Mitofusin 2 gene mutation (R94Q) causing severe early-onset axonal polyneuropathy (CMT2A).

abstract：:Recently, diagnostic clinical and imaging criteria for primary progressive aphasia (PPA) have been revised by an international consortium (Gorno-Tempini et al. Neurology 2011;76:1006-14). The aim of this study was to validate the specificity of the new imaging criteria and investigate whether different imaging modalit...

journal_title：European journal of neurology

authors： Bisenius S,Neumann J,Schroeter ML

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Superficial siderosis of the central nervous system is a sporadic finding in magnetic resonance imaging, resulting from recurrent bleedings into the subarachnoid space. This study aimed to determine the frequency of spinal dural cerebrospinal fluid (CSF) leaks amongst patients with a symmetric in...

journal_title：European journal of neurology

authors： Friedauer L,Rezny-Kasprzak B,Steinmetz H,du Mesnil de Rochemont R,Foerch C

更新日期：2020-10-24 00:00:00

abstract：BACKGROUND:Motor symptoms form the hallmark of Parkinson's Disease (PD), although features like depression are often present. Depression rating scales [e.g. Montgomery-Asberg Depression Rating Scale (MADRS)] used in PD measure affective, cognitive and somatic symptoms. An important clinical question is which items of t...

journal_title：European journal of neurology

authors： Koerts J,Leenders KL,Koning M,Bouma A,van Beilen M

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Rapid eye movement sleep behaviour disorder (RBD) is related to striatal dopamine depletion. This study was performed to confirm whether clinically probable RBD (cpRBD) in patients with Parkinson's disease (PD) is associated with a specific pattern of striatal dopamine depletion. METHODS:A prosp...

journal_title：European journal of neurology

authors： Chung SJ,Lee Y,Lee JJ,Lee PH,Sohn YH

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Depigmentation of the substantia nigra (SN) and locus coeruleus (LC) is a conspicuous pathological feature of Parkinson's disease (PD) and is related to the loss of neuromelanin, whose paramagnetic properties result in high signal on specific T1-weighted magnetic resonance imaging (MRI). Recent studies have ...

journal_title：European journal of neurology

authors： Reimão S,Pita Lobo P,Neutel D,Correia Guedes L,Coelho M,Rosa MM,Ferreira J,Abreu D,Gonçalves N,Morgado C,Nunes RG,Campos J,Ferreira JJ

更新日期：2015-03-01 00:00:00

abstract：:To establish the phenotypic variation and frequency of SPAST mutations or deletions in Norwegian patients with hereditary spastic paraplegia (HSP), we examined 59 unrelated patients with HSP and screened for DNA point mutations and microdeletions in SPG4. Forty-one had a familial history, 35 had a clear dominant inher...

journal_title：European journal of neurology

authors： Erichsen AK,Inderhaug E,Mattingsdal M,Eiklid K,Tallaksen CM

更新日期：2007-07-01 00:00:00

abstract：:Visual recognition memory was assessed in terms of delay duration, memory load and amount of interference(s) in non-demented patients with Parkinson's disease (PD) using an automated delayed non-matching-to-sample (DNMS) task with trial-unique stimuli. Special attention was focused on the different cognitive functions...

journal_title：European journal of neurology

authors： Blanchet S,Marié RM,Dauvillier F,Landeau B,Benali K,Eustache F,Chavoix C

更新日期：2000-09-01 00:00:00

abstract：:Cocaine abuse is a well known cause of cerebrovascular complications. An inflammatory vasculopathy hypothesis has been proposed, but the medical literature has only reported a few pathological confirmations. We report a case with a biopsy demonstrating cerebral inflammatory vascular changes that are associated with co...

journal_title：European journal of neurology

authors： Diez-Tejedor E,Frank A,Gutierrez M,Barreiro P

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Studies investigating the association between 25-hydroxyvitamin D [25(OH)D] and cognition in the very old (85+) are lacking. METHODS:Cross-sectional (baseline) and prospective data (up to 3 years follow-up) from 775 participants in the Newcastle 85+ Study were analysed for global (measured by th...

journal_title：European journal of neurology

authors： Granic A,Hill TR,Kirkwood TB,Davies K,Collerton J,Martin-Ruiz C,von Zglinicki T,Saxby BK,Wesnes KA,Collerton D,Mathers JC,Jagger C

更新日期：2015-01-01 00:00:00

abstract：:Cytokines have a central role in multiple sclerosis (MS) pathogenesis and may contribute to the aetiology of MS. A polymorphism in the IFNA17 gene with an allele carrying a pre-mature stop codon has been suggested to convey a 26-fold increased risk for MS. We investigated the possible association between this polymorp...

