The risk of epilepsy in children with celiac disease: a population-based cohort study.

Abstract:

BACKGROUNDAND PURPOSE:The purpose was to estimate the risk of epilepsy in a cohort of young individuals with celiac disease (CD) compared to that of matched references. METHODS:The cohort consisted of 213 635 individuals born during 1989-2011 and residing in Friuli-Venezia Giulia (Italy). 1215 individuals affected by CD and 6075 reference individuals matched by sex and age were identified. Epilepsy was defined by means of hospital diagnosis or drug prescriptions. Conditional logistic regression was used to estimate the odds ratios (ORs) of having epilepsy amongst individuals with CD, before CD diagnosis and in the entire period, compared with those of their matched references. Cox regression was used to calculate the hazard ratios for epilepsy diagnosed after CD diagnosis. Different definitions of epilepsy were used for sensitivity analyses. RESULTS:Thirty-one (2.6%) individuals with CD and 78 (1.3%) reference individuals had epilepsy [adjusted OR 2.03; 95% confidence interval (CI) 1.33-3.10]. The risk of epilepsy was increased prior to CD (adjusted OR 2.29; 95% CI 1.33-3.94), with similar estimates after CD diagnosis (adjusted hazard ratio 1.96; 95% CI 0.95-4.02). The increased risk of epilepsy was not explained by a peak in epilepsy diagnosis just around CD diagnosis. Sex stratification found a significantly higher risk of epilepsy amongst female individuals with CD. Sensitivity analyses confirmed the positive association between CD and epilepsy. CONCLUSION:Children and youths with CD were at increased risk of epilepsy. Patients with epilepsy without a clear etiology should be screened for CD since an early diagnosis and treatment might improve the response to antiepileptic therapies.

journal_name

Eur J Neurol

authors

Canova C,Ludvigsson J,Barbiellini Amidei C,Zanier L,Zingone F

doi

10.1111/ene.14160

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

1089-1095

issue

6

eissn

1351-5101

issn

1468-1331

journal_volume

27

pub_type

杂志文章
  • Myocardial injury in transient global amnesia: a case-control study.

    abstract:BACKGROUND AND PURPOSE:Elevation of cardiac troponin (cTn), a sensitive biomarker of myocardial injury, is frequently observed in severe acute neurological disorders. Case reports suggest that cardiac dysfunction may also occur in patients with transient global amnesia (TGA). Until now, no study has systematically asse...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.13920

    authors: Erdur H,Siegerink B,Ganeshan R,Audebert HJ,Endres M,Nolte CH,Scheitz JF

    更新日期:2019-07-01 00:00:00

  • Changes in serum complements and their regulators in generalized myasthenia gravis.

    abstract:OBJECTIVE:To investigate changes in serum complements and their regulators in the pathogenesis of myasthenia gravis (MG). METHODS:Forty-four patients with acetylcholine receptor antibody-positive MG, as well as 20 patients with non-inflammatory neurological disorders were enrolled. Serum complements (C3, C4 and solubl...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.14500

    authors: Ozawa Y,Uzawa A,Yasuda M,Kojima Y,Oda F,Himuro K,Kawaguchi N,Kuwabara S

    更新日期:2021-01-01 00:00:00

  • Novel mutation of the Notch3 gene in a Japanese patient with CADASIL.

    abstract::We report a novel missense mutation of the Notch3 gene in a Japanese family with CADASIL. The Cys49Gly mutation in this family is located in exon 2 of the Notch3 gene. Most of the documented Notch3 gene mutations occur in exons 3 or 4. On the other hand, there are few reports around the world of mutations in exon 2 of...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2007.01641.x

    authors: Oki K,Nagata E,Ishiko A,Shimizu A,Tanaka K,Takahashi K,Tabira T,Katayama T,Suzuki N

    更新日期:2007-04-01 00:00:00

  • Social deprivation and stroke severity on admission: a French cohort study in Burgundy and the West Indies - Guyana region.

    abstract:BACKGROUND AND PURPOSE:Although there is growing and convincing evidence that socially deprived patients are at higher risk of stroke and worse outcomes, it remains controversial whether or not they suffer more severe stroke. This study aimed to evaluate the influence of social deprivation on initial clinical severity ...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.13271

    authors: Béjot Y,Guilloteau A,Joux J,Lannuzel A,Mimeau E,Mislin-Tritsch C,Fournel I,Bonithon-Kopp C,INDIA Study Group.

