Abstract:
:We performed a placebo-controlled cross-over trial of riluzole (100 mg b.i.d.) in 10 patients with probable multiple system atrophy (MSA) administering riluzole and placebo for 4 weeks each with a 4-week washout period. Outcome measures evaluated short-term anti-Parkinsonian effects using the Unified Parkinson's Disease Rating Scale (UPDRS) subscales (UPDRS-II, activities of daily living; UPDRS-III, motor examination; sum of UPDRS-II and -III) before and at the end of each treatment phase. Delta values were calculated by subtracting the UPDRS scores measured at the end of each treatment arm from those before onset of each medication phase. Riluzole was generally well tolerated. There were no significant anti-Parkinsonian effects of riluzole comparing the UPDRS delta values for both treatment arms using the Wilcoxon signed-rank test. It is unlikely that riluzole treatment could have clinically meaningful anti-Parkinsonian effects in MSA. A trial assessing the disease-modifying potential of riluzole in MSA is underway.
journal_name
Eur J Neuroljournal_title
European journal of neurologyauthors
Seppi K,Peralta C,Diem-Zangerl A,Puschban Z,Mueller J,Poewe W,Wenning GKdoi
10.1111/j.1468-1331.2006.01452.xsubject
Has Abstractpub_date
2006-10-01 00:00:00pages
1146-8issue
10eissn
1351-5101issn
1468-1331pii
ENE1452journal_volume
13pub_type
杂志文章,随机对照试验abstract::The aim of this study was to compare the clinically based prevalence of myasthenia gravis (MG) with the prevalence of laboratory-confirmed cases. All patients with a diagnosis of MG living in Estonia as on 1 January 1997 were asked to participate in re-examination. The criteria for laboratory-supported MG were weaknes...
journal_title:European journal of neurology
pub_type: 杂志文章
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journal_title:European journal of neurology
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journal_title:European journal of neurology
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journal_title:European journal of neurology
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journal_title:European journal of neurology
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pub_type: 杂志文章,实务指引
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journal_title:European journal of neurology
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journal_title:European journal of neurology
pub_type: 杂志文章,评审
doi:10.1111/ene.14754
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2006.01574.x
更新日期:2007-02-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
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更新日期:2008-12-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
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journal_title:European journal of neurology
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journal_title:European journal of neurology
pub_type: 杂志文章
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journal_title:European journal of neurology
pub_type: 共识发展会议,杂志文章,实务指引
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journal_title:European journal of neurology
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journal_title:European journal of neurology
pub_type: 杂志文章,实务指引
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更新日期:2011-06-01 00:00:00
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journal_title:European journal of neurology
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journal_title:European journal of neurology
pub_type: 杂志文章,实务指引
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更新日期:2017-10-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章,多中心研究
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更新日期:2013-01-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
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更新日期:2014-05-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
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更新日期:2016-07-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
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更新日期:2009-07-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2008.02164.x
更新日期:2008-09-01 00:00:00