A registry-based, case-control investigation of Parkinson's disease with and without cognitive impairment.

abstract：:To evaluate prevalence of use and prescribing patterns of antiepileptic drugs (AEDs) in Italian general practice. Primary care data were obtained from the Health Search Database, a longitudinal observational database implemented by the Italian College of General Practitioners (GPs). We selected 465 061 subjects regist...

journal_title：European journal of neurology

authors： Savica R,Beghi E,Mazzaglia G,Innocenti F,Brignoli O,Cricelli C,Caputi AP,Musolino R,Spina E,Trifirò G

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Depressed mood is a common psychiatric problem associated with Parkinson's disease (PD), and studies have suggested a benefit of rasagiline treatment. METHODS:ACCORDO (see the ) was a 12-week, double-blind, placebo-controlled trial to evaluate the effects of rasagiline 1 mg/day on depressive sym...

journal_title：European journal of neurology

authors： Barone P,Santangelo G,Morgante L,Onofrj M,Meco G,Abbruzzese G,Bonuccelli U,Cossu G,Pezzoli G,Stanzione P,Lopiano L,Antonini A,Tinazzi M

更新日期：2015-08-01 00:00:00

abstract：:Digital subtraction angiography (DSA) is considered to be the 'gold standard' for confirmation of severe (70-99%) stenoses of internal carotid arteries (ICAs). However, it is associated with a risk of complications. The aim of this study was to assess the accuracy of ultrasonography (US), computed tomographic angiogra...

journal_title：European journal of neurology

authors： Herzig R,Burval S,Krupka B,Vlachová I,Urbánek K,Mares J

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Histamine N-methyltransferase (HNMT) is the main metabolizing enzyme of histamine (a mediator of inflammation implicated in the pathogenesis of multiple sclerosis-MS) in the CNS. We have investigated the possible association between a single nucleotide polymorphism of the HNMT (chromosome 2q22.1), that cause...

journal_title：European journal of neurology

authors： García-Martín E,Martínez C,Benito-León J,Calleja P,Díaz-Sánchez M,Pisa D,Alonso-Navarro H,Ayuso-Peralta L,Torrecilla D,Agúndez JA,Jiménez-Jiménez FJ

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Oxidative stress is a central factor in the pathogenesis of Parkinson's disease (PD). Heme oxygenase-1 (HO-1) is an antioxidant protein expressed in response to oxidative challenge, and its expression levels are inversely correlated with glycogen synthase kinase-3beta (GSK3beta) activity. Underexpression of ...

journal_title：European journal of neurology

authors： Infante J,García-Gorostiaga I,Sánchez-Juan P,Sierra M,Martín-Gurpegui JL,Terrazas J,Mateo I,Rodríguez-Rodríguez E,Berciano J,Combarros O

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The influence of metabolic syndrome (MetS) on cognitive and affective functions in patients with Alzheimer's disease (AD) was examined. METHODS:A total of 570 AD patients were divided into two subgroups depending on waist circumference (WC) (normal versus achieving Japanese diagnostic criteria o...

journal_title：European journal of neurology

authors： Hishikawa N,Fukui Y,Sato K,Kono S,Yamashita T,Ohta Y,Deguchi K,Abe K

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Impaired cortical inhibiton and maladaptive cortical plasticity are functional hallmarks of sporadic focal dystonias. Whether or not these mechanisms translate to generalized dystonias and whether these features reflect state or trait characteristics are topics of research in hereditary dystonias. METHODS:W...

journal_title：European journal of neurology

authors： Carbon M,Argyelan M,Eidelberg D

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Fatigue and pain have been previously shown to be important determinants for decreasing quality of life (QoL) in one report in patients with non-dystrophic myotonia. The aims of our study were to assess QoL in skeletal muscle channelopathies (SMC) using INQoL (individualized QoL) and SF-36 questi...

journal_title：European journal of neurology

authors： Sansone VA,Ricci C,Montanari M,Apolone G,Rose M,Meola G,INQoL Group.

更新日期：2012-11-01 00:00:00

abstract：BACKGROUNDAND PURPOSE:The purpose was to estimate the risk of epilepsy in a cohort of young individuals with celiac disease (CD) compared to that of matched references. METHODS:The cohort consisted of 213 635 individuals born during 1989-2011 and residing in Friuli-Venezia Giulia (Italy). 1215 individuals affected by ...

journal_title：European journal of neurology

authors： Canova C,Ludvigsson J,Barbiellini Amidei C,Zanier L,Zingone F

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:The frequency of sural sensory nerve action potential (SNAP) abnormalities in large fibre sensory neuropathy (LFSN) is uncertain. When sural SNAPs are normal, the sural/radial amplitude ratio (SRAR) was found to improve diagnostic yield in some studies. Motor parameters have been studied rarely, but may be h...

