Abstract:
OBJECTIVE:To investigate changes in serum complements and their regulators in the pathogenesis of myasthenia gravis (MG). METHODS:Forty-four patients with acetylcholine receptor antibody-positive MG, as well as 20 patients with non-inflammatory neurological disorders were enrolled. Serum complements (C3, C4 and soluble C5b-9) and complement regulators (vitronectin, clusterin and properdin) were extensively analysed by enzyme-linked immunosorbent assay and their associations with clinical profiles of MG were examined. RESULTS:Serum C3, C4 and clusterin levels were not significantly different between patients with MG and controls. The patients with MG had higher soluble C5b-9 (P = 0.09) and vitronectin (P = 0.001) levels than the controls; moreover, vitronectin levels decreased after treatment (P = 0.09). Serum properdin (P = 0.03) levels were lower in the patients with MG than in the controls, and negatively correlated with the MG Activities of Daily Living score (rs = -0.26, P = 0.09) and with the presence of bulbar palsy (P = 0.04). CONCLUSION:Our results show that activation of complements and an altered complement network could contribute to the inflammatory pathogenesis of MG.
journal_name
Eur J Neuroljournal_title
European journal of neurologyauthors
Ozawa Y,Uzawa A,Yasuda M,Kojima Y,Oda F,Himuro K,Kawaguchi N,Kuwabara Sdoi
10.1111/ene.14500subject
Has Abstractpub_date
2021-01-01 00:00:00pages
314-322issue
1eissn
1351-5101issn
1468-1331journal_volume
28pub_type
杂志文章abstract::There are at least seven clinically indistinguishable but genetically different types of autosomal dominant pure spastic paraplegia (ADPSP). In this study we investigated electrophysiological characteristics in patients with ADPSP linked to chromosome 2p (SPG4). Twelve patients from six different families with ADPSP l...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2001.00249.x
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Routine screening for asymptomatic cranial-carotid stenosis (ACCS) is controversial and recommendation in clinical practice is vague. The ankle-brachial index (ABI) is reported as a predictor for cardiovascular disease. However, there is a scarcity of data about the association between abnormal A...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12935
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Benign paroxysmal positional vertigo (BPPV) is a frequently encountered condition that can severely affect the quality of life. In this study, we aimed to assess the possible relations between serum uric acid (SUA) levels and BPPV. METHODS:Fifty patients with BPPV, and 40 age- and sex-matched co...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12248
更新日期:2014-01-01 00:00:00
abstract::Myelitis is one of the most severe central nervous system complications seen in association with Mycoplasma pneumoniae infections and both acute transverse myelitis (ATM) as well as acute disseminated encephalomyelitis (ADEM) have been observed. We reviewed all available literature on cases of Mycoplasma spp. associat...
journal_title:European journal of neurology
pub_type: 杂志文章,评审
doi:10.1111/j.1468-1331.2006.01174.x
更新日期:2006-02-01 00:00:00
abstract::To evaluate prevalence of use and prescribing patterns of antiepileptic drugs (AEDs) in Italian general practice. Primary care data were obtained from the Health Search Database, a longitudinal observational database implemented by the Italian College of General Practitioners (GPs). We selected 465 061 subjects regist...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2007.01970.x
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Amyotrophic lateral sclerosis (ALS)-related genes and mutations have been increasingly discovered recently and an improved understanding of genotype-phenotype relationships may help to predict the disease course and refine genetic diagnosis. METHODS:We collected clinical data and blood samples f...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14213
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Many patients with multiple sclerosis (MS) present swallowing difficulties. Dysphagia is associated with significant morbidity and mortality, has a profound impact on the quality of life but is under-reported by patients. The objective was to investigate the psychometric properties of the Dysphag...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14219
更新日期:2020-07-01 00:00:00
abstract::Among patients who underwent cerebrospinal fluid (CSF) and magnetic resonance imaging (MRI) examination during a 5-year period, we found 18 patients at the multiple sclerosis center of the University of Rome and clinically definite multiple sclerosis, MRI white matter abnormalities, normal CSF examination, a disease d...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.1994.tb00060.x
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Headache has been associated with various lifestyle and psychosocial factors, one of which is smoking. The aim of the present study was to investigate whether the association between smoking intensity and headache is likely to be causal. METHOD:A total of 58 316 participants from the Nord-Trønde...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13675
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND: A low ankle-brachial index (ABI) is predictive of peripheral arterial disease (PAD). For unknown reasons, patients with PAD demonstrate higher vascular mortality during follow-up than do those without. Initial stroke severity is a strong predictor of long-term outcome and may be different between patients ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2011.03652.x
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cranial nerve palsy is occasionally present in patients with chronic inflammatory demyelinating polyneuropathy (CIDP), but its prevalence, characteristics and relations with the CIDP subtypes have rarely been investigated. The aim of this study was to systematically assess cranial nerve involveme...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14497
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The purpose was to identify statistically factors that correlate with the presence of a colony-stimulating factor 1 receptor (CSF1R) mutation and to reevaluate the accuracy of the current diagnostic criteria for CSF1R-related leukoencephalopathy. METHODS:CSF1R testing was conducted on 145 consec...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14086
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:To assess the efficacy and safety of olesoxime, a molecule with neuroprotective properties, in patients with amyotrophic lateral sclerosis (ALS) treated with riluzole. METHODS:A double-blind, randomized, placebo-controlled, multicenter trial of 18 months' duration was conducted in 512 subjects, ...
