both lungs, and inflammation in the nasal mucosa and vocal cords developed an i...

journal_title：European journal of neurology

authors： Jiménez Caballero PE,Segura Martín T

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Screening batteries to narrow down a target-at-risk population are essential for trials testing neuroprotective compounds aiming to delay or prevent onset of Parkinson's disease (PD). METHODS:The PRIPS study focuses on early detection of incident PD in 1847 at baseline PD-free subjects, and asse...

journal_title：European journal of neurology

authors： Berg D,Godau J,Seppi K,Behnke S,Liepelt-Scarfone I,Lerche S,Stockner H,Gaenslen A,Mahlknecht P,Huber H,Srulijes K,Klenk J,Fassbender K,Maetzler W,Poewe W,PRIPS study group.

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Friedreich's ataxia (FRDA) is the most common autosomal-recessive ataxia worldwide. It is characterized by early onset, sensory abnormalities and slowly progressive ataxia. All magnetic resonance imaging (MRI)-based studies have focused on the evaluation of adult patients. Therefore, we designed ...

journal_title：European journal of neurology

authors： Rezende TJR,Martinez ARM,Faber I,Girotto Takazaki KA,Martins MP,de Lima FD,Lopes-Cendes I,Cendes F,França MC Jr

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The incidence of hospitalizations, treatment and case fatality of ischaemic stroke were assessed utilizing a comprehensive multinational database to attempt to compare the healthcare systems in six European countries, aiming also to identify the limitations and make suggestions for future improve...

journal_title：European journal of neurology

authors： Malmivaara A,Meretoja A,Peltola M,Numerato D,Heijink R,Engelfriet P,Wild SH,Belicza É,Bereczki D,Medin E,Goude F,Boncoraglio G,Tatlisumak T,Seppälä T,Häkkinen U

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Histamine N-methyltransferase (HNMT) is the main metabolizing enzyme of histamine (a mediator of inflammation implicated in the pathogenesis of multiple sclerosis-MS) in the CNS. We have investigated the possible association between a single nucleotide polymorphism of the HNMT (chromosome 2q22.1), that cause...

journal_title：European journal of neurology

authors： García-Martín E,Martínez C,Benito-León J,Calleja P,Díaz-Sánchez M,Pisa D,Alonso-Navarro H,Ayuso-Peralta L,Torrecilla D,Agúndez JA,Jiménez-Jiménez FJ

更新日期：2010-02-01 00:00:00

abstract：:Cytokines have a central role in multiple sclerosis (MS) pathogenesis and may contribute to the aetiology of MS. A polymorphism in the IFNA17 gene with an allele carrying a pre-mature stop codon has been suggested to convey a 26-fold increased risk for MS. We investigated the possible association between this polymorp...

journal_title：European journal of neurology

authors： Nyström M,Ruuth K,Lundgren E,Sundström P

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Prevalence rates of headache in multiple sclerosis (MS) patients varied widely in recent studies. This study aimed to investigate the 1 year prevalence of headache in MS compared with the general population. METHODS:Population-based case-control study in Germany. RESULTS:We included 491 patients with defin...

journal_title：European journal of neurology

authors： Putzki N,Pfriem A,Limmroth V,Yaldizli O,Tettenborn B,Diener HC,Katsarava Z

更新日期：2009-02-01 00:00:00