Abstract:
BACKGROUND AND PURPOSE:Cognitive impairment is common in Parkinson's disease (PD), even in the early stages. We aimed to assess the relationship between insulin-like growth factor-1 (IGF-1) and cognitive functions in early, drug-naïve patients with PD. METHODS:Serum IGF-1 was measured in 65 early, drug-naïve patients with PD that underwent a complete neuropsychological battery at baseline and after 2 years. Linear regression analysis was used to evaluate the relationships between neuropsychological scores and IGF-1. Repeated-measures anova was applied to assess changes in neuropsychological variables over time. RESULTS:At baseline, IGF-1 levels were related to phonological fluency. At follow-up, IGF-1 levels were associated with the Rey auditory verbal learning test (RAVLT) - immediate and delayed recall, Frontal Assessment Battery, verbal span and Benton judgement of the line orientation test. Patients with low IGF-1 levels at baseline showed a significantly faster decline of performances than patients with high IGF-1 levels on immediate and delayed recall of the RAVLT and interference task of the Stroop test. CONCLUSIONS:Low serum IGF-1 levels are related to poor performance on executive tasks in early, drug-naïve patients with PD, and may predict poor performance on attention/executive and verbal memory tasks after a 2-year follow-up.
journal_name
Eur J Neuroljournal_title
European journal of neurologyauthors
Pellecchia MT,Santangelo G,Picillo M,Pivonello R,Longo K,Pivonello C,Vitale C,Amboni M,De Rosa A,Moccia M,Erro R,De Michele G,Santoro L,Colao A,Barone Pdoi
10.1111/ene.12137subject
Has Abstractpub_date
2014-05-01 00:00:00pages
802-7issue
5eissn
1351-5101issn
1468-1331journal_volume
21pub_type
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