Abstract:
BACKGROUND AND PURPOSE:Intracerebral hemorrhage (ICH) is a common and severe form of stroke but is scarcely studied in young adults. Our aim was to study risk factors, clinical presentation and early mortality of ICH in the young and compare these features with older patients. METHODS:All consecutive patients aged between 16 and 49 diagnosed with a first-ever ICH at the Departments of Neurology or Neurosurgery of the Helsinki University Central Hospital between January 2000 and March 2010 (n = 336) were analyzed retrospectively. Comparisons were performed amongst demographic subgroups and with patients over 49 years of age enrolled between January 2005 and March 2010 (n = 921). RESULTS:In the young patients, median age was 42 years (interquartile range 34-47), 59.5% were male, and annual incidence was 4.9 (95% confidence interval 4.5-5.3) per 100 000. The most prevalent risk factors were hypertension (29.8%) and smoking (22.3%). Compared with older patients hypertensive microangiopathy was less common (25.0% vs. 34.3%, P = 0.002) and structural lesions more common (25.0% vs. 4.9%, P < 0.001) assumed etiologies of ICH. The cause remained elusive in 32.1% of all young patients and in 22.5% of those who underwent magnetic resonance imaging and any angiography (n = 89, P = 0.023). Three-month mortality rate was lower in young patients compared with older ones (17.0% vs. 32.7%, P < 0.001). Hematoma volumes were similar across all ages (P = 0.324) and independently predicted mortality in older patients but not in the young. CONCLUSIONS:Intracerebral hemorrhage (ICH) in the young appears less fatal and has a different spectrum of causes and factors associated with short-term mortality than for the elderly.
journal_name
Eur J Neuroljournal_title
European journal of neurologyauthors
Koivunen RJ,Satopää J,Meretoja A,Strbian D,Haapaniemi E,Niemelä M,Tatlisumak T,Putaala Jdoi
10.1111/ene.12543subject
Has Abstractpub_date
2015-01-01 00:00:00pages
123-32issue
1eissn
1351-5101issn
1468-1331journal_volume
22pub_type
杂志文章abstract::In approximately 40% of the patients, Parkinson's disease (PD) is complicated by cognitive impairment. The objective of this study was to evaluate the impact of cognitive impairment on disease severity and motor function in idiopathic PD patients. Forty-one PD patients with cognitive impairment (PD-CI) (Mini-Mental St...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2004.00826.x
更新日期:2004-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Hereditary sensory and autonomic neuropathies (HSANs) are a group of clinically and genetically heterogeneous neurological disorders characterized by sensory dysfunctions. Here, 21 affected Chinese families are reported, including 19 with congenital insensitivity to pain with anhidrosis (CIPA; na...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14234
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Migraine with aura (MA) has been found to be a risk factor for cardiovascular disease including ischaemic stroke and myocardial infarction. Studies have also reported a higher prevalence of unfavourable cardiovascular risk factors amongst migraineurs, but results have been conflicting as to whether this is r...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2010.03199.x
更新日期:2011-03-01 00:00:00
abstract::This study is aimed at assessing the prevalence and features of psychotic symptoms in a sample of 180 patients with Alzheimer's disease (AD). Sixty-four patients (35.5% of the sample) showed one or more psychotic symptoms. The presence of these symptoms correlated with the severity of the patients' cognitive impairmen...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.1998.560553.x
更新日期:1998-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Evidence for effective treatment options for orthostatic hypotension (OH) in Parkinson's disease (PD) is scarce. Elevation of cholinergic tone with pyridostigmine bromide has been reported as a way to improve blood pressure (bp) regulation in neurogenic hypotension without causing supine hyperten...
journal_title:European journal of neurology
pub_type: 杂志文章,随机对照试验
doi:10.1111/ene.13260
更新日期:2017-04-01 00:00:00
abstract::We performed a 2-year population-based study on status epilepticus (SE) in adults in the rural area of Lugo di Romagna, northern Italy, to verify whether an area of low-level urbanization has a lower risk of occurrence of SE (as recently suggested), different clinical features and short-term prognosis than areas of hi...