journal_title:European journal of neurology
pub_type: 杂志文章,随机对照试验
doi:10.1111/ene.12344
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There is increasing interest in using patient-reported outcome measures (PROMs) in clinical studies to capture individual changes over time. However, PROMs have also been criticized because they are entirely subjective. Our objective was to examine the relationship between a subjective PROM and a...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13025
更新日期:2016-07-01 00:00:00
abstract::Population-based epidemiological studies on epilepsy are available mainly from the UK and the Nordic, Baltic and western Mediterranean countries. No studies were identified from large areas of Europe, especially from the former eastern Europe (except the Baltic countries) and the eastern Mediterranean countries. Based...
journal_title:European journal of neurology
pub_type: 杂志文章,评审
doi:10.1111/j.1468-1331.2004.00992.x
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Epilepsy is a frequent complication of central nervous system (CNS) infections. Post-infectious epilepsy is commonly refractory to medical treatment and plays a pivotal role for the poor long-term outcome of CNS infections. OBJECTIVES:To provide an overview of clinical characteristics and risk f...
journal_title:European journal of neurology
pub_type: 杂志文章,评审
doi:10.1111/j.1468-1331.2012.03842.x
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The 'hot cross bun' sign (HCBS), typically seen in the patients with multiple system atrophy, refers to a cruciform hyperintensity in the pons on T2-weighted MRI. Little is known about its pathological basis and prevalence in other degenerative cerebellar diseases and healthy population. We inves...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2008.02524.x
更新日期:2009-04-01 00:00:00
abstract::We report a 69-year-old male patient whose motor aphasia started at the age of 61. The language disability remained isolated and progressed over a period of eight years without any additional cognitive deficits. Computed tomography (CT) and magnetic resonance imaging (MRI) showed moderate cortical atrophy with frontal...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.1999.640515.x
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:Efficacy and safety data have not previously been compiled for intramuscular interferon beta-1a (IM IFNβ-1a) in patients with multiple sclerosis (MS) ≥ 50 years of age. We investigated the efficacy and safety of IM IFNβ-1a in patients segregated by 50 and 40 years of age in separate meta-analyses. METHODS:T...
journal_title:European journal of neurology
pub_type: 杂志文章,meta分析
doi:10.1111/j.1468-1331.2011.03460.x
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The etiological classification of patients with transient ischaemic attack (TIA) is a difficult endeavor and the use of serum biomarkers could improve the diagnostic accuracy. The aim of this study was to correlate atrial fibrillation, the main cardioembolic etiology (CE), with different serum bi...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12222
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Since the outbreak of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic, several reports indicated neurological involvement in COVID-19 disease. Muscle involvement has also been reported as evidenced by creatine kinase (CK) elevations and reports of myalgia. METHODS:Creat...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14564
更新日期:2020-09-30 00:00:00
abstract:BACKGROUND AND PURPOSE:In patients with spinal muscular atrophy (SMA), functional disease scores are frequently used to evaluate the course of the disease and the efficacy of treatment. The aim of the present study was to propose minimal clinically important difference (MCID) values for motor scores in order to estimat...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14472
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Oxidative stress is a central factor in the pathogenesis of Parkinson's disease (PD). Heme oxygenase-1 (HO-1) is an antioxidant protein expressed in response to oxidative challenge, and its expression levels are inversely correlated with glycogen synthase kinase-3beta (GSK3beta) activity. Underexpression of ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2009.02908.x
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Chronic progressive external ophthalmoplegia (CPEO) is a relatively common mitochondrial disorder. In addition to extraocular muscle weakness, various other organs can typically be affected, including laryngeal and limb muscles, cerebrum, cerebellum, and peripheral nerves. Given this multi-organ involvement,...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2011.03496.x
更新日期:2012-01-01 00:00:00
abstract::The Mini-Mental State Examination (MMSE), a brief test to assess cognitive status, is heavily influenced by age and education. It was administered to 1019 elderly subjects (aged 65-89 years) living in three different Italian cities. A statistical non-linear regression model was built up in order to obtain adjustment c...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.1996.tb00423.x
更新日期:1996-05-01 00:00:00
abstract::We examined the peripheral-central sensory conduction by using somatosensory evoked potential (SEP) in a 48 year old diabetic patient with acute painful neuropathy. The sural, ulnar and median sensory nerve conduction and SEP elicited by wrist stimulation showed no abnormalities, nevertheless, the tibial nerve SEP rev...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.1996.tb00433.x
更新日期:1996-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Recent studies have demonstrated that Alzheimer's disease (AD) and subcortical vascular dementia (SVaD) have white matter (WM) microstructural changes. However, previous studies on AD and SVaD rarely eliminated the confounding effects of patients with mixed Alzheimer's and cerebrovascular disease...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12645
更新日期:2015-04-01 00:00:00
abstract::The objective of this study was to investigate the efficacy, safety and tolerability of triptans in patients who suffer from familial or sporadic hemiplegic migraine. Seventy-six subjects had used triptans at least once as an abortive treatment. Average triptan response was 6.9 (SD +/-3.1) and adverse event severity 4...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2007.01900.x
更新日期:2007-09-01 00:00:00
abstract::The purpose of these experiments was to compare the spread of three formulations of botulinum neurotoxin A. A gelatin/phosphate buffer (C), DysportR (D {0.5 U}, BotoxR (B {0.167 U}), or a purified preparation of botulinum neurotoxin A [Bont A] (BA {0.5 U}) was injected into the tibialis anterior of male, Wistar rats. ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.1998.520181.x
更新日期:1998-03-01 00:00:00
abstract::Levodopa-carbidopa (LD) in low dosages adequately controls symptoms in most patients with Parkinson's disease and delays the appearance of fluctuations and dyskinesias. It has been suggested that early combination therapy with bromocriptine and levodopa delays or prevents the onset of late treatment complication assoc...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.1998.530255.x
更新日期:1998-05-01 00:00:00