    更新日期:2017-05-01 00:00:00

  • Therapeutic effect of repetitive transcranial magnetic stimulation on motor function in Parkinson's disease patients.

    abstract::Cortical excitability of the primary motor cortex is altered in patients with Parkinson's disease (PD). Therefore, modulation of cortical excitability by high frequency repetitive transcranial magnetic stimulation (rTMS) of the motor cortex might result in beneficial effects on motor functions in PD. The present study...

    journal_title:European journal of neurology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1468-1331.2003.00649.x

    authors: Khedr EM,Farweez HM,Islam H

    更新日期:2003-09-01 00:00:00

  • Onset and progression of primary torsion dystonia in sporadic and familial cases.

    abstract::Four hundred and sixty records of patients with primary torsion dystonia (296 women and 164 men) were evaluated. The mean age at disease onset was 48.3 +/- 17.7 years; 13 patients carried the DYT1 CAG deletion. The distribution of age at onset was represented by a bi-modal curve, with a nadir at 21 year separating ear...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2006.01387.x

    authors: Elia AE,Filippini G,Bentivoglio AR,Fasano A,Ialongo T,Albanese A

    更新日期:2006-10-01 00:00:00

  • The distribution of cerebral microbleeds determines their association with arterial stiffness in non-cardioembolic acute stroke patients.

    abstract:BACKGROUND AND PURPOSE:Increased arterial stiffness causes vessel damage in the end-organs. Therefore small vessels in the brain may be susceptible to increased arterial stiffness. Cerebral microbleeds (CMBs) are topographically or pathophysiologically categorized as deep or infratentorial type and strictly lobar type....

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.12332

    authors: Song TJ,Kim J,Kim YD,Nam HS,Lee HS,Nam CM,Heo JH

    更新日期:2014-03-01 00:00:00

  • Minimum effective betamethasone dosage on the neurological phenotype in patients with ataxia-telangiectasia: a multicenter observer-blind study.

    abstract:BACKGROUND AND PURPOSE:Ataxia-telangiectasia (A-T) is a rare neurodegenerative disease, due to A-T mutated (ATM) gene mutations, which typically presents with signs of progressive neurological dysfunction, cerebellar ataxia and uncoordinated movements. A-T severely affects patients' quality of life. Successful treatmen...

    journal_title:European journal of neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/ene.13606

    authors: Cirillo E,Del Giudice E,Micheli R,Cappellari AM,Soresina A,Dellepiane RM,Pietrogrande MC,Dell'Era L,Specchia F,Pession A,Plebani A,Pignata C

    更新日期:2018-06-01 00:00:00

  • In-vivo signatures of neurodegeneration in isolated rapid eye movement sleep behaviour disorder.

    abstract:BACKGROUND AND PURPOSE:Isolated rapid eye movement sleep behaviour disorder (iRBD) is a parasomnia, recently recognized as a risk factor for progression to Parkinson's disease, dementia with Lewy body and multiple system atrophy. Biomarker studies in iRBD are relevant due to lack of evidence in this condition. The iden...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.14215

    authors: Carli G,Caminiti SP,Galbiati A,Marelli S,Casoni F,Padovani A,Ferini-Strambi L,Perani D

    更新日期:2020-07-01 00:00:00

  • Rhabdomyolysis and fluctuating asymptomatic hyperCKemia associated with CACNA1S variant.

    abstract:BACKGROUND AND PURPOSE:CACNA1S encodes Cav 1.1, a voltage sensor for muscle excitation-contraction coupling, which activates the ryanodine receptor 1 (RYR1) leading to calcium release from the sarcoplasmic reticulum. CACNA1S mutations cause hypokalemic periodic paralysis, malignant hyperthermia and congenital myopathy....