journal_title：European journal of neurology

authors： Nyström M,Ruuth K,Lundgren E,Sundström P

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Action tremor may occur in patients with Parkinson's disease and cause misdiagnosis with other movement disorders such as essential tremor and dystonia. Data on the frequency of action tremor in Parkinson's disease and on the relationships with other motor and non-motor signs are limited. METHOD...

journal_title：European journal of neurology

authors： Gigante AF,Bruno G,Iliceto G,Guido M,Liuzzi D,Mancino PV,De Caro MF,Livrea P,Defazio G

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:People with multiple sclerosis (MS) have to face important decisions with regard to their medical treatment. The aim of this study was to evaluate whether a targeted cognitive training reduces framing effects and thus improves medical judgments. METHODS:This was a randomized, double-blind, cross...

journal_title：European journal of neurology

authors： Zamarian L,Delazer M,Ehling R,Pertl MT,Bsteh G,Wenter J,Glatzl S,Brenneis C,Benke T,Berger T

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Randomized trials and meta-analyses indicate positive effects of stroke unit (SU) care on survival and dependency of patients with stroke. However, data on the advantages of SU in 'real-world' settings are limited. We prospectively assessed, in a large University Hospital, the effect of SU versus other conve...

journal_title：European journal of neurology

authors： Di Carlo A,Lamassa M,Wellwood I,Bovis F,Baldereschi M,Nencini P,Poggesi A,Cramaro A,Pescini F,Lucente G,Wolfe CD,Inzitari D,European Registers of Stroke (EROS) Project.

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Predicting the course of behavioural variant frontotemporal dementia (bvFTD) remains a major clinical challenge. This study aimed to identify factors that predict survival and clinical progression in bvFTD. METHODS:Consecutive patients with clinically probable bvFTD were prospectively followed u...

journal_title：European journal of neurology

authors： Agarwal S,Ahmed RM,D'Mello M,Foxe D,Kaizik C,Kiernan MC,Halliday GM,Piguet O,Hodges JR

更新日期：2019-05-01 00:00:00

abstract：AIM:To investigate the corticomotor projection to the upper limb in children with hemiplegic cerebral palsy (CP) and the changes that occur with botulinum toxin (BTX)-A. METHODS:The study design is a pilot prospective randomized trial. Twenty-two children with hemiplegic CP aged 7 years to 13 years 11 months were recr...

journal_title：European journal of neurology

authors： Redman TA,Gibson N,Finn JC,Bremner AP,Valentine J,Thickbroom GW

更新日期：2008-08-01 00:00:00

abstract：:Therapy-induced binding and neutralizing antibodies is a major problem in interferon (IFN)-beta treatment of multiple sclerosis. The objective of this study was to provide guidelines outlining the methods and clinical use of the measurements of binding and neutralizing antibodies. Systematic search of the Medline data...

journal_title：European journal of neurology

authors： Sørensen PS,Deisenhammer F,Duda P,Hohlfeld R,Myhr KM,Palace J,Polman C,Pozzilli C,Ross C,EFNS Task Force on Anti-IFN-beta Antibodies in Multiple Sclerosis.

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We previously reported that certain optical coherence tomography (OCT) measures were sensitive and reliable in identifying idiopathic intracranial hypertension (IIH). This prospective study aimed to define OCT measures that allow differentiation of IIH with and without papilledema, thereby helpin...

journal_title：European journal of neurology

authors： Huang-Link Y,Eleftheriou A,Yang G,Johansson JM,Apostolou A,Link H,Jin YP

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The purpose was to evaluate the association between the left ventricular ejection fraction (LVEF) and cerebral small vessel disease (cSVD) in ischaemic stroke patients. METHODS:Consecutive first-ever ischaemic stroke patients between 2010 and 2013 were included. White matter hyperintensity (WMH)...

journal_title：European journal of neurology

authors： Nam KW,Kwon HM,Kim HL,Lee YS

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Approximately 9000 people in the UK are affected by Huntington's disease (HD). People with HD require ongoing health and social care support. There is a knowledge gap about costs of health and social care use associated with HD in the UK. This paper estimates the economic cost in the UK. METHODS...

journal_title：European journal of neurology

authors： Jones C,Busse M,Quinn L,Dawes H,Drew C,Kelson M,Hood K,Rosser A,Edwards RT

更新日期：2016-10-01 00:00:00

abstract：:In this paper we report about the Danish Year of the Brain 1997 because it may serve as a model for other countries. It was possible in Denmark to organize a very large scale effort which has been well received by the general public and which has significantly improved the image of the neurological disciplines. The re...