journal_title:European journal of neurology
pub_type: 信件
doi:10.1111/j.1468-1331.2005.01073.x
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:For Parkinson's disease (PD), an extended-release (ER) pramipexole formulation taken once daily, has shown efficacy, safety, and tolerability resembling those of immediate-release (IR) pramipexole taken three times daily. The present study assessed, in advanced PD, the success of an overnight swi...
journal_title:European journal of neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1468-1331.2012.03822.x
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Acute severe exacerbations of myasthenia gravis (MG) are common in both early and late onset MG. We wished to examine the current management in the intensive care unit (ICU) of severe exacerbations of MG and to study the long-term prognosis of MG following discharge from the ICU. METHODS:We retr...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12115
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Consensus guidelines on the definition, investigation, and treatment of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) have been previously published in European Journal of Neurology and Journal of the Peripheral Nervous System. OBJECTIVES:To revise these guidelines. METHODS:Disease exper...
journal_title:European journal of neurology
pub_type: 共识发展会议,杂志文章,实务指引
doi:10.1111/j.1468-1331.2009.02930.x
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND: Therapy for multiple sclerosis (MS) has a partial efficacy, and a significant proportion of treated patients will develop a suboptimal response with first-line disease-modifying drugs (DMD). Therapy switch in patients with MS can be a strategy after a treatment failure. We studied the change in clinical ac...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2011.03648.x
更新日期:2012-06-01 00:00:00
abstract::Wegener granulomatosis is a systemic vasculitis that mainly affects the upper and lower respiratory tract and the kidneys. The presence of an ischemic stroke in this disease is very rare. A 40-year-old man, smoker with cavitated lesions in both lungs, and inflammation in the nasal mucosa and vocal cords developed an i...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2007.01726.x
更新日期:2007-06-01 00:00:00
abstract::Botulinum A toxin (BT) has been successfully used for the management of spasticity in cerebral palsy (CP). However, the long-term results of BT have not yet been determined. We have studied the evolution of a homogeneous group of patients with CP treated with BT. All these patients had an equinus gait resulting from c...
journal_title:European journal of neurology
pub_type: 临床试验,杂志文章
doi:10.1046/j.1468-1331.2000.00043.x
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Headache has been associated with various lifestyle and psychosocial factors, one of which is smoking. The aim of the present study was to investigate whether the association between smoking intensity and headache is likely to be causal. METHOD:A total of 58 316 participants from the Nord-Trønde...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13675
更新日期:2018-09-01 00:00:00
abstract:AIM:To investigate the corticomotor projection to the upper limb in children with hemiplegic cerebral palsy (CP) and the changes that occur with botulinum toxin (BTX)-A. METHODS:The study design is a pilot prospective randomized trial. Twenty-two children with hemiplegic CP aged 7 years to 13 years 11 months were recr...
journal_title:European journal of neurology
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1468-1331.2008.02194.x
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Very-long-chain acyl-CoA dehydrogenase deficiency (VLCADD) is a hereditary disorder of mitochondrial long-chain fatty acid oxidation that has variable presentations, including exercise intolerance, cardiomyopathy and liver disease. The aim of this study was to describe the clinical and genetic ma...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14402
更新日期:2020-11-01 00:00:00
abstract::There is no report of patients in whom pathological laughter, a rare condition characterized by uncontrollable episodes of laughter usually triggered by unrelated stimuli, was ever closely associated with a loss of consciousness overtly linked with the onset of such uncontrollable laughter, also referred to as a gelas...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2007.01784.x
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Melkersson-Rosenthal syndrome (MRS) is a rare neuro-mucocutaneous disease. In addition to the traditional clinical triad, there is also a diversity of clinical signs, and it may be related to other systemic diseases. METHODS:In the present study, we report a case of MRS with endocrine disorders ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14615
更新日期:2020-12-03 00:00:00
abstract::We used 123I-Ioflupane SPECT to study striatal dopamine transporter (DAT) binding in 36 Parkinson's disease (PD) patients with history of severe occupational exposure to hydrocarbons. Data were compared with 38 PD patients without exposure history as well as healthy controls. Both PD cohorts showed significant striata...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2006.01642.x
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Despite advances in the understanding of Huntington's disease (HD), treatment remains symptomatic. Multidisciplinary rehabilitation, however, appears to impact disease progression. Here we show the feasibility, safety and efficacy of a 9-month multidisciplinary rehabilitation programme in a small...