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.13528

    authors: Anandan C,Cipriani MA,Laughlin RS,Niu Z,Milone M

    更新日期:2018-02-01 00:00:00

  • Is high socioeconomic status a risk factor for multiple sclerosis? A systematic review.

    abstract::High socioeconomic status (SES) is generally associated with better health outcomes, but some research has linked it with an increased risk of multiple sclerosis (MS). The evidence for this association is inconsistent and has not previously been systematically reviewed. A systematic review of cohort and case-control s...

    journal_title:European journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1111/ene.12586

    authors: Goulden R,Ibrahim T,Wolfson C

    更新日期:2015-06-01 00:00:00

  • The association between ankle-brachial index and asymptomatic cranial-carotid stenosis: a population-based, cross-sectional study of 5440 Han Chinese.

    abstract:BACKGROUND AND PURPOSE:Routine screening for asymptomatic cranial-carotid stenosis (ACCS) is controversial and recommendation in clinical practice is vague. The ankle-brachial index (ABI) is reported as a predictor for cardiovascular disease. However, there is a scarcity of data about the association between abnormal A...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.12935

    authors: Qiu J,Zhou Y,Yang X,Zhang Y,Li Z,Yan N,Wang Y,Ge S,Wu S,Zhao X,Wang W

    更新日期:2016-04-01 00:00:00

  • Predictors of long-term neurological sequelae of tuberculous meningitis: a multivariate analysis.

    abstract::There is paucity of studies on predictors of long-term sequelae of tuberculous meningitis (TBM). We report the neurological sequelae of TBM at 1 year and their predictors. Patients with TBM who were followed up for 1 year were included. The diagnosis of TBM was based on clinical, cerebrospinal fluid (CSF) and computed...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2006.01534.x

    authors: Kalita J,Misra UK,Ranjan P

    更新日期:2007-01-01 00:00:00

  • Incidence of Guillain-Barré syndrome in Sweden 1996.

    abstract::We describe the incidence of Guillain-Barré syndrome (GBS) in Sweden in 1996. Information of incident GBS patients was mainly collected by a multicentre network of 18 neurologists prospectively monitoring a general population with 4.48 million inhabitants across the country and complemented with data from the national...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:

    authors: Cheng Q,Jiang GX,Fredrikson S,Link H,De Pedro-Cuesta J

    更新日期:2000-01-01 00:00:00

  • One-year follow up of patients with chronic tinnitus treated with left temporoparietal rTMS.

    abstract:BACKGROUND AND PURPOSE:Although there are a number of positive reports on the therapeutic effects of repetitive transcranial magnetic stimulation (rTMS) for treatment of tinnitus, there are few details about the duration of treatment effects or the relative efficiency of different rTMS protocols. METHODS:Sixty six pat...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2008.02522.x

    authors: Khedr EM,Rothwell JC,El-Atar A

    更新日期:2009-03-01 00:00:00

  • The basis for day and night-time control of symptoms of Parkinson's disease.

    abstract::While optimal treatment strategies are widely established for daytime treatment of Parkinson's disease (PD), nighttime problems of PD are often not adequately addressed in clinical practice. Nocturnal/sleep disturbance is common in PD and occurs due to a combination of the disease process and effect of dopaminergic an...

    journal_title:European journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1468-1331.9.s3.5.x

    authors: Chaudhuri KR

    更新日期:2002-11-01 00:00:00

  • Prestroke antiplatelet therapy and early prognosis in stroke patients: the Dijon Stroke Registry.

    abstract:BACKGROUND AND PURPOSE:Previous antiplatelet therapy (APT) in cardiovascular prevention is common in patients with first-ever stroke. We aimed to evaluate the prognostic value of APT on early outcome in stroke patients. METHODS:All first-ever strokes from 1985 to 2011 were identified from the population-based Stroke R...

    journal_title:European journal of neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/ene.12060

    authors: Béjot Y,Aboa-Eboulé C,de Maistre E,Jacquin A,Troisgros O,Hervieu M,Osseby GV,Rouaud O,Giroud M

    更新日期:2013-06-01 00:00:00

  • Disease course after clinically isolated syndrome in children versus adults: a prospective cohort study.

    abstract:BACKGROUND AND PURPOSE:Clinically isolated syndrome (CIS) is a first demyelinating event of the central nervous system and can be a single event. After CIS, a chronic disease course with ongoing inflammation and relapses might occur, resulting in a diagnosis of multiple sclerosis (MS). As yet, there has been no prospec...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.13196

    authors: van der Vuurst de Vries RM,van Pelt ED,Mescheriakova JY,Wong YY,Ketelslegers IA,Siepman TA,Catsman CE,Neuteboom RF,Hintzen RQ

