Abstract:
BACKGROUND AND PURPOSE:Many patients with multiple sclerosis (MS) present swallowing difficulties. Dysphagia is associated with significant morbidity and mortality, has a profound impact on the quality of life but is under-reported by patients. The objective was to investigate the psychometric properties of the Dysphagia in Multiple Sclerosis (DYMUS) questionnaire and examine whether item reduction improves them. METHODS:The participants, 153 patients with MS and 104 healthy controls, completed the DYMUS and the Eating Assessment Tool 10 (EAT-10). The study consisted of factor, reliability and validity analysis of DYMUS, and item reduction, reliability, validity analysis and normative data generation for the modified DYMUS (mod-DYMUS). RESULTS:The internal consistency of DYMUS was excellent (Cronbach's alpha 0.886). Test-retest reliability was good for all the items. Factor and reliability analysis, along with other psychometric features, supported item reduction. The mod-DYMUS (consisting of items 1 and 3-7) showed improved internal consistency (Cronbach's alpha 0.903) and inter-item correlation coefficients (0.558-0.657), good test-retest reliability, excellent criterion validity and improved convergent validity. Patients had significantly higher mean mod-DYMUS score than controls (P < 0.001), and dysphagic patients (EAT-10 ≥ 3) had significantly higher mod-DYMUS than non-dysphagic patients (P < 0.001). A strong positive and significant correlation was noted between the mod-DYMUS and the EAT-10 (P < 0.001). A mod-DYMUS score of 1 or higher indicates dysphagia. CONCLUSIONS:Item reduction improves the psychometric properties of DYMUS. The mod-DYMUS is a valid, reliable, low-burden, screening tool for the detection of dysphagia in MS, which can enhance personalized assessment and guide management decisions that better respond to individual patients' needs.
journal_name
Eur J Neuroljournal_title
European journal of neurologyauthors
Printza A,Boziki M,Bakirtzis C,Nikolaidis I,Kalaitzi M,Triaridis S,Grigoriadis Ndoi
10.1111/ene.14219subject
Has Abstractpub_date
2020-07-01 00:00:00pages
1231-1237issue
7eissn
1351-5101issn
1468-1331journal_volume
27pub_type
杂志文章abstract:BACKGROUND AND PURPOSE:Accumulation of iron (Fe) is often detected in brains of people suffering from neurodegenerative diseases. However, no studies have compared the Fe load between these disease entities. The present study investigates by T2*-weighted gradient-echo 7.0 T magnetic resonance imaging (MRI) the Fe conte...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12432
更新日期:2014-07-01 00:00:00
abstract::Polycythemia rubra vera (PRV) is a rare haematological disorder that has a high risk of stroke, although the pathophysiological origin of the cerebral ischaemia in this disease is not well known. We report a case of a stroke patient with PRV in whom bilateral embolic signals were detected by transcranial Doppler (TCD)...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2000.00008.x
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Dermatomyositis (DM) with anti-nuclear matrix protein-2 (NXP-2) antibodies usually shows multifocal ischaemic lesions in muscle. Here, we aimed to investigate the microarteriopathy underlying muscle ischaemia in anti-NXP-2-positive DM. METHODS:A total of 16 patients diagnosed with anti-NXP-2-pos...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14097
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Non-Western immigrants to Norway acquire an increased risk of multiple sclerosis (MS) after migration. Ethnicity and the presence of oligoclonal bands (OCBs) in the cerebrospinal fluid (CSF) might influence the disease course. The aim of this study was to investigate differences in disease severi...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12227
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Patients with ischaemic stroke (IS) caused by a spontaneous cervical artery dissection (CeAD) worry about an increased risk for stroke in their families. The occurrence of stroke in relatives of patients with CeAD and in those with ischaemic stroke attributable to other (non-CeAD) causes were com...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12437
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:The purpose of the study is to investigate the epidemiology and medical expenses of Wilson's disease in Taiwan. METHODS:Cases of Wilson's disease were identified from the National Health Insurance Research Database with corresponding International Classification of Diseases, Ninth Revision (ICD-9) code 275....