journal_title：European journal of neurology

authors： Rajabally YA,Beri S,Bankart J

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Superficial siderosis of the central nervous system is a sporadic finding in magnetic resonance imaging, resulting from recurrent bleedings into the subarachnoid space. This study aimed to determine the frequency of spinal dural cerebrospinal fluid (CSF) leaks amongst patients with a symmetric in...

journal_title：European journal of neurology

authors： Friedauer L,Rezny-Kasprzak B,Steinmetz H,du Mesnil de Rochemont R,Foerch C

更新日期：2020-10-24 00:00:00

abstract：:We report a novel missense mutation of the Notch3 gene in a Japanese family with CADASIL. The Cys49Gly mutation in this family is located in exon 2 of the Notch3 gene. Most of the documented Notch3 gene mutations occur in exons 3 or 4. On the other hand, there are few reports around the world of mutations in exon 2 of...

journal_title：European journal of neurology

authors： Oki K,Nagata E,Ishiko A,Shimizu A,Tanaka K,Takahashi K,Tabira T,Katayama T,Suzuki N

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The incidence of hospitalizations, treatment and case fatality of ischaemic stroke were assessed utilizing a comprehensive multinational database to attempt to compare the healthcare systems in six European countries, aiming also to identify the limitations and make suggestions for future improve...

journal_title：European journal of neurology

authors： Malmivaara A,Meretoja A,Peltola M,Numerato D,Heijink R,Engelfriet P,Wild SH,Belicza É,Bereczki D,Medin E,Goude F,Boncoraglio G,Tatlisumak T,Seppälä T,Häkkinen U

更新日期：2015-02-01 00:00:00

abstract：:The objective of this study was to investigate the efficacy, safety and tolerability of triptans in patients who suffer from familial or sporadic hemiplegic migraine. Seventy-six subjects had used triptans at least once as an abortive treatment. Average triptan response was 6.9 (SD +/-3.1) and adverse event severity 4...

journal_title：European journal of neurology

authors： Artto V,Nissilä M,Wessman M,Palotie A,Färkkilä M,Kallela M

更新日期：2007-09-01 00:00:00

abstract：INTRODUCTION:An association between parental smoking and multiple sclerosis (MS) in offspring has been reported. This study examined whether maternal smoking during pregnancy is associated with MS in offspring. METHODS:Swedish general population registers provided prospectively recorded information on maternal smoking...

journal_title：European journal of neurology

authors： Montgomery SM,Bahmanyar S,Hillert J,Ekbom A,Olsson T

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Several small retrospective studies have observed that patients with a purely ocular manifestation of myasthenia gravis (MG) are significantly less likely to convert to a generalized disease when treated early on with corticosteroids. However, given the limited number of reported patients in the ...

journal_title：European journal of neurology

authors： Zach H,Cetin H,Hilger E,Paul A,Wuschitz B,Jung R,Auff E,Zimprich F

更新日期：2013-04-01 00:00:00

abstract：:We examined the peripheral-central sensory conduction by using somatosensory evoked potential (SEP) in a 48 year old diabetic patient with acute painful neuropathy. The sural, ulnar and median sensory nerve conduction and SEP elicited by wrist stimulation showed no abnormalities, nevertheless, the tibial nerve SEP rev...

journal_title：European journal of neurology

authors： Shimamura H,Baba M,Ozaki I,Matsunaga M,Onuma T

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The multiple sclerosis prodrome remains poorly understood. We aimed to examine the prodrome in people with relapsing remitting multiple sclerosis at onset (RMS) and primary progressive multiple sclerosis (PPMS). METHODS:We conducted a matched cohort study using clinical and linked health adminis...

journal_title：European journal of neurology

authors： Wijnands JMA,Zhu F,Kingwell E,Zhao Y,Evans C,Fisk JD,Marrie RA,Tremlett H

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Associations with multiple sclerosis (MS) of living conditions in childhood and characteristics in adolescence including physical fitness, cognitive function and psychological stress resilience were investigated. METHODS:A cohort of male Swedish residents born 1952-1956 who were included in the ...

journal_title：European journal of neurology

authors： Gunnarsson M,Udumyan R,Bahmanyar S,Nilsagård Y,Montgomery S

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Hereditary sensory and autonomic neuropathies (HSANs) are a group of clinically and genetically heterogeneous neurological disorders characterized by sensory dysfunctions. Here, 21 affected Chinese families are reported, including 19 with congenital insensitivity to pain with anhidrosis (CIPA; na...

journal_title：European journal of neurology

authors： Zhao F,Mao B,Geng X,Ren X,Wang Y,Guan Y,Li S,Li L,Zhang S,You Y,Cao Y,Yang T,Zhao X