journal_title:European journal of neurology
pub_type: 杂志文章,随机对照试验
doi:10.1111/ene.12053
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The association between past stroke subtypes and recurrent stroke subtypes in non-cardiogenic stroke remains unknown. METHODS:Patients with ischaemic stroke who had a past history of large-artery disease (LAD) or small-artery disease (SAD) subtypes were assessed. LAD was subdivided into intracra...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12101
更新日期:2013-06-01 00:00:00
abstract::Migraine is one of the most frequent disabling neurological conditions with a major impact on the patients' quality of life. To give evidence-based or expert recommendations for the different drug treatment procedures of the different migraine syndromes based on a literature search and an consensus in an expert panel....
journal_title:European journal of neurology
pub_type: 杂志文章,实务指引
doi:10.1111/j.1468-1331.2006.01411.x
更新日期:2006-06-01 00:00:00
abstract::A 53-year-old man presented with optic neuritis, followed within 10 weeks by a subacute progression of weakness, ataxia, and multiple cranial nerve palsies. Cranial magnetic resonance imaging demonstrated multiple T2-hyperintense lesions extending from the ponto-medullary junction to the thalamus and internal capsule....
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2003.00543.x
更新日期:2003-01-01 00:00:00
abstract::We here present the case of a patient with a sleep disturbance attributed to the exploding head syndrome, recently redefined as 'episodic cranial sensory shock'. The patient, who suffered with concomitant migraine, was treated for headache prevention with daily single-pulse transcranial magnetic stimulation. Following...
journal_title:European journal of neurology
pub_type:
doi:10.1111/ene.14747
更新日期:2021-01-18 00:00:00
abstract:BACKGROUND AND PURPOSE:Patients with chronic focal epilepsy may have atrophy of brain structures important for the generation and maintenance of seizures. However, little research has been conducted in patients with newly diagnosed focal epilepsy (NDfE), despite it being a crucial point in time for understanding the un...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14565
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There is large variability in the diagnostic approach and clinical management in functional movement disorders (FMD). This study aimed to examine whether opinions and clinical practices related to FMD have changed over the past decade. METHODS:Adapted from a 2008 version, we repeated the survey ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14200
更新日期:2020-06-01 00:00:00
abstract::Cocaine abuse is a well known cause of cerebrovascular complications. An inflammatory vasculopathy hypothesis has been proposed, but the medical literature has only reported a few pathological confirmations. We report a case with a biopsy demonstrating cerebral inflammatory vascular changes that are associated with co...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.1998.510103.x
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In patients with spinal muscular atrophy (SMA), functional disease scores are frequently used to evaluate the course of the disease and the efficacy of treatment. The aim of the present study was to propose minimal clinically important difference (MCID) values for motor scores in order to estimat...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14472
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The 'hot cross bun' sign (HCBS), typically seen in the patients with multiple system atrophy, refers to a cruciform hyperintensity in the pons on T2-weighted MRI. Little is known about its pathological basis and prevalence in other degenerative cerebellar diseases and healthy population. We inves...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2008.02524.x
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Clinical presentation and DYT1 status amongst Chinese patients with primary dystonia have not been well studied. METHODS:One hundred and twenty patients with primary dystonia from South-West China were studied in a prospective survey for 3.5 years. Severity and the resulting disability were assessed using t...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2009.02944.x
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Multiple sclerosis (MS) patients discontinuing natalizumab are at risk of rebound of disease activity. METHODS:In the present multi-center, open-label, non-randomized, prospective, pilot study, we tested whether treatment with glatiramer acetate (GA) is safe and effective after natalizumab in MS...
journal_title:European journal of neurology
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1468-1331.2012.03794.x
更新日期:2013-01-01 00:00:00