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2009.02946.x
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Up to now, there are few systematic studies in a sufficient number of patients with lesions involving the insular cortex (IC) examining whether damage of the IC is directly related to dysarthria. Thus, this is the first study applying modern voxel-lesion behaviour mapping (VLBM) aimed to examine whether the ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2011.03473.x
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The association between vascular risk factors and dementia is of interest. Several studies have shown that cerebral small vessel disease (SVD) is associated with dementia. However, the association between cerebral large vessel disease (LVD) and dementia has not been thoroughly examined. METHODS:...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12553
更新日期:2015-01-01 00:00:00
abstract::Spontaneous intracranial hypotension (SIH) is characterized by orthostatic headache and the cause is usually cerebrospinal fluid leaks in spine level. Most patients with SIH have a benign course. Epidural blood patch (EBP) is the treatment of choice when initial conservative managements are ineffective. We reported a ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2006.01369.x
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:For Parkinson's disease (PD), an extended-release (ER) pramipexole formulation taken once daily, has shown efficacy, safety, and tolerability resembling those of immediate-release (IR) pramipexole taken three times daily. The present study assessed, in advanced PD, the success of an overnight swi...
journal_title:European journal of neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1468-1331.2012.03822.x
更新日期:2013-01-01 00:00:00
abstract::The prognosis of cerebellar hemorrhage with brain stem compression is known to be poor, and patients who can usually survive are severely disabled with limited benefit from conventional rehabilitation. An innovative cutaneous stimulation was administered to a chronic patient (2 years after the incidence) who has sever...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2003.00573.x
更新日期:2003-05-01 00:00:00
abstract:INTRODUCTION:An association between parental smoking and multiple sclerosis (MS) in offspring has been reported. This study examined whether maternal smoking during pregnancy is associated with MS in offspring. METHODS:Swedish general population registers provided prospectively recorded information on maternal smoking...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2008.02331.x
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There is increasing interest in using patient-reported outcome measures (PROMs) in clinical studies to capture individual changes over time. However, PROMs have also been criticized because they are entirely subjective. Our objective was to examine the relationship between a subjective PROM and a...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13025
更新日期:2016-07-01 00:00:00
abstract::Multiple sclerosis (MS) is a T-cell-mediated autoimmune demyelinating disease of the central nervous system, associated with an altered cytokine network. We previously assayed peripheral blood T-lymphocyte binding for two prototypic cytokines, tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), and foun...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2000.00139.x
更新日期:2000-11-01 00:00:00
abstract::Recently, a novel protein-interaction partner of alpha-synuclein, designated synphilin-1, is identified as a constituent of Lewy bodies (LB) in Parkinson's disease (PD) brains. To investigate an involvement of genetic variations of synphilin-1 in development of sporadic PD, a possible single nucleotide polymorphism (S...
journal_title:European journal of neurology
pub_type: 临床试验,杂志文章
doi:10.1046/j.1468-1331.2002.00333.x
更新日期:2002-01-01 00:00:00
abstract::We performed a placebo-controlled cross-over trial of riluzole (100 mg b.i.d.) in 10 patients with probable multiple system atrophy (MSA) administering riluzole and placebo for 4 weeks each with a 4-week washout period. Outcome measures evaluated short-term anti-Parkinsonian effects using the Unified Parkinson's Disea...
journal_title:European journal of neurology
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1468-1331.2006.01452.x
更新日期:2006-10-01 00:00:00
abstract::Multiple sclerosis (MS) is a chronic and potentially highly disabling disorder with considerable social impact and economic consequences. It is the major cause of non-traumatic disability in young adults. The social costs associated with MS are high because of its long duration, the early loss of productivity, the nee...
journal_title:European journal of neurology
pub_type: 杂志文章,评审
doi:10.1111/j.1468-1331.2006.01342.x
更新日期:2006-07-01 00:00:00
abstract::Moyamoya angiopathy (MA) is a progressive cerebrovascular disease with a poorly understood pathophysiology. It is mainly characterized by progressive bilateral stenosis of the terminal intracranial part of the supraclinoid internal carotid arteries and the proximal parts of the middle and anterior cerebral arteries, a...