更新日期：2020-08-01 00:00:00

abstract：:An alanin-9valin (Ala-9Val) polymorphism in the mitochondrial targeting sequence of manganese-containing superoxide dismutase (Mn-SOD) has recently been described. We studied this polymorphism in 72 Swedish patients with sporadic motor neuron diseases (MND) and controls using an oligonucleotide ligation assay. There w...

journal_title：European journal of neurology

authors： Van Landeghem GF,Tabatabaie P,Beckman G,Beckman L,Andersen PM

更新日期：1999-11-01 00:00:00

abstract：:We report on a patient who presented with isolated transient headache as the only manifestation of pituitary apoplexy. A high index of suspicion and MRI led to the diagnosis. Copyright 1998 Lippincott Williams & Wilkins ...

journal_title：European journal of neurology

authors： Hernandez A,Angeles Del Real M,Aguirre M,Vaamonde J,Gudin M,Ibanez R

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Accumulation of iron (Fe) is often detected in brains of people suffering from neurodegenerative diseases. However, no studies have compared the Fe load between these disease entities. The present study investigates by T2*-weighted gradient-echo 7.0 T magnetic resonance imaging (MRI) the Fe conte...

journal_title：European journal of neurology

authors： De Reuck JL,Deramecourt V,Auger F,Durieux N,Cordonnier C,Devos D,Defebvre L,Moreau C,Caparros-Lefebvre D,Leys D,Maurage CA,Pasquier F,Bordet R

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder with varied prevalence in different populations, which may be associated with specific haplotypes. This study aimed to explore the haplotypes encompassing the HTT gene in the Chinese population. METHODS:A total of 406...

journal_title：European journal of neurology

authors： Li XY,Li HL,Dong Y,Gao B,Cheng HR,Ni W,Gan SR,Liu ZJ,Burgunder JM,Wu ZY

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In amyotrophic lateral sclerosis, studies using threshold-tracking transcranial magnetic stimulation (TMS) have identified corticomotoneuronal dysfunction as a key pathogenic mechanism. Some patients, however, display no motor response at maximal TMS intensities, termed here an 'inexcitable' moto...

journal_title：European journal of neurology

authors： Dharmadasa T,Howells J,Matamala JM,Simon NG,Burke D,Vucic S,Kiernan MC

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Essential tremor (ET) is the most common movement disorder worldwide. Three susceptibility loci on chromosomes 3q13, 2p24.1, and 6p23 have been reported, but no causative genes were found. The Ser9Gly variant of dopamine D3 receptor (DRD3) receptor was found associated to ET in a French and US population. M...

journal_title：European journal of neurology

authors： Vitale C,Gulli R,Ciotti P,Scaglione C,Bellone E,Avanzino L,Lantieri F,Abbruzzese G,Martinelli P,Barone P,Mandich P

更新日期：2008-09-01 00:00:00

abstract：:Myelitis is one of the most severe central nervous system complications seen in association with Mycoplasma pneumoniae infections and both acute transverse myelitis (ATM) as well as acute disseminated encephalomyelitis (ADEM) have been observed. We reviewed all available literature on cases of Mycoplasma spp. associat...

journal_title：European journal of neurology

authors： Tsiodras S,Kelesidis T,Kelesidis I,Voumbourakis K,Giamarellou H

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The diagnosis of cytomegalovirus encephalitis (CMV-E) in AIDS patients is challenging as other illnesses may obscure the symptoms. Here, we characterize the clinical symptoms of CMV-E and link them to post-mortem findings. Patients and methods In 254 homosexual men with AIDS, followed from HIV di...

journal_title：European journal of neurology

authors： Pirskanen-Matell R,Grützmeier S,Nennesmo I,Sandström E,Ehrnst A

更新日期：2009-01-01 00:00:00

abstract：:We reviewed the magnetic resonance imaging (MRI) database of the Dent Neurologic Institute to study the abnormal findings in myelitis. We identified 22 patients, and compared non-MS-related acute transverse myelitis (ATM, n = 9), to myelitis associated with multiple sclerosis (MS-myelitis, n = 13). The ATM patients we...

journal_title：European journal of neurology

authors： Bakshi R,Kinkel PR,Mechtler LL,Bates VE,Lindsay BD,Esposito SE,Kinkel WR

更新日期：1998-01-01 00:00:00

abstract：:Normal subjects use an open-loop motor control strategy in handwriting, but they are able to switch to closed-loop motor control when the demands on accuracy increase. These closed-loop handwriting movements of normal subjects resemble the inefficient movements found in writing-impaired patients. The hypothesis that s...

journal_title：European journal of neurology

authors： Schenk T,Walther EU,Mai N

更新日期：2000-05-01 00:00:00