journal_title：European journal of neurology

authors： Olesen J,Oberg G,Vestergaard P

更新日期：1998-11-01 00:00:00

abstract：:The muscle overactivity seen in spasticity results in limb stiffness and muscle spasm, to which there is both a neurogenic and a biomechanical component. Spasticity does not always cause harm and can assist in the rehabilitation process enabling a patient to stand when their limb weakness would not otherwise allow it....

journal_title：European journal of neurology

authors： Ward AB

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Non-Western immigrants to Norway acquire an increased risk of multiple sclerosis (MS) after migration. Ethnicity and the presence of oligoclonal bands (OCBs) in the cerebrospinal fluid (CSF) might influence the disease course. The aim of this study was to investigate differences in disease severi...

journal_title：European journal of neurology

authors： Berg-Hansen P,Smestad C,Sandvik L,Harbo HF,Celius EG

更新日期：2013-12-01 00:00:00

abstract：:Although visual hallucinations (VH) are relatively frequent in Parkinson's disease (PD) patients, their neural substrates are only known from neuropathological and functional magnetic resonance studies. The aim of this study was to investigate possible structural brain changes on MRI in non-demented PD patients with V...

journal_title：European journal of neurology

authors： Ramírez-Ruiz B,Martí MJ,Tolosa E,Giménez M,Bargalló N,Valldeoriola F,Junqué C

更新日期：2007-07-01 00:00:00

abstract：:Migraine is one of the most frequent disabling neurological conditions with a major impact on the patients' quality of life. To give evidence-based or expert recommendations for the different drug treatment procedures of the different migraine syndromes based on a literature search and an consensus in an expert panel....

journal_title：European journal of neurology

authors： Members of the task force:.,Evers S,Afra J,Frese A,Goadsby PJ,Linde M,May A,Sándor PS

更新日期：2006-06-01 00:00:00

abstract：:This study examined the relative anti-Parkinson's disease (PD) tremor potencies of pergolide and pramipexole in people with PD, using a 3-month double-blind cross-over design. Patients were randomly assigned to receive either pergolide and then pramipexole (n=9) or vice versa (n=8). The dose of the respective dopamine...

journal_title：European journal of neurology

authors： Navan P,Findley LJ,Undy MB,Pearce RK,Bain PG

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Intracerebral hemorrhage (ICH) is a common and severe form of stroke but is scarcely studied in young adults. Our aim was to study risk factors, clinical presentation and early mortality of ICH in the young and compare these features with older patients. METHODS:All consecutive patients aged bet...

journal_title：European journal of neurology

authors： Koivunen RJ,Satopää J,Meretoja A,Strbian D,Haapaniemi E,Niemelä M,Tatlisumak T,Putaala J

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Educating the public to screen for vascular risk factors and have them treated is a major public health issue. We assessed the vascular risk factor awareness and frequency of treatment in a cohort of patients with cerebral ischaemia. METHODS:Data on awareness and pharmacological treatment of vas...

journal_title：European journal of neurology

authors： Nolte CH,Jungehulsing GJ,Rossnagel K,Roll S,Haeusler KG,Reich A,Willich SN,Villringer A,Muller-Nordhorn J

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Essential tremor (ET) is the most common movement disorder worldwide. Three susceptibility loci on chromosomes 3q13, 2p24.1, and 6p23 have been reported, but no causative genes were found. The Ser9Gly variant of dopamine D3 receptor (DRD3) receptor was found associated to ET in a French and US population. M...

journal_title：European journal of neurology

authors： Vitale C,Gulli R,Ciotti P,Scaglione C,Bellone E,Avanzino L,Lantieri F,Abbruzzese G,Martinelli P,Barone P,Mandich P

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Epilepsy is a frequent complication of central nervous system (CNS) infections. Post-infectious epilepsy is commonly refractory to medical treatment and plays a pivotal role for the poor long-term outcome of CNS infections. OBJECTIVES:To provide an overview of clinical characteristics and risk f...

journal_title：European journal of neurology

authors： Sellner J,Trinka E

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:CACNA1A encodes the α1 subunit of the neuronal calcium channel P/Q. CACNA1A mutations underlie three allelic disorders: familial hemiplegic migraine type 1 (FHM1), episodic ataxia type 2 (EA2) and spinocerebellar ataxia type 6 (SCA6). A clear-cut genotype-phenotype correlation is often lacking si...

journal_title：European journal of neurology

authors： Indelicato E,Nachbauer W,Karner E,Eigentler A,Wagner M,Unterberger I,Poewe W,Delazer M,Boesch S

更新日期：2019-01-01 00:00:00