journal_title:European journal of neurology
pub_type: 杂志文章,评审
doi:10.1111/ene.14754
更新日期:2021-01-23 00:00:00
abstract:BACKGROUND AND PURPOSE:Charcot-Marie-Tooth (CMT) 1C due to mutations in LITAF/SIMPLE is a rare subtype amongst the autosomal dominant demyelinating forms of CMT. Our objective was to report the clinical and electrophysiological characteristics of 18 CMT1C patients and compare them to 20 patients with PMP22 mutations: 1...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13239
更新日期:2017-03-01 00:00:00
abstract::To determine whether eosinophils play a critical role in muscle fiber damage in patients with eosinophilic myositis (EM). We investigated expression of eosinophilic major basic protein (MBP) and interleukin (IL)-5 at the protein and mRNA levels in muscle biopsies from three patients with idiopathic EM. MBP deposits we...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2003.00481.x
更新日期:2003-01-01 00:00:00
abstract::In visual evoked potential studies, habituation during stimulus repetition with the same stimulus at a constant intensity has been found to be abnormal in migraineurs between attacks. The purpose of this study was to investigate habituation of somatosensory evoked potentials (SEPs) and the effects of migraine on them....
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2002.00387.x
更新日期:2002-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Comorbidity in myasthenia gravis (MG) is important for diagnosis, treatment and prognosis. Disease complexity was assessed by examining total drug treatment, immune therapy and comorbidity in a complete national MG cohort. METHODS:All recipients of the MG-specific drug pyridostigmine 2004-2010 r...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12439
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:High levels of glutamic acid decarboxylase (GAD)-ab were initially described in patients with stiff person syndrome, and have since also been observed in patients with other neurological diseases. Temporal lobe epilepsy (TLE) seems to be specially associated. Our purpose is to describe the preval...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2011.03609.x
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Impaired cortical inhibiton and maladaptive cortical plasticity are functional hallmarks of sporadic focal dystonias. Whether or not these mechanisms translate to generalized dystonias and whether these features reflect state or trait characteristics are topics of research in hereditary dystonias. METHODS:W...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2010.03054.x
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Diagnosis of pharyngeal dysphagia caused by myasthenia gravis (MG) based on clinical examination alone is often challenging. Flexible endoscopic evaluation of swallowing (FEES) combined with Tensilon (edrophonium) application, referred to as the FEES-Tensilon test, was developed to improve diagno...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13688
更新日期:2018-10-01 00:00:00
abstract:INTRODUCTION:Limited information is available about the impact of seizures on stroke outcome, health care delivery and resource utilization. OBJECTIVE:To determine whether the presence of seizures after stroke increases disability, mortality and health care utilization (length of hospital stay, ICU admission, consults...
journal_title:European journal of neurology
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1468-1331.2009.02739.x
更新日期:2010-01-01 00:00:00
abstract::We here present the case of a patient with a sleep disturbance attributed to the exploding head syndrome, recently redefined as 'episodic cranial sensory shock'. The patient, who suffered with concomitant migraine, was treated for headache prevention with daily single-pulse transcranial magnetic stimulation. Following...
journal_title:European journal of neurology
pub_type:
doi:10.1111/ene.14747
更新日期:2021-01-18 00:00:00
abstract:BACKGROUND AND PURPOSE:Mutations in the PLA2G6 gene are causative of PLA2G6-associated neurodegeneration (PLAN), a spectrum of neurodegenerative conditions including infantile, childhood and adult onset forms. METHODS:Seventeen North African patients with a clinical suspicion of infantile-onset PLAN underwent clinical...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12552
更新日期:2015-01-01 00:00:00
abstract::Intracranial internal carotid artery (ICA) aneurysms are frequently treated either by microsurgical clipping of the aneurysm neck, by endovascular coiling of the aneurysm sac or by balloon occlusion of the parent vessel. For some broad-based aneurysms that may not be suitable for any of these options, microsurgical wr...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2003.00546.x
更新日期:2003-03-01 00:00:00
abstract:BACKGROUND:X-linked Charcot-Marie-Tooth disease (CMTX), caused by mutations in the gene encoding connexin32, is the second most common form of inherited demyelinating neuropathy, next to CMT 1A, and accounts for 10-20% of all hereditary demyelinating neuropathies. AIMS OF THE STUDY:To describe clinical and electrophys...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2008.02263.x
更新日期:2008-10-01 00:00:00