Abstract:
:Visual system dysfunction has been reported in Parkinson's disease (PD). The objective of the present study was to evaluate a putative association of distorted colour vision and delayed initiation and execution of movement in PD. We performed the Farnsworth-Munsell 100-hue test and estimated the total error score in 30 previously untreated parkinsonian patients and 30 age- and sex-matched controls. We then determined slowness in motor readiness and motor programming in the parkinsonian subjects on the same day. Subjects were asked to press a start button and release it after the randomized appearance of a visual stimulus and to move their right index finger to a reaction button as quickly as possible. Reaction time was considered as elapsed time between onset of the stimulus light and release of the start button, movement time was the time period between release of the start button and the pressing of the reaction button. Significant differences appeared between parkinsonian patients' and controls' reaction times (P = 0.007), movement time (P = 0.001) and total error score (P = 2.23E-08). A significant relation (Spearman R = 0.473, P = 0.008) was found between movement time and total error score, but not between reaction time and total error score (Spearman R = 0.259, P = 0.166). We conclude, that visual dysfunction and execution of movement are more influenced by altered dopaminergic neurotransmission in PD in comparison to the initiation of movement.
journal_name
Eur J Neuroljournal_title
European journal of neurologyauthors
Müller T,Kuhn W,Büttner T,Przuntek Hdoi
10.1046/j.1468-1331.1999.660711.xsubject
Has Abstractpub_date
1999-11-01 00:00:00pages
711-5issue
6eissn
1351-5101issn
1468-1331pii
NE060612journal_volume
6pub_type
杂志文章abstract:BACKGROUND:We investigated whether the prevalence of primary headaches was higher in patients with primary Sjøgren's syndrome (PSS) than in healthy individuals. METHODS:This retrospective cohort study included 71 patients with PSS (patients) based on the American European Consensus Classification criteria, and 71 age-...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12033
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although there are a number of positive reports on the therapeutic effects of repetitive transcranial magnetic stimulation (rTMS) for treatment of tinnitus, there are few details about the duration of treatment effects or the relative efficiency of different rTMS protocols. METHODS:Sixty six pat...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2008.02522.x
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journal_title:European journal of neurology
pub_type: 杂志文章
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更新日期:2020-12-16 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章,评审
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更新日期:2006-02-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
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journal_title:European journal of neurology
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更新日期:2014-07-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
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pub_type: 杂志文章,实务指引
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journal_title:European journal of neurology
pub_type: 杂志文章
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journal_title:European journal of neurology
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journal_title:European journal of neurology
pub_type: 杂志文章
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更新日期:1999-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Thirty per cent of amyotrophic lateral sclerosis (ALS) patients have non-motor symptoms, including executive and memory deficits. The in vivo anatomical basis of memory deficits in ALS has not been elucidated. In this observational study, brain atrophy in relation to memory function was investiga...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12615
更新日期:2015-03-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2007.01986.x
更新日期:2007-12-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章,评审
doi:10.1111/j.1468-1331.2012.03842.x
更新日期:2013-03-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14406
更新日期:2020-11-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2012.03714.x
更新日期:2012-10-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2006.01488.x
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2012.03821.x
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2002.00408.x
更新日期:2002-05-01 00:00:00
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journal_title:European journal of neurology
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doi:10.1111/j.1468-1331.2005.01098.x
更新日期:2005-12-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2012.03825.x
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Despite recent advances in neurogenetics that have facilitated the identification of a number of dystonia genes, many familial dystonia syndromes remain without known cause. The aim of the study was to identify the cause of autosomal dominant tremulous myoclonus-dystonia in a UK kindred with affe...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14228
更新日期:2020-08-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章,多中心研究
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更新日期:2010-02-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12560
更新日期:2015-02-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章,评审
doi:10.1111/ene.13775
更新日期:2019-03-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章
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更新日期:2006-10-01 00:00:00
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journal_title:European journal of neurology
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1468-1331.2008.02194.x
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:X-linked Charcot-Marie-Tooth disease (CMTX), caused by mutations in the gene encoding connexin32, is the second most common form of inherited demyelinating neuropathy, next to CMT 1A, and accounts for 10-20% of all hereditary demyelinating neuropathies. AIMS OF THE STUDY:To describe clinical and electrophys...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2008.02263.x
更新日期:2008-10-01 00:00:00