    更新日期:2017-02-01 00:00:00

  • Predicting outcomes after acute reperfusion therapy for basilar artery occlusion.

    abstract:BACKGROUND AND PURPOSE:Basilar artery occlusion (BAO) leads to high rates of morbidity and mortality, despite successful recanalization. The discordance between flow restoration and long-term functional status clouds clinical decision-making regarding further aggressive care. We sought to develop and validate a practic...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.14406

    authors: Jadhav AP,Desai SM,Panczykowski DM,Rangaraju S,Campbell D,Ritvonen JK,Schreiner M,Silvennoinen H,Gerber J,Puetz V,Raza SA,Haussen DC,Nogueira RG,Strbian D,Jovin TG,Lindsberg PJ

    更新日期:2020-11-01 00:00:00

  • Stroke in first-degree relatives of patients with cervical artery dissection.

    abstract:BACKGROUND AND PURPOSE:Patients with ischaemic stroke (IS) caused by a spontaneous cervical artery dissection (CeAD) worry about an increased risk for stroke in their families. The occurrence of stroke in relatives of patients with CeAD and in those with ischaemic stroke attributable to other (non-CeAD) causes were com...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.12437

    authors: Kloss M,Grond-Ginsbach C,Pezzini A,Metso TM,Metso AJ,Debette S,Leys D,Dallongeville J,Caso V,Thijs V,Bersano A,Touzé E,Bonati LH,Tatlisumak T,Arnold ML,Lyrer PA,Engelter ST,Cervical Artery Dissection and Ischemic Stroke

    更新日期:2014-08-01 00:00:00

  • Fatigue and depression predict quality of life in patients with early multiple sclerosis: a longitudinal study.

    abstract:BACKGROUND AND PURPOSE:The clinical predictors of health-related quality of life (HRQoL) in multiple sclerosis (MS) have mainly been studied in patients with long-standing disease. The objective of this study was to investigate the longitudinal association among HRQoL and clinical characteristics in early MS. METHODS:...

    journal_title:European journal of neurology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/ene.13102

    authors: Nourbakhsh B,Julian L,Waubant E

    更新日期:2016-09-01 00:00:00

  • The 'hot cross bun' sign in the patients with spinocerebellar ataxia.

    abstract:BACKGROUND AND PURPOSE:The 'hot cross bun' sign (HCBS), typically seen in the patients with multiple system atrophy, refers to a cruciform hyperintensity in the pons on T2-weighted MRI. Little is known about its pathological basis and prevalence in other degenerative cerebellar diseases and healthy population. We inves...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2008.02524.x

    authors: Lee YC,Liu CS,Wu HM,Wang PS,Chang MH,Soong BW

    更新日期:2009-04-01 00:00:00

  • Thymus histology and concomitant autoimmune diseases in Japanese patients with muscle-specific receptor tyrosine kinase-antibody-positive myasthenia gravis.

    abstract:BACKGROUND AND PURPOSE:The differences in the characteristics of thymus histology, coexisting autoimmune diseases and related autoantibodies between anti-muscle-specific receptor tyrosine kinase (MuSK)-antibody (Ab)-positive myasthenia gravis (MG) patients, and anti-acetylcholine receptor (AChR)-Ab-positive MG patients...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.12169

    authors: Nakata R,Motomura M,Masuda T,Shiraishi H,Tokuda M,Fukuda T,Ando T,Yoshimura T,Tsujihata M,Kawakami A

    更新日期:2013-09-01 00:00:00

  • The functional MAOA-uVNTR promoter polymorphism in patients with frontotemporal dementia.

    abstract::The genetic underpinnings of frontotemporal dementia (FTD), a rare yet early onset disorder still remains elusive. As FTD is characterized by a serotonergic deficit in the frontal lobe, and as some symptoms of FTD resemble conditions of monoamino oxidase A (MAO-A) deficiency, MAO-A is an attractive candidate gene for ...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2008.02142.x

    authors: Reif A,Scarpini E,Venturelli E,Töpner T,Fenoglio C,Lesch KP,Galimberti D

    更新日期:2008-06-01 00:00:00

  • Mutational spectrum of GNAL, THAP1 and TOR1A genes in isolated dystonia: study in a population from Spain and systematic literature review.

    abstract:OBJECTIVE:We aimed to investigate the prevalence of TOR1A, GNAL and THAP1 variants as the cause of dystonia in a cohort of Spanish patients with isolated dystonia and in the literature. METHODS:A population of 2028 subjects (including 1053 patients with different subtypes of isolated dystonia and 975 healthy controls)...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/ene.14638

    authors: Gómez-Garre P,Jesús S,Periñán MT,Adarmes A,Alonso-Canovas A,Blanco-Ollero A,Buiza-Rueda D,Carrillo F,Catalán-Alonso MJ,Del Val J,Escamilla-Sevilla F,Espinosa-Rosso R,Fernández-Moreno MC,García-Moreno JM,García-Ruiz PJ,Giaco

    更新日期:2020-11-11 00:00:00

  • Fulminant acute disseminated encephalomyelitis mimicking acute bacterial menigoencephalitis.

    abstract::Most patients with acute disseminated encephalomyelitis (ADEM) recover quickly under corticosteroid treatment and have a favourable long-term prognosis. We report on a young woman with acute onset of an extensive and solitary white-matter lesion in the left hemisphere. Fever, high pleocytosis and elevated protein in c...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2004.01015.x

    authors: Harloff A,Rauer S,Hofer M,Klisch J,Els T

    更新日期:2005-01-01 00:00:00

  • Cost-effectiveness of decompressive craniectomy in non-traumatic neurological emergencies.

    abstract:BACKGROUND:Decompressive craniectomy is used regularly in traumatic brain injury (TBI) and malignant middle cerebral artery infarction. Its benefits for other causes of non-traumatic brain swelling, if any, are unclear, especially after a devastating primary event. METHODS:We evaluated the outcomes as well as treatmen...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2010.03162.x

    authors: Malmivaara K,Ohman J,Kivisaari R,Hernesniemi J,Siironen J

    更新日期:2011-03-01 00:00:00

  • Lesion patterns in patients with cryptogenic stroke with and without right-to-left-shunt.

    abstract:BACKGROUND AND PURPOSE:Despite numerous studies, the role of patent foramen ovale (PFO) as a risk factor for stroke due to paradoxical embolism is still controversial. On the assumption that specific lesion patterns, in particular multiple acute ischaemic lesions on diffusion-weighted magnetic resonance imaging, indica...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2009.02692.x

    authors: Feurer R,Sadikovic S,Esposito L,Schwarze J,Bockelbrink A,Hemmer B,Sander D,Poppert H

    更新日期:2009-10-01 00:00:00

  • Aspirin versus anticoagulation in intra- and extracranial vertebral artery dissection.

    abstract:BACKGROUND AND PURPOSE:To evaluate the incidence and predictors of ischaemic recurrent stroke and the adverse events of antithrombotic therapy in patients with first intra- or extracranial vertebral artery dissection (VAD) who were treated with aspirin or oral anticoagulation (OA). METHODS:A 21-year database of consec...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2012.03825.x

    authors: Arauz A,Ruiz A,Pacheco G,Rojas P,Rodríguez-Armida M,Cantú C,Murillo-Bonilla L,Ruiz-Sandoval JL,Barinagarrementeria F

    更新日期:2013-01-01 00:00:00

  • Cerebral blood flow velocity changes during meaningful and meaningless gestures--a functional transcranial Doppler study.

    abstract::The aim of the study was to use functional transcranial Doppler to investigate the possibility of revealing different activation patterns during healthy subjects' performance of meaningful and meaningless actions. Mean flow velocity (MFV) changes were recorded in middle cerebral arteries (MCAs) of 26 normal subjects d...

    journal_title:European journal of neurology

    pub_type: 杂志文章

    doi:10.1111/j.1468-1331.2006.01219.x

    authors: Matteis M,Federico F,Troisi E,Pasqualetti P,Vernieri F,Caltagirone C,Petrosini L,Silvestrini M

    更新日期:2006-01-01 